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| 1 | STI571 (Glivec) suppresses the expression of vascular endothelial growth factor in the gastrointestinal stromal tumor cell line,GIST-T1显示文摘AIM:To estimate whether STI571 inhibits the expressionof vascular endothelial growth factor(VEGF)in thegastrointestinal stromal tumor(GIST)cells.METHODS:We used GIST cell line,GIST-T1.It hasa heterogenic 57-bp deletion in exon 11 to produce amutated c-KIT,which results in constitutive activationof c-KIT.Cells were treated with/without STI571 orstem cell factor(SCF).Transcription and expression ofVEGF were determined by RT-PCR and flow cytometryor Western blotting,respectively.Activated c-KIT wasestimated by immunoprecipitation analysis.Cell viabilitywas determined by MTT assay.RESULTS:Activation of c-KIT was inhibited bySTI571 treatment.VEGF was suppressed at both thetranscriptional and translational levels in a temporal anddose-dependent manner by STI571.SCF upregulatedthe expression of VEGF and it was inhibited by STI571.STI571 also reduced the cell viability of the GIST-T1cells,as determined by MTT assay.CONCLUSION:Activation of c-KIT in the GIST-T1regulated the expression of VEGF and it was inhibited bySTI571.STI571 has antitumor effects on the GIST cellswith respect to not only the inhibition of cell growth,butalso the suppression of VEGF expression. | Toufeng Jin Hajime Nakatani Takahiro Taguchi Takumi Nakano Takehiro Okabayashi Takeki Sugimoto Michiya Kobayashi Keijiro Araki | 2006 | World Journal of Gastroenterology2006，12，5： | 14 |
| 2 | Oral supplementation of branched-chain amino acids reduces early recurrence after hepatic resection in patients with hepatocellular carcinoma: a prospective study显示文摘 | Kengo Ichikawa Takehiro Okabayashi Hiromichi Maeda Tsutomu Namikawa Tatsuo Iiyama Takeki Sugimoto Michiya Kobayashi Toshiki Mimura Kazuhiro Hanazaki | 2013 | Surgery Today2013，，7： | 2 |
| 3 | Branched-chain amino acid-enriched nutrients stimulate antioxidant DNA repair in a rat model of liver injury induced by carbon tetrachloride显示文摘 | Kengo Ichikawa Takehiro Okabayashi Yasuo Shima Tatsuo Iiyama Yuka Takezaki Masaya Munekage Tsutomu Namikawa Takeki Sugimoto Michiya Kobayashi Toshiki Mimura Kazuhiro Hanazaki | 2012 | Molecular Biology Reports2012，，12： | 1 |
| 4 | A case with synchronous multiple liver metastases from gastric carcinoma: postoperative long-term disease-free survival显示文摘 | Masaya Munekage Takehiro Okabayashi Norihiro Hokimoto Takeki Sugimoto Hiromichi Maeda Tsutomu Namikawa Ken Dabanaka Michiya Kobayashi Keijiro Araki Kazuhiro Hanazaki | 2009 | Langenbeck’s Archives of Surgery2009，，4： | 1 |
| 5 | Identification of glutathione depletion-responsive genes using phorone-treated rat liver 显示文摘 | Naoki KIYOSAWA Takeki UEHARA Weihua GAO | 2007 | Toxicol Sci2007，32，5： | 1 |
| 6 | Transcriptional analysis of genes for energy catabolism and hydrolytic enzymes in the filamentous fungus Aspergillus oryzae using cDNA microarrays and expressed sequence tags显示文摘 | Hiroshi Maeda Motoaki Sano Yutaka Maruyama Takeki Tanno Takeshi Akao Yoshiteru Totsuka Misako Endo Rumi Sakurada Youhei Yamagata Masayuki Machida Osamu Akita Fumihiko Hasegawa Keietsu Abe Katsuya Gomi Tasuku Nakajima Yasutaka Iguchi | 2004 | Applied Microbiology and Biotechnology2004，，1： | 1 |
