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| 1 | 二期尿道成型术更适合于需要横断尿道板并伴有严重弯曲畸形的近段型尿道下裂显示文摘对于伴有严重阴茎弯曲的尿道下裂,横断尿道板后是选择一期还是二期手术仍存在争议。这项回顾性研究比较评价了这两种方法的优劣。本研究共收集66例伴有严重阴茎弯曲的近端型尿道下裂的患者,根据手术方式分成两组,其中32例行一期手术(Duckett),34例行二期手术。一期和二期手术组的中位年龄分别为7.5岁和11.0岁,中位随访时间分别为28.5个月和35个月。所有患者术后尿道外口均位于龟头顶端。随访期间无患者出现阴茎弯曲复发,患者及其家属对阴茎的长度和外观均满意。术后两组各有8例患者出现并发症,两组间并发症率无统计学差异。一期手术尿道狭窄的远期并发症率高j(18.75%1,JO%)。在一期手术组中,青春期前患者的并发症率显著低于青春期后患者(10.52%w46.15%3。中期随访结果提示,横断尿道板可有效矫正近端型尿道下裂合并的重度阴茎弯曲。考虑到一期手术组中较高的尿道狭窄发生率,本文认为分期手术更适合伴有严重阴茎弯曲需要横断尿道板的近端型尿道下裂。 | Da-Chao Zheng Hai-Jun Yao Zhi-Kang Cai Jun Da Qi Chen Yan-Bo Chen Ke Zhang Ming-Xi Xu Mu-Jun Lu Zhong Wang | 2015 | Asian Journal of Andrology2015，17，1： | 13 |
| 2 | On-treatment monitoring of liver fibrosis with serum hepatitis B core-related antigen in chronic hepatitis B显示文摘BACKGROUND Non-invasive evaluation for liver fibrosis is clinically important,especially in patients with undetectable hepatitis B virus(HBV)DNA treated with nucleoside analogs.AIM To clarify the monitoring power of hepatitis B core-related antigen(HBcrAg)for hepatic histologic changes in patients with chronic hepatitis B(CHB)treated with entecavir.METHODS This prospective multicenter study used multiple ordinal and multivariate logistics regression analysis to assess variables associated with Ishak fibrosis score and regression for fibrosis regression,respectively,in 403 CHB patients,including 374 with entecavir for 72 weeks(291 underwent paired liver biopsy)and 29 as controls.RESULTS Level of HBcrAg correlated negatively with liver fibrosis staging(γ=-0.357,P<0.001)in hepatitis B e antigen(HBeAg)-positive patients,and positively with liver fibrosis staging in HBeAg-negative patients.Higher HBcrAg concentration was associated with younger age,HBeAg positive status,high HBV DNA loads,high level of hepatitis B surface antigen(HBsAg)and higher necroinflammation,but not with HBV genotype.Serum concentration of HBcrAg,basal core promoter/precore(BCP/PC)mutant,quantitation of HBsAg(qHBsAg)and platelet counts were independently associated with Ishak fibrosis score on multiple ordinal regression.HBV DNA was undetectable in 88.37%of patients treated with entecavir at week 72,while their level of HBcrAg was still detectable.A greater reduction in post-treatment HBcrAg concentration was associated with the regression of hepatic fibrosis and histological improvement.HBcrAg concentration>6.33 log IU/mL at baseline and logarithmic reduction>1.03 log IU/mL at week 72 were associated with a higher chance of regression of liver fibrosis and histological improvement,respectively.CONCLUSION HBcrAg level is associated with liver fibrosis progression.HBcrAg is an excellent monitor of hepatic histological changes,especially in CHB patients treated with nucleoside analogs. | Xiu-Juan Chang Chao Sun Yan Chen Xiao-Dong Li Zu-Jiang Yu Zheng Dong Wen-Lin Bai Xiao-Dong Wang Zhi-Qin Li Da Chen Wen-Juan Du Hao Liao Qi-Yu Jiang Li-Jun Sun Yin-Yin Li Cui-Hong Zhang Dong-Ping Xu Yong-Ping Chen Qin Li Yong-Ping Yang | 2019 | World Journal of Gastroenterology2019，25，32： | 12 |
| 3 | The Early Jurassic magmatism in northern Guangdong Province, southeastern China: Constraints from SHRIMP zircon U-Pb dating of Xialan complex显示文摘This paper reports SHRIMP zircon U-Pb ages of 196±2 Ma for granite, and 195±1 Ma for gabbro from the Xialan complex in the Meizhou area, northern Guangdong Province. These results shed new light on the calm stage of magmatic activity in southeastern China during 200-180 Ma, and revealed that the back-arc extension induced by the subduction of the western Pacific plate may have begun at 195 Ma at least. Field observation