|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | AJCN:过敏症来袭怎么办?新型益生菌组合疗法显神效显示文摘当进入过敏季节我们可能并不太会拿出手帕或者打喷嚏来预防过敏。日前,一项刊登在国际杂志The American Journal of Clinical Nutrition上的研究报告中。来自佛罗里达大学的研究人员通过研究发现。一种益生菌组合或许能够帮助减轻花粉症的症状。 | Jennifer C Dennis-Wall Tyler Culpepper Carmelo Nieves Jr. Cassie C Rowe Alyssa M Burns Carley T Rusch Ashton Federico Maria Ukhanova Sheldon Waugh Volker Mai Mary C Christman Bobbi Langkamp-Henken | 2017 | 现代生物医学进展2017，17，18： | 3 |
| 2 | The genome and gene editing system of sea barleygrass provide a novel platform for cereal domestication and stress tolerance studies显示文摘The tribe Triticeae provides important staple cereal crops and contains elite wild species with wide geneticdiversity and high tolerance to abiotic stresses. Sea barleygrass (Hordeum marinum Huds.), a wildTriticeae species, thrives in saline marshlands and is well known for its high tolerance to salinity and waterlogging. Here, a 3.82-Gb high-quality reference genome of sea barleygrass is assembled de novo, with 3.69Gb (96.8%) of its sequences anchored onto seven chromosomes. In total, 41 045 high-confidence (HC)genes are annotated by homology, de novo prediction, and transcriptome analysis. Phylogenetics, nonsynonymous/synonymous mutation ratios (Ka/Ks), and transcriptomic and functional analyses provide genetic evidence for the divergence in morphology and salt tolerance among sea barleygrass, barley, andwheat. The large variation in post-domestication genes (e.g. IPA1 and MOC1) may cause interspecies differences in plant morphology. The extremely high salt tolerance of sea barleygrass is mainly attributed tolow Na+ uptake and root-to-shoot translocation, which are mainly controlled by SOS1, HKT, and NHX transporters. Agrobacterium-mediated transformation and CRISPR/Cas9-mediated gene editing systems weredeveloped for sea barleygrass to promote its utilization for exploration and functional studies of hubgenes and for the genetic improvement of cereal crops. | Liuhui Kuang Qiufang Shen Liyang Chen Lingzhen Ye Tao Yan Zhong-Hua Chen Robbie Waugh Qi Li Lu Huang Shengguan Cai Liangbo Fu Pengwei Xing Kai Wang Jiari Shao Feibo Wu Lixi Jiang Dezhi Wu Guoping Zhang | 2022 | Plant Communications2022，3，5： | 2 |
| 3 | Detection of genetic diversity in tea (Camellia sinensis) using RAPD markers显示文摘 | Wachira F N Waugh R Hackett C A | 1995 | Genome1995，38，2： | 2 |
| 4 | Distribution and molecular forms of urotensin Ⅱ and its role in cardiovascular regulation in vertebrates 显示文摘 | Gonlon JM Yano K Waugh D | 1996 | J Exp Zool1996，275，2： | 2 |
| 5 | Use of siRNA molecular beacons to detect and attenuate mycobacterial infection in macrophages显示文摘Tuberculosis is one of the leading infectious diseases plaguing mankind and is mediated by the facultative pathogen, Mycobacterium tuberculosis(MTB). Once the pathogen enters the body, it subverts the host immune defenses and thrives for extended periods of time within the host macrophages in the lung granulomas, a condition called latent tuberculosis(LTB). Persons with LTB are prone to reactivation of the disease when the body's immunity is compromised. Currently there are no reliable and effective diagnosis and treatment options for LTB, which necessitates new research in this area. The mycobacterial proteins and genes mediating the adaptive responses inside the macrophage is largely yet to be determined. Recently, it has been shown that the mce operon genes are critical for host cell invasion by the mycobacterium and for establishing a persistent infection in both in vitro and in mouse models of tuberculosis. The Yrb E and Mce proteins which are encoded by the MTB mce operons display high degrees of homology to the permeases and the surface binding protein of the ABC transports, respectively. Similarities