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| 1 | Vascular endothelial growth factor for the treatment of femoral head osteonecrosis: An experimental study in canines显示文摘AIM To evaluate the treatment of osteonecrosis of the femoral head(ONFH) with the use of vascular endothelial growth factor(VEGF).METHODS In 30 mature beagles(6 groups of 5 beagles) ONFH was induced cryosurgically and one of the following solutions was administered locally in the femoral head(FH) in each group: Single injection of 500 μg VEGF(t-VEGFμ group); single injection of 500 ng VEGF(t-VEGFn group); continuous delivery of 500 μg VEGF through osmotic micropump(t-VEGFpump-μ group); continuous delivery of 500 ng VEGF through osmotic micropump(t-VEGFpump-n group); single injection of 0.9% sodium chloride(t-NS group), while one group that served as control group did not receive any local solution(No-t group). FHs were retrieved 12 wk postoperatively, underwent decalcification and hematoxylin/eosin and toluidine blue staining. In two canines per group, one half of FH was processed without decalcification and stained with modified Masson Trichrome. Histological sections were observed by light microscopy and measured with a semi-automatized bone histomorphometry system and Bone Volume/Total Volume(BV/TV), Marrow Volume/Total Volume(MaV/TV), and Trabecular Thickness(TbT h) were assessed. Standard and robust tests(Welch, Brown Forsythe) of analysis of variance along with multiple comparisons, were carried out among the categories.RESULTS The untreated(No-t) group had signs of osteonecrosis, whereas the VEGF groups revealed reversal of the osteonecrosis. Statistical analysis of the decalcified specimens revealed a significantly better BV/TV ratio and a higher Tb Th between the VEGF treatment groups(except the t-VEGFn group) and the No-t group or the control t-NS group. Single dose 500 μg VEGF group had significantly better BV/TV ratio and higher Tb Th when compared to the No-t group(50.45 ± 6.18 vs 29.50 ± 12.27, P = 0.002 and 151.44 ± 19.07 vs 107.77 ± 35.15, P = 0.161 respectively) and the control t-NS group(50.45 ± 6.18 vs 30.9 ± 6.67, P = 0.004 and 151.44 ± 19.07 vs 107.14 ± 35.71, P = 0.151 respectively). Similar differences were found for the prolonged VEGF delivery/pump groups of 500 μg and 500 ng. Analysis of the totality of specimens(decalcified/non-decalcified) enhanced the aforementioned differences and additionally revealed significant differences in the comparison of the TbT h.CONCLUSION In an experimental model of ONFH in canines it was found that local treatment with VEGF leads to bone tissue remodeling and new bone formation. | Zoe H Dailiana Nikolaos Stefanou Lubna Khaldi Georgios Dimakopoulos James R Bowers Cristian Fink James R Urbaniak | 2018 | World Journal of Orthopedics2018，9，9： | 13 |
| 2 | 宇宙成因核素^26Al/^10Be埋藏测年法在宁夏沙坡头黄河砾石阶地年代研究中的应用显示文摘本文利用宇宙成因核素^26Al/^10Be埋藏测年法对宁夏沙坡头地区黄河左岸的T5、T6、T8和T9阶地开展了年代学研究。采用简单快速埋藏模式获得4级阶地的^26Al/^10Be埋藏年龄分别约为0.25Ma、0.36Ma、0.59Ma和1.06Ma,如果考虑后期剥蚀作用的影响(E≈5m/Ma),则4级阶地的年龄分别约为0.42Ma、0.39Ma、1.02Ma和1.59Ma。本研究未发现砾石大小与^10Be、^26Al核素浓度及^26Al/^10Be比值有明显相关性。 | 韩非 顾兆炎 尹功明 David Fink 王躲 | 2016 | 第四纪研究2016，36，5： | 11 |
