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| 1 | KaKs_Calculator:Calculating Ka and Ks Through Model Selection and Model Averaging显示文摘KaKs_Calculator is a software package that calculates nonsynonymous (Ka) andsynonymous (Ks) substitution rates through model selection and model averag-ing. Since existing methods for this estimation adopt their specific mutation(substitution) models that consider different evolutionary features, leading todiverse estimates, KaKs Calculator implements a set of candidate models in amaximum likelihood framework and adopts the Akaike information criterion tomeasure fitness between models and data, aiming to include as many featuresas needed for accurately capturing evolutionary information in protein-coding se-quences. In addition, several existing methods for calculating Ka and Ks arealso incorporated into this software. KaKs Calculator, including source codes,compiled executables, and documentation, is freely available for academic use athttp://gffzz5c65aa98f6514e89h6n5fq5k90xu065pv.ffgz.tsg.suse.edu.cn/software.htm. | Zhang Zhang Jun Li Xiao-Qian Zhao Jun Wang Gane Ka-Shu Wong Jun Yu | 2006 | Genomics, Proteomics & Bioinformatics2006，4，4： | 86 |
| 2 | 亚太地区慢性乙型肝炎治疗共识(2012最新版)显示文摘自2008年至今,有大量关于慢性HBV感染的自然史和治疗的最新数据不断涌现。其中包括慢性HBV感染的无症状感染者,以社区为基础的队列研究,HBV基因型的作用,非药物诱导的自然HBV变异型毒株,无创性肝纤维化评估方法的应用,HBsAg定量在临床中的应用,更有效的新治疗药物和新治疗方案等等。来自亚太地区的专家审查和评估了相关数据,并共同商讨了近年来报道的最有意义的发现,基于此,对2008年版的亚太地区慢性乙型肝炎治疗共识进行修订,同时对2008年版治疗指南定义的关键词组进行了修订。修订后的指南包括以下几方面内容:一般治疗,肝纤维化评价适应证,何时开始治疗或停药,初始抗病毒治疗药物的选择,如何监测治疗中和治疗后的患者。关于特殊人群的治疗建议中包括了对妊娠妇女,已发生耐药,合并其他病毒感染,肝功能失代偿,接受免疫抑制治疗、化疗,肝移植或肝细胞癌患者的具体治疗建议。 | 廖运范 Jia-HorngKao Teerha Piratvisuth Henry Lik Yuen Chan Rong-Nan Chien Chun-Jen Liu Ed Gane Stephen Locarnini Seng-Gee Lim Kwang-Hyub Han Deepak Amarapurkar Graham Cooksley Wasim Jafri Rosmawati Mohamed Wan-Long Chuang Laurentius A.Lesmana Jose D.Sollano Dong-Jin Suh Masao Omata 刘颖 徐莹 李芸 黄祖雄 樊蓉 李小溪 吕国涛 周彬 孙剑 侯金林 | 2012 | 临床肝胆病杂志2012，28，8： | 182 |
| 3 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 4 | Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study显示文摘 | Patrick Marcellin Edward Gane Maria Buti Nezam Afdhal William Sievert Ira M Jacobson Mary Kay Washington George Germanidis John F Flaherty Raul Aguilar Schall Jeffrey D Bornstein Kathryn M Kitrinos G Mani Subramanian John G McHutchison E Jenny Heathcote | 2012 | The Lancet2012，，： | 14 |
| 5 | 2-Year GLOBE Trial Results: Telbivudine Is Superior to Lamivudine in Patients With Chronic Hepatitis B显示文摘 | Yun–Fan Liaw Edward Gane Nancy Leung Stefan Zeuzem Yuming Wang Ching Lung Lai E. Jenny Heathcote Michael Manns Natalie Bzowej Junqi Niu Steven–Huy Han Seong Gyu Hwang Yilmaz Cakaloglu Myron J. Tong George Papatheodoridis Yagang Chen Nathaniel A. Brown Efs | 2009 | Gastroenterology2009，，2： | 13 |