on the fresh outcrops allows us to recognize some features formed by magma mixing. A part of the gabbro has a fine-grained rim of 20-30 cm at the margin, and thins gradually to-ward the granite; numerous dark fine-grained to microcrystalline dioritic enclaves developed in the granite. These enclaves vary in shape and size, dark minerals concentrated at the margin of enclaves, and the contact between enclaves and host rock is either obvious or obscure, or gradational. In addi-tion, needle-shaped apatites are included in the enclaves. The REE patterns of gabbros, as well as the trace element patterns, are generally consistent with those of granitic rocks. The above characters further suggest that in the Early Jurassic the injection of basic magma had melted deep continental crust and produced acidic magma, and the Xialan complex was produced by the mixing of them. | YU XinQi DI YongJun WU GanGuo ZHANG Da ZHENG Yong DAI YanPei | 2009 | Science China Earth Sciences2009，52，4： | 12 |
| 4 | Efficacy and safety of Shaoyang Xibi decoction in patients with knee osteoarthritis:a multi-center,single-blind,randomized controlled trial显示文摘PURPOSE: To observe the efficacy and safety of Shaoyang Xibi decoction(SYXBD) in patients with knee osteoarthritis(KOA), and to verify that the theory of 'Shaoyang dominating bone' in Traditional Chinese Medicine(TCM) can be applied to KOA treatment.METHODS: Participants were randomly allocated to two groups: SYXBD(treatment group, n = 66)and Meloxicam(control group, n = 66). Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC) and 36-Item Short Form Health Survey(SF-36) were used to assess efficacy before the treatment and 8 weeks after the treatment.RESULTS: Baseline data before the treatment between the two groups were similar. The WOMAC scores significantly decreased and the SF-36 scores significantly increased after 8-week treatment in both groups compared with before the treatment(P < 0.05). SYXBD significantly decreased pain scores(P < 0.001), physical function scores(P <0.001) and the total scores(P < 0.001) in WOMAC compared to Meloxicam. SYXBD significantly improved physical function(P = 0.021), bodily pain(P = 0.002) and general health(P = 0.014), with no significant difference in role emotional(P = 0.053),role physical(P = 0.517), vitality(P = 0.241), social function(P = 0.712) and mental health(P = 0.800)in SF-36 compared to Meloxicam. No adverse events were reported in the treatment group while13 adverse events happened in the control group during the study.CONCLUSION: SYXBD, prepared based on the theory of 'Shaoyang dominating bone', has a better curative efficay and safety in patients with KOA compared with Meloxicam. The TCM theory of 'Shaoyang dominating bone' may be useful in KOA treatment. | Si Yuhao Ma Yong Guo Yang Pan Yalan Zheng Suyang Xu Guihua Da Weiwei Xu Lili | 2018 | Journal of Traditional Chinese Medicine2018，38，5： | 11 |
| 5 | A Novel Semiconductor CIGS Photovoltaic Material and Thin-Film ED Technology显示文摘In order to achieve low cost high efficiency thin film solar cells,a novel Semiconductor Photovoltaic (PV) active material CuIn 1-x Ga x Se 2 (CIGS) and thin film Electro Deposition (ED) technology is explored.Firstly,the PV materials and technologies is investigated,then the detailed experimental processes of CIGS/Mo/glass structure by using the novel ED technology and the results are reported.These results shows that high quality CIGS polycrystalline thin films can be obtained by the ED method,in which the polycrystalline CIGS is definitely identified by the (112),(204,220) characteristic peaks of the tetragonal structure,the continuous