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| 1 | MicroRNAs as a potential prognostic factor in gastric cancer显示文摘AIM:To compare the microRNA (miR) profiles in the primary tumor of patients with recurrent and non-recurrent gastric cancer.METHODS:The study group included 45 patients who underwent curative gastrectomies from 1995 to 2005 without adjuvant or neoadjuvant therapy and for whom adequate tumor content was available.Total RNA was extracted from formalin-fixed paraffin-embedded tumor samples,preserving the small RNA fraction.Initial profiling using miR microarrays was performed to identify potential biomarkers of recurrence after resection.The expression of the differential miRs was later verified by quantitative real-time polymerase chain reaction (qRT-PCR).Findings were compared between patients who had a recurrence within 36 mo of surgery (bad-prognosis group,n=14,31%) and those who did not (good-prognosis group,n=31,69%).RESULTS:Three miRs,miR-451,miR-199a-3p and miR-195 were found to be differentially expressed in tumors from patients with good prognosis vs patients with bad prognosis (P<0.0002,0.0027 and 0.0046 respectively).High expression of each miR was associated with poorer prognosis for both recurrence and survival.Using miR-451,the positive predictive value for non-recurrence was 100% (13/13).The expression of the differential miRs was verified by qRT-PCR,showing high correlation to the microarray data and similar separation into prognosis groups.CONCLUSION:This study identified three miRs,miR-451,miR-199a-3p and miR-195 to be predictive of recurrence of gastric cancer.Of these,miR-451 had the strongest prognostic impact. | Baruch Brenner Moshe B Hoshen Ofer Purim Miriam Ben David Karin Ashkenazi Gideon Marshak Yulia Kundel Ronen Brenner Sara Morgenstern Marisa Halpern Nitzan Rosenfeld Ayelet Chajut Yaron Niv Michal Kushnir | 2011 | World Journal of Gastroenterology2011，17，35： | 31 |
| 2 | 土壤斥水性对含水率的响应模型研究显示文摘选用以色列3类不同质地的10种不同斥水性的土壤为研究对象,采用滴水穿透时间法测定土壤斥水性对含水率的响应关系,得到了不同土壤斥水持续时间随含水率变化的规律,通过Gaussian模型、Lorentzian模型和Lognormal模型对这种规律进行回归分析,最终得出了土壤斥水持续时间随含水率的变化规律符合Lorentzian模型。由此响应模型,就可以根据某种土壤部分斥水性对含水率响应的实测数据,计算出土壤斥水性的峰值含水率、峰值斥水性以及临界含水率,为不同土壤斥水性进行对比和土壤改良提供理论依据。 | 陈俊英 吴普特 张智韬 Gideon Oron 汪志农 | 2012 | 农业机械学报2012，43，1： | 28 |
| 3 | 土壤斥水性影响因素及改良措施的研究进展显示文摘论述了森林火灾、土壤含水率、有机质含量、pH值、生物膜和粘土矿物质等因素对土壤斥水性的影响以及国内外土壤斥水性改良措施的研究进展,并提出当前土壤斥水性研究的重点和今后的研究方向是土壤毛孔或粒子范围方面的研究、土壤含水率和斥水性的表达、大范围田间斥水性对不同水文学要素的定量影响,同时指出国内土壤斥水性的研究发展方向。 | 陈俊英 张智韬 汪志农 Gideon Oron Leionid Gillerman | 2010 | 农业机械学报2010，41，7： | 20 |
| 4 | FTO: linking m^6A demethylation to adipogenesis显示文摘 | Moshe Shay Ben-Haim Sharon Moshitch-Moshkovitz Gideon Rechavi | 2015 | Cell Research2015，25，1： | 8 |
| 5 | Efficacy and safety of tenofovir in chronic hepatitis B: Australian real world experience显示文摘AIM To evaluate the long-term treatment outcomes of tenofovir therapy in patients in a real world Australian tertiary care setting.METHODS We performed a retrospective analysis of treatment outcomes among treatment-na?ve and treatment-experienced patients receiving a minimum 3 mo tenofovir therapy through St Vincent's Hospital Melbourne, Australia. We included patients receiving tenofovir [tenofovir disoproxil fumarate(TDF)] monotherapy, as well as patients treated with TDF in combination with a second antiviral agent. Patients were excluded if they demonstrated human immune-deficiency virus/hepatitis C virus/hepatitis delta virus coinfection or were less than 18 years of age. We