| 3 | Plants as concept generators for biomimetic light-weight structures with variable stiffness and self-repair mechanisms显示文摘Plants possess many structural and functional properties that have a high potential to serve as concept generators for the production of biomimetic technical materials and structures. We present data on two features of plants (variable stiffness due to pressure changes in cellular structures and rapid self-repair functions) that may be used as models for biomimetic projects. | Thomas Speck Tom Masselter Bettina Prüm Olga Speck Rolf Luchsinger Siegfried Fink | 2004 | Journal of Bionic Engineering2004，1，4： | 10 |
| 4 | Differential effects on apoptosis induction in hepatocyte lines by stable expression of hepatitis B virus X protein显示文摘瞄准:肝炎 B 蛋白质 X (HBx ) 被显示了是弱 oncogenic 在试管内。HBx 的转变活动与肿瘤的功能压制的几的抑制或 p53 被连接了。我们学习了 HBx 是否可以在取决于房间类型的 p53 上有不同效果。方法:我们使用了人的肝细胞瘤房间线 HepG2 和使不朽的鼠科的 hepatocyte 线 AML12 并且稳定地分析了表示了 HBx 的生理的数量的 transfected 克隆。P53 被紫外照耀导致。结果:由紫外照耀的 p53 正式就职由 HBx 的稳定的表示是未受影响的。然而,变得被 p53 激活的 cyclin 激酶禁止者 p21 (waf/cip/sdi ) 的表示在 HBx 被影响转变房间线 AML12-HBx9,然而并非在 HepG2。在 AML-HBx9,房间, p21 (waf/cip/sdi ) 蛋白质表示和 p21 (waf/cip/sdi ) 抄写是 deregulated。而且, apoptosis 的过程在调查的二根房间线以相反的方法被影响。当 HBx 的稳定的表示提高了紫外照耀在 HepG2 房间导致的 apoptosis 时, apoptosis 在 HBx 被减少转变 AML12-HBx9。P53 镇压了从 HBV enhancer 的抄写我,当由紫外照耀从表示向量或在内长的 p53 的正式就职以后表示了时。由内长的 p53 的压抑由在两根房间线的稳定地表示的 HBx 部分是可逆的。结论:HBx 的稳定的表示导致取决于使用的房间线的紫外照耀导致的 apoptosis 的解除管制。而在癌的表示导出 hepatocyte 线 HBx,在一根使不朽的 hepatocyte 线, HBx 扮演了 anti-apoptotic 提高的 apoptosis。 | Nicola Fiedler Ellen Quant Ludger Fink Jianguang Sun Ralph Schuster Wolfram H Gerlich Stephan Schaefer | 2006 | World Journal of Gastroenterology2006，12，29： | 8 |
| 5 | 东南极格罗夫山萨哈罗夫岭漂砾暴露年龄初探显示文摘首次对格罗夫山地区漂砾的暴露年龄进行的研究表明,萨哈罗夫岭冰原岛峰的两块漂砾样品的^(10)Be最小暴露年龄分别为1.24±0.11Ma和1.37±0.12Ma,^(26)Al最小暴露年龄分别为0.90±0.12Ma和0.44±0.04Ma。萨哈罗夫岭附近冰面上的漂砾样品的^(10)Be和^(26)Al最小暴露年龄分别是0.47±0.3Ma和0.44±0.04Ma。考虑到误差,萨哈罗夫岭三块漂砾的最小暴露年龄与相近高程的基岩样品的最小暴露年龄基本一致。因此,在利用原地生成宇宙成因核素测年技术对东南极内陆格罗夫山地区的冰川消涨历史进行研究时,基岩和漂砾暴露年龄所反映出的冰川演化历史是明显吻合的。 | 李广伟 刘小汉 黄费新 孔屏 David Fink 韦利杰 方爱民 | 2009 | 极地研究2009，21，4： | 7 |
| 6 | 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference显示文摘 | Mitchell M. Levy Mitchell P. Fink John C. Marshall Edward Abraham Derek Angus Deborah Cook Jonathan Cohen Steven M. Opal Jean-Louis Vincent Graham Ramsay | 2003 | Critical Care Medicine2003，，4： | 7 |
| 7 | Chromium Adsorption in Different Mineralogical Fractions from Subtropical Soils显示文摘Safe application of chromium(Cr)-containing organic industrial wastes to soil requires considering the ability of the soil to adsorb Cr.In this study,the maximum Cr adsorption capacity was assessed for the bulk samples and their clay and iron-free clay fractions of four subtropical soils differing in mineralogy.To this end,the samples were supplied with Cr(III) nitrate solutions at pH 4.5 or5.5.The results of Cr(III) adsorption fitted to a Freundlich equation and the adsorption capacity was positively correlated with soil organic matter and iron oxide contents.The clay fractions adsorbed more Cr per unit mass than the bulk soils and the iron-free clay fractions.The Cr(III) adsorption capacity increased with increasing soil pH due to more charges on adsorbing surfaces.Our results suggest that the soils rich in organic matter and iron oxides and having a pH above 4.5 are suitable for application of Cr(III)-loaded industrial wastes. | Jovana BAVARESCO Jesse R. FINK Maria Lucia K. RODRIGUES Clesio GIANELLO Vidal BARRON Jose TORRENT | 2017 | Pedosphere2017，27，1： | 6 |
