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| 1 | Prognosis of ulcerative colitis differs between patients with complete and partial mucosal healing, which can be predicted from the platelet count显示文摘AIM:To determine the difference in clinical outcome between ulcerative colitis(UC)patients with Mayo endoscopic subscore(MES)0 and those with MES 1.METHODS:UC patients with sustained clinical remission of 6 mo or more at the time of colonoscopy were examined for clinical outcomes and the hazard ratios of clinical relapse according to MES.Parameters,including blood tests,to identify predictive factors for MES 0and slight endoscopic recurrence in clinically stablepatients were assessed.Moreover,a receiver operating characteristic curve was generated,and the area under the curve was calculated to indicate the utility of the parameters for the division between complete and partial mucosal healing.All P values were two-sided and considered significant when less than 0.05.RESULTS:A total of 183 patients with clinical remission were examined.Patients with MES 0(complete mucosal healing:n=80,44%)were much less likely to relapse than those with MES 1(partial mucosal healing:n=89,48%)(P<0.0001,log-rank test),and the hazard ratio of risk of relapse in patients with MES 1 vs MES0 was 8.17(95%CI:4.19-17.96,P<0.0001).The platelet count(PLT)<26×104/μL was an independent predictive factor for complete mucosal healing(OR=4.1,95%CI:2.15-7.99).Among patients with MES 0 at the initial colonoscopy,patients of whom colonoscopy findings shifted to MES 1 showed significant increases in PLT compared to those who maintained MES 0(3.8×104/μL vs-0.6×104/μL,P<0.0001).CONCLUSION:The relapse rate differed greatly between patients with complete and partial mucosal healing.A shift from complete to partial healing in clinically stable UC patients can be predicted by monitoring PLT. | Asuka Nakarai Jun Kato Sakiko Hiraoka Toshihiro Inokuchi Daisuke Takei Yuki Moritou Mitsuhiro Akita Sakuma Takahashi Keisuke Hori Keita Harada Hiroyuki Okada Kazuhide Yamamoto | 2014 | World Journal of Gastroenterology2014，20，48： | 11 |
| 2 | Long-term follow-up of ulcerative colitis patients treated on the basis of their cytomegalovirus antigen status显示文摘AIM:To clarify the impact of cytomegalovirus(CMV)activation and antiviral therapy based on CMV antigen status on the long-term clinical course of ulcerative colitis(UC)patients.METHODS:UC patients with flare-up were divided into CMV-positive and-negative groups according to the CMV antigenemia assay.The main treatment strategy provided for the patients in the CMV-positive group comprised a dose reduction of corticosteroids and administration of ganciclovir.RESULTS:The median number of days to initial remission was significantly greater for the patients in the CMV-positive group(21 d vs 16 d,P=0.009).However,the relapse rate after remission and colectomy rate during more than 30 mo of observation did not differ between the two groups.Multivariate analysis revealed that administration of ganciclovir was the only independent factor for avoiding colectomy in patients of the CMV-positive group.CONCLUSION:CMV antigen status did not significantly affect the long-term prognosis in UC patients under treatment with appropriate antiviral therapy. | Toshihiro Inokuchi Jun Kato Sakiko Hiraoka Hideyuki Suzuki Asuka Nakarai Tomoko Hirakawa Mitsuhiro Akita Sakuma Takahashi Keita Harada Hiroyuki Okada Kazuhide Yamamoto | 2014 | World Journal of Gastroenterology2014，20，2： | 6 |