considered virological and biochemicalresponse, as well as safety outcomes. Virological response was determined by measurement of hepatitis B virus(HBV) DNA using sensitive assays; biochemical response was determined via serum liver function tests; histological response was determined from liver biopsy and fibroscan; safety analysis focused on glomerular renal function and bone mineral density. The primary efficacy endpoint was complete virological suppression over time, defined by HBV DNA < 20 IU/m L. Secondary efficacy endpoints included rates of biochemical response, and HB e antigen(HBe Ag)/HB surface antigen loss and seroconversion over time.RESULTS Ninety-two patients were identified who fulfilled the enrolment criteria. Median follow-up was 26 mo(range 3-114). Mean age was 46(24-78) years, 64(70%) were male and 77(84%) were of Asian origin. 55(60%) patients were treatment-na?ve and 62 patients(67%) were HBe Ag-negative. Complete virological suppression was achieved by 45/65(71%) patients at 12 mo, 37/46(80%) at 24 mo and 25/28(89%) at 36 mo. Partial virological response(HBV DNA 20-2000 IU/m L) was achieved by 89/92(96.7%) of patients. Multivariate analysis showed a significant relationship between virological suppression at end of follow-up and baseline HBV DNA level(OR = 0.897, 95%CI: 0.833-0.967, P = 0.0046) and HBe Ag positive status(OR = 0.373, 95%CI: 0.183-0.762, P = 0.0069). There was no difference in response comparing treatment-na?ve and treatment-experienced patients. Three episodes of virological breakthrough occurred in the setting of noncompliance. Tenofovir therapy was well tolerated.CONCLUSION Tenofovir is an efficacious, safe and well-tolerated treatment in an Australian real-world tertiary care setting. Our data are similar to the reported experience from registration trials. | Grace C Lovett Tin Nguyen David M Iser Jacinta A Holmes Robert Chen Barbara Demediuk Gideon Shaw Sally J Bell Paul V Desmond Alexander J Thompson | 2017 | World Journal of Hepatology2017，9，1： | 7 |
| 6 | 土壤斥水性与有机质质量分数的变化关系研究显示文摘土壤有机质质量分数是影响土壤斥水性的最主要因素之一,为研究二者之间的关系,选用以色列3类不同质地斥水性土壤为对象,分别在田间和实验室测定土壤斥水性和有机质质量分数,并绘制土壤斥水性和有机质质量分数的等值线图和关系图。结果表明,对于粘性土壤和沙质土壤,土壤斥水性随有机质质量分数成幂指数关系,但对于壤土,二者之间没有非常明显的线性关系。研究结果可为分析不同土壤的斥水性影响因素和土壤改良提供理论依据。 | 陈俊英 吴普特 张智韬 Gideon Oron 汪志农 | 2012 | 灌溉排水学报2012，31，3： | 7 |
| 7 | 不同污染程度的水对土壤斥水性的影响显示文摘污水在农业灌溉中的回用是一种有效的节水途径,但长期应用会导致土壤斥水性的提高。本研究以以色列西南部Berry的原状土壤为例,研究了8种不同污染程度的灌溉用水对土壤斥水性的影响,并用统计分析方法从多个水质参数中找出主要的影响因素。结果表明,土壤斥水性与综合水质指标F值具有很高的相关性,相关系数为0.957,呈极显著正相关;多元回归分析发现,水质中有机质含量指标化学需氧量(COD)是影响土壤斥水性的最主要因素,其次是浑浊度(Turbidity),它们与土壤斥水性建立的多元回归方程的相关系数达0.997。仅用化学需氧量(COD)与土壤斥水性建立关系,相关系数为0.877。这为进一步研究土壤斥水性和节水灌溉提供理论依据。 | 陈俊英 张智韬 Leionid Gillerman Gideon Oron 汪志农 | 2009 | 节水灌溉2009，，10： | 7 |
| 8 | Structural effects of three-dimensional angle-interlock woven composite undergoing bending cyclic loading显示文摘This paper reports the structural effects of three-dimensional(3-D)angle-interlock woven composite(3DAWC)undergoing three-point bending cyclic loading from experimental and finite element analysis(FEA)approaches.In experiment,the fatigue tests were conducted to measure the bending deflection and to observe the damage morphologies.By the FEA approach,a micro-structural unit-cell model of the 3DAWC was established at the yarn level to simulate the fatigue damage.The stress degradation at the loading condition of constant deformation amplitude was calculated to show the degradation of mechanical properties.In addition,the stress distribution,fatigue damage evolution and critical damage regions were also obtained to qualitatively reveal the structural effects and damage mechanisms of the 3DAWC subjected to three-point bending cyclic loading. | JIN LiMin YAO Yao YU YiMin ROTICH Gideon SUN BaoZhong GU BoHong | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，3： | 5 |