| 8 | 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference显示文摘 | Mitchell M. Levy Mitchell P. Fink John C. Marshall Edward Abraham Derek Angus Deborah Cook Jonathan Cohen Steven M. Opal Jean-Louis Vincent Graham Ramsay | 2003 | Critical Care Medicine2003，，4： | 6 |
| 9 | Limb symmetry index in competitive alpine ski racers:Reference values and injury risk identification according to age-related performance levels显示文摘Purpose: The aims of this study were to assess differences of limb symmetry index(LSI) in strength-and coordination-related tasks between high-level, competitive, noninjured ski racers of different age-related performance levels and to prospectively assess limb differences as a possible risk factor for traumatic and overuse injury in youth ski racers.Methods: The study(Study 1) included 285 high-level competitive ski racers(125 females, 160 males) of 3 age-related performance levels and based on the school system: 95 youth(10à14 years, secondary modern school), 107 adolescent(15à19 years, grammar school), and 83 elite athletes(20à34 years). To investigate the second aim(Study 2), 67 of the 95 youth athletes were included and any traumatic or overuse injuries were prospectively recorded over 2 seasons. All athletes performed 4 unilateral tests(strength related: one-leg counter movement jump(OL-CMJ) and one-leg isometric/isokinetic press strength test(OL-ILS); coordination related: one-leg stability test(OL-ST) and one-leg speedy jump test(OL-SJ)). The LSI was calculated by dividing the dominant leg by the nondominant leg and multiplying by 100. Kruskal-Wallis H tests and binary logistic regression analyses were conducted.Results: There were significant differences between the LSI of the 3 age-related performance-level groups only in the strength-related tests: the OL-CMJ(x2(2, 285) = 9.09; p = 0.01) and the OL-ILS(x2(2, 285) = 14.79; p < 0.01). The LSI for OL-ILS was found to be a significant risk factor for traumatic injury in youth ski racers(Wald = 7.08; p < 0.01). No significant risk factors were found for overuse injuries.Conclusion: Younger athletes display slightly greater LSI values only in the strength-related tests. The cut-off value of limb differences of <10%for return to sport decisions seems to be appropriate for elite athletes, but for youth and adolescent athletes it has to be critically discussed. It seems to be necessary to define thresholds based on specific performance tasks(strength vs. coordination related) rather than on generalizations,and age-related performance levels must be considered. Limb differences in unilateral leg extension strength represent a significant injury risk factor in youth ski racers. | Lisa Steidl-Müller Carolin Hildebrandt Erich Müiller Christian Fink Christian Raschner | 2018 | Journal of Sport and Health Science2018，7，4： | 6 |
| 10 | 海螺沟现代冰碛物中的宇生核素^(10)Be浓度分析显示文摘尽管许多学者都意识到继承性宇生核素对冰碛物暴露年代测量可能会带来一定的误差,然而影响究竟有多大,还缺乏对现代冰碛物宇生核素浓度的研究。对采自贡嘎山海螺沟冰川现代冰碛物碎屑和冰碛砾石的本地生宇生核素^(10)Be浓度的分析表明,即使是海洋性冰川(暖底冰川),其冰碛物碎屑和冰碛砾石都残留一定量的本地生宇生核素;即使是具有明显磨蚀痕迹的现代冰碛砾石表面,也残留一定量的本地生宇生核素。因此,进行宇生核素测年时要给予充分的重视。当然,其冰碛物基质和具有明显磨蚀痕迹的现代冰碛砾石表面的本地生宇生核素^(10)Be浓度比较低,一般不大于2×10~4atoms/g。对暴露年代的影响一般不大于0.61ka。尽管其适用范围还有待于更多的研究结果的进一步证实,但是却为残留影响的研究提供了一个研究的实例和一组可以参考的数据。 | 王建 徐晓彬 张志刚 张茂恒 孔屏 David Fink | 2010 | 第四纪研究2010，30，5： | 4 |
