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| 1 | Role of illness perception and self-efficacy in lifestyle modification among non-alcoholic fatty liver disease patients显示文摘AIM To describe the relationships between non-alcoholic fatty-liver disease(NAFLD) patient's disease consequences and treatment perceptions, self-efficacy, and healthy lifestyle maintenance. METHODS A cross-sectional study among 146 ultrasound diagnosed NAFLD patients who visited the fatty liver clinic at the TelAviv Medical Center. Eighty-seven of these individuals, participated in a clinical trial of physical activity and underwent fasting blood tests, analyzed at the same lab. Exclusion criteria included positivity for serum HBsA g or anti-HCV antibodies; fatty liver suspected to be secondary to hepatotoxic drugs; excessive alcohol consumption(≥ 30 g/d in men or ≥ 20 g/d in women) and positive markers of genetic or immune-mediated liver diseases. Patients were asked to complete a selfreport structured questionnaire, assembled by the Israeli Center for Disease Control. Nutrition habits were measured using six yes/no questions(0 = no, 1 = yes) adopted from the national survey questionnaire. Participants in the clinical trial completed a detailed semi-quantitative food frequency questionnaire(FFQ) reporting their habitual nutritional intake during the past year. Self-efficacy was assessed by the Self-Efficacy Scale questionnaire, emotional representation, degree of illness understanding, timeline perception, treatment perception and symptoms were measured by the Brief Illness Perception questionnaire. Illness consequences were measured by the Personal Models of Diabetes Interview questionnaire. A path analysis was performed to describe the interrelationships between the patients' illness perceptions, and assess the extent to which the data fit a prediction of nutritional habits.RESULTS The study sample included 54.1% men, with a mean age of 47.76 ± 11.68 years(range: 20-60) and mean body mass index of 31.56 ± 4.6. The average perceived nutrition habits score was 4.73 ± 1.45 on a scale between 0-6, where 6 represents the healthiest eating habits. Most of the study participants(57.2%) did not feel they fully understood what NAFLD is. Better nutritional habits were positively predicted by the degree of illness understanding(β = 0.26; P = 0.002) and selfefficacy(β = 0.25; P = 0.003). Perceptions of more severe illness consequences were related with higher emotional representation(β = 0.55; P < 0.001), which was related with lower self-efficacy(β =-0.17; P = 0.034). The perception of treatment effectiveness was positively related with self-efficacy(β = 0.32; P < 0.001). In accordance with the correlation between self-efficacy and the perceived nutrition habits score, self-efficacy was also correlated with nutrient intake evaluated by the FFQ; negatively with saturated fat(percent of saturated fat calories from total calories)(r =-0.28, P = 0.010) and positively with fiber(r = 0.22, P = 0.047) and vitamin C intake(r = 0.34, P = 0.002). In a sub analysis of the clinical trial participants, objectively measured compliance to physical activity regimen was positively correlated with the self-efficacy level(r = 0.34, P = 0.046). CONCLUSION Self-efficacy and illness understanding are major determinants of lifestyle-modification among NAFLD patients. This information can assist clinicians in improving compliance with lifestyle changes among these patients. | Shira Zelber-Sagi Shiran Bord Gali Dror-Lavi Matthew Lee Smith Samuel D Towne Jr Assaf Buch Muriel Webb Hanny Yeshua Assy Nimer Oren Shibolet | 2017 | World Journal of Gastroenterology2017，23，10： | 6 |