| 3 | Topical nitrate drip infusion using cystic duct tube for retained bile duct stone:A six patients case series显示文摘A retained bile duct stone after operation for cholelithiasis still occurs and causes symptoms such as biliary colic and obstructive jaundice.An endoscopic retrograde cholangiopancreatography with endoscopic sphincterotomy(EST),followed by stone extraction,are usually an effective treatment for this condition.However,these procedures are associated with severe complications including pancreatitis,bleeding,and duodenal perforation.Nitrates such as glyceryl trinitrate(GTN) and isosorbide dinitrate(ISDN) are known to relax the sphincter of Oddi.In 6 cases in which a retained stone was detected following cholecystectomy,topical nitrate drip infusion via cystic duct tube(C-tube) was carried out.Retained stones of 2-3 mm diameter and no dilated common bile duct in 3 patients were removed by drip infusion of 50 mg GTN or 10 mg ISDN,which was the regular dose of intravenous injection.Three other cases failed,and EST in 2 cases and endoscopic biliary balloon dilatation in 1 case were performed.One patient developed an adverse event of nausea.Severe complications were not observed.We consider the topical nitrate drip infusion via C-tube to be old but safe,easy,and inexpensive procedure for retained bile duct stone following cholecystectomy,inasmuch as removal rate was about 50% in our cases. | Masatoshi Shoji Hiroshi Sakuma Yutaka Yoshimitsu Tsutomu Maeda Masuo Nakai Hiroshi Ueda | 2013 | World Journal of Gastrointestinal Surgery2013，5，6： | 4 |
| 4 | 几种疱疹病毒可在严重的药物诱发的多器官反应中与在移植物抗宿主病中一样以相同顺序复活 | Kano Y. Hiraharas K. Sakuma K. Shiohara T. 罗素菊 | 2006 | 世界核心医学期刊文摘(皮肤病学分册)2006，0，10： | 4 |
| 5 | A High-Precision US-Guided Robot-Assisted HIFU Treatment System for Breast Cancer显示文摘乳腺癌是女性中最常见的癌症。高强度聚焦超声(波)(HIFU)是一种很有前景的非介入式治疗方法。为了提高HIFU治疗的精确度和降低治疗成本,开发了一套基于超声引导(US)的五自由度辅助HIFU系统。搭建了一套功能齐全的样机,它可以轻松地实现三维超声图像重建、目标分割、治疗路径生成和HIFU自动照射等功能。利用线模型实现点定位,并且在异构组织模型上对凝固区域进行评估。在超声引导下,HIFU治疗区域的中心偏离目标治疗区域中心不到2 mm。规划治疗区域周围出现的超调值远低于在临床使用的允许值。对于乳腺癌的治疗,本系统有足够的准确性。 | Tianhan Tang Takashi Azuma Toshihide Iwahashi Hideki Takeuchi Etsuko Kobayashi Ichiro Sakuma | 2018 | Engineering2018，4，5： | 3 |
| 6 | Exploitation of shape memory alloy actuator using resistance feedback control and its development | Hiroki CHO Takaei YAMAMOTO Yuji TAKEDA Akihiko SUZUKI Toshio SAKUMA | 2010 | Progress in Natural Science:Materials International2010，20，1： | 3 |
| 7 | DNA-Binding Specificity of the ERF/AP2 Domain of Arabidopsis DREBs, Transcription Factors Involved in Dehydration- and Cold-Inducible Gene Expression显示文摘 | Yoh Sakuma Qiang Liu Joseph G. Dubouzet Hiroshi Abe Kazuo Shinozaki Kazuko Yamaguchi-Shinozaki | 2002 | Biochemical and Biophysical Research Communications2002，，3： | 3 |
| 8 | Global histone modification of H3K27 correlates with the outcomes in patients with metachronous liver metastasis of colorectal cancer显示文摘 | H. Tamagawa T. Oshima M. Numata N. Yamamoto M. Shiozawa S. Morinaga Y. Nakamura M. Yoshihara Y. Sakuma Y. Kameda M. Akaike N. Yukawa Y. Rino M. Masuda Y. Miyagi | 2013 | European Journal of Surgical Oncology2013，，6： | 2 |