| 6 | Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2008 update显示文摘 | Yun-Fan Liaw Nancy Leung Jia-Horng Kao Teerha Piratvisuth Edward Gane Kwang-Hyub Han Richard Guan George K. K. Lau Stephen Locarnini | 2008 | Hepatology International2008，，3： | 10 |
| 7 | RIG-I-like receptor-induced IRF3 mediated pathway of apoptosis (RIPA): a new antiviral pathway显示文摘天生的有免疫力的反应是主人防卫的第一根线消除病毒的感染。在 cytosol 的模式识别受体例如 RIG-I-like 受体( RLR )和像点头的受体( NLR ),并且如同受体( TLR )检测病毒的感染并且开始抗病毒的基因的一个队的抄写,膜绑了使用费,包括干扰素( IFN )和干扰素刺激了基因( ISG ),它最终堵住病毒的复制。减少病毒的传播的另一机制通过 RIPA, apoptosis 的导致 RLR 的调停 IRF3 的小径,哪个原因经历早熟的死亡的感染的房间。抄写因素 IRF3 能调停由两个都导致抗病毒的基因并且通过 RIPA 的激活触发 apoptosis 的细胞的抗病毒的回答。在 RIPA 的 IRF3 激活的机制从 transcriptional 激活的是不同的;它要求 IRF3 的特定的离氨酸残余的线性 polyubiquitination。用 RIPA 活跃,却 transcriptionally 不活跃, IRF3 异种,它被看那 RIPA 能在老鼠阻止病毒的复制和致病。 | Saurabh Chattopadhyay Ganes C. Sen | 2017 | Protein & Cell2017，8，3： | 7 |
| 8 | Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2008 update显示文摘 | Yun-Fan Liaw Nancy Leung Jia-Horng Kao Teerha Piratvisuth Edward Gane Kwang-Hyub Han Richard Guan George K. K. Lau Stephen Locarnini | 2008 | Hepatology International2008，，3： | 7 |
| 9 | Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2012 update显示文摘 | Yun-Fan Liaw Jia-Horng Kao Teerha Piratvisuth Henry Chan Rong-Nan Chien Chun-Jen Liu Ed Gane Stephen Locarnini Seng-Gee Lim Kwang-Hyub Han Deepak Amarapurkar Graham Cooksley Wasim Jafri Rosmawati Mohamed Jin-Lin Hou Wan-Long Chuang Laurentius Lesmana Jose | 2012 | Hepatology International2012，，3： | 6 |
| 10 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 11 | Viral degradasome hijacks mitochondria to suppress innate immunity显示文摘在主人和病原体的能力的天生的免疫之间的平衡影响致病和毒力强烈躲避它。二 nonstructural (NS ) 蛋白质, NS1 和 NS2,呼吸 syncytial,病毒(RSV ) 极其为 RSV 被要求毒力。一起,他们强烈压制类型我干扰素(IFN ) 调停了由降级或禁止多重细胞的因素的主人房间的天生的免疫为 IFN 正式就职或反应要求了小径包括 RIG-I, IRF3, IRF7, TBK1 和 STAT2。这里,我们为 NS 蛋白质装配的大、异构的 degradative 建筑群的存在提供证据,我们把它称为 “ NS-degradasome”(NSD ) 。NSD 是粗略地,在尺寸的 ~ 300-750 kD,和它的 degradative 活动被净化的线粒体的增加在 vitro 提高。在房间, NS 蛋白质的多数和到在 RSV 感染之上的线粒体的 NSD translocated 的底层内。基因并且药理学证据证明天生的豁免的最佳的抑制要求 mitochondrial MAVS 和 mitochondrial 活动性。一起,我们建议在的一个新奇范例线粒体,知道为主人的天生的有免疫力的激活重要,为天生的免疫的病毒的抑制也是重要的。 | Ramansu Goswami Tanmay Majumdar Jayeeta Dhar Saurabh Chattopadhya3~ Sudip K Bandyopadhyay Valentina Verbovetskaya Ganes C Sen Sailen Barik | 2013 | Cell Research2013，23，8： | 6 |
| 12 | Three-Year Efficacy and Safety of Tenofovir Disoproxil Fumarate Treatment for Chronic Hepatitis B显示文摘 | E. Jenny Heathcote Patrick Marcellin Maria Buti Edward Gane Robert A. De Man Zahary Krastev George Germanidis Samuel S. Lee Robert Flisiak Kelly Kaita Michael Manns Iskren Kotzev Konstantin Tchernev Peter Buggisch Frank Weilert Oya Ovunc Kurdas Mitchell L | 2011 | Gastroenterology2011，，1： | 5 |
