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| 1 | Psychosocial issues in evidence-based guidelines on inflammatory bowel diseases: A review显示文摘AIM:To study statements and recommendations on psychosocial issues as presented in international evidence-based guidelines on the management of inflammatory bowel diseases(IBD).METHODS:MEDLINE,guidelines International Network,National Guideline Clearing House and National Institute for Health and Care Excellence were searched from January 2006 to June 30,2013 for evidencebased guidelines on the management of IBD.RESULTS:The search yielded 364 hits.Thirteen guidelines were included in the review,of which three wereprepared in Asia,eight in Europe and two in the United States.Eleven guidelines made statements and recommendations on psychosocial issues.The guidelines were concordant in that mental health disorders and stress do not contribute to the aetiology of IBD,but that they can influence its course.It was recommended that IBD-patients should be screened for psychological distress.If indicated,psychotherapy and/or psychopharmacological therapy should be recommended.IBDcentres should collaborate with mental health care specialists.Tobacco smoking patients with Crohn’s disease should be advised to quit.CONCLUSION:Patients and mental health specialists should be able to participate in future guideline groups to contribute to establishing recommendations on psychosocial issues in IBD.Future guidelines should acknowledge the presence of psychosocial problems in IBD-patients and encourage screening for psychological distress. | Winfried Huser Gabriele Moser Petra Klose Antonina Mikocka-Walus | 2014 | World Journal of Gastroenterology2014，20，13： | 14 |
| 2 | Transcranial direct current stimulation in psychiatric disorders显示文摘The interest in non-invasive brain stimulation techniques is increasing in recent years. Among these techniques, transcranial direct current stimulation(t DCS) has been the subject of great interest among researchers because of its easiness to use, low cost, benign profile of side effects and encouraging results of research in the field. This interest has generated several studies and randomized clinical trials, particularly in psychiatry. In this review, we provide a summary of the development of the technique and its mechanism of action as well as a review of the methodological aspects of randomized clinical trials in psychiatry, including studies in affective disorders, schizophrenia, obsessive compulsive disorder, child psychiatry and substance use disorder. Finally,we provide an overview of t DCS use in cognitive enhancement as well as a discussion regarding its clinical use and regulatory and ethical issues. Although many promising results regarding t DCS efficacy were described, the total number of studies is still low, highlighting the need of further studies aiming to replicate these findings in larger samples as to provide a definite picture regarding t DCS efficacy in psychiatry. | Gabriel Tortella Roberta Casati Luana V M Aparicio Antonio Mantovani Natasha Senco Giordano D’Urso Jerome Brunelin Fabiana Guarienti Priscila Mara Lorencini Selingardi Débora Muszkat Bernardo de Sampaio Pereira Junior Leandro Valiengo Adriano H Moffa Marcel Simis Lucas Borrione André R Brunoni | 2015 | World Journal of Psychiatry2015，5，1： | 6 |