| 9 | Comparative analysis of the predictive power of different endothelial progenitor cell phenotypes on cardiovascular outcome显示文摘AIM: To compare the predictive power of different endothelial progenitor cell (EPC) phenotypic markers for future cardiovascular events. METHODS: Peripheral blood was collected from 76 consecutive patients with acute coronary syndromes (ACS) who underwent percutaneous coronary intervention in our institute. The various EPC phenotypes of peripheral blood mononuclear cells were CD34+CD133+, CD34+KDR+, and CD 133+KDR+. The outcome endpoint included cardiovascular mortality, recurrent ACS, and hospitalization for decompensated heart failure during a 24-mo follow-up period.RESULTS: CD34+CD133+ cells (P = 0.034), but not CD34+KDR+ (P = 0.35) or CD 133+KDR+ cells (P = 0.19), were found to predict recurrent ACS. We found no correlation between EPCs measured by any of the three phenotypic combinations of accepted CD markers and the total combination of these separate outcomes. CONCLUSION: The EPC CD34+CD133+ phenotype, but not the CD34+KDR+ or the CD 133+KDR+ phenotypes, is predictive of future adverse cardiovascular outcomes. | Shmuel Schwartzenberg Arnon Afek Gideon Charach Ardon Rubinstein Yossi Ben-Shoshan Sarina Kissil Sofia Maisel-Auslender Gad Keren Jacob George | 2010 | World Journal of Cardiology2010，2，9： | 5 |
| 10 | 5-methylcytosine mediates nuclear export of mRNA显示文摘 | Dan Dominissini Gideon Rechavi | 2017 | Cell Research2017，27，6： | 4 |
| 11 | Overlap syndromes: The International Autoimmune Hepatitis Group (IAIHG) position statement on a controversial issue显示文摘 | Kirsten Muri Boberg Roger W. Chapman Gideon M. Hirschfield Ansgar W. Lohse Michael P. Manns Erik Schrumpf | 2010 | Journal of Hepatology2010，，2： | 4 |
| 12 | Preventive treatment of alveolar pulmonary edema of cardiogenic origin显示文摘Objective To evaluate the efficacy of preventive treatment (PT) on alveolar pulmonary edema (APE) of cardiogenic origin using a monitor based on principles of internal thoracic impedance (ITI) measurements.Methods We conducted blinded clinical trials on patients with ST-elevation myocardial infarction (STEMI) and monitored whether the condition would progress to APE. ITI was measured noninvasively by the Edema Guard Monitor (EGM, model RS-207) every 30 min. The measurement threshold for the diagnosis of APE was fixed at > 12% decrease in ITI from baseline as described in our methodology. The patients were divided into one group that received standard treatment after the appearance of clinical signs of APE without considering the prediction of APE by EGM devise (Group 1), and another group of asymptomatic patients in whom development of APE was predicted by using only EGM measurements (Group 2). The latter participants’PT consisted of furosemide, intravenous nitroglycerine and supplemental oxygen. Results One-hundred and fifty patients with acute STEMI were enrolled into this study. Group 1 included 100 patients (53% males, age 64.1 ±12.6 years). Treatment was started after the clinical appearance of overt signs of APE. Group 2 included 50 patients (54% males, age 65.2 ±11.9 years) who