| 2 | Response of Rice to Insect Elicitors and the Role of OsJAR1 in Wound and Herbivory-Induced JA-lle Accumulation显示文摘Plants produce jasmonic acid(JA) and its amino acid conjugate,jasmonoyl-L-isoleucine(JA-lle) as major defense signals in response to wounding and herbivory.In rice(Oryza sativa),JA and JA-lle rapidly increased after mechanical damage,and this increase was further amplified when the wounds were treated with oral secretions from generalist herbivore larvae,lawn armyworms(Spodoptera mauritia),revealing for the first time active perception mechanisms of herbivore-associated elicitor(s) in rice.In the rice genome, two OsJAR genes can conjugate JA and lle and form JA-lle in vitro;however,their function in herbivoryinduced accumulation of JA-lle has not been investigated.By functional characterization of TOS17 retrotransposon-tagged Osjar1 plants and their response to simulated herbivory,we show that OsJAR1 is essential for JA-lle production in herbivore-attacked,field-grown plants.In addition,OsJAFM was required for normal seed development in rice under field conditions.Our results suggest that OsJAR1 possesses at least two major functions in rice defense and development that cannot be complemented by the additional OsJAR2 gene function,although this gene previously showed overlapping enzyme activity in vitro. | Kaori Fukumoto Kabir Md Alamgir Yuko Yamashita Izumi C.Mori Hideyuki Matsuura Ivan Galis | 2013 | Journal of Integrative Plant Biology2013，55，8： | 5 |
| 3 | Functional optoacoustic neuro-tomography for scalable whole-brain monitoring of calcium indicators显示文摘Non-invasive observation of spatiotemporal activity of large neural populations distributed over entire brains is a longstanding goal of neuroscience.We developed a volumetric multispectral optoacoustic tomography platform for imaging neural activation deep in scattering brains.It can record 100 volumetric frames per second across scalable fields of view ranging between 50 and 1000 mm^(3) with respective spatial resolution of 35–200μm.Experiments performed in immobilized and freely swimming larvae and in adult zebrafish brains expressing the genetically encoded calcium indicator GCaMP5G demonstrate,for the first time,the fundamental ability to directly track neural dynamics using optoacoustics while overcoming the longstanding penetration barrier of optical imaging in scattering brains.The newly developed platform thus offers unprecedented capabilities for functional whole-brain observations of fast calcium dynamics;in combination with optoacoustics'well-established capacity for resolving vascular hemodynamics,it could open new vistas in the study of neural activity and neurovascular coupling in health and disease. | X Luís Deán-Ben Gali Sela Antonella Lauri Moritz Kneipp Vasilis Ntziachristos Gil G Westmeyer Shy Shoham Daniel Razansky | 2016 | Light(Science & Applications)2016，5，1： | 5 |
| 4 | 柴达木盆地西部第四纪气候变化和流域风化显示文摘长期以来关于构造隆升、气候变化和大陆化学风化的相互关系存在诸多争议。在气候和构造相互作用典型区域建立高精度大陆化学风化序列是解决上述科学问题的有效途径之一。位于青藏高原东北缘长期封闭的柴达木盆地,其独特的位置和连续的沉积使其成为研究构造隆升、气候变化和大陆化学风化的理想场所。本文以柴达木盆地西部千米深钻SG—1钻孔高质量的连续细粒湖相岩芯为研究对象,使用盐类矿物的硫酸根和钾离子含量、碳酸盐锰含量和硅酸盐化学蚀变指数(CIA)和Nd同位素分析,重建该区第四纪以来湖泊流域气候变化过程和硅酸盐化学风化及可能的物源变化。结果表明柴达木盆地西部第四纪以来流域物源相对稳定,流域整体呈现出气候干旱化、流域硅酸盐风化强度减弱、湖水盐度增加和湖面降低的长期一致性演化过程;上述演化进程在2.2Ma到2.0Ma期间短暂加强,在约1.2Ma和约0.6~0.5Ma出现逐步加强趋势。过去60万年,柴达木盆地西部在冰期存在的相对高湖面时期与黄土高原粒度指标反映的冬季风减弱阶段可以很好对比。北大西洋海表温度反映的高纬过程是长时间尺度(〉10 5年)驱动柴达木盆地西部气候变化和流域硅酸盐风化强度变化的主要因素;西伯利亚高压系统和西风系统的“跷跷板关系”可能是冰期一间冰期或者更短尺度影响柴达木盆地西部气候变化的主要因素。 | 杨一博 方小敏 Albert Galy 杨戎生 | 2018 | 第四纪研究2018，38，1： | 5 |
| 5 | Ab initio theory of the negatively charged boron vacancy qubit in hexagonal boron nitride显示文摘Highly correlated orbitals coupled with phonons in two-dimension are identified for paramagnetic and optically active boron vacancy in hexagonal boron nitride by first principles methods which are responsible for recently observed optically detected magnetic resonance signal.Here,we report ab initio analysis of the correlated electronic structure of this center by density matrix renormalization group and Kohn-Sham density functional theory methods.By establishing the nature of the bright and dark states as well as the position of the energy levels,we provide a complete description of the magneto-optical properties and corresponding radiative and non-radiative routes which are responsible for the optical spin polarization and spin dependent luminescence of the defect.Our findings pave the way toward advancing the identification and characterization of room temperature quantum bits in two-dimensional solids. | Viktor Ivády Gergely Barcza GergőThiering Song Li Hanen Hamdi Jyh-Pin Chou Örs Legeza Adam Gali | 2020 | npj Computational Materials2020，，1： | 4 |
