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| 1 | Antioxidative and anti-endotoxin effects of propofol on endothelial cells显示文摘Objective To investigate the antioxidant and anti-endotoxin effects of propofol on endothelial cells and the possible mechanisms.Methods Cultured endothelial cells were treated with hydrogen peroxide (H 2O 2), propofol + H 2O 2, lipopolysaccharide (LPS) and propofol + LPS, respectively. Endothelial cell damage was monitored for possible lactic dehydrogenase (LDH) release. The transcription and the protein expression levels of endothelial nitric oxide synthase (eNOS) were measured.Results LDH release was higher in groups treated with H 2O 2 or LPS than in the control group. After pretreatment with propofol, the effects induced by H 2O 2 were attenuated, but propofol did not decrease the LDH release induced by LPS. Both H 2O 2 and LPS significantly increased the eNOS transcript levels and the increases were significantly attenuated after pretreatment with propofol. Both H 2O 2 and LPS significantly increased the eNOS protein expression and the increase was attenuated after pretreatment with propofol. Conclusion Propofol could protect endothelial cells against oxidative stress by inhibiting eNOS transcription and protein expression, but could not antagonise endotoxin induced cell injuries. | 彭志勇 罗敏 叶仕桥 Critchley Lester AH Joynt Gavin M Ho Anthony MH 姚尚龙 | 2003 | Chinese Medical Journal2003，，5： | 7 |
| 2 | Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-1igase signaling effector DWARF3显示文摘 | Li-Hua Zhao X Edward Zhou Wei Yi Zhongshan Wu Yue Liu Yanyong Kang Li Hou Parker W de Waal Suling Li Yi Jiang Adrian Scaffidi Gavin R Flematti Steven M Smith Vinh Q Lam Patrick R Griffin YonghongWang Jiayang Li Karsten Melcher H Eric Xu | 2015 | Cell Research2015，25，11： | 7 |
| 3 | 动态88小时:美国地质调查局国家地震信息中心对2011年3月11日M_W9.0日本地震的响应显示文摘引言
2011年3月11日日本本州岛东海岸附近海域发生的M9.0地震(Tohoku earthquake,以下称“东日本大地震”——译者注)及其引发的海啸造成数以万计的人员死亡,造成的财产损失可能超过1万亿美元,这是有历史记录以来最严重的自然灾害之一。 | Gavin P Hayes Paul S Earle Harley M Benz David J Wald Richard W Briggs 左玉玲(译) 郑需要(校) | 2011 | 国际地震动态2011，，8： | 4 |
| 4 | CD133 expression is not restricted to stem cells, and both CD133^sup +^ and CD133^sup -^ metastatic colon cancer cells initiate tumors显示文摘 | Shmelkov Sergey V Butler Jason M Hooper Andrea T Hormigo Adilia Kushner Jared Milde Till Clair Ryan St Baljevic Muhamed White Ian Jin David K Chadburn Amy Murphy Andrew J Valenzuela David M Gale Nicholas W Thurston Gavin Yancopoulos George | 2008 | Journal of Clinical Investigation2008，，： | 2 |
| 5 | A next-generation marker genotyping platform(AmpSeq)in heterozygous crops:a case study for marker-assisted selection in grapevine显示文摘Marker-assisted selection(MAS)is often employed in crop breeding programs to accelerate and enhance cultivar development,via selection during the juvenile phase and parental selection prior to crossing.Next-generation sequencing and its derivative technologies have been used for genome-wide molecular marker discovery.To bridge the gap between marker development and MAS implementation,this study developed a novel practical strategy with a semi-automated pipeline that incorporates trait-associated single nucleotide polymorphism marker discovery,low-cost genotyping through amplicon sequencing(AmpSeq)and decision making.The results document the development of a MAS package derived