| 9 | Pediatric living donor liver transplantation for congenital hepatic fibrosis using a mother's graft with von Meyenburg complex: A case report显示文摘This is the first report of living donor liver transplantation(LDLT) for congenital hepatic fibrosis(CHF) using a mother's graft with von Meyenburg complex. A 6-year-old girl with CHF, who suffered from recurrent gastrointestinal bleeding, was referred to our hospital for liver transplantation. Her 38-year-old mother was investigated as a living donor and multiple biliary hamartoma were seen on her computed tomography and magnetic resonance imaging scan. The mother's liver function tests were normal and she did not have any organ abnormality, including polycystic kidney disease. LDLT using the left lateral segment(LLS) graft from the donor was performed. The donor LLS graft weighed 250 g; the graft recipient weight ratio was 1.19%. The operation and post-operative course of the donor were uneventful and she was discharged on post-operative day(POD) 8. The graft liver function was good, and the recipient was discharged on POD 31. LDLT using a graft with von Meyenburg complex is safe and useful. Long-term follow-up is needed with respect to graft liver function and screening malignant tumors. | Naoya Yamada Yukihiro Sanada Takumi Katano Masahisa Tashiro Yuta Hirata Noriki Okada Yoshiyuki Ihara Atsushi Miki Hideki Sasanuma Taizen Urahashi Yasunaru Sakuma Koichi Mizuta | 2016 | World Journal of Gastroenterology2016，22，44： | 2 |
| 10 | On-chip 3D rotation of oocyte based on a vibration-induced local whirling flow显示文摘We propose a novel on-chip 3D cell rotation method based on a vibration-induced flow.When circular vibration is applied to a microchip with micropillar patterns,a highly localized whirling flow is induced around the micropillars.The direction and velocity of this flow can be controlled by changing the direction and amplitude of the applied vibration.Furthermore,this flow can be induced on an open chip structure.In this study,we adopted a microchip with three micropillars arranged in a triangular configuration and an xyz piezoelectric actuator to apply the circular vibration.At the centre of the micropillars,the interference of the vibration-induced flows originating from the individual micropillars induces rotational flow.Consequently,a biological cell placed at this centre rotates under the influence of the flow.Under three-plane circular vibrations in the xy,xz or yz plane,the cell can rotate in both the focal and vertical planes of the microscope.Applying this 3D cell rotation method,we measured the rotational speeds of mouse oocytes in the focal and vertical planes as 63.7±4.0°s^(−1) and 3.5±2.1°s^(−1),respectively.Furthermore,we demonstrated the transportation and rotation of the mouse oocytes and re-positioned their nuclei into a position observable by microscope. | Takeshi Hayakawa Shinya Sakuma Fumihito Arai | 2015 | Microsystems & Nanoengineering2015，1，1： | 2 |
| 11 | Right anterior segmental hepatic duct emptying directly into the cystic duct in a living donor显示文摘A 35-year-old mother was scheduled to be the living donor for liver transplantation to her second son,who suffered from biliary atresia complicated with biliary cirrhosis at the age of 2 years.The operative plan was to recover the left lateral segment of the mother's liver for living donor transplantation.With the use of cholangiography at the time of surgery,we found the right anterior segmental duct(RASD) emptying directly into the cystic duct,and the catheter passed into the RASD.After repairing the incision in the cystic duct,transplantation was successfully performed.Her postoperative course was uneventful.Biliary