| 3 | 猪霉菌毒素中毒的新概念显示文摘霉菌毒素是真菌的次级代谢产物,可以降低畜禽生产性能和改变新陈代谢(wannemacher等,1991)。动物采食被霉菌毒素污染的饲料而引发的病理状态称为霉菌毒素中毒。猪霉菌毒素中毒会对养猪生产造成严重的不良影响。本文综述了各种霉菌毒素对猪生长性能、繁殖性能和免疫功能的影响,各种霉菌毒素间的协同作用以及猪霉菌毒素中毒的最新研究成果。 | Trevor K Smith Gabriel Diaz Swamy H V LN 苗朝华(摘译) | 2007 | 养猪2007，，5： | 6 |
| 4 | Second European evidence-based consensus on the diagnosis and management of ulcerative colitis: Special situations显示文摘 | Gert Van Assche Axel Dignass Bernd Bokemeyer Silvio Danese Paolo Gionchetti Gabriele Moser Laurent Beaugerie Fernando Gomollón Winfried H?user Klaus Herrlinger Bas Oldenburg Julian Panes Francisco Portela Gerhard Rogler Jürgen Stein Herbert Tilg Simon Tra | 2012 | Journal of Crohn’s and Colitis2012，，： | 4 |
| 5 | Inhibition of the G9a/GLP histone methyltransferase complex modulates anxiety-related behavior in mice显示文摘Epigenetic 基因规定畸形包括精神分裂症和消沉在各种各样的 neuropsychiatric 混乱,以及在心情和焦虑的规定被含有。另外, epigenetic 机制涉及精神病学的药的行动。当前的 anxiolytic 药有新药的重要缺点,和开发被保证。二蛋白质, G9a (也作为 EHMT2 或 KMT1C 知道) 并且 GLP (象 G9a 一样蛋白质,也作为 EHMT1 或 KMT1D 知道) ,它甲醇化物离氨酸 9 histone H3 (H3K9 ) ,能正在答应 anxiolytic 目标。G9a 的出生后的基因大美人减少焦虑相关的行为,与由过去常对待焦虑(amitriptyline, imipramine 和 paroxetine ) 的一些药的 G9a 层次的减小一致。相反地,在有 GLP haplodeficiency 的老鼠有增加的像焦虑的行为。我们寻求了决定是否 G9a/GLP, UNC0642 和 A-366 的二个药理学禁止者,将有类似的效果到基因 G9a/GLP 不足。当予成年老鼠以时,我们发现有任何一个化合物的 G9a/GLP 抑制减少了像焦虑的行为,与在大脑的减少的 H3K9 methylation 一起。相反,到这些的暴露从胚胎的白天加重(E9.5 ) 9.5 增加了像焦虑的行为直到出生并且减少在成人生活的社会相互作用,当 H3K9 methylation 在在成年老鼠的大脑的正常层次时。这些调查结果增强 G9a/GLP 在大脑开发的不同阶段在像焦虑的行为上有不同效果的基因证据,并且建议指向这条 histone methyltransferase 小径能为开发新 anxiolytic 药是有用的。这些数据也建议在 utero 的抗抑郁剂暴露能在成人生活有否定效果,并且这些效果的进一步的调查被保证。 | Dong-yao WANG Joel KOSOWAN James SAMSOM Laura LEUNG Kai-lai ZHANG Ying-xiang LI Yan XIONG Jian JIN Arturas PETRONIS Gabriel OH Albert H C WONG | 2018 | Acta Pharmacologica Sinica2018，39，5： | 4 |
| 6 | Dexamethasone mediates protection against acute pancreatitis via upregulation of pancreatitis-associated proteins显示文摘AIM: To examine the influence of dexamethasone on pancreatitis-associated protein (PAP) gene expression using both in vitro and in vivo models of acute pancreati- tis and to study how PAP gene expression correlates with severity of pancreatitis. METHODS: In vitro, IL-6 stimulated pancreas acinar AR42J cells were cultured with increasing concentrations of dexamethasone and assayed for PAP expression (RT-PCR). In vivo , pancreatitis was induced in rats by retrograde injection of 40 g/L taurocholate into the pancreatic duct. Animals were pretreated with dexamethasone (2 mg/kg) daily or saline for 4 d. Pancreata and serum were harvested after 24 h and gene expression levels of PAPⅠ, Ⅱ and Ⅲ were measured by RT-PCR. Severity of pancreatitis was based on serum amylase, pancreatic wet weight, and histopathological score. RESULTS: In vitro, dexamethasone and IL-6 induced a marked transcription of PAPⅠ, Ⅱ and Ⅲ genes in AR42J cells at 24 h (P < 0.05 for all comparisons). In vivo, pancreas mRNA levels of PAPⅠ, Ⅱ or Ⅲ increased by 2.6-fold, 1.9-fold, and 1.3-fold respectively after dexa- methasone treatment, compared with saline treated ani- mals. Serum amylase levels and edema were significantly lower in the dexamethasone group compared with the saline group. Histopathologic evaluation revealed less inflammation and necrosis in pancreata obtained from dexamethasone treated animals (P < 0.05). CONCLUSION: Dexamethasone significantly decreases the severity of pancreatitis. The protective mechanism ofdexamethasone may be via upregulating PAP gene ex- pression during injury. | Emad Kandil Yin-Yao Lin Martin H Bluth Hong Zhang Gabriel Levi Michael E Zenilman | 2006 | World Journal of Gastroenterology2006，12，42： | 3 |
