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| 1 | Neointimal coverage of sirolimus-eluting stents 6 months and 12 months after implantation: evaluation by optical coherence tomography显示文摘背景:光连贯断层摄影术(10 月) 是有约 10 microm 的分辨率的一种新成像形式并且能被采用设想 intracoronary 特征。Sirolimus-eluting stents (SES ) 由于在斯滕特氏印模膏神气上的推迟的 re-endothelialization 产生迟了的血栓,它可以导致尖锐心肌的梗塞或死亡。这研究被设计在培植以后与 10 月 6 日月和 12 个月评估 SES 的 re-endothelialization 和 neointimal 范围。方法:在学习注册的 36 个病人的一个总数在 SES 培植以后经历了 10 月检查 6 月(17 个病人) 和 12 个月(19 个病人) 。到 SES 神气上的容器墙和 neointimal 范围的神气并置被 10 月结果评估:46 SES 和 6561 口神气被分析。在 6 个月, 3041 口神气(98.7%) 是好添的, 39 口神气(1.3%) 是 malapposed。在 12 个月, 3434 口神气(98.6%) 是好添的, 47 口神气(1.4%) 是 malapposed。而且,仅仅在 6 个月(18.2%) 的 4SES 和在 12 个月(41.7%) 的 10 SES 被 neointimal 生长充分盖住。在 6 个月和 12 个月盖住分析神气的平均 neointimal 厚度是(42+/-28 ) microm 并且(88+/-32 ) microm 分别地。与 neointimal 厚度 <100 microm 在 12 个月(45.6%) 在 6 个月(72.1%) 和 1461 口神气有 1989 口神气。结论:10 月能在 SES 神气上设想神气并置到容器墙和 neointimal 范围。在 6 月、 12 月的后续考试,大多数神气被薄 neointima 盖住,但是很少全部 SES 显示出完整的范围。为了面对揭开的斯滕特氏印模膏阻止 late-stent 血栓,炫耀,更长双的反血小板药治疗应该被推荐。 | YAO Zhu-hua Tetsuo Matsubara Tsuyoshi Inada Yasuyoshi Suzuki Takahiko Suzuki | 2008 | Chinese Medical Journal2008，，6： | 9 |
| 2 | 高炉内型对炉内状态的影响显示文摘调查了高炉内型对操作的影响。采用数学模拟模型进行了研究。该模型能够分析如下操作条件 :压差、燃料比和炉况稳定性 (防止管道行程 )。在高炉内容积、有效高度和炉缸直径等数据的基础上 ,评价了大量的高炉内型数据。在这次调查过程中 ,弄清了炉型几何参数对高炉状态的影响 。 | Takanobu INADA 孙永芳 | 2004 | 鞍钢技术2004，，3： | 8 |
| 3 | 布南色林治疗精神分裂症的临床应用中日专家建议显示文摘第二代(非典型)抗精神病药布南色林对多巴胺D_(2)、D_(3)受体和5-HT_(2A)受体均有较高亲和力,而对肾上腺素α_(1)、5-HT_(2c)、组胺H_(1)、毒蕈碱M_(1)和M_(3)等受体亲和力较低。多项短期和长期临床研究显示:该药对精神分裂症的阳性症状、阴性症状均有较好疗效,并改善患者的部分认知症状和社会功能。本文在循证证据和多位中日专家临床用药经验基础上撰写,希望为临床精神科医生提供用药参考,帮助精神分裂症患者早日康复,回归社会。 | 于欣 司天梅 陆峥 石川 IYO Masaomi IWATA Nakao UENO Takefumi INADA Ken HORI Hikaru | 2021 | 中国心理卫生杂志2021，35，9： | 7 |
| 4 | ARID1A expression in gastric adenocarcinoma:Clinicopathological significance and correlation with DNA mismatch repair status显示文摘AIM:To analyze the mismatch repair(MMR)status and the ARID1A expression as well as their clinicopathological significance in gastric adenocarcinomas.METHODS:We examined the expressions of MMR proteins and ARID1A by immunohistochemistry in consecutive 489 primary gastric adenocarcinomas.The results were further correlated with clinicopathological variables.RESULTS:The loss of any MMR protein expression,indicative of MMR deficiency,was observed in 38cases(7.8%)and was significantly associated with an older age(68.6±9.2 vs 60.4±11.7,P<0.001),a female sex(55.3%vs 31.3%,P=0.004),an antral location(44.7%vs 25.7%,P=0.021),and a differentiated histology(57.9%vs 39.7%,P=0.023).Abnormal ARID1A expression,including reduced or loss of ARID1A expression,was observed in 109 cases(22.3%)and was significantly correlated with lymphatic invasion(80.7%vs 69.5%,P=0.022)and lymph node metastasis(83.5%vs 73.7%,P=0.042).The tumors with abnormal ARID1A expression more frequently indicated MMR deficiency(47.4%vs 20.2%,P<0.001).A multivariate analysis identified abnormal ARID1A expression as an independent poor prognostic factor(HR=1.36,95%CI:1.01-1.84;P=0.040).CONCLUSION:Our observations suggest that the AIRD1A inactivation is associated with lymphatic invasion,lymph node metastasis,poor prognosis,and MMR deficiency in gastric adenocarcinomas. | Ryo Inada Shigeki Sekine Hirokazu Taniguchi Hitoshi Tsuda Hitoshi Katai Toshiyoshi Fujiwara Ryoji Kushima | 2015 | World Journal of Gastroenterology2015，21，7： | 7 |