from genotyping-by-sequencing using three traits(flower sex,disease resistance and acylated anthocyanins)in grapevine breeding.The vast majority of sequence reads(⩾99%)were from the targeted regions.Across 380 individuals and up to 31 amplicons sequenced in each lane of MiSeq data,most amplicons(83 to 87%)had<10%missing data,and read depth had a median of 220–244×.Several strengths of the AmpSeq platform that make this approach of broad interest in diverse crop species include accuracy,flexibility,speed,high-throughput,low-cost and easily automated analysis. | Shanshan Yang Jonathan Fresnedo-Ramíre Minghui Wang Linda Cote Peter Schweitzer Paola Barba Elizabeth M Takacs Matthew Clark James Luby David C Manns Gavin Sacks Anna Katharine Mansfield Jason Londo Anne Fennell David Gadoury Bruce Reisch Lance Cadle-Davidson Qi Sun | 2016 | Horticulture Research2016，3，1： | 2 |
| 6 | TGF-betal maintains suppressor function and Foxp3 expression in CD4^+ CD25^+ regulatory T cells显示文摘 | Marie J C Letterio J J Gavin M Rudensky A Y | 2005 | J Exp Med2005，201，： | 1 |
| 7 | Foxp3 programs the development and function of CD4 + CD25 + regulatory T cells显示文摘 | Gavin M A Rudensky A Y | 2003 | Nature Immunology2003，4，4： | 1 |
| 8 | FoxP3 programs the development and function of CD4+CD25+ regulatory T cells显示文摘 | Fontenot J D Gavin M A Rudensky A Y | 2003 | Nat Immunol2003，4，4： | 1 |
| 9 | Base resistance of jacked pipe piles in sand显示文摘 | LEHANE B M GAVIN K G | 2001 | Journal of Geotechnical and Geoenvironmental Engineering2001，127，6： | 1 |
| 10 | TGF-bl maintains suppressor function and Foxp3 expression in CD4^ + CD25 ^+ regulatory T cells 显示文摘 | Marie JC Letterio JJ Gavin M | 2005 | J Exp Med2005，201，： | 1 |
| 11 | TGF-betal maintains suppressor function and Foxp3 expression in CD4^+CD25^+ regulatory T cells 显示文摘 | Marie JC Letterio JJ Gavin M | 2005 | J Exp Med2005，201，7： | 1 |
| 12 | Foxp3 pro- grams the development and function of CD4 + CD25 + reg- ulatory T cells显示文摘 | Fontenot J D Gavin M A Rudensky A Y | 2003 | Nat Immunol2003，4，4： | 1 |
| 13 | Centering decisions in hier- archical linear models: implications for research in organizations 显示文摘 | Hofmann D A Gavin M B | 1998 | Journal of Management1998，24，5： | 1 |
| 14 | Novel clinical markers of vascular wall inflammation显示文摘 | Gavin J Blake Paul M Rider | 2001 | Circ Res2001，89，： | 1 |
| 15 | Spatial statistical methods in environmental epidemiology:a critique显示文摘 | Paul E Marco M Gavin S | 1995 | Statistical Methods in Medical Research1995，4，： | 1 |
| 16 | FOXP3 and NFAT: partners in tolerance 显示文摘 | Rudensky AY Gavin M Zheng Y | 2006 | Cell2006，126，2： | 1 |
| 17 | An antigen produced by splicing of noncontiguous peptides in the reverse order 显示文摘 | Warren E H Vigneron N J Gavin M A | 2006 | Science2006，313，5792： | 1 |
| 18 | Foxp3 programs the development and function of CD4^+ CD25^+ regulatory T cells 显示文摘 | Fontenot J D Gavin M A Rudensky A Y | 2003 | Nat Immunol2003，4，： | 1 |
| 19 | Safety and efficacy of perioperative cell salvage and autotransfusion after coronary artery bypass grafting: a randomized trial 显示文摘 | Gavin J Murphy MD Simon M | 2004 | Ann thorac surg2004，77，： | 1 |
| 20 | Foxp3 programs the development and function of CD4+CD25+ regulatory T cells显示文摘 | Fontenot J D Gavin M A Rudensky A Y | 2003 | Nat Immunol2003，4，4： | 1 |
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