CIGS thin film layers with particle average size of about 2μm of length and around 1 6μm of thickness.The thickness and solar grade quality of CIGS thin films can be produced with good repeatability.Discussion and analysis on the ED technique,CIGS energy band and sodium (Na) impurity properties,were also performed.The alloy CIGS exhibits not only increasing band gap with increasing x ,but also a change in material properties that is relevant to the device operation.The beneficial impurity Na originating from the low cost soda lime glass substrate becomes one prerequisite for high quality CIGS films.These novel material and technology are very useful for low cost high efficiency thin film solar cells and other devices. | ZHENG Guang fu 1,YANG Hong xing 1,MAN Cheuk ho 1,WONG Wing lok 2, AN Da wei 1 and John BURNETT 1(1 Centre for Development of Solar Energy Technology,Department of Building Services Engineering, The Hong Kong Polytechnic University,Hong Kong,C | 2001 | Journal of Semiconductors2001，22，11： | 10 |
| 6 | Nicotinamide overload may play a role in the development of type 2 diabetes显示文摘AIM: To investigate whether nicotinamide overload plays a role in type 2 diabetes. METHODS: Nicotinamide metabolic patterns of 14diabetic and 14 non-diabetic subjects were compared using HPLC. Cumulative effects of nicotinamide and N1-methylnicotinamide on glucose metabolism, plasma H2O2 levels and tissue nicotinamide adenine dinucleotide (NAD) contents of adult Sprague-Dawley rats were observed. The role of human sweat glands and rat skin in nicotinamide metabolism was investigated using sauna and burn injury, respectively. RESULTS: Diabetic subjects had significantly higher plasma N 1-methylnicotinamide levels 5 h after a 100-mg nicotinamide load than the non-diabetic subjects (0.89 ± 0.13 μmol/L vs 0.6 ± 0.13 μmol/L, P < 0.001). Cumulative doses of nicotinamide (2 g/kg) significantly increased rat plasma N 1-methy lnico-tinamide concentrations associated with severe insulin resistance, which was mimicked by N1-methy-lnicotinamide. Moreover, cumulative exposure to N1-methylnicotinamide (2 g/kg) markedly reduced rat muscle and liver NAD contents and erythrocyte NAD/NADH ratio, and increased plasma H2O2 levels. Decrease in NAD/NADH ratio and increase in H2O2 generation were also observed in human erythrocytes after exposure to N1-methylnicotinamide in vitro. Sweating eliminated excessive nicotinamide (5.3-fold increase in sweat nicotinamide concentration 1 h after a 100-mg nicotinamide load). Skin damage or aldehyde oxidase inhibition with tamoxifen or olanzapine, both being notorious for impairing glucose tolerance, delayed N1-methylnicotinamide clearance. CONCLUSION: These f indings suggest that nicotinamide overload, which induced an increase in plasma N 1-methylnicotinamide, associated with oxidative stress and insulin resistance, plays a role in type 2 diabetes. | Shi-Sheng Zhou Da Li Wu-Ping Sun Ming Guo Yong-Zhi Lun Yi-Ming Zhou Fu-Cheng Xiao Li-Xin Jing Shen-Xia Sun Li-Bin Zhang Ning Luo Fu-Ning Bian Wei Zou Lai-Bin Dong Zhi-Gang Zhao Sheng-Fan Li Xiao-Jie Gong Zeng-Guo Yu Chang-Bin Sun Cong-Long Zheng Dong-Ju Jiang Zheng-Ning Li | 2009 | World Journal of Gastroenterology2009，15，45： | 8 |
| 7 | A prospective study of vertical transmission of hepatitis C virus显示文摘AprospectivestudyofverticaltransmissionofhepatitisCvirusSUNDeGui1,LIUCaiYun1,MENGZongDa2,SUNYongDe2,WANGShuCong1,YANGYu... | SUN De Gui 1, LIU Cai Yun 1, MENG Zong Da 2, SUN Yong De 2, WANG Shu Cong 1, YANG Yu Qi 1, LIANG Zheng Lun 3 and ZHUANG Hui 3 | 1997 | World Journal of Gastroenterology1997，3，2： | 8 |
