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| 1 | Helicobacter pylori : Friend or foe?显示文摘Helicobacter pylori(H. pylori) is a Gram-negative spiral bacterium that is present in nearly half the world's population. It is the major cause of peptic ulcer disease and a recognized cause of gastric carcinoma. In addition, it is linked to non-ulcer dyspepsia, vitamin B12 deficiency, iron-deficient anemia and immune thrombocytopenic purpura. These conditions are indications for testing and treatment according to current guidelines. An additional indication according to the guidelines is 'anyone with a fear of gastric cancer' which results in nearly every infected person being eligible for eradication treatment. There may be beneficial effects of H. pylori in humans, including protection from gastroesophageal reflux disease and esophageal adenocarcinoma. In addition, universal treatment will be extremely expensive(more than $32 billion in the United States), may expose the patients to adverse effects such as anaphylaxis and Clostridium difficile infection, as well as contributing to antibiotic resistance. There may also be an as yet uncertain effect on the fecal microbiome. There is a need for robust clinical data to assist in decision-making regarding treatment of H. pylori infection. | Stephen David Howard Malnick Ehud Melzer Malka Attali Gabriel Duek Jacob Yahav | 2014 | World Journal of Gastroenterology2014，20，27： | 15 |
| 2 | Human pharmacology of positive GABA-A subtype-selective receptor modulators for the treatment of anxiety显示文摘Anxiety disorders arise from disruptions among the highly interconnected circuits that normally serve to process the streams of potentially threatening stimuli. The resulting imbalance among these circuits can cause a fundamental misinterpretation of neural sensory information as threatening and can lead to the inappropriate emotional and behavioral responses observed in anxiety disorders. There is considerable preclinical evidence that the GABAergic system, in general, and its α2- and/or α5-subunit-containing GABA(A) receptor subtypes, in particular, are involved in the pathophysiology of anxiety disorders. However, the clinical ef?cacy of GABA-A α2-selective agonists for the treatment of anxiety disorders has not been unequivocally demonstrated. In this review, we present several human pharmacological studies that have been performed with the aim of identifying the pharmacologically active doses/exposure levels of several GABA-A subtype-selective novel compounds with potential anxiolytic effects. The pharmacological selectivity of novel α2-subtype-selective GABA(A) receptor partial agonists has been demonstrated by their distinct effect profiles on the neurophysiological and neuropsychological measurements that reflect the functions of multiple CNS domains compared with those of benzodiazepines, which are nonselective, full GABA(A) agonists. Normalizing the undesired pharmacodynamic side effects against the desired on-target effects on the saccadic peak velocity is a useful approach for presenting the pharmacological features of GABA(A)-ergic modulators. Moreover, combining the anxiogenic symptom provocation paradigm with validated neurophysiological and neuropsychological biomarkers may provide further construct validity for the clinical effects of novel anxiolytic agents. In addition, the observed drug effects on serum prolactin levels support the use of serum prolactin levels as a complementary neuroendocrine biomarker to further validate the pharmacodynamic measurements used during the clinical pharmacological study of novel anxiolytic agents. | Xia Chen Joop van Gerven Adam Cohen Gabriel Jacobs | 2019 | Acta Pharmacologica Sinica2019，40，5： | 2 |
