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| 1 | Inflammation and fibrosis in chronic liver diseases including nonalcoholic fatty liver disease and hepatitis C显示文摘At present chronic liver disease(CLD),the third commonest cause of premature death in the United Kingdom is detected late,when interventions are ineffective,resulting in considerable morbidity and mortality.Injury to the liver,the largest solid organ in the body,leads to a cascade of inflammatory events.Chronic inflammation leads to the activation of hepatic stellate cells that undergo transdifferentiation to become myofibroblasts,the main extra-cellular matrix producing cells in the liver;over time increased extra-cellular matrix production results in the formation of liver fibrosis.Although fibrogenesis may be viewed as having evolved as a“wound healing”process that preserves tissue integrity,sustained chronic fibrosis can become pathogenic culminating in CLD,cirrhosis and its associated complications.As the reference standard for detecting liver fibrosis,liver biopsy,is invasive and has an associated morbidity,the diagnostic assessment of CLD by non-invasive testing is attractive.Accordingly,in this review the mechanisms by which liver inflammation and fibrosis develop in chronic liver diseases are explored to identify appropriate and meaningful diagnostic targets for clinical practice.Due to differing disease prevalence and treatment efficacy,disease specific diagnostic targets are required to optimally manage individual CLDs such as non-alcoholic fatty liver disease and chronic hepatitis C infection.To facilitate this,a review of the pathogenesis of both conditions is also conducted.Finally,the evidence for hepatic fibrosis regression and the mechanisms by which this occurs are discussed,including the current use of antifibrotic therapy. | Sudeep Tanwar Freya Rhodes Ankur Srivastava Paul M Trembling William M Rosenberg | 2020 | World Journal of Gastroenterology2020，26，2： | 17 |
| 2 | Interleukin-6: a villain in the drama of pancreatic cancer development and progression显示文摘BACKGROUND: Pancreatic ductal adenocarcinoma(PDAC)is a devastating malignancy with a poor prognosis and little treatment options. The development and progression of the disease is fostered by inflammatory cells and cytokines. One of these cytokines is interleukin-6(IL-6), which plays an important role in a wide range of biologic activities.DATA SOURCES: A systematic search of PubMed was performed to identify relevant studies using key words such as interleukin-6,inflammatory cytokines, inflammation and pancreatic cancer or PDAC. Articles related to IL-6 and pancreatic cancer were systematically reviewed.RESULTS: IL-6 is elevated in the serum of pancreatic cancer patients and correlates with cachexia, advanced tumor stage and poor survival. Its expression is enhanced by hypoxia and proteins involved in pancreatic cancer development like Kras,mesothelin or ZIP4. IL-6 in turn contributes to the generation of a pro-tumorigenic microenvironment and is probably involved in angiogenesis and metastasis. In experimental mouse models of PDAC, IL-6 was important for the development and progression of precursor lesions.CONCLUSION: IL-6 emerges as a key player in pancreatic cancer development and progression, and hence should be considered as a new therapeutic target. | Reinhild Holmer Freya A Goumas Georg H Waetzig Stefan Rose-John Holger Kalthoff | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，4： | 16 |