| 13 | Sofosbuvir and Ribavirin Prevent Recurrence of HCV Infection after Liver Transplantation: An Open-Label Study显示文摘 | Michael P. Curry Xavier Forns Raymond T. Chung Norah A. Terrault Robert Brown Jonathan M. Fenkel Fredric Gordon Jacqueline O’Leary Alexander Kuo Thomas Schiano Gregory Everson Eugene Schiff Alex Befeler Edward Gane Sammy Saab John G. McHutchison G. Mani S | 2014 | Gastroenterology2014，，： | 3 |
| 14 | Randomized clinical trial: efficacy and safety of telbivudine and lamivudine in treatment‐na?ve patients with HBV‐related decompensated cirrhosis显示文摘 | H. L.Y. Chan Y. C. Chen E. J. Gane S. K. Sarin D. J. Suh T. Piratvisuth B. Prabhakar S. G. Hwang G. Choudhuri R. Safadi T. Tanwandee A. Chutaputti C. Yurdaydin W. Bao C. Avila A. Trylesinski | 2012 | Journal of Viral Hepatitis2012，，10： | 3 |
| 15 | O68 SOFOSBUVIR AND RIBAVIRIN FOR THE TREATMENT OF CHRONIC HCV WITH CIRRHOSIS AND PORTAL HYPERTENSION WITH AND WITHOUT DECOMPENSATION: EARLY VIROLOGIC RESPONSE AND SAFETY显示文摘 | N. Afdhal G. Everson J.L. Calleja G. McCaughan W.T. Symonds J. Denning L. McNair J.G. McHutchison S. Arterburn M. Charlton R. Reddy T. Asselah E. Gane X. Forns | 2014 | Journal of Hepatology2014，，1： | 3 |
| 16 | Efficacy and safety of continuous 4‐year telbivudine treatment in patients with chronic hepatitis B显示文摘 | Y. Wang S. Thongsawat E. J. Gane Y.‐F. Liaw J. Jia J. Hou H. L. Y. Chan G. Papatheodoridis M. Wan J. Niu W. Bao A. Trylesinski N. V. Naoumov | 2012 | J Viral Hepat2012，，4： | 3 |
| 17 | Telbivudine Improves Renal Function in Patients With Chronic Hepatitis B显示文摘 | Edward J. Gane Gilbert Deray Yun-Fan Liaw Seng Gee Lim Ching-Lung Lai Jens Rasenack Yuming Wang George Papatheodoridis Adrian Di Bisceglie Maria Buti Didier Samuel Alkaz Uddin Sophie Bosset Aldo Trylesinski | 2014 | Gastroenterology2014，，1： | 2 |
| 18 | Sofosbuvir and Ribavirin for Treatment of Compensated Recurrent Hepatitis C Virus Infection After Liver Transplantation显示文摘 | Michael Charlton Edward Gane Michael P. Manns Robert S. Brown Michael P. Curry Paul Y. Kwo Robert J. Fontana Richard Gilroy Lewis Teperman Andrew J. Muir John G. McHutchison William T. Symonds Diana Brainard Brian Kirby Hadas Dvory-Sobol Jill Denning Sara | 2014 | Gastroenterology2014，，： | 2 |
| 19 | 高速喷墨打印纸涂层表面性能研究显示文摘在印刷领域,喷墨打印作为一种非接触式的打印方式,其市场份额正在逐渐上升。喷墨打印可用于家庭、办公,并在3D、电子和生物材料印刷方面有很大潜力。在高速喷墨打印中广泛应用的两种墨滴成形技术是,连续喷墨技术(CIJ)和按需喷墨技术(DOD)。按照油墨的基质划分,喷墨打印机所用的油墨可分为水性油墨、溶剂型油墨、相变油墨和紫外光固化油墨;按着色剂划分,可分为颜料型和染料型油墨。油墨固着时会与纸基发生多种反应,这些反应与着色剂的固着和油墨液相的运动有关,会影响印品的质量。 | Author John Kettle Taina Lamminm aki Patrick Gane 许英(编译) | 2011 | 中国印刷与包装研究2011，3，1： | 2 |
| 20 | Erratum to: Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2012 update显示文摘 | Yun-Fan Liaw Jia-Horng Kao Teerha Piratvisuth Henry Lik Yuen Chan Rong-Nan Chien Chun-Jen Liu Ed Gane Stephen Locarnini Seng-Gee Lim Kwang-Hyub Han Deepak Amarapurkar Graham Cooksley Wasim Jafri Rosmawati Mohamed Jin-Lin Hou Wan-Long Chuang Laurentius A. | 2012 | Hepatology International2012，，4： | 2 |
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