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| 1 | 肝内胆管细胞癌诊断及治疗的现状与挑战显示文摘肝内胆管细胞癌(intrahepatic cholangiocarcinoma,ICC)是一类起源于肝内胆管上皮细胞的恶性肿瘤。ICC发病较隐匿,早期无明显的临床症状,临床上尚缺少特异度高的早期筛查诊断标志物,很多患者在发现时已进展到中晚期,失去采取根治性切除术治疗的机会;即使手术切除,复发及转移等诸多因素也会导致ICC患者病死率高、远期生存预后差的局面。国际上尚无成熟的ICC个体化精准治疗推荐策略,现有的分期及预后模型主要基于手术切除的患者所创建,缺少普适性,临床应用受限。因此提高ICC患者早期确诊率、制定精准的治疗策略、探索预后风险因素是临床改善生存结局的途径。本文结合ICC研究进展,分析了ICC的诊断和治疗现状以及面临的挑战。 | 张宁 卢姗姗 Rifaat Safadi Roberts R.Lewis 陆荫英 | 2018 | 传染病信息2018，31，1： | 8 |
| 2 | Heat shock protein 90 promotes RNA helicase DDX5 accumulation and exacerbates hepatocellular carcinoma by inhibiting autophagy显示文摘Objective:Hepatocellular carcinoma(HCC),the main type of liver cancer,has a high morbidity and mortality,and a poor prognosis.RNA helicase DDX5,which acts as a transcriptional co-regulator,is overexpressed in most malignant tumors and promotes cancer cell growth.Heat shock protein 90(HSP90)is an important molecular chaperone in the conformational maturation and stabilization of numerous proteins involved in cell growth or survival.Methods:DDX5 m RNA and protein expression in surgically resected HCC tissues from 24 Asian patients were detected by quantitative real-time PCR and Western blot,respectively.The interaction of DDX5-HSP90 was determined by molecular docking,immunoprecipitation,and laser scanning confocal microscopy.The autophagy signal was detected by Western blot.The cell functions and signaling pathways of DDX5 were determined in 2 HCC cell lines.Two different murine HCC xenograft models were used to determine the function of DDX5 and the therapeutic effect of an HSP90 inhibitor.Results:HSP90 interacted directly with DDX5 and inhibited DDX5 protein degradation in the AMPK/ULK1-regulated autophagy pathway.The subsequent accumulation of DDX5 protein induced the malignant phenotype of HCC by activating theβ-catenin signaling pathway.The silencing of DDX5 or treatment with HSP90 inhibitor both blocked in vivo tumor growth in a murine HCC xenograft model.High levels of HSP90 and DDX5 protein were associated with poor prognoses.Conclusions:HSP90 interacted with DDX5 protein and subsequently protected DDX5 protein from AMPK/ULK1-regulated autophagic degradation.DDX5 and HSP90 are therefore potential therapeutic targets for HCC. | Ting Zhang Xinrui Yang Wanping Xu Jing Wang Dawei Wu Zhixian Hong Shengxian Yuan Zhen Zeng Xiaodong Jia Shanshan Lu Rifaat Safadi Sen Han Zhihong Yang Leonard M.Neckers Suthat Liangpunsakul Weiping Zhou Yinying Lu | 2021 | Cancer Biology & Medicine2021，18，3： | 7 |
| 3 | Long‐term entecavir therapy results in the reversal of fibrosis/cirrhosis and continued histological improvement in patients with chronic hepatitis B显示文摘 | Ting‐Tsung Chang Yun‐Fan Liaw Shun‐Sheng Wu Eugene Schiff Kwang‐Hyub Han Ching‐Lung Lai Rifaat Safadi Samuel S. Lee Waldemar Halota Zachary Goodman Yun‐Chan Chi Hui Zhang Robert Hindes Uchenna Iloeje Suzanne Beebe Bruce Kreter | 2010 | Hepatology2010，，： | 4 |