| 6 | First principles calculation of spin-related quantities for point defect qubit research显示文摘Point defect research in semiconductors has gained remarkable new momentum due to the identification of special point defects that can implement qubits and single photon emitters with unique characteristics.Indeed,these implementations are among the few alternatives for quantum technologies that may operate even at room temperature,and therefore discoveries and characterization of novel point defects may highly facilitate future solid state quantum technologies.First principles calculations play an important role in point defect research,since they provide a direct,extended insight into the formation of the defect states.In the last decades,considerable efforts have been made to calculate spin-dependent properties of point defects from first principles.The developed methods have already demonstrated their essential role in quantitative understanding of the physics and application of point defect qubits.Here,we review and discuss accuracy aspects of these novel ab initio methods and report on their most relevant applications for existing point defect qubits in semiconductors.We pay attention to the advantages and limitations of the methodological solutions and highlight additional developments that are expected in the near future.Moreover,we discuss the opportunity of a systematic search for potential point defect qubits,as well as the possible development of predictive spin dynamic simulations facilitated by ab initio calculations of spin-dependent quantities. | Viktor Ivády Igor A.Abrikosov Adam Gali | 2018 | npj Computational Materials2018，，1： | 4 |
| 7 | Farinose fiavonoids are associated with high freezing tolerance in fairy primrose (Primula malacoides) plants显示文摘The deposition of surface(farinose)fiavonoids on aerial parts of some Primula species is a well-documented but poorly understood phenomenon.Here,we show thatfiavonoid deposition on the leaves and winter buds may contribute strongly to preventing freezing damage in these plants.The ice nucleation temperature of fairy primrose(Primula malacoides)leaves covered with naturalfiavone was approximately 6°C lower compared to those that had theirfiavone artificially removed.Additionally,farinosefiavonoids on the leaves reduced subsequent electrolyte leakage(EL)from the cells exposed to freezing temperatures.Interestingly,exogenous application offiavone at4 mg/g fresh weight to P.malacoides leaves,which had the originalfiavone mechanically removed,restored freezing tolerance,and diminished EL from the cells to pretreatment values.Our results suggest that farinosefiavonoids may function as mediators of freezing tolerance in P.malacoides,and exogenous application offiavone could be used to reduce freezing damage during sudden but predictable frost events in other plant species. | Ryutaro Isshiki Ivan Galis Shigemi Tanakamaru | 2014 | Journal of Integrative Plant Biology2014，56，2： | 3 |
| 8 | Preparation of novel methyl methacrylate/fluorinated silsesquioxane copolymer film with low surface energy显示文摘Random copolymers of methyl methacrylate and fluorinated polyhedral oligomeric silsesquioxane(F-POSS) were synthesized and the corresponding thin films were prepared from solvent casting.Their microstructure was confirmed by 1H NMR,elemental analysis and GPC.Separation occurs in the bulk of the film during solvent evaporation which can be evidenced by Transmission Electron Microscopy,TEM,with POSS-rich nanophase sizes from 20 to 50 nm.Nanostructuration is attributed to the self-assembly of F-POSS due to the cluster-cluster interactions resulting from the nature of their ligands,i.e.,cycloaliphatic ligands and perfluorinated chains.Thermogravimetric analysis was used to investigate the thermal degradation temperature.It was shown that when F-POSS content is higher than 2.8 mol%,the incorporation of F-POSS could improve the thermal stability of PMMA significantly.In addition,it was shown that these fluorinated POSS-based copolymer surfaces could reduce the surface energy and could be used to design water-repellant nanocomposite coatings. | GALY Jocelyne GéRARD Jean-Franois | 2010 | Science China Chemistry2010，53，9： | 3 |
| 9 | Matrix Metalloproteinases in Vascular Remodeling and Atherogenesis: The Good, the Bad, and the Ugly显示文摘 | Zorina S. Galis Jaikirshan J. Khatri | 2002 | Circulation Research: Journal of the American Heart Association2002，，3： | 3 |
