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| 1 | Cyclooxygenase-2 plays a central role in the genesis of pancreatitis and associated lung injury显示文摘BACKGROUND: The exact mechanism by which cyclooxy- genase-2 (COX-2) promotes inflammation in pancreatitis in obscure. This study was undertaken to investigate the role of COX-2 inhibition in an animal model of pancreati- tis , a disease process characterized by a systemic inflamma- tory response and ensuing neutrophil-mediated lung injury. METHODS: Pancreatitis was induced in 24 Sprague-Daw- ley rats by intraperitoneal injection of 20% L-arginine (500 mg/100 g body weight). The animals were randomized into 3 groups (8 rats in each group); controls and rats with pancreatitis intravenously resuscitated with either normal saline (0.9% NaCl 3 ml/kg) at 24 and 48 hours or COX-2 inhibitor (parecoxib 1 mg/kg). Pancreatic and lung inju- ries were assessed histologically. Lung injury was assessed utilizing wet;dry ratio and myeloperoxidase activity to in- dicate pulmonary neutrophil infiltration. A Western blot was used to determine COX-2 protein expression in pancrea- tic tissue. RESULTS: The animals treated with COX-2 inhibitors dis- played significantly less pancreatic and lung injuries than their normal saline counterparts. Histological pancreatic and lung injury scores were significantly reduced (P <0.05) in the COX-2 treated group. Lung wet: dry ratios were sig- nificantly improved and pulmonary neutrophil infiltration was attenuated in the COX-2 group (P<0.05). Western blot analysis confirmed attenuated COX-2 protein expression. CONCLUSION: This study shows, for the first time in a rat model, that adjuvant COX-2 inhibition significandy attenu- ates the severity of both pancreatitis and its associated sys- temic inflammatory response and end-organ injury. | Gavin O'Brien Conor J Shields Desmond C Winter John P Dillon | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，1： | 12 |
| 2 | Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies显示文摘在地岬基因的 Oncogenic 变化在人的癌症是很普通的,导致有描绘得好的选择优点,而且不太听说得好的危险的房间。我们执行了一幅大规模 loss-of-function 屏幕识别被转变 KRAS 的结肠癌房间,然而并非由缺乏这 oncogene 的衍生物要求的基因。最高得分的基因然后在 KRAS 变异、野类型的癌症房间的一块更大的面板被测试。表示 oncogenic KRAS 的癌症房间被发现高度依赖于抄写因素 GATA2 和 DNA 复制开始管理者 CDC6。与已知的目标用许多药扩大这分析,我们发现有变异的 KRAS 的癌症房间与 topoisomerase 抑制显示出选择嗜好到 proteasome 功能,以及合成致命性。联合指向引起的这些功能改善了相对野类型的房间 KRAS 变异的房间杀死。这些观察建议新奇目标和在地岬变异的癌症为最佳的效果联合存在治疗的新方法,它传统地被看作对治疗高度倔强。 | Michael Steckel Miriam Molina-Arcas Britta Weigelt Michaela Marani Patricia H Warne Hanna Kuznetsov Gavin Kelly Becky Saunders Michael Howell Julian Downward David C Hancock | 2012 | Cell Research2012，22，8： | 5 |
| 3 | A next-generation marker genotyping platform(AmpSeq)in heterozygous crops:a case study for marker-assisted selection in grapevine显示文摘Marker-assisted selection(MAS)is often employed in crop breeding programs to accelerate and enhance cultivar development,via selection during the juvenile phase and parental selection prior to crossing.Next-generation sequencing and its derivative technologies have been used for genome-wide molecular marker discovery.To bridge the gap between marker development and MAS implementation,this study developed a novel practical strategy with a semi-automated pipeline that incorporates trait-associated single nucleotide polymorphism marker discovery,low-cost genotyping through amplicon sequencing(AmpSeq)and decision making.The results document the development of a MAS package derived from genotyping-by-sequencing using three traits(flower sex,disease resistance and acylated anthocyanins)in grapevine breeding.The vast majority of sequence reads(⩾99%)were from the targeted regions.Across 