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| 1 | Utility of linked color imaging for endoscopic diagnosis of early gastric cancer显示文摘BACKGROUND Linked color imaging(LCI) is a method of endoscopic imaging that emphasizes slight differences in red mucosal color.AIM To evaluate LCI in diagnostic endoscopy of early gastric cancer and to compare LCI and pathological findings.METHODS Endoscopic images were obtained for 39 patients(43 lesions) with early gastric cancer. Three endoscopists evaluated lesion recognition with white light imaging(WLI) and LCI. Color values in Commission Internationale de l'Eclairage(CIE)1976 L*a*b* color space were used to calculate the color difference(ΔE) between cancer lesions and non-cancer areas. After endoscopic submucosal dissection,blood vessel density in the surface layer of the gastric epithelium was evaluated pathologically. The identical region of interest was selected for analyses of endoscopic images(WLI and LCI) and pathological analyses.RESULTS LCI was superior for lesion recognition(P < 0.0001), and ΔE between cancer and non-cancer areas was significantly greater with LCI than WLI(29.4 vs 18.6, P <0.0001). Blood vessel density was significantly higher in cancer lesions(5.96% vs4.15%, P = 0.0004). An a* cut-off of ≥ 24 in CIE 1976 L*a*b* color space identified a cancer lesion using LCI with sensitivity of 76.7%, specificity of 93.0%, and accuracy of 84.9%.CONCLUSION LCI is more effective for recognition of early gastric cancer compared to WLI as a result of improved visualization of changes in redness. Surface blood vessel density was significantly higher in cancer lesions, and this result is consistent with LCI image analysis. | Toshihisa Fujiyoshi Ryoji Miyahara Kohei Funasaka Kazuhiro Furukawa Tsunaki Sawada Keiko Maeda Takeshi Yamamura Takuya Ishikawa Eizaburo Ohno Masanao Nakamura Hiroki Kawashima Masato Nakaguro Masahiro Nakatochi Yoshiki Hirooka | 2019 | World Journal of Gastroenterology2019，25，10： | 12 |
| 2 | 人类白细胞抗原DRB1等位基因与幽门螺杆菌感染的关系显示文摘目的 研究人类白细胞抗原 (HLA)DRB1等位基因与幽门螺杆菌 (Hp)感染的关系。 方法 用BioseedHp IgG定量酶联免疫试剂盒检测 46例胃癌、75例食道癌和 10 0例人群对照的Hp IgG抗体 ,用Biotest低解析水平HLA DRB酶联免疫探针杂交测定试剂盒检测HLA DRB1等位基因。结果 (1)Hp IgG阳性组DRB1 0 8基因频度显著高于Hp IgG阴性组 (13.1%vs 4.4% ;χ2 =11.14,P <0 .0 0 1)。Hp IgG阳性组DRB1 12基因频度显著低于Hp IgG阴性组 (5 .4%vs 11.3 % ;χ2 =4.49,P <0 .0 5 )。 (2 )胃癌组中DRB1 0 2基因频度显著高于对照组 ,而DRB1 0 7基因频度显著低于对照组 ,但在胃癌、对照的Hp IgG阳性组和Hp IgG阴性组之间的DRB1 0 2、DRB1 0 7基因频度差异均无显著性。结论 (1)HLA DRB1 0 8基因阳性可能增加对Hp的易感性 ,DRB1 12基因可能是抵御Hp感染的保护性基因。 (2 )DRB1 0 2基因阳性可能是胃癌的宿主遗传危险因素、DRB1 0 7基因可能是胃癌的保护性因素 ,但DRB1 0 2、DRB1 0 | 高长明 李忠佑 丁建华 王建东 胡旭 刘体康 徐天亮 李洪川 Fujiyoshi Toshinobu Takezaki Toshiro Tajima Kazuo | 2000 | 中华流行病学杂志2000，21，6： | 10 |
| 3 | Int J Cardiol:非高密度脂蛋白胆固醇与冠心病的死亡率相关显示文摘非高密度脂蛋白(HDL)的胆固醇水平,一般不受空腹状态或血清甘油三酯水平的影响,可能有助于预测未来的心血管事件。2016年6月15日的《International Journal of Cardiology》刊载了一项研究,旨在探讨一般日本人群中,非高密度脂蛋白胆固醇在致命性冠状动脉事件和卒中的发展中的作用。 | Ito T Arima H Fujiyoshi A | 2016 | 疾病监测2016，31，7： | 6 |
| 4 | Structural determinants of water permeation through aquaporin-1 显示文摘 | MIYAMOTO K MITSUOKA K HIRAI T WALZ T AGRE P HEYMANN J B ENGEL A FUJIYOSHI Y | 2000 | Nature2000，407，： | 1 |