| 3 | Ipsilateral breast tumor recurrence in early stage breast cancer patients treated with breast conserving surgery and adjuvant radiation therapy: Concordance of biomarkers and tumor location from primary tumor to in-breast tumor recurrence显示文摘BACKGROUND Patients with an in-breast tumor recurrence(IBTR)after breast-conserving therapy have a high risk of distant metastasis and disease-related mortality.Classifying clinical parameters that increase risk for recurrence after IBTR remains a challenge.AIM To describe primary and recurrent tumor characteristics in patients who experience an IBTR and understand the relationship between these characteristics and disease outcomes.METHODS Patients with stage 0-II breast cancer treated with lumpectomy and adjuvant radiation were identified from institutional databases of patients treated from 2003-2017 at our institution.Overall survival(OS),disease-free survival,and local recurrence-free survival(LRFS)were estimated using the Kaplan Meier method.We identified patients who experienced an isolated IBTR.Concordance of hormone receptor status and location of tumor from primary to recurrence was evaluated.The effect of clinical and treatment parameters on disease outcomes was also evaluated.RESULTS We identified 2164 patients who met the eligibility criteria.The median follow-up for all patients was 3.73[interquartile range(IQR)2.27-6.07]years.Five-year OS was 97.7%(95%CI:96.8%-98.6%)with 28 deaths;5-year LRFS was 98.0%(97.2-98.8)with 31 IBTRs.We identified 37 patients with isolated IBTR,19(51.4%)as ductal carcinoma in situ and 18(48.6%)as invasive disease,of whom 83.3%had an in situ component.Median time from initial diagnosis to IBTR was 1.97(IQR:1.03-3.5)years.Radiotherapy information was available for 30 of 37 patients.Median whole-breast dose was 40.5 Gy and 23 patients received a boost to the tumor bed.Twenty-five of thirty-two(78.1%)patients had concordant hormone receptor status,HER-2 receptor status,and estrogen receptor(ER)(P=0.006)and progesterone receptor(PR)(P=0.001)status from primary to IBTR were significantly associated.There were no observed changes in HER-2 status from primary to IBTR.The concordance between quadrant of primary to IBTR was 10/19[(62.2%),P=0.008].Tumor size greater than 1.5 cm(HR=0.44,95%CI:0.22-0.90,P=0.02)and use of endocrine therapy upfront(HR=0.36,95%CI:0.18-0.73,P=0.004)decreased the risk of IBTR.CONCLUSION Among patients with early stage breast cancer who had breast conserving surgery treated with adjuvant RT,ER/PR status and quadrant were highly concordant from primary to IBTR.Tumor size greater than 1.5 cm and use of adjuvant endocrine therapy were significantly associated with decreased risk of IBTR. | Juhi M Purswani Fauzia Shaikh S Peter Wu Jennifer Chun Kim Freya Schnabel Nelly Huppert Carmen A Perez Naamit K Gerber | 2020 | World Journal of Clinical Oncology2020，11，1： | 2 |
| 4 | PACS infrastructure supporting e-learning显示文摘 | Peter Mildenberger Kerstin Brtiggemann Freya RCisner et cd | 2011 | European Journal of Radiol- ogy2011，78，： | 1 |
| 5 | A natural analog of res- veratrol, inhibits progression through the S phase of the cell cycle in colorectal cancer cell lines 显示文摘 | FREYA W ANTJE C BORA A | 2002 | J Nutr2002，132，2： | 1 |
| 6 | Coenzyme Q 10 in cardiovascular disease显示文摘 | Salvatore Pepe Silvana F. Marasco Steven J. Haas Freya L. Sheeran Henry Krum Franklin L. Rosenfeldt | 2007 | Mitochondrion2007，，： | 1 |
| 7 | Pure mucinous carcinoma of the breast显示文摘 | Ian K Komenaka Mahmoud B El-Tamer Andrea Troxel Diane Hamele-Bena Kathie-Ann Joseph Elizabeth Horowitz Beth-Ann Ditkoff Freya R Schnabel | 2004 | The American Journal of Surgery2004，，4： | 1 |
| 8 | More than an “industry”: The forgotten power of tourism as a social force显示文摘 | Freya Higgins-Desbiolles | 2005 | Tourism Management2005，，6： | 1 |
| 9 | Ultrasound guided strategy for provisional stenting with focal balloon combination catheter:resuits from the randomized Strategy for Intracoronary Ultrasound guided PTCA and Stenting(SIPS) trial显示文摘 | Freya W Hodgson M Muller C | 2000 | Circulation2000，102，20： | 1 |
| 10 | Stromal Fibroblasts in Colorectal Liver Metastases Originate From Resident Fibroblasts and Generate an Inflammatory Microenvironment显示文摘 | Lars Mueller Freya A. Goumas Marianne Affeldt Susanne Sandtner Ursula M. Gehling Silke Brilloff Jessica Walter Nadia Karnatz Katrin Lamszus Xavier Rogiers Dieter C. Broering | 2007 | The American Journal of Pathology2007，，5： | 1 |