| 8 | Prognostic factors and therapeutic effects of different treatment modalities for colorectal cancer liver metastases显示文摘BACKGROUND Colorectal cancer(CRC)is one of the most common malignant tumors in China,and the liver is the most common metastatic site in patients with advanced CRC.Hepatectomy is the gold standard treatment for colorectal liver metastases.For patients who cannot undergo radical resection of liver metastases for various reasons,ablation therapy,interventional therapy,and systemic chemotherapy can be used to improve their quality of life and prolong their survival time.AIM To explore the prognostic factors and treatments of liver metastases of CRC.METHODS A retrospective analysis was conducted on 87 patients with liver metastases from CRC treated at the Liaoning Cancer Hospital and Institute between January 2005 and March 2011.According to different treatments,the patients were divided into the following four groups:Surgical resection group(36 patients);ablation group(23 patients);intervention group(15 patients);and drug group(13 patients).The clinicopathological data and postoperative survival of the four groups were analyzed.The Kaplan-Meier method was used for survival analysis,and the Cox proportional hazards regression model was used for multivariate analysis.RESULTS The median survival time of the 87 patients was 38.747±3.062 mo,and the 1-and 3-year survival rates were 87.5%and 53.1%,respectively.The Cox proportional hazards model showed that the following factors were independent factors affecting prognosis:The degree of tumor differentiation,the number of metastases,the size of metastases,and whether the metastases are close to great vessels.The results of treatment factor analysis showed that the effect of surgical treatment was better than that of drugs,intervention,or ablation alone,and the median survival time was 48.83±4.36 mo.The drug group had the worst prognosis,with a median survival time of only 13.5±0.7 mo(P<0.05).For patients with liver metastases of CRC near the great vessels,the median survival time(27.3 mo)of patients undergoing surgical resection was better than that of patients using other treatments(20.6 mo)(P<0.05).CONCLUSION Patients with a low degree of primary tumor differentiation,multiple liver metastases(number of tumors>4),and maximum diameter of liver metastases>5 cm have a poor prognosis.Among drug therapy,intervention,ablation,and surgical treatment options,surgical treatment is the first choice for liver metastases.When liver metastases are close to great vessels,surgical treatment is significantly better than drug therapy,intervention,and ablation alone. | Zuo-Hong Ma Yong-Peng Wang Wen-Heng Zheng Ji Ma Xue Bai Yong Zhang Yuan-He Wang Da Chi Xi-Bo Fu Xiang-Dong Hua | 2020 | World Journal of Gastrointestinal Oncology2020，12，10： | 7 |
| 9 | Tailoring interface of lead-halide perovskite solar cells显示文摘铅卤化物 perovskite 太阳能电池(PSC ) 在过去几年期间吸引了巨大的注意由于他们的非凡电子并且 photonic 性质。改进 PSC 的表演,许多研究人员集中了于组合工程,溶剂工程,和电影制造方法论。PSC 的界面的工程成为了研究人员们在试图深深地理解房间的机制并且从而增加 PSC 的效率和稳定性的一个发芽领域。这评论集中于铅卤化物 PSC 定制的接口,包括房间结构的每层的修正(即, perovskite 吸收器,电子运输层,和洞运输层) 并且能被介绍进 PSC 的界面的材料。 | Peimei Da Gengfeng Zheng | 2017 | Nano Research2017，10，5： | 6 |
| 10 | Chemical Studies on the Glycosides in the Leaves of Oplopanax Elatus Nakai(Ⅳ)显示文摘ChemicalStudiesontheGlycosidesintheLeavesofOplopanaxElatusNakai(Ⅳ)*WANGGuang-shuandXUJing-da(NormanBethuneUniversityofMedical... | WANG Guang shu and XU Jing da (Norman Bethune University of Medical Sciences, Changchun, 130021) MA Xiu li, SUN Yun xiu and LIU Ju zheng (Department of Chemistry, Jilin University, Changchun, 130023) Tetsuya Murayama and Junzo Shoji (Schoo | 1997 | Chemical Research in Chinese Universities1997，13，1： | 6 |