| 3 | In vitro bioconversion of polyphenols from black tea and red wine/grape juice by human intestinal microbiota displays strong interindividual variability显示文摘 | Gross Gabriele Jacobs Doris M Peters Sonja | 2011 | Journal of agricultural and food chemistry2011，58，10： | 1 |
| 4 | Revision Surgery Following Cervical Laminoplasty: Etiology and Treatment Strategies显示文摘 | Gabriel Liu Jacob M. Buchowski Torphong Bunmaprasert Jin S. Yeom Hongxing Shen K Daniel Riew | 2009 | Spine2009，，25： | 1 |
| 5 | Evolution and Functional Impact of Rare Coding Variation from Deep Sequencing of Human Exomes显示文摘 | Jacob A. Tennessen Abigail W. Bigham Timothy D. O’Connor Wenqing Fu Eimear E. Kenny Simon Gravel Sean McGee Ron Do Xiaoming Liu Goo Jun Hyun Min Kang Daniel Jordan Suzanne M. Leal Stacey Gabriel Mark J. Rieder Goncalo Abecasis David Altshuler Deborah A. N | 2012 | Science2012，，6090： | 1 |
| 6 | Elevated 13C Urea Breath Test Values Females Infected With Helicobacter pylori显示文摘 | Haim Shmuely Jacob Yahav Zmira Samra Gabriel Chodick Itzhak Ofek | 2007 | Digestive Diseases and Sciences2007，，2： | 1 |
| 7 | A new law for allocation of donor organs in Israel 显示文摘 | Jacob L Tamar A Gabriel G | 2010 | Lancet2010，375，： | 1 |
| 8 | 汽油机用可变截面涡轮增压器显示文摘多年来,BorgWarner Turbo Systems公司已为柴油机提供了可变截面涡轮增压器。以往,这一完全成熟的涡轮增压器技术用在汽油机上却因为外源点火发动机高得多的排气温度和较大的流量范围而失败。2005年底,这项技术在新的Porsche 911 Turbo型车上成功获得批量应用,表明了这一挑战已经被战胜。 | Gabriel H | 2008 | 国外内燃机2008，40，3： | 0 |
| 9 | DSSylation, a novel protein modification targets proteins induced by oxidative stress, and facilitates their degradation in cells显示文摘氧化地损坏的蛋白质的及时移动为暴露于氧化压力的房间是批评的;然而,为变清的细胞的机制氧化了蛋白质不是清楚的。我们的学习揭示可以在指向氧化蛋白质起一个作用并且移开他们的蛋白质修正的一种新奇类型。在这个过程, DSS1 (在裂口传递 / 切开脚 1 删除了) ,进化地保存的小蛋白质,被结合到氧化压力在 vitro 并且在 vivo 导致的蛋白质,暗示氧化蛋白质是 DSS1 顾客。指向 DSS1 蛋白质的随后的 ubiquitination 使内收被观察了,建议顾客蛋白质通过 ubiquitin-proteasome 小径被降级。到它的顾客的 DSS1 附件被证实是未辩别出的 ATPase 调制的一个酶的过程。我们作为 DSSylation 说出这新奇蛋白质修正在哪个 DSS1 作为一个修饰词玩,谁的附件可以显示目标蛋白质导致他们的随后的 ubiquitination 的签名,从而降级的成员 proteasome 他们。 | Yinghao Zhang Fang-Mei Chang Jianjun Huang Jacob J. Junco Shivani K. Maffi Hannah I. Pridgen Gabriel Catano Hong Dang Xiang Ding Fuquan Yang Dae Joon Kim Thomas J. Slaga Rongqiao He Sung-Jen Wei | 2014 | Protein & Cell2014，5，2： | 0 |
| 10 | 79&PARK住宅区显示文摘位于G?rdet国家公园边缘,Kullen有意识地塑造了一个尊重且适应环境的形式,并展现出与众不同的社区和壮丽的景色。为直接回应周围环境,建筑的西北和东南角高起至临近周边的高度;而距离公园最远、且本是视野最不好的东北角被拉高以使其拥有公园和港口最壮阔的景色。建筑西南角延伸至最远处的G?rdet国家公园;为了在建筑和自然之间创造一个人性化的柔和边缘,西南角被尽可能地压低. | H■gni Laksáfoss Agata Wozniczka Agne Tamasauskaite Alberto Herzog Borko Nikolic Christin Svensson Claudio Moretti Dominic Black Eva Seo-Andersen Frederik Wegener Gabrielle Nadeau Jacob Lykkefold Aaen Jaime Peiro Suso Jan Magasanik Jesper Boye Andersen Jonas Aars■Larsen Julian Andres Ocampo Salazar Karl Johan Nyqvist Karol Bogdan Borkowski Katarina Mácková Katrine Juul Kristoffer Negendahl Lucian Racovitan Maria Teresa Fernandez Rojo Max Gabriel Pinto Min Ter Lim Narisara Ladawal Schr■der Romea Muryn Ryohei Koike Sergiu Calacean Song He Taylor McNally-Anderson Terrence Chew Thomas Sebastian Krall Tiago Sá Tobias Vall■S■rensen Tore Banke Laurian Ghinitoiu 朱翰林(译) | 2019 | 城市环境设计2019，0，2： | 0 |
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