| 11 | From minimal to maximal surgery in the treatment of hepatocarcinoma:A review显示文摘Hepatocellular carcinoma represents one of the most challenging frontiers in liver surgery. Surgeons have to face a broad spectrum of aspects,from the underlying liver disease to the new surgical techniques. Safe liver resection can be performed in patients with portal hypertension and well-compensated liver function witha 5-year survival rate of 50%,offering good longterms results in selected patients. With the advances in laparoscopic surgery,major liver resections can be performed with minimal harm,avoiding the wound and leak complications related to the laparotomies. Studies have shown that oncological margins are the same as in open surgery. In patients submitted to liver resection(either laparoscopic or open) who experience recurrence,re-resection or salvage liver transplantation has been showing to be an alternative approach in well selected cases. The decision making approach to the cirrhotic patient is becoming more complex and should involve hepatologists,liver surgeons,radiologists and oncologists. Better understanding of the different risk factors for recurrence and survival should be aimed in these multidisciplinary discussions. We here in discuss the hot topics related to surgical risk factors regarding the surgical treatment of hepatocellular carcinoma: anatomical resection,margin status,macrovascular tumor invasion,the place of laparoscopy,salvage liver transplantation and liver transplantation. | Marcos Vinicius Perini Graham Starkey Michael A Fink Ramesh Bhandari Vijayaragavan Muralidharan Robert Jones Christopher Christophi | 2015 | World Journal of Hepatology2015，7，1： | 4 |
| 12 | Heterogeneity in mouse spasmolytic polypeptide-expressing metaplasia lineages identifies markers of metaplastic progression显示文摘 | Victoria G Weis Josane F Sousa Bonnie J LaFleur Ki Taek Nam Jared A Weis Paul E Finke Nadia A Ameen James G Fox James R Goldenring | 2013 | Gut2013，，9： | 3 |
| 13 | 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference显示文摘 | Mitchell M. Levy Mitchell P. Fink John C. Marshall Edward Abraham Derek Angus Deborah Cook Jonathan Cohen Steven M. Opal Jean-Louis Vincent Graham Ramsay | 2003 | Intensive Care Medicine2003，，4： | 3 |
| 14 | IFNβ/TNFa synergism induces a non-canonical STAT2/IRF9-dependent pathway triggering a novel DUOX2 NADPH Oxidase-mediated airway antiviral response显示文摘 | Karin Fink Lvdie Martin Esperance Mukawera St&any Chartier Xavier De Deken Emmanuelle Brochiero Francoise Mi Nathalie Grandvaux | 2013 | Cell Research2013，23，5： | 3 |
| 15 | Temperature measurement in power plant equipment using distributed fiber optic sensing显示文摘 | Boiarski A A Pilate O Fink T | 1995 | IEEE Transactions onPowerDelivery1995，10，4： | 3 |
| 16 | Neoadjuvant chemotherapy with cisplatin, 5-FU, and leucovorin (PLF) in locally advanced gastric cancer: a prospective phase II study显示文摘 | Katja Ott Andreas Sendler Karen Becker Hans-Joachim Dittler Hermann Helmberger Raimonde Busch Christian Kollmannsberger J. Rüdiger Siewert Ulrich Fink | 2003 | Gastric Cancer2003，，3： | 3 |