anatomical variations were frequently encountered,however,this variation has very rarely been reported.If the RASD was divided,the repair would be very difficult because the duct will not dilate sufficiently in an otherwise healthy donor.Meticulous preoperative evaluation of the living donor's biliary anatomy,especially using magnetic resonance cholangiography and careful intraoperative techniques,is important to prevent bile duct injury and avoid the risk to the healthy donor. | Yasunao Ishiguro Masanobu Hyodo Takehito Fujiwara Yasunaru Sakuma Nobuyuki Hojo Koichi Mizuta Hideo Kawarasaki Alan T Lefor Yoshikazu Yasuda | 2010 | World Journal of Gastroenterology2010，16，29： | 2 |
| 12 | Structure, transcription and post-transcriptional regulation of the bread wheat orthologs of the barley cleistogamy gene Cly1显示文摘 | Shunzong Ning Ning Wang Shun Sakuma Mohammad Pourkheirandish Jianzhong Wu Takashi Matsumoto Takato Koba Takao Komatsuda | 2013 | Theoretical and Applied Genetics2013，，5： | 2 |
| 13 | Malignant Transformation Arising From Mature Cystic Teratoma of the Ovary: A Retrospective Study of 20 Cases显示文摘 | Michiko Sakuma Takeo Otsuki Kosuke Yoshinaga Hiroki Utsunomiya Satoru Nagase Tadao Takano Hitoshi Niikura Kiyoshi Ito Keiko Otomo Toru Tase Yoh Watanabe Nobuo Yaegashi | 2010 | International Journal of Gynecological Cancer2010，，5： | 2 |
| 14 | Differential adaptation of growth and differentiation factor 8/myostatin,fibroblast growth factor 6 and leukemia inhibitory factor in overloaded,regenerating and denervated rat muscles显示文摘 | Sakuma K Watanabe K Sano M | 2000 | Biochim Biophys Acta2000，1497，1： | 2 |
| 15 | 光合作用系统II外周蛋白——P23k去折叠的热力学和动力学显示文摘利用荧光光谱学等方法结合高压力技术研究了光合作用系统II中的一个外周蛋白——— 2 3kD(以P2 3k表示 )蛋白的去折叠。热力学研究表明 ,在 2 0℃、180MPa(1MPa =10 .0大气压 )可使该蛋白质完全去折叠 ,而在3℃ ,16 0MPa即可使该蛋白质完全去折叠 ,这是迄今为止有关研究中最易被高压力去折叠的一个蛋白质。在2 0℃ ,该蛋白质在常压下去折叠反应的标准自由能与标准体积变化分别为 2 3.4 5kJ mol和 - 15 0 .3ml mol;动力学研究揭示该蛋白质的折叠反应的活化体积ΔV f 为正值 (84 .1ml mol) ,而去折叠反应的活化体积ΔV u 为负值(- 6 6 .2ml mol)。在常压下 ,折叠和去折叠反应的速度常数 (K0f,K0u)分别为 1.87s- 1 和 1.3× 10 - 4s- 1 。 | 谭翠燕 徐春和 沈均人 SAKUMA Shinsuke YAMAMOTO Yasushi BALNY Claude 阮康成 | 2003 | 生物化学与生物物理学报2003，35，7： | 2 |
| 16 | Further insights into the no-reflow phenomenon after primary angioplasty in acute myocardial infarction:the role of microthromboemboli显示文摘 | Sakuma T Leong-Poi H Fisher NG | 2003 | J Am Soc Echocardiogr2003，16，： | 1 |
| 17 | Two transcription factors, DREB 1 and DREB2, with an EREBP/AP2 DNA binding domain separate two cellular signal transduction pathways in drought and lowtemperature-responsive gene expression respectively in Arabidopsis显示文摘 | LIU Q KASUGA M SAKUMA Y ABE H MIURA S YAMAQUCHI-SHINOZAKI K SHINOZAKI K | 1998 | Plant Cell1998，10，8： | 1 |
| 18 | Value of diffusion- weighted imaging and apparent diffusion coefficient in recent cerebral infractions: a correlative study with contrast- enhanced T1- weighted imaging显示文摘 | Yamade N Imakita S Sakuma T | 1999 | AJNR Am J Neuroradid1999，20，2： | 1 |
| 19 | Method for Recovery of Cobalt From Spent Lithium Batteries显示文摘 | Kudo Misluhiko Sakuma Yukio | 2000 | Kokai Tokkyo Koho J P2000，，11： | 1 |
| 20 | Two tranription factors,DREB1 and DREB2,with an EREBP/AP2 DNA binding domain separate two cellular signal transduction pathways in drought and low-temperature-responsive gene expression,respectively,in Arabidopsis显示文摘 | Liu Q Kasuga M Sakuma Y | 1998 | Plant Cell1998，10，： | 1 |
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