| 11 | VO2·0.2H2O nanocuboids anchored onto graphene sheets as the cathode material for ultrahigh capacity aqueous zinc ion batteries显示文摘Aqueous Zinc-ion batteries(ZIBs),using zinc negative electrode and aqueous electrolyte,have attracted great attention in energy storage field due to the reliable safety and low-cost.A composite material comprised of VO2·0.2H2O nanocuboids anchored on graphene sheets(VOG)is synthesized through a facile and efficient microwave-assisted solvothermal strategy and is used as aqueous ZIBs cathode material.Owing to the synergistic effects between the high conductivity of graphene sheets and the desirable structural features of VO2·0.2H2O nanocuboids,the VOG electrode has excellent electronic and ionic transport ability,resulting in superior Zn ions storage performance.The Zn/VOG system delivers ultrahigh specific capacity of 423 mAh·g^−1 at 0.25 A·g^−1 and exhibits good cycling stability of up to 1,000 cycles at 8 A·g^−1 with 87%capacity retention.Systematical structural and elemental characterizations confirm that the interlayer space of VO2·0.2H2O nanocuboids can adapt to the reversible Zn ions insertion/extraction.The as-prepared VOG composite is a promising cathode material with remarkable electrochemical performance for low-cost and safe aqueous rechargeable ZIBs. | Dedong Jia Kun Zheng Ming Song Hua Tan Aitang Zhang Lihua Wang Lijun Yue Da Li Chenwei Li Jingquan Liu | 2020 | Nano Research2020，13，1： | 6 |
| 12 | Room temperature ferromagnetism in ultra-thin van der Waals crystals of 1T-CrTe2显示文摘Although many emerging new phenomena have been unraveled in two dimensional(2D)materials with long-range spin orderings,the usually low critical temperature in van der Waals(vdW)magnetic material has thus far hindered the related practical applications.Here,we show that ferromagnetism can hold above 300 K in a metallic phase of 1T-CrTe2 down to the ultra-thin limit.It thus makes CrTe2 so far the only known exfoliated ultra-thin vdW magnets with intrinsic long-range magnetic ordering above room temperature.An in-plane room-temperature negative anisotropic magnetoresistance(AMR)was obtained in ultra-thin CrTe2 devices,with a sign change in the AMR at lower temperature,with−0.6%and+5%at 300 and 10 K,respectively.Our findings provide insights into magnetism in ultra-thin CrTe2,expanding the vdW crystals toolbox for future room-temperature spintronic applications. | Xingdan Sun Wanying Li Xiao Wang Qi Sui Tongyao Zhang Zhi Wang Long Liu Da Li Shun Feng Siyu Zhong Hanwen Wang Vincent Bouchiat Manuel Nunez Regueiro Nicolas Rougemaille Johann Coraux Anike Purbawati Abdellali Hadj-Azzem Zhenhua Wang Baojuan Dong Xing Wu Teng Yang Guoqiang Yu Bingwu Wang Zheng Han Xiufeng Han Zhidong Zhang | 2020 | Nano Research2020，13，12： | 6 |
| 13 | Accommodation of curtailed wind power by electric water heaters based on a new hybrid prediction approach显示文摘Wind power curtailment is of great importance with the increase of large-scale wind power connected to the grid. A new concept of redundant wind power accommodated by dispatching electric water heaters(EWHs) is developed in the paper. Precise predictions of wind power and EWHs load power are the basis for this work. A hybrid multi-kernel prediction approach integrating an adaptive fruit fly optimization algorithm(AFOA)and multi-kernel relevance vector machine(MKRVM) is proposed to deal with the sample distribution of multisource heterogeneous features uncovered by an energy entropy method, where AFOA is used to determine the kernel parameters in MKRVM adaptively and avoid the