| 5 | Impact of time from diagnosis to chemotherapy in advanced gastric cancer: A Propensity Score Matching Study to Balance Prognostic Factors显示文摘BACKGROUND It is unclear whether treatment delay affects the clinical outcomes of chemotherapy in advanced gastric cancer(A-GC).AIM To assess whether treatment delay affects the clinical outcomes of chemotherapy in A-GC.METHODS This single-center retrospective study examined consecutive patients with A-GC between April 2012 and July 2018. In total, 110 patients with stage Ⅳ A-GC who underwent chemotherapy were enrolled. We defined the wait time(WT) as the interval between diagnosis and chemotherapy initiation. We evaluated the influence of WT on overall survival(OS).RESULTS The mean OS was 303 d. The median WT was 17 d. We divided the patients into early and elective WT groups, with a 2-wk cutoff point. There were 46 and 64 patients in the early and elective WT groups, respectively. Compared with the elective WT group, the early WT group had significantly lower albumin(Alb)levels and higher neutrophil/lymphocyte ratios and C-reactive protein(CRP)levels but not a lower performance status. The elective WT group underwent more combination chemotherapy than did the early WT group. OS was different between the two groups(230 d vs 340 d, respectively). Multivariate analysis revealed that higher CRP levels, lower Alb levels and monotherapy were significantly related to a poor prognosis. To minimize potential selection bias,patients in the elective WT group were 1:1 propensity score matched with patients in the early WT group; no significant difference in OS was found(303 d vs 311 d, respectively, log-rank P = 0.9832).CONCLUSION A longer WT in patients with A-GC does not appear to be associated with a worse prognosis. | Tsutomu Nishida Aya Sugimoto Ryo Tomita Yu Higaki Naoto Osugi Kei Takahashi Kaori Mukai Tokuhiro Matsubara Dai Nakamatsu Shiro Hayashi Masashi Yamamoto Sachiko Nakajima Koji Fukui Masami Inada | 2019 | World Journal of Gastrointestinal Oncology2019，11，1： | 4 |
| 6 | Combination of two-hour post-endoscopic retrograde cholangiopancreatography amylase levels and cannulation times is useful for predicting post-endoscopic retrograde cholangiopancreatography pancreatitis显示文摘AIM To estimate the efficacy of 2 h post-endoscopic retrograde cholangiopancreatography(ERCP) serum amylase levels and other factors for predicting postERCP pancreatitis.METHODS This was a retrospective,single-center cohort study of consecutive patients who underwent ERCP from January 2010 to December 2013.Serum amylase levels were measured 2 h post-procedure,and patient- and procedure-related pancreatitis(PEP) risk factors wereanalyzed using a logistic model.RESULTS A total of 1520 cases(average age 72 ± 12 years,60% male) were initially enrolled in this study,and 1403 cases(725 patients) were ultimately analyzed after the exclusion of 117 cases.Fifty-five of these cases developed PEP.We established a 2 h serum amylase cutoff level of two times the upper limit of normal for predicting PEP.Multivariate analysis revealed that a cannulation time of more than 13 min [odds ratio(OR) 2.28,95%CI:1.132-4.651,P=0.0210] and 2 h amylase levels greater than the cutoff level(OR=24.1,95%CI:11.56-57.13,P<0.0001) were significant predictive factors for PEP.Forty-seven of the 55 patients who developed PEP exhibited 2 h amylase levels greater than the cutoff level(85%),and six of the remaining eight patients who developed PEP(75%) required longer cannulation times.Only 2 of the 1403 patients(0.14%) who developed PEP did not exhibit concerning 2 h amylase levels or require longer cannulation times.CONCLUSION These findings indicate that the combination of 2 h post-ERCP serum amylase levels and cannulation times represents a valuable marker for identifying patients at high risk for PEP. | Shiro Hayashi Tsutomu Nishida Hiromi Shimakoshi Akiyoshi Shimoda Takahiro Amano Aya Sugimoto Kei Takahashi Kaori Mukai Tokuhiro Matsubara Masashi Yamamoto Sachiko Nakajima Koji Fukui Masami Inada | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，20： | 4 |