| 17 | Further geological and palaeoanthropological investigations at the Maludong hominin site, Yunnan Province, Southwest China显示文摘Three-dimensional mapping and section work undertaken by us in 2008 have identified 11 stratigraphic units at Maludong site.AMS radiocarbon dating of charcoal established an accurate and internally consistent age profile for the sequence of 17.8±0.2 ka to 13.2±0.1 ka.Archaeomagnetic analysis showed changes in externally derived pedogenically enhanced material consistent with a warming in climate between the cold period of Henrich Event 1 and the B lling-Aller d interstadial.Human remains recovered during the 1989 excavation were derived from a deposit dating to this interstadial,or between 14.3±0.3 ka and 13.5±0.1 ka.Anthropogenic features,including burnt rocks,baked sediment and thick charcoal and ash layers,were identified and examined through archaeomagnetic analysis.Two monkey fossils are described here,one of them being reassigned from Macaca robustus to M.aff.M.assamensis.They confirm the young age of the site and also show signs of anthropogenic alteration in the form of burning.Additional human cranial remains are reported for the first time and new data are provided for some specimens described previously.A range of new features is identified that strengthen the affinities of the Maludong remains to archaic humans.The presence of this globally unique mosaic of archaic and modern features raises important questions about human evolutionary history in East Asia during the Late Upper Pleistocene. | JI XuePing CURNOE Darren BAO ZhenDe HERRIES Andy I R FINK David ZHU YunSheng HELLSTROM John LUO Yun TACON Paul S C | 2013 | Chinese Science Bulletin2013，58，35： | 3 |
| 18 | Noninvasive In Vivo Liver Fibrosis Evaluation Using Supersonic Shear Imaging: A Clinical Study on 113 Hepatitis C Virus Patients显示文摘 | éric Bavu Jean-Luc Gennisson Mathieu Couade Jeremy Bercoff Vincent Mallet Mathias Fink Anne Badel Ana?s Vallet-Pichard Bertrand Nalpas Micka?l Tanter Stanislas Pol | 2011 | Ultrasound in Medicine & Biology2011，，9： | 3 |
| 19 | 计算机控制系统简化试井/监控显示文摘作业者经常需要测量油、水、气的产量,以便对油田开采权的拥有者进行正确分配。精确测量产量还可以: 1.优化气举效率; 2.确定对正在被评价井的修井要求。 本文介绍的是由哈里伯顿能源服务公司开发的一种净流量计算机见图1,它可显著减少监控设备和工作量。美国墨西哥湾正应用此系统试井和确定矿区使用费的支付额。 | Kevin Fink 刘先刚 | 1996 | 天然气与石油1996，14，2： | 2 |
| 20 | Dynamic full-field optical coherence tomography:3D live-imaging of retinal organoids显示文摘Optical coherence tomography offers astounding opportunities to image the complex structure of living tissue but lacks functional information.We present dynamic full-field optical coherence tomography as a technique to noninvasively image living human induced pluripotent stem cell-derived retinal organoids.Coloured images with an endogenous contrast linked to organelle motility are generated,with submicrometre spatial resolution and millisecond temporal resolution,creating a way to identify specific cell types in living tissue via their function. | Jules Scholler Kassandra Groux Olivier Goureau Jose-Alain Sahel Mathias Fink Sacha Reichman Claude Boccara Kate Grieve | 2020 | Light(Science & Applications)2020，9，1： | 2 |
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