arbitrariness. For the large computation of the prediction approach, parallel computation based on the Hadoop cluster is used to accelerate the calculation. Then, an economic dispatching model for accommodating wind power is built taking into account the penalty of curtailed wind power and the operation cost of EWHs. The proposedscheme is implemented in an intelligent residential district.The results show that the optimization performance of the hybrid prediction approach is superior to those of four usual optimization algorithms in this case. Regular or orderly scheduling of EWHs enables accommodation of superfluous wind power and reduces dispatch cost. | Yang YU Zengqiang MI Xiaoming ZHENG Da CHANG | 2019 | Journal of Modern Power Systems and Clean Energy2019，7，3： | 6 |
| 14 | Cyclic load testing of pre-stressed rock anchors for slope stabilization显示文摘The objective of this research was to assess the characteristics of seismic induced damage and the deformation patterns of pre-stressed cement-grouted cables that are used for rock slope stabilization projects subjected to quasi-static cyclic loading.The experimental configuration includes the installation of 15 pre-stressed cables in a slope model made of concrete blocks(theoretically rigid rock mass) on top of a pre-existing sliding surface.The study showed that:(i) The pre-stressed cables exhibited great seismic performance.Rapid displacement of the model blocks was observed after the complete loss of the initial pre-stress load under continued applied cyclic loads and exceedance of the state of equilibrium,which implies the higher the initial pre-stress load,the better the seismic performance of the rock anchor;(ii) The failure of the pre-stressed cables was due to fracture at the connection of the tendons and cable heads under cyclic loading.The sequence of failure had a distinct pattern.Failure was first observed at the upper row of cables,which experienced the most severe damage,including the ejection of cable heads.No evidence of de-bonding was observed during the cyclic loading;(iii) The stress distribution of the bond length for pre-stressed cables was highly non-uniform.High stress concentrations were observed at both the fixed end and the free end of the bond length both before and immediately after the state of equilibrium is exceeded.The results obtained can be used to evaluate the overall performance of pre-stressed rock anchors subject to seismic loading and their potential as rockfall prevention and stabilization measures. | ZHENG Da LIU Fang-zhou JU Neng-pan FROST J.David HUANG Run-qiu | 2016 | Journal of Mountain Science2016，13，1： | 5 |
| 15 | Exogenous hydrogen sulfide inhibits apoptosis by regulating endoplasmic reticulum stress-autophagy axis and improves myocardial reconstruction after acute myocardial infarction显示文摘During acute myocardial infarction,endoplasm ic reticulum(ER)stress-induced autophagy and apoptosis have been shown as im portant pathogeneses of myocardial reconstruction.Im portantly,hydrogen sulfide(H2S),as a third endogenous gas signaling molecule,exerts strong cytoprotective effect on anti-ER stress,autophagy regulation and antiapoptosis.Here,we showed that H2 S treatm ent inhibits apoptosis by regulating ER stress-autophagy axis and im proves myocardial reconstruction after acute myocardial infarction.We found that H2S intervention im proved left ventricle function,reduced glycogen deposition in myocardial tissue mesenchyme,and inhibited apoptosis.Moreover,the expressions of fibrosis indicators(Col3a1 and Col1a2),ER stress-related proteins(CHOP and BIP/ERP78),autophagy-related proteins(Beclin and ATG5),apoptosis