| 7 | Dialysate Vascular Endothelial Growth Factor Is an Independent Determinant of Serum Albumin Levels and Predicts Future Withdrawal From Peritoneal Dialysis in Uremic Patients显示文摘 | Takuma Hazama Kei Fukami Sho‐ichi Yamagishi Takuo Kusumoto Kazuko Sakai Takeki Adachi Kazuhiro Sonoda Syumon Kasuga Seiji Ueda Seiya Okuda | 2014 | Ther Apher Dial2014，，5： | 1 |
| 8 | Effect of FTY720,a novel immunosuppressant,on adjuvant-and collagen-induced arthritis in rats显示文摘 | Mamoru Matsuura Tomonori Imayoshi Takeki Okumoto | 2000 | Int J Immunopharmacol2000，22，： | 1 |
| 9 | Oral supplementation of branched-chain amino acids reduces early recurrence after hepatic resection in patients with hepatocellular carcinoma: a prospective study显示文摘 | Kengo Ichikawa Takehiro Okabayashi Hiromichi Maeda Tsutomu Namikawa Tatsuo Iiyama Takeki Sugimoto Michiya Kobayashi Toshiki Mimura Kazuhiro Hanazaki | 2013 | Surgery Today2013，，7： | 1 |
| 10 | Cell -transforming activity and mutagenicity of 5 phytoestrogens in cultured mammalin cells显示文摘 | Takeki T Yukiko T Eiichi Y | 2003 | Int J Cancer2003，105，： | 1 |
| 11 | Branched-chain amino acid-enriched nutrients stimulate antioxidant DNA repair in a rat model of liver injury induced by carbon tetrachloride显示文摘 | Kengo Ichikawa Takehiro Okabayashi Yasuo Shima Tatsuo Iiyama Yuka Takezaki Masaya Munekage Tsutomu Namikawa Takeki Sugimoto Michiya Kobayashi Toshiki Mimura Kazuhiro Hanazaki | 2012 | Molecular Biology Reports2012，，12： | 1 |
| 12 | Promotion of beta cell differentiation by conophylline in fetal and neonatal rat pancreas 显示文摘 | Takeki Ogata Lei Li Satoko Yamada | 2004 | Diabetes2004，53，10： | 1 |
| 13 | Recurrence of gastric cancer in the jejunal pouch after completion gastrectomy显示文摘 | Tsutomu Namikawa Michiya Kobayashi Ken Okamoto Takehiro Okabayashi Toyokazu Akimori Takeki Sugimoto Kazuhiro Hanazaki | 2007 | Gastric Cancer2007，，4： | 1 |
| 14 | Nephrotoxicity of a novel antineoplastic platinum complex, nedaplatin: a comparative study with cisplatin in rats显示文摘 | Takeki Uehara Hiroshi Watanabe Fumio Itoh Satoshi Inoue Hikaru Koshida Masuhisa Nakamura Jyoji Yamate Toshiyuki Maruyama | 2005 | Archives of Toxicology2005，，8： | 1 |
| 15 | Evaluation of the minimally invasive parathyroidectomy in patients with primary hyperparathyroidism:a retrospective cohort study显示文摘 | Sayoko T Takeki S Norihiro H | 2016 | Annals of Medicine and Surgery2016，7，1： | 1 |
| 16 | Kimura's disease with bilateral auricular masses显示文摘 | Akio H Kanehiro H Takeki S | 1999 | AJNR1999，20，： | 1 |
| 17 | In?ammasome activation of cardiac ? broblasts is essential for myocardial ischemia/reperfusion injury显示文摘 | Masanori Kawaguchi Masafumi Takahashi Takeki Hata | | 0，，06： | 1 |
| 18 | Early gastric cancer of the small type显示文摘 | Takeki F Yoshihisa O Tadashi Z | 1988 | Am J Gastroenterol1988，83，： | 1 |
| 19 | Diagnostic Study of the Effects of a Large City on Heavy Rainfall as Revealed by an Ensemble Simulation: A Case Study of Central Tokyo, Japan显示文摘 | Inamura Tomohiko Izumi Takeki Matsuyama Hiroshi | 2011 | Journal of Applied Meteorology and Climatology2011，，3： | 1 |
| 20 | 显示文摘 | Masanori K Yoshihisa K Takeki Y | 2004 | Biomaterials2004，25，28： | 1 |
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