| 10 | Molecular evidence for biochemical diversification of phenolamide biosynthesis in rice plants显示文摘Two phenolamides(PAs), p-coumaroylputrescine and feruloylputrescine strongly accumulate in rice(Oryza sativa cv. Nipponbare) leaves subjected to attack of chewing and sucking herbivores. Here we identified and characterized in vitro three novel rice genes that mediated coumaroyl-Co A/feruloyl-Co A conjugation to polyamines, putrescine and agmatine. Interestingly, two genes were highly specific for their polyamine substrates, encoding putrescine N-hydroxycinnamoyltransferase and agmatine N-hydroxycinnamoyltransferase, while the third enzyme could use both polyamines and it was therefore annotated as putrescine/agmatine N-hydroxycinnamoyltransferase. All genes were preferentially expressed in rice roots and developing flowers,and in addition, the putrescine/agmatine N-hydroxycinnamoyltransferase transcripts were strongly induced by wounding in the young rice leaves. Because the wound response of this gene was only partially suppressed in the jasmonoyl-L-isoleucine deficient plants(Osjar1), it suggests that its upregulation(as well as inducible PAs in rice) may be largely independent of jasmonoyl-L-isoleucine signaling pathway. The finding of three closely related genes with a similar and/or overlapping activity in PA biosynthesis provides another striking example of rapid diversification of plant metabolism in response to environmental stresses in nature. | Kimiaki Tanabe Yuko Hojo Tomonori Shinya Ivan galis | 2016 | Journal of Integrative Plant Biology2016，58，11： | 3 |
| 11 | NOTES FOR A NEW GUIDE TO KEYNES (I): WAGES, AGGREGATE DEMAND, AND EMPLOYMENT显示文摘 | Jordi Gali | 2013 | Journal of the European Economic Association2013，，5： | 2 |
| 12 | Ambrisentan for the Treatment of Pulmonary Arterial Hypertension: Results of the Ambrisentan in Pulmonary Arterial Hypertension, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Efficacy (ARIES) Study 1 and 2显示文摘 | Nazzareno Galiè Horst Olschewski Ronald J. Oudiz Fernando Torres Adaani Frost Hossein A. Ghofrani David B. Badesch Michael D. McGoon Vallerie V. McLaughlin Ellen B. Roecker Michael J. Gerber Christopher Dufton Brian L. Wiens Lewis J. Rubin | 2008 | Circulation2008，，23： | 2 |
| 13 | Late Pliocene–Quaternary evolution of redox conditions in the western Qaidam paleolake (NE Tibetan Plateau) deduced from Mn geochemistry in the drilling core SG-1显示文摘 | Yibo Yang Xiaomin Fang Erwin Appel Albert Galy Minghui Li Weilin Zhang | 2013 | Quaternary Research2013，，3： | 2 |
| 14 | Quaternary paleolake nutrient evolution and climatic change in the western Qaidam Basin deduced from phosphorus geochemistry record of deep drilling core SG-1显示文摘 | Yibo Yang Xiaomin Fang Albert Galy Erwin Appel Minghui Li | 2013 | Quaternary International2013，，： | 2 |
| 15 | Evaporite minerals and geochemistry of the upper 400<ce:hsp sp='0.25'/>m sediments in a core from the Western Qaidam Basin, Tibet显示文摘 | Minghui Li Xiaomin Fang Chaolu Yi Shaopeng Gao Weilin Zhang Albert Galy | 2009 | Quaternary International2009，，1： | 2 |
| 16 | Development of a DOPO-containing benzoxazine and its high-performance flame retardant copolybenzoxazines显示文摘 | M. Spontón G. Lligadas J.C. Ronda M. Galià V. Cádiz | 2009 | Polymer Degradation and Stability2009，，10： | 2 |
| 17 | Association of H . pylori Infection with Insulin Resistance and Metabolic Syndrome Among L ebanese Adults显示文摘 | Farah Naja Lara Nasreddine Nahla Hwalla Patricia Moghames Hikma Shoaib Maamoun Fatfat Abla Sibai Hala Gali‐Muhtasib | 2012 | Helicobacter2012，，6： | 2 |
| 18 | Severe acute toxicity associated with high - dose methotrexate (MTX) therapy:Use of therapeutic drug monitoring and test - dose to guide carboxypeptidase G2 rescue and MTX continuation 显示文摘 | Esteve MA Devictor- Pierre B Galy G | 2007 | Eur J Clin Pharmacol2007，63，1： | 1 |
| 19 | Targeted disruption of the matrix metalloproteinase-9 gene impairs smooth muscle cell migration and geometrical arterial remodeling显示文摘 | Galis ZS Johnson C Godin D | 2002 | Circ Res2002，91，9： | 1 |
| 20 | Two ways to achieve an anammox influent from real reject water treatment at lab-scale: Partial SBR nitrification and SHARON process 显示文摘 | Gali A Dosta J Van Loosdrecht M C M | 2007 | Process Biochemistry2007，42，4： | 1 |
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