protein(Bax),as well as fibrosis protein Col4a3bp were all decreased after treatm ent w ith H2 S.H2 S adm inistration also m aintained MMP/TIMP balance.Mechanistically,H2S activated the PI3K/AKT signaling pathway.In addition,H2S treatm ent also reduced the expressions of ER stress-related proteins,autophagy-related proteins,and apoptins in in wtro experiments.Interestingly,activation of ER stress-autophagy axis could reverse the inhibitory effect of H2S on myocardial apoptosis.Altogether,these results suggested that exogenous H2S suppresses myocardial apoptosis by blocking ER stress-autophagy axis,which in turn reverses cardiac rem odeling after myocardial infarction. | Yaling Li Maojun Liu Jiali Yi Xiong Song Xia Zheng Da Liu Sen Wang Chun Chu Jun Yang | 2020 | Acta Biochimica et Biophysica Sinica2020，52，12： | 5 |
| 16 | Face Detection Detection, Alignment Alignment, Quality Assessment and Attribute Analysis with Multi-Task Hybrid Convolutional Neural Networks显示文摘This paper proposes a universal framework,termed as Multi-Task Hybrid Convolutional Neural Network(MHCNN),for joint face detection,facial landmark detection,facial quality,and facial attribute analysis.MHCNN consists of a high-accuracy single stage detector(SSD)and an efficient tiny convolutional neural network(T-CNN)for joint face detection refinement,alignment and attribute analysis.Though the SSD face detectors achieve promising results,we find that applying a tiny CNN on detections further boosts the detected face scores and bounding boxes.By multi-task training,our T-CNN aims to provide five facial landmarks,facial quality scores,and facial attributes like wearing sunglasses and wearing masks.Since there is no public facial quality data and facial attribute data as we need,we contribute two datasets,namely FaceQ and FaceA,which are collected from the Internet.Experiments show that our MHCNN achieves face detection performance comparable to the state of the art in face detection data set and benchmark(FDDB),and gets reasonable results on AFLW,FaceQ and FaceA. | GUO Da ZHENG Qingfang PENG Xiaojiang LIU Ming | 2019 | ZTE Communications2019，17，3： | 5 |
| 17 | Metabolism Study on Tobacco-specific N-Nitrosamines in Rabbit by Solid-phase Extraction and Liquid Chromatography-electrospray Ionization-mass Spectrometry Method显示文摘Metabolism of four tobacco-specific N-nitrosamines (TSNAs), N′-nitrosonornicotine (NNN), N′-nitrosoanatabine (NAT), N′-nitrosoanabasine (NAB) and 4-(methyl nitrosamino)-1- (3-pyridyl)-1-butanone (NNK) was studied by solid-phase extraction (SPE) and liquid chromato- graphy-electrospray ionization-mass spectrometry (LC-ESI-MS). SPE and LC-ESI-MS method was evaluated to be rapid, simple, sensitive and selective for analysis of TSNAs in rabbit serum. The doses of TSNAs administrated were 4.666 μgkg and 11.665 μgkg according to different levels in cigarettes. Metabolic curves of four TSNAs and 4-(methyl nitrosamino)-1-(3-pyridyl)- 1-butanone (NNAL), the metabolite of NNK, were obtained. | Jian Xun ZHANG Chen Chen LI Zheng CHEN Zhi Hua RAO Da Wei WEN Ke An LI Hu Wei LIU | 2005 | Chinese Chemical Letters2005，16，12： | 5 |