| 7 | Effect of closure of live poultry markets on poultry-to-person transmission of avian influenza A H7N9 virus: an ecological study显示文摘 | Hongjie Yu Joseph T Wu Benjamin J Cowling Qiaohong Liao Vicky J Fang Sheng Zhou Peng Wu Hang Zhou Eric H Y Lau Danhuai Guo Michael Y Ni Zhibin Peng Luzhao Feng Hui Jiang Huiming Luo Qun Li Zijian Feng Yu Wang Weizhong Yang Gabriel M Leung | 2013 | The Lancet2013，，： | 2 |
| 8 | Stent Thrombosis With Ticagrelor Versus Clopidogrel in Patients With Acute Coronary Syndromes: An Analysis From the Prospective, Randomized PLATO Trial显示文摘 | P. Gabriel Steg Robert A. Harrington H?kan Emanuelsson Hugo A. Katus Kenneth W. Mahaffey Bernhard Meier Robert F. Storey Daniel M. Wojdyla Basil S. Lewis Gerald Maurer Lars Wallentin Stefan K. James | 2013 | Circulation2013，，10： | 2 |
| 9 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 10 | Highlights of marine invertebrate-derived biosynthetic products: Their biomedical potential and possible production by microbial associants显示文摘 | Ocky K. Radjasa Yvette M. Vaske Gabriel Navarro Hélène C. Vervoort Karen Tenney Roger G. Linington Phillip Crews | 2011 | Bioorganic & Medicinal Chemistry2011，，22： | 2 |
| 11 | Dielectronic satellite spectra for highly charged helium -like ions: Ⅵ-iron spectra with improved inner-shell and helium- like excitation rates 显示文摘 | Bely-dubau F Faucher P Dubau J Gabriel A H | 1982 | Mon Not R Astron Soc1982，198，： | 1 |
| 12 | Is determineation of exercise intensityies as percentages of VO2max or HRmax adequate?显示文摘 | Meyer T Gabriel H H W Kindermann W | 1999 | Med Sci Sports Exert1999，31，： | 1 |
| 13 | Human activities and global warming: a cointegration analysis 显示文摘 | Liu H Rodriguez Gabriel | 2005 | Environmental Modelling & Software2005，20，6： | 1 |
| 14 | Comparison of Frequencies of Left Ventricular Systolic and Diastolic Heart Failure in Chinese Living in Hong Kong 显示文摘 | Gabriel Y Pearl H Kam W | 1999 | Am J Cardiol1999，84，5： | 1 |
| 15 | The structure of haplotype blocks in the human genome 显示文摘 | GABRIEL S B SEHAFFNER S F NGUYEN H | 2002 | Science2002，296，5576： | 1 |
| 16 | Cost-effectiveness analysis of a lidocaine 5 % medicated plaster compared with gabapentin and pregaba- lin for treating postherpetic neuralgia: a german perspective 显示文摘 | Liedgens H Hertel N Gabriel A | 2008 | Clin Drug Investig2008，28，9： | 1 |
| 17 | Ageretated increase of CD45 RD ^+ lymphocytes in physicallg active adult 显示文摘 | Gabriel H Sehmitt B Kindermann W | 1993 | Eur J Immunol1993，23，： | 1 |
| 18 | EGFR mutations in hmg cancer: Correlation with clinical response to gefitinib therapy 显示文摘 | Paez JG Janne PA Lee JC Traey S Greulich H Gabriel S el al | 2004 | Science2004，304，4： | 1 |
| 19 | Impaired pituitary hormonal response to exhaustive exereise in overtrained enduranee athletes 显示文摘 | Urhausen A Gabriel H H Kindermann W | 1998 | Med Sei Sports Exere1998，30，3： | 1 |
| 20 | CD28-induction of proliferation in resting T cells in vitro and vivo without engagement of the T cell receptor:evidence for function distinct forms of CD28显示文摘 | Michael T Gabriele H Thomas H | 1997 | Eur J Immunol1997，27，1： | 1 |
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