380 individuals and up to 31 amplicons sequenced in each lane of MiSeq data,most amplicons(83 to 87%)had<10%missing data,and read depth had a median of 220–244×.Several strengths of the AmpSeq platform that make this approach of broad interest in diverse crop species include accuracy,flexibility,speed,high-throughput,low-cost and easily automated analysis. | Shanshan Yang Jonathan Fresnedo-Ramíre Minghui Wang Linda Cote Peter Schweitzer Paola Barba Elizabeth M Takacs Matthew Clark James Luby David C Manns Gavin Sacks Anna Katharine Mansfield Jason Londo Anne Fennell David Gadoury Bruce Reisch Lance Cadle-Davidson Qi Sun | 2016 | Horticulture Research2016，3，1： | 2 |
| 4 | TGF-betal maintains suppressor function and Foxp3 expression in CD4^+ CD25^+ regulatory T cells显示文摘 | Marie J C Letterio J J Gavin M Rudensky A Y | 2005 | J Exp Med2005，201，： | 1 |
| 5 | Proteome survey reveals modularity of the yeast cell machinery 显示文摘 | GAVIN A C ALOY P GRANDI P | 2006 | Nature2006，440，7084： | 1 |
| 6 | Protein complexes and proteome organization from yeast to man显示文摘 | Gavin A C Superti Furga G | 2003 | Curr Opin Chem Biol2003，7，1： | 1 |
| 7 | Hysterectomy is associat- ed with large artery stiffening in estrogen - deficient postmenopausal women 显示文摘 | Gavin KM Jankowski C Kohrt WM | 2012 | Menopause2012，19，9： | 1 |
| 8 | Effect of friction fatigue on pile capacity in dense sand显示文摘 | Gavin Kenneth G O'Kelly Brendan C | 2007 | Journal of Geotechnical and Geo-environmental Engineering2007，133，1： | 1 |
| 9 | Mechanisms of resistance to the cytotoxic effects of oxysterols in human leukemic cells显示文摘 | Claudia C Gregorio-King Tamara Gough Gavin J Van Der Meer Jane B Hosking Caryll M Waugh Janet L McLeod Fiona Mc Collier Mark A Kirkland | 2004 | Journal of Steroid Biochemistry and Molecular Biology2004，，3： | 1 |
| 10 | Proteome survey reveals modularity of the yeast cell machinery 显示文摘 | GAVIN A C ALOY P GRANDI P | 2006 | Na- ture2006，440，7084： | 1 |
| 11 | Manganese and calcium transport in mitochondria: implications for manganese toxicity 显示文摘 | GAVIN C E GUNTER K K GUNTER T E | 1999 | Neurotoxicology1999，20，23： | 1 |
| 12 | Functional organization of the yeast proteome by systematic analysis of protein complexes显示文摘 | Gavin A C Bosche M Krause R | 2002 | Nature2002，415，6868： | 1 |
| 13 | An early and sustained peripheral inflammatory response in acute ischaemic stroke :relationships with infection and atherosclerosis显示文摘 | Emsley HC Smith C J Gavin CM | 2003 | J Neuroimmuno12003，139，1： | 1 |
| 14 | Medial artery calcification as an indicator of diabetic peripheral vascular disease 显示文摘 | David Smith C Gavin Bilmen J ighal S | 2008 | Foot Ankle Int2008，29，2： | 1 |
| 15 | High power,low frequency uhrasound:meniscal tissue interaction and ablation characteristics 显示文摘 | Morris E Gavin GP O' Keane C | 2011 | Ultrasound Med Biol2011，37，4： | 1 |
| 16 | Drug target identification using side-effect similarity 显示文摘 | Campillos M Kuhn M Gavin A C | 2008 | Science2008，321，5886： | 1 |
| 17 | Synaptosomal toxicity and nucleophilic targets of 4-hydroxy-2-nonenal 显示文摘 | LOPACHINRM GEOHAGEN B C GAVIN T | 2009 | Toxicol Sci2009，107，1： | 1 |
| 18 | Notch signaling in development and disease显示文摘 | Emil MH Urban L Gavin C | 2004 | Seminars in Cancer Biology2004，14，5： | 1 |
| 19 | Lung function prediction equations derived from health South African gold miners显示文摘 | Eva H Gavin C Rob D | 2000 | Occup Environ Med2000，57，： | 1 |
| 20 | TGF-batel maintains suppressor function and Foxp3 expression in CD4CD25+ regulatory T cells 显示文摘 | MAIE J C LETYERIO J J GAVIN M A | 2005 | J ExpMed2005，201，： | 1 |
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