| 4 | Randomized clinical trial: efficacy and safety of telbivudine and lamivudine in treatment‐na?ve patients with HBV‐related decompensated cirrhosis显示文摘 | H. L.Y. Chan Y. C. Chen E. J. Gane S. K. Sarin D. J. Suh T. Piratvisuth B. Prabhakar S. G. Hwang G. Choudhuri R. Safadi T. Tanwandee A. Chutaputti C. Yurdaydin W. Bao C. Avila A. Trylesinski | 2012 | Journal of Viral Hepatitis2012，，10： | 3 |
| 5 | Tympanomentric screening norms for adults显示文摘 | Poup CM Wiley TL Safady SH | 1998 | J Am Audiol1998，7，： | 1 |
| 6 | Prostaglandin E2 exacerbates collagen-induced arthritis in mice through the in- flammatory interleukin-23/interleukin-17 axis显示文摘 | Sheibanie AF Khayrullina T Safadi FF | 2007 | Arthritis Rheum2007，56，： | 1 |
| 7 | Hepatic fibrosis-role of hepatic stellate cell activation显示文摘 | Safadi R Friedman SL | 2002 | Med Gen Med2002，4，3： | 1 |
| 8 | Hepatic fibrosis - role of hepatic stellate cell activation显示文摘 | Safadi R Friedman SL | 2002 | MedGenMed2002，4，3： | 1 |
| 9 | A phase -2, random- ized, double blind, placebo -controlled trial of aramchol for the treatment of nonalcoholic fatty liver disease (NAFLD) 显示文摘 | SAFADI R KONIKOFF FM OREN R | 2012 | J Hepatology2012，56，： | 1 |
| 10 | Safety and efficacy of the vi- brating capsule, an innovative non-pharmacological treatment mo- dality for chronic constipation 显示文摘 | Ron Y Halpem Z Safadi R | 2015 | Neurogastroenterol Motil2015，27，1： | 1 |
| 11 | Hepatic fibrosis role of hepatic stellate cell activation显示文摘 | Safadi R Friedman SL | 2002 | J Med Gen Med2002，4，3： | 1 |
| 12 | Pulmonary calcification in hemodialysis patients: Correlation with pulmonary artery pressure values显示文摘 | Yigla M KeidarZ Safadi I | 2004 | Kidney Int2004，66，： | 1 |
| 13 | An epidemiological overview of di- abetes across the world 显示文摘 | Meetoo D McGovem P Safadi R | 2007 | Br J Nuts2007，16，16： | 1 |
| 14 | Involvement of the CXCL12/ CXCR4 pathway in the advanced liver disease that is associated with hepatitis C virus or hepatitis B virus显示文摘 | Wald O Pappo O Safadi R | 2004 | Eur J Immunol2004，34，4： | 1 |
| 15 | Prostaglandin E2 ex-acerbates collagen-inducedarthritis in mice through the inflammato-ry interleukin-23/interleukin-17 axis显示文摘 | Sheibanie AF Khayrullina T Safadi FF | 2007 | Arthritis Rheum2007，56，8： | 1 |
| 16 | An epidemiological overview of diabetes across the world 显示文摘 | Meetoo D McGovern P Safadi R | 2007 | Br J Nurs2007，16，： | 1 |
| 17 | Two -component system RgfA/C activates the l'bsB gene encoding major fibrinogen - binding protein in highly virulent CC17 clone group B Streptococcus 显示文摘 | A1 Safadi R Mereghetti L Salloum M | 2011 | PLoS One2011，6，14： | 1 |
| 18 | Hepatic fibrosis-role of hepatic stellate cell activation显示文摘 | SAFADI R FRIEDMAN SL | 2002 | Med Gen Med2002，4，： | 1 |
| 19 | Cloning the full-length cDNA for rat connective tissue growth factor: implications for skeletal development显示文摘 | Smock SL Safadi FF | 2000 | J Cell Biochem2000，77，1： | 1 |
| 20 | Coronal caries experience in dentate Jordanian adults显示文摘 | Hamasha AA Safadi RA | 2008 | Community Dent Health2008，25，1： | 1 |
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