| 18 | Granular porous calcium carbonate particles for scalable and high-performance solar-driven thermochemical heat storage显示文摘Calcium carbonate is promising thermochemical heat storage material for next-generation solar power systems due to its high energy storage density,low cost,and high operation temperature.Researchers have tried to improve energy storage performances of calcium carbonate recently,but most researches focus on powders,which are not suitable for scalable applications.Here,novel granular porous calcium carbonate particles with very high solar absorptance,energy storage density,abrasive resistances,and energy storage rate are proposed for direct solar thermochemical heat storage.The average solar absorptance is improved by 234%compared with ordinary particles.Both cycle stability and abrasive resistances are excellent with almost no decay of energy storage density over 25 cycles nor apparent particle weight loss over 24 h of continuous operation insides a planetary ball mill.In addition,the decomposition temperature is reduced by 2.8%–5.6%while the reaction rate of heat storage is enhanced by 80%–205%depending on the CO_(2) partial pressure.The decomposition process of doped granular porous CaCO_(3) particles is found to involve three overlapping processes.This work provides new routes to achieve scalable direct solar thermochemical heat storage for next-generation high-temperature solar power systems. | SONG Chao LIU XiangLei XUAN YiMin ZHENG HangBin GAO Ke TENG Liang DA Yun LI Chuan LI YongLiang DING YuLong | 2021 | Science China(Technological Sciences)2021，64，10： | 4 |
| 19 | A System Simulation Platform for 3G显示文摘A 3G system simulation platform is designed to research on and evaluate the effects of various techniques of the 3G network performance. The basic structure and principle of the simulation platform is presented and the simulation process is addressed in detail. | LU Zheng xing, YANG Da cheng (Wireless Research Center of Beijing University of Posts and Telecommunications, Beijing 100876, P. R. China) | 2003 | The Journal of China Universities of Posts and Telecommunications2003，10，3： | 4 |
| 20 | Detection of enteroviruses and hepatitis a virus in water by consensus primer multiplex RT-PCR显示文摘AIM: To develop a rapid detection method ofenteroviruses and Hepatitis A virus (HAV).METHODS: A one-step, single-tube consensus primersmultiplex RT-PCR was developed to simultaneouslydetect Poliovirus, Coxsackie virus, Echovirus and HAV.A general upstream primer and a HAV primer and fourdifferent sets of primers (5 primers) specific forPoliovirus, Coxsacki evirus, Echovirus and HAV cDNAwere mixed in the PCR mixture to reverse transcriptand amplify the target DNA.Four distinct amplified DNAsegments representing Poliovirus, Coxsackie virus,Echovirus and HAV were identified by gelelectrophoresis as 589-,671-, 1084-, and 1128bpsequences, respectively. Semi-nested PCR was used toconfirm the amplified products for each enterovirus andHAV.RESULTS: All four kinds of viral genome RNA weredetected, and producing four bands which could bedifferentiated by the band size on the gel.To confirmthe specificity of the multiplex PCR products, semi-nested PCR was performed. For all the four strainstested gave positive results .The detection sensitivityof multiplex PCR was similar to that of monoplex RT-PCR which was 24 PFU for Poliovrus, 21 PFU forCoxsackie virus,60 PFU for Echovirus and 105 TCID50for HAV. The minimum amount of enteric viral RNAdetected by semi-nested PCR was equivalent to 2.4 PFUfor Poliovrus, 2.1 PFU for Coxsackie virus, 6.0 PFU forEchovirus and 10.5 TCID50 for HAV.CONCLUSION: The consensus primers multiplex RT-PCRhas more advantages over monoplex RT-PCR for entericviruses detection, namely, the rapid turnaround timeand cost effectiveness. | Jun-Wen Li Xin-Wei Wang Chang-Qing Yuan Jin-Lai Zheng Min Jin Nong Song Xiu-Quan Shi Fu-Huan Chao Department of Environment and Health,Institute of Health and Environmental Medicine of Tianiin,1 Da Li Road.Tianjin 300050,China | 2002 | World Journal of Gastroenterology2002，8，4： | 4 |
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