| 7 | The Straightness Backstroke Kick Makes Fast Speed and Increased Lactate Acid. A Case Study Using 3-Times Olympian显示文摘 | Takahisa Ide William F. Johnson Yutaka Yoshimura Noriko Inada Sadafumi Takise | 2017 | Journal of Sports Science2017，5，2： | 3 |
| 8 | Diffusion-weighed MR imaging of pancreatic carcinoma显示文摘 | M. Matsuki Y. Inada G. Nakai F. Tatsugami M. Tanikake I. Narabayashi D. Masuda Y. Arisaka K. Takaori N. Tanigawa | 2007 | Abdominal Imaging2007，，4： | 2 |
| 9 | Association of primary biliary cirrhosis with idiopathic thrombocytopenic purpura显示文摘Although both primary biliary cirrhosis (PBC) and idiopathic thrombocytopenic purpura (ITP) are autoimmune diseases, the association of the 2 diseases is rare. Here, we report a case of ITP that developed during the follow-up of PBC in a 74-year- old man. The patient had been diagnosed with PBC 12 years previously, and had received treatment with ursodeoxycholic acid. The platelet count decreased from approximately 60 × 109/L to 8 × 109/L, and the association of decompensated liver cirrhosis (PBC) with ITP was diagnosed. Steroid and immune gamma globulin therapy were successful in increasing the platelet count. Interestingly, human leukocyte antigen genotyping detected the alleles DQB10601 and DRB10803, which are related to both PBC and ITP in Japanese patients. This case suggests common immunogenetic factors might be involved in the development of PBC and ITP. | Nobuyuki Toshikuni Ryumei Yamato Haruhiko Kobashi Ken Nishino Nobu Inada Ritsuko Sakanoue Mitsuhiko Suehiro Yoshinori Fujimura Gotaro Yamada | 2008 | World Journal of Gastroenterology2008，14，15： | 2 |
| 10 | Body diffusion-weighted MR imaging of uterine endometrial cancer: Is it helpful in the detection of cancer in nonenhanced MR imaging?显示文摘 | Yuki Inada Mitsuru Matsuki Go Nakai Fuminari Tatsugami Masato Tanikake Isamu Narabayashi Takashi Yamada Motomu Tsuji | 2007 | European Journal of Radiology2007，，1： | 2 |
| 11 | Targeted Disruption of Cbfa1 Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts显示文摘 | T Komori H Yagi S Nomura A Yamaguchi K Sasaki K Deguchi Y Shimizu R.T Bronson Y.-H Gao M Inada M Sato R Okamoto Y Kitamura S Yoshiki T Kishimoto | 1997 | Cell1997，，5： | 2 |
| 12 | Clinically diagnosed late-onset fulminant Wilson's disease without cirrhosis: A case report显示文摘A 64-year-old woman was referred to our hospital with jaundice of the bulbar conjunctiva and general fatigue. After admission, she developed hepatic encephalopathy and was diagnosed with fulminant hepatitis based on the American Association for the Study of Liver Disease(AASLD) position paper. Afterwards, additional laboratory findings revealed that serum ceruloplasmin levels were reduced, urinary copper levels were greatly elevated and Wilson's disease(WD)-specific routine tests were positive, but the Kayser-Fleischer ring was not clear. Based on the AASLD practice guidelines for the diagnosis and treatment of WD, the patient was ultimately diagnosed with fulminant WD. Then, administration of penicillamine and zinc acetate was initiated; however, the patient unfortunately died from acute pneumonia on the 28 th day of hospitalization. At autopsy, the liver did not show a bridging pattern of fibrosis suggestive of chronic liver injury. Here, we present the case of a patient with clinically diagnosed late-onset fulminant WD without cirrhosis, who had positive disease-specific routine tests. | Takahiro Amano Tokuhiro Matsubara Tsutomu Nishida Hiromi Shimakoshi Akiyoshi Shimoda Aya Sugimoto Kei Takahashi Kaori Mukai Masashi Yamamoto Shiro Hayashi Sachiko Nakajima Koji Fukui Masami Inada | 2018 | World Journal of Gastroenterology2018，24，2： | 2 |