| 11 | QTL analysis for ascorbic acid content in strawberry fruit reveals a complex genetic architecture and association with GDP-L-galactose phosphorylase显示文摘Strawberry(Fragaria×ananassa)fruits are an excellent source of L-ascorbic acid(AsA),a powerful antioxidant for plants and humans.Identifying the genetic components underlying AsA accumulation is crucial for enhancing strawberry nutritional quality.Here,we unravel the genetic architecture of AsA accumulation using an F1 population derived from parental lines‘Candonga’and‘Senga Sengana’,adapted to distinct Southern and Northern European areas.To account for environmental effects,the F1 and parental lines were grown and phenotyped in five locations across Europe(France,Germany,Italy,Poland and Spain).Fruit AsA content displayed normal distribution typical of quantitative traits and ranged five-fold,with significant differences among genotypes and environments.AsA content in each country and the average in all of them was used in combination with 6,974 markers for quantitative trait locus(QTL)analysis.Environmentally stable QTLs for AsA content were detected in linkage group(LG)3A,LG 5A,LG 5B,LG 6B and LG 7C.Candidate genes were identified within stable QTL intervals and expression analysis in lines with contrasting AsA content suggested that GDP-L-Galactose Phosphorylase FaGGP(3A),and the chloroplast-located AsA transporter gene FaPHT4;4(7C)might be the underlying genetic factors for QTLs on LG 3A and 7C,respectively.We show that recessive alleles of FaGGP(3A)inherited from both parental lines increase fruit AsA content.Furthermore,expression of FaGGP(3A)was two-fold higher in lines with high AsA.Markers here identified represent a useful resource for efficient selection of new strawberry cultivars with increased AsA content. | Pilar Muñoz Cristina Castillejo JoséAntonio Gómez Luis Miranda Silke Lesemann Klaus Olbricht Aurélie Petit Philippe Chartier Annika Haugeneder Johanna Trinkl Luca Mazzoni Agnieszka Masny Edward Zurawicz Freya Maria Rosemarie Ziegler Björn Usadel Wilfried Schwab Béatrice Denoyes Bruno Mezzetti Sonia Osorio JoséFSánchez-Sevilla Iraida Amaya | 2023 | Horticulture Research2023，10，3： | 1 |
| 12 | Productive conflict in group decision making: genuine and contrived dissents strategies to counteract biased information seeking显示文摘 | Schulz-Hardt S Jochims M Freya D | 2002 | Organizational Behavior and Human Decision Processes2002，88，： | 1 |
| 13 | Phytoliths from Archaeological Sites in the Tropical Forest of Ituri,Democratic Republic of Congo显示文摘 | FREYA R | 2000 | Quaternary Research2000，54，： | 1 |
| 14 | Molecular mechanisms of the chemopreventive effects of resveratrol and its analogs in colorectal cancer:key role of polymines显示文摘 | Freya W Sandra U Jurgen S | 2004 | J Nutr2004，134，12： | 1 |
| 15 | Asexual reproduction, habitat colonization and habitat maintenance in bryophytes显示文摘 | Freya W Kurschnerb H | 2011 | Flora-Morphology Distribution Functional Ecology of Plants2011，206，3： | 1 |
| 16 | Remote ischemic preconditioning in cyanosed neonates undergoing cardiopulmonary bypass: A randomized controlled trial显示文摘 | Bryn O. Jones Salvatore Pepe Freya L. Sheeran Susan Donath Pollyanna Hardy Lara Shekerdemian Daniel J. Penny Ian McKenzie Stephen Horton Christian P. Brizard Yves d’Udekem Igor E. Konstantinov Michael M.H. Cheung | 2013 | The Journal of Thoracic and Cardiovascular Surgery2013，，： | 1 |
| 17 | Quantitative comparison of the operational NOAA-AVHRR LSTproduct of DLR and the MODIS LST product V005显示文摘 | Corinne Myrtha Freya Claudia Kuenzerb Stefan Dechb | 2012 | International Journal of Remote Sensing2012，33，22： | 1 |
| 18 | Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple显示文摘 | Freya Q. Schafer Garry R. Buettner | 2001 | Free Radical Biology and Medicine2001，，11： | 1 |
| 19 | Characterization of municipal solid waste combustion in a grate furnace 显示文摘 | FREYA H H PETERSA B HUNSINGER H | 2003 | Waste Management2003，23，： | 1 |
| 20 | Microbial biomass, functional capacity,and community structure after 12 years of soil warming显示文摘 | FREYA S D DRIJBER R SMITH H | 2008 | Soil Biology and Biochemistry2008，40，1： | 1 |
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