in structure and cell surface location impute a role in cell invasion at cholesterol rich regions and immunomodulation. The mce4 operon is also thought to encode a cholesterol transport system that enables the mycobacterium to derive both energy and carbon from the host membrane lipids and possibly generating virulence mediating metabolites, thus enabling the bacteria in its long term survival within the granuloma. Various deletion mutation studies involving individual or whole mce operon genes have shown to be conferring varying degrees of attenuation of infectivity or at times hypervirulence to the host MTB, with the deletion of mce4 A operon gene conferring the greatest degree of attenuation of virulence. Antisense technology using synthetic si RNAs has been used in knocking down genes in bacteria and over the years this has evolvedinto a powerful tool for elucidating the roles of various genes mediating infectivity and survival in mycobacteria. Molecular beacons are a newer class of antisense RNA tagged with a fluorophore/quencher pair and their use for in vivo detection and knockdown of mR NA is rapidly gaining popularity. | Remo George Renata Cavalcante Celso Carvalho Jr Elyana Marques Jonathan B Waugh M Tino Unlap | 2015 | World Journal of Experimental Medicine2015，5，3： | 2 |
| 6 | Urine protein estimation in hypertensive pregnancy: which thresholds and laboratory assay best predict clinical outcome? 显示文摘 | Waugh J Bell SC Kilby MD | 2005 | Hypertens Pregnancy2005，24，3： | 1 |
| 7 | Computational and experimental character- ization of physically clustered simple sequence repeats in plants显示文摘 | CARDLE L RAMSAY L MILBOURNE D MACAULAY M MARSHALL D WAUGH R | 2000 | Genetics2000，156，： | 1 |
| 8 | Latex condom breakage and slippage in a controlled clinical trial显示文摘 | Rosenberg MJ Waugh MS | 1997 | Contraception1997，56，1： | 1 |
| 9 | Detection of genetic diversity in tea(Camellia sinensis) using RAPD Markers显示文摘 | Wachira F N Waugh R Hackett C A | 1995 | Genome1995，38，： | 1 |
| 10 | Detection of genetic diversity in tea (Camellia sinensis) using RAPD Markers显示文摘 | Wachira F N Waugh R Hackett C A | 1995 | Genome1995，38，： | 1 |
| 11 | The nature and designation of osteoarthrisis determined by its histopathology显示文摘 | SOREN A COOPER N S WAUGH T R | 1988 | Clin Exp Rheumatol1988，6，1： | 1 |
| 12 | Differentialeffects of short affinity tags on the crystallization of Pyro-coccus furiosus maltodextrin-binding protein显示文摘 | Bucher M H Evdokimov A G Waugh D S | 2002 | ActaCrystallogr Biol Crystallogr2002，58，3： | 1 |
| 13 | Calibration Precision of Capacitance and Neutron Soil Water Content Gauges in Arid Soils显示文摘 | WAUGH W J BAKER D A KASTENS M K | 1996 | Arid Soil Research and Rehabilitation1996，10，： | 1 |
| 14 | Detection of genetic diversity in tea (Camellia Sinensis) using RAPD markers显示文摘 | Wichita F N Waugh R Hackett C A | 1995 | Genome1995，38，： | 1 |
| 15 | Escitalopram a review of its use in the manage- ment of major depressive and anxiety disorders显示文摘 | Waugh J Coa K I | 2003 | CNS Drugs2003，17，5： | 1 |
| 16 | Incidental gallblad- der cancer:Analysis of surgical findings and survivor显示文摘 | Butte JM Waugh E Meneses M | 2010 | J Surg 0ncol2010，102，6： | 1 |
| 17 | Improving the Social Skills of Children with HFASD:an intervention study显示文摘 | Waugh C Peskin J | 2015 | J Autism Dev Disord2015，45，9： | 1 |
| 18 | Incidental gallbladder cancer: Analysis of surgical findings and survivor 显示文摘 | Butte JM Waugh E Meneses M | 2010 | J Surg Oncol2010，102，6： | 1 |
| 19 | Methanol synthesis 显示文摘 | Waugh K C | 1992 | Catalysis Today1992，15，： | 1 |
| 20 | Approach to high-resolution NMR in solids显示文摘 | Waugh J S Huber L M Haeberlen U | 1968 | Phys Rev Lett1968，20，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员