| 13 | PiggyBac transposon-mediated gene delivery efficiently generates stable transfectants derived from cultured primary human deciduous tooth dental pulp cells(HDDPCs) and HDDPC-derived iPS cells显示文摘The ability of human deciduous tooth dental pulp cells(HDDPCs) to differentiate into odontoblasts that generate mineralized tissue holds immense potential for therapeutic use in the field of tooth regenerative medicine. Realization of this potential depends on efficient and optimized protocols for the genetic manipulation of HDDPCs. In this study, we demonstrate the use of a Piggy Bac(PB)-based gene transfer system as a method for introducing nonviral transposon DNA into HDDPCs and HDDPC-derived inducible pluripotent stem cells. The transfection efficiency of the PB-based system was significantly greater than previously reported for electroporation-based transfection of plasmid DNA. Using the neomycin resistance gene as a selection marker, HDDPCs were stably transfected at a rate nearly 40-fold higher than that achieved using conventional methods. Using this system, it was also possible to introduce two constructs simultaneously into a single cell. The resulting stable transfectants, expressing td Tomato and enhanced green fluorescent protein, exhibited both red and green fluorescence. The established cell line did not lose the acquired phenotype over three months of culture. Based on our results, we concluded that PB is superior to currently available methods for introducing plasmid DNA into HDDPCs. There may be significant challenges in the direct clinical application of this method for human dental tissue engineering due to safety risks and ethical concerns. However, the high level of transfection achieved with PB may have significant advantages in basic scientific research for dental tissue engineering applications, such as functional studies of genes and proteins. Furthermore, it is a useful tool for the isolation of genetically engineered HDDPC-derived stem cells for studies in tooth regenerative medicine. | Emi Inada Issei Saitoh Satoshi Watanabe Reiji Aoki Hiromi Miura Masato Ohtsuka Tomoya Murakami Tadashi Sawami Youichi Yamasaki Masahiro Sato | 2015 | International Journal of Oral Science2015，7，3： | 2 |
| 14 | Endoscopic ultrasound-guided fine-needle aspiration biopsy for the diagnosis of gastrointestinal stromal tumors in the stomach显示文摘 | Kenji Okubo Kenji Yamao Tsuneya Nakamura Masahiro Tajika Akira Sawaki Kazuo Hara Hiroki Kawai Yoshitaka Yamamura Yoshinari Mochizuki Takashi Koshikawa Ken-ichi Inada | 2004 | Journal of Gastroenterology2004，，8： | 2 |
| 15 | Tenascin-C Regulates Recruitment of Myofibroblasts during Tissue Repair after Myocardial Injury显示文摘 | Masashi Tamaoki Kyoko Imanaka-Yoshida Kazuto Yokoyama Tomohiro Nishioka Hiroyasu Inada Michiaki Hiroe Teruyo Sakakura Toshimichi Yoshida | 2005 | The American Journal of Pathology2005，，： | 2 |
| 16 | Clinical characteristics of 12 cases of appendiceal diverticulitis: a comparison with 378 cases of acute appendicitis显示文摘 | Ippei Yamana Shunji Kawamoto Kazuo Inada Shuji Nagao Takahisa Yoshida Yuichi Yamashita | 2012 | Surgery Today2012，，4： | 2 |
| 17 | Flavonoid glycosides of the roots of Glycyrrhiza uralensis 显示文摘 | Inada A Kambayashi K | 1985 | Phytochemistry1985，24，2： | 1 |
| 18 | Synthesis of zeolite from coal fly ashes with different silica-alumina composition显示文摘 | MiKi inada Yukari Eguchi Naoya Enomoto Junichui HoJo | 2005 | Fuel2005，84，23： | 1 |
| 19 | Regulation of matrix metalloproteinases (MMP 2, 3, -9, and 13) by interleukin-1 and interleukin-6 in mouse calvaria: association of MMP induction with bone resorption显示文摘 | Kusano K Miyaura C Inada M Tamura T ho A Nagase H | 1998 | Endocrinology1998，139，： | 1 |
| 20 | Immunosuppre- ssive effect of cholera toxin B on allergic conjunctivitis model in guinea pig 显示文摘 | SAITO K SHOJI J INADA N | 2001 | Jpn J Ophthalmol2001，45，4： | 1 |
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