| 5 | VL- SI module placement based on rectangle-packing by the sequence-pair显示文摘 | Murata H Fujiyoshi K Nakatake S Kaiitani Y | 1996 | IEEE Transactions on Computer- Aided Design oI Integrated Circuits and Systems1996，15，12： | 1 |
| 6 | Neurosteroid pregnenolone sulfate enhances glutamatergic synaptic transmission by facilitating presynaptic calcium currents at the calyx of Held of immature rats显示文摘 | Hige T Fujiyoshi Y Takahashi T | 2006 | Eur J Neurosci2006，24，7： | 1 |
| 7 | Atomic model of plant light-harvesting complex by electron crystallography显示文摘 | Kühlbrandt W Wang D N Fujiyoshi Y | 1994 | Nature1994，367，： | 1 |
| 8 | Measurement of overall temperature coefficient of reactivity of VHTRC-1 core by pulsed neutron method显示文摘 | TSUYOSHI Y HIDESHI Y FUJIYOSHI A | 1995 | J Nue Sci Tech1995，27，： | 1 |
| 9 | Structure and function of water channels显示文摘 | Fujiyoshi Y Mitsuoka K de Groot B L | 2002 | Curr Opin Struct Biol2002，12，4： | 1 |
| 10 | Vlsi module placement based on rectangle-packing by the sequencepair显示文摘 | Murata H Fujiyoshi K Nakatake S | 1996 | IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems (TCAD)1996，12，： | 1 |
| 11 | VLSI module placement based on rectangle-packing by the se- quence-pair显示文摘 | MURATE H FUJIYOSHI K NAKATAKE S | 1996 | IEEE Transactions on Computer-Aided De sign of Integrated Circuits and System1996，15，2： | 1 |
| 12 | A system for video surveillance and monitoring显示文摘 | Collins R T Lipton A J Fujiyoshi H | 2001 | Proc of the IEEE2001，89，： | 1 |
| 13 | VLSI rood-ule placement based on rectangle-packing by the se- quence-pair显示文摘 | Murata H Fujiyoshi K Nakatake S | 1997 | IEEE Transactions on Computer-Ai- ded Design of Integrated Circuits and Systems1997，15，12： | 1 |
| 14 | Reproductive cycle and shell growth of transplanted Manila clam Ruclitapes philippinarum in Saroma Lagoon显示文摘 | Goshima S Ide N Fujiyoshi Y | 1996 | Nippon Suisan Gakkaishi1996，62，： | 1 |
| 15 | Posterior decompression with instrumented fusion for thoracic myelopathy caused by ossification of the posterior longitudinal ligament显示文摘 | Yamazaki M Okawa A Fujiyoshi T | 2010 | Eur Spine J2010，19，5： | 1 |
| 16 | Struetion and fuction of water channels 显示文摘 | Fujiyoshi Y Mitsuoka K de Groot BL | 2002 | Curr Opin Struct Biol2002，12，4： | 1 |
| 17 | Simulated surgery for a patient with neurofibromatosis type-I who had severe cervicothoracic kyphoscoliosis and an anomalous vertebral artery 显示文摘 | Yamazaki M Okawa A Fujiyoshi T | 2010 | Spine2010，35，9： | 1 |
| 18 | IEICE Transactions on Fundamentals of Electronics 显示文摘 | Hirakawa Natsumi Fujiyoshi Kunihiro | 2009 | Communications and Computer Sciences2009，92，2： | 1 |
| 19 | Concurrent chemoradiotherapy with low-dose daily cisplatin for high risk uterine cervical cancer: a long-term follow-up study显示文摘 | Ushijima K Fujiyoshi K Kawano K | 2013 | J Gynecol Oncol2013，24，2： | 1 |
| 20 | Role of the outermost subdomain of Salmonella flagellin in the filament structure revealed by electron cryomicroscopy显示文摘 | Mimori Kiyosue Y Yamashita I Fujiyoshi Y | 1998 | J Mol Biol1998，284，： | 1 |
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