received PT based on EGMmeasurements. Group 2 had significantly fewer cases of APE (n = 4, 8%) than Group 1 (n = 100, 100%) (P > 0.001). While APE was lethal in six (6%) Group 1 patients, PT resulted in prompt resolution of APE in all four (8%) Group 2 patients. Conclusion ITI is a usefulmodality for early diagnosis and PT of pulmonary edema of cardiogenic origin. | Gideon Charach Michael Shochat Alexander Rabinovich Oded Ayzenberg Jacob George Lior Charach Pavel Rabinovich | 2012 | Journal of Geriatric Cardiology2012，9，4： | 3 |
| 13 | Factors influencing time course of pain after depot oil intramuscular injection of testosterone undecanoate显示文摘疼痛追随者仓库肌内(IM ) 油的注射基于车辆的药是学习的很少。这研究试图有希望地在 4-mL 海狸油车辆在 1 000 mg 睾丸激素 undecanoate (TU ) 的 IM 注射以后在这个星期期间决定流行,决定因素,严厉和疼痛的功能的后果。在一个学术 andrology 诊所收到常规 T 代替治疗的雄激素缺乏的人被招募在深 IM 臀的注射以后在第一天和日报在七次用有色的视觉线性类似物规模报导疼痛分数一个星期。时间功课和 covariables 影响疼痛分数被变化(ANOVA ) 的混合模型分析分析。在 125 个人,的追随者 168 注射疼痛被 80% 人报导,在注射以后立即达到顶点,到达仅仅中等的严厉,持续 1 鈥?天并且在白天回到基线 4。疼痛几乎没要求很少止痛使用并且在每日的活动生产了最小的干扰。疼痛分数的时间功课在经历了二连续注射的 43 个人是可再现的。疼痛在有更早痛苦的注射,而是在严重的更少的人是更严重的更旧并且更多的肥胖的人。根据在管理注射的富有经验的护士之间的注射以后的疼痛经验有可以忽略的差别。在 4-mL 海狸油的仓库 TU 的深 IM 臀的注射很好被容忍,注射以后的疼痛被更早痛苦的注射经验,以及年龄和肥胖影响。 | Gideon Sartorius Carolyn Fennell Sasa Spasevska Leo Turner Ann J. Conway David J. Handelsman | 2010 | Asian Journal of Andrology2010，12，2： | 3 |
| 14 | Unmet clinical need in autoimmune liver diseases显示文摘 | Jessica K. Dyson Gwilym Webb Gideon M. Hirschfield Ansgar Lohse Ulrich Beuers Keith Lindor David E.J. Jones | 2014 | Journal of Hepatology2014，，： | 2 |
| 15 | 番茄渣可作肉鸡饲料中维生素E的来源显示文摘干的番茄渣,作为番茄加工过程中的副产品,含有丰富的维生素E,常在肉鸡饲料中作抗氧化剂。在饲喂试验中,添加番茄渣的小鸡体增重、料肉比和对照组相比并没有显著的差异。番茄渣可以作为维生素的来源饲喂肉鸡,以减少在加热和长期冷冻时肉中的脂肪氧化(脂肪衰败),延长保质期。番茄的副产品中不胞和脂肪酸含量较高,番茄渣是脱脂的且没有损失维生素E,从而将氧化的可能性降到最低。 | Annie J.King Gideon Zeidler 黄彪(译) | 2008 | 饲料与畜牧(新饲料)2008，，9： | 2 |
| 16 | 辽宁阜新地区区域性考古调查阶段性报告(2012—2013)显示文摘2012—2103年在辽宁阜新地区查海遗址东部开展了区域性田野考古调查,调查范围104.46平方公里,共在1152个采集点进行了人工遗物的采集,发现了属于小河西、兴隆洼、赵宝沟、红山、夏家店下层、高台山、凌河类型和战国—汉时期的遗存,大体上勾勒出调查区域内从新石器时代早期,经青铜时代,一直到战国—汉时期的遗址分布格局。调查中确认了一些此前没有发现的早期新石器时代时期(也许还有前新石器时代)的遗址,而部分遗址人工遗物分布密度较高表现出当时人类活动已具有一定的强度。调查中还发现并记录了大量的细石器和一般石器,这是在此前中国东北地区系统性田野考古调查中从未做过的工作,这些石器的具体年代或文化属性还有待于进一步的比较与分析。如果有些石器的年代确实属于前新石器时代,那么这些石器的分布将会提供研究这一地区采集狩猎人群活动的重要证据。 | 滕铭予 Gideon SHELACH 万雄飞 Ofer MARDER Ido WACHTEL | 2014 | 北方文物2014，，3： | 2 |
| 17 | Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development显示文摘 | Assaf C. Bester Maayan Roniger Yifat S. Oren Michael M. Im Dan Sarni Malka Chaoat Aaron Bensimon Gideon Zamir Donna S. Shewach Batsheva Kerem | 2011 | Cell2011，，3： | 2 |
| 18 | Removal of viruses from surface water and secondary effluents by sand filtration显示文摘 | Revital Aronino Christina Dlugy Elizabeth Arkhangelsky Semion Shandalov Gideon Oron Asher Brenner Vitaly Gitis | 2008 | Water Research2008，，1： | 2 |
| 19 | The Phenotypic Expression of Inflammatory Bowel Disease in Patients with Primary Sclerosing Cholangitis Differs in the Distribution of Colitis显示文摘 | David F. Schaeffer Lay Lay Win Sara Hafezi-Bakhtiari Maria Cino Gideon M. Hirschfield Hala El-Zimaity | 2013 | Digestive Diseases and Sciences2013，，9： | 2 |
| 20 | 润湿灌溉条件下不同施氮水平对黄瓜苗期生长的影响显示文摘设置6个施氮水平,对比研究润湿灌溉技术和传统灌溉技术对黄瓜幼苗生长的影响。结果表明:润湿灌溉技术能显著提高黄瓜幼苗对氮肥的利用效率。在第0、2、4、8、12、18、24 d时,通过测定黄瓜幼苗的株高等生长指标,发现采用润湿灌溉技术栽培的黄瓜,其幼苗株高在6个施氮水平上均明显高于传统灌溉栽培方式。在第24 d施氮水平为220 mg/L的润湿灌溉条件下,黄瓜幼苗的株高为传统灌溉栽培方式的1.92倍,而要出现同样的生长状况,用传统灌溉栽培方式则需280 mg/L的氮素供应水平。 | 马娜 李伟 严俊 王方 Gideon Oron 程剑平 | 2010 | 山地农业生物学报2010，29，3： | 2 |
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