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| 1 | COVID-19 Outbreak Caused by Contaminated Packaging of Imported Cold-Chain Products—Liaoning Province,China,July 2020显示文摘Summary What is known about this topic?Few major outbreaks of coronavirus disease 2019(COVID-19)have occurred in China after major nonpharmaceutical interventions and vaccines have been deployed and implemented.However,sporadic outbreaks that had high possibility to be linked to cold chain products were reported in several cities of China..What is added by this report?In July 2020,a COVID-19 outbreak occurred in Dalian,China.The investigations of this outbreak strongly suggested that the infection source was from COVID-19 virus-contaminated packaging of frozen seafood during inbound unloading personnel contact.What are the implications for public health practice?Virus contaminated paper surfaces could maintain infectivity for at least 17–24 days at-25℃.Exposure to COVID-19 virus-contaminated surfaces is a potential route for introducing the virus to a susceptible population.Countries with no domestic transmission of COVID-19 should consider introducing prevention strategies for both inbound travellers and imported goods.Several measures to prevent the introduction of the virus via cold-chain goods can be implemented. | Huilai Ma1 Jianqun Zhang Ji Wang Ying Qin Cao Chen Yang Song Liang Wang Jun Meng Lingling Mao Fengqin Li Ning Li Jian Cai Yong Zhang Dayan Wang Yunting Xia Hong Wang Shaofeng Jiang Xiang Zhao Peihua Niu Wenjie Tan Tao Ma Yecheng