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| 1 | Endocytoscopic narrow-band imaging efficiency for evaluation of inflammatory activity in ulcerative colitis显示文摘AIM:To assess the efficacy of endocytoscopic narrowband imaging(EC-NBI)for evaluating the severity of inflammation in ulcerative colitis(UC).METHODS:This retrospective study was conducted at a single tertiary care referral center.We included UC patients who underwent colonoscopy with endocytoscopy from July 2010 to December 2013.ECNBI was performed,and the images were evaluated by assessing visibility,increased vascularization,and the increased calibers of capillaries and were classified as Obscure,Visible or Dilated.Obscure was indicative of inactive disease,while Visible and Dilated were indicative of acute inflammation.This study received Institutional Review Board approval.The primary outcome measures included the diagnostic ability of EC-NBI to distinguish between active and inactive UC on the basis of histological activity.The conventional endoscopic images were classified according to the Mayo endoscopic score.A score of 0 or 1 indicated inactive disease,whereas a score of 2 indicated active disease.RESULTS:Fifty-two patients were enrolled.There was a strong correlation between the EC-NBI findings and the histological assessment(r=0.871,P<0.01).The sensitivity,specificity,positive predictive value,negative predictive value,and accuracy of EC-NBI for diagnosing acute inflammation were 84.0%,100%,87.1%,100%,and 92.3%,respectively,while those for the Mayo endoscopic score were 100%,40.7%,100%,61.0%,and 69.2%,respectively.Compared with conventional endoscopy,EC-NBI was superior in diagnostic specificity,negative predictive value,and accuracy(P<0.001,P=0.001 and P=0.047,respectively).CONCLUSION:The EC-NBI finding of capillaries in the rectal mucosa was strongly correlated with histological inflammation and aided in the differential diagnosis between active and inactive UC. | Yasuharu Maeda Kazuo Ohtsuka Shin-ei Kudo Kunihiko Wakamura Yuichi Mori Noriyuki Ogata Yoshiki Wada Masashi Misawa Akihiro Yamauchi Seiko Hayashi Toyoki Kudo Takemasa Hayashi Hideyuki Miyachi Fuyuhiko Yamamura Fumio Ishida Haruhiro Inoue Shigeharu Hamatani | 2015 | World Journal of Gastroenterology2015，21，7： | 4 |
| 2 | Non-transmissible Sendai virus vector encoding c-myc suppressor FBP-interacting repressor for cancer therapy显示文摘AIM:To investigate a novel therapeutic strategy to target and suppress c-myc in human cancers using far up stream element(FUSE)-binding protein-interacting repressor(FIR).METHODS:Endogenous c-Myc suppression and apoptosis induction by a transient FIR-expressing vector was examined in vivo via a HA-tagged FIR(HA-FIR)expression vector.A fusion gene-deficient,non-transmissible,Sendai virus(SeV)vector encoding FIR cDNA,SeV/dF/FIR,was prepared.SeV/dF/FIR was examined for its gene transduction efficiency,viral dose dependency of antitumor effect and apoptosis induction in HeLa(cervical squamous cell carcinoma)cells and SW480(colon adenocarcinoma)cells.Antitumor efficacy in a mouse xenograft model was also examined.The molecular mechanism of the anti-tumor effect and c-Myc suppression by SeV/dF/FIR was examined using Spliceostatin A(SSA),a SAP155 inhibitor,or SAP155siRNA which induce c-Myc by increasing FIR△exon2 in HeLa cells.RESULTS:FIR was found to repress c-myc transcription and in turn the overexpression of FIR drove apoptosis through c-myc suppression.Thus,FIR expressing vectors are potentially applicable for cancer therapy.FIR is alternatively spliced by SAP155 in cancer cells lacking the transcriptional repression domain within exon 2(FIR△exon2),counteracting FIR for c-Myc protein expression.Furthermore,FIR forms a complex with SAP155 and inhibits mutual well-established functions.Thus,both the valuable effects and side effects of exogenous FIR stimuli should be tested for future clinical application.SeV/dF/FIR,a cytoplasmic RNA virus,was successfully prepared and showed highly efficient gene transduction in in vivo experiments.Furthermore,in nude mouse tumor xenograft models,SeV/dF/FIR displayed high antitumor efficiency against human cancer cells.SeV/dF/FIR suppressed SSA-activated c-Myc.SAP155 siRNA,potentially produces FIR△exon2,and led to c-Myc overexpression with phosphorylation at Ser62.HA-FIR suppressed endogenous c-Myc expression and induced apoptosis in HeLa and SW480 cells.A c-myc transcriptional suppressor FIR expressing SeV/dF/FIR showed high gene transduction efficiency with significant antitumor effects and apoptosis induction in HeLa and SW480 cells.CONCLUSION:SeV/dF/FIR showed strong tumor growth suppression with no significant side effects in an animal xenograft model,thus SeV/dF/FIR is potentially applicable for future clinical cancer treatment. | Kazuyuki Matsushita Hideaki Shimada Yasuji Ueda Makoto Inoue Mamoru Hasegawa Takeshi Tomonaga Hisahiro Matsubara Fumio Nomura | 2014 | World Journal of Gastroenterology2014，20，15： | 2 |
| 3 | Determination of perfluorooctane sulfonate, perfluorooctanoate and perfluorooctane sulfonylamide in human plasma by column- switc-hing liquid chromatography-electrospray mass spectro- metry coupled with solid-phase extraction 显示文摘 | Koichi Inoue Fumio Okada Rielto | 2004 | Journal of Chromatography B2004，810，： | 1 |
| 4 | Overcoming hybrid lethality in a cross between Japanese pear and apple using gamma irradiation and confirmation of hybrid status using flow cytometry and SSR markers显示文摘 | Takeru Gonai Toru Manabe Eiichi Inoue Mikio Hayashi Toshiya Yamamoto Tateki Hayashi Fumio Sakuma Masakazu Kasumi | 2006 | Scientia Horticulturae2006，，1： | 1 |
| 5 | Effect of additives on dechlorination of PVC by mechanochemical treatment显示文摘 | Shu Saeki Junya Kano Fumio Saito Kaoru Shimme Seiichi Masuda Tsuyoshi Inoue | 2001 | Journal of Material Cycles and Waste Management2001，，1： | 1 |
| 6 | Assessment of coronary artery abnormalities in a patient with Kawasaki disease by multislice computed tomography显示文摘 | Yuichi Sato Naoya Matsumoto Fumio Inoue | 2004 | Heart Vessels2004，19，16： | 1 |
| 7 | A new development of dyestuffs degradation system using ultrasound 显示文摘 | Marcio Inoue Fumio Okada Akihiko Sakumi | 2006 | Ultrasonics Sonochemistry2006，13，4： | 1 |
| 8 | Measurement of 4-nonylphenol and 4-tertoctylphenol in human urine by columnswitching liquid chromatographymass spectrometry显示文摘 | Migaku Kawaguchi Fumio Okada | 2003 | Anal Chimica Acta2003，486，： | 1 |
| 9 | Hemodynamic Effects of Combined Therapy Using Partial Splenic Embolization and Transjugular Retrograde Obliteration for Gastric Varices with Gastrorenal Shunt显示文摘 | Fumio Chikamori Atsushi Inoue Hiroshi Okamoto Nobutoshi Kuniyoshi Takahiko Kawashima Yasuhiro Takase | 2010 | World Journal of Surgery2010，，5： | 1 |
| 10 | A giant left circumflex coronary artery – right atrium arteriovenous fistula detected by multislice spiral computed tomography显示文摘 | Yuichi Sato Masayasu Mitsui Hiroshi Takahashi Takuya Miyazawa Hiroyuki Okabe Fumio Inoue Junji Kusama Toshiyuki Horie Naoya Matsumoto Yoshitaka Hori Satoru Furuhashi Motoichiro Takahashi Katsuo Kanmatsuse | 2004 | Heart and Vessels2004，，1： | 1 |
| 11 | Nephrotoxicity of a novel antineoplastic platinum complex, nedaplatin: a comparative study with cisplatin in rats显示文摘 | Takeki Uehara Hiroshi Watanabe Fumio Itoh Satoshi Inoue Hikaru Koshida Masuhisa Nakamura Jyoji Yamate Toshiyuki Maruyama | 2005 | Archives of Toxicology2005，，8： | 1 |
| 12 | Measurement of 4-nonyl phenol and 4-tert-octylphenol in human urine by column-switching liquid chromatographymass spectrometry显示文摘 | Koichi Inoue Migaku Kawaguchi Fumio Okada | 2003 | Anal Chimica Acta2003，486，： | 1 |
| 13 | A new development of dyestuffs degradation system using ultrasound显示文摘 | Marcio Inoue Fumio Okada Akihiko Sakurai | 2006 | Ultrasonics Sonochemistry2006，13，4： | 1 |
| 14 | Column-switching high-performance liquid chromatography electrospray mass spectrometry coupled with on-line of extraction for the determination of mono- and di-(2-ethylhexyl) phthalate in blood samples显示文摘 | Koichi Inoue Migaku Kawaguchi Fumio Okada Yoshihiro Yoshimura Hiroyuki Nakazawa | 2003 | Analytical and Bioanalytical Chemistry2003，，4： | 1 |
| 15 | Determination of perfluorooctane sulfonate,perfluorooctanoate and perfluorooctane sulfonylamide in human plasma by column-switching liquid chromatography-electrospray mass spectrometry coupled with solid-phase extraction显示文摘 | Okada Fumio Ito Rie | 2004 | Journal of Chromatography B2004，810，115： | 1 |
| 16 | Determination of perfluorooctane sulfonate, perfluorooctanoate and perfluo- rooctane sulfonylamide in human plasma by column - switching liquid chromatography - electrospray mass spectrometry coupled with solid - phase extraction 显示文摘 | Koichi Inoue Fumio Okada Rie Ito | 2004 | Journal of Chromatography B2004，810，： | 1 |
| 17 | Influence of Polymer Impurity on the Mechanochemical Dechlorination Reaction of Polyvinyl Chloride 显示文摘 | Inoue T Junya J Fumio F | 2006 | Advanced Powder Technology2006，17，4： | 1 |
| 18 | Treatment of salivary gland hypofunction by transplantation with dental pulp cells显示文摘 | Yuka Yamamura Hiroyuki Yamada Takashi Sakurai Fumio Ide Hiroko Inoue Takashi Muramatsu Kenji Mishima Yoshiki Hamada Ichiro Saito | 2013 | Archives of Oral Biology2013，，8： | 1 |
| 19 | Ca2+/Calmodulin-Dependent Kinase IIδ Causes Heart Failure by Accumulation of p53 in Dilated Cardiomyopathy显示文摘 | Haruhiro Toko Hidehisa Takahashi Yosuke Kayama Toru Oka Tohru Minamino Sho Okada Sachio Morimoto Dong-Yun Zhan Fumio Terasaki Mark E. Anderson Masashi Inoue Atsushi Yao Ryozo Nagai Yasushi Kitaura Toshiyuki Sasaguri Issei Komuro | 2010 | Circulation2010，，9： | 1 |
| 20 | Short-Segment Fixation Without Fusion for Thoracolumbar Burst Fractures With Neurological Deficit Can Preserve Thoracolumbar Motion Without Resulting in Post-traumatic Disc Degeneration: A 10-Year Follow-up Study显示文摘 | Tomoaki Toyone Tomoyuki Ozawa Kunimasa Inada Toshiyuki Shirahata Ryutaro Shiboi Atsuya Watanabe Keisuke Matsuki Fumio Hasue Takayuki Fujiyoshi Yasuchika Aoki Gen Inoue Sumihisa Orita Seiji Ohtori Yuichi Wada Tadashi Tanaka Kazuhisa Takahashi | 2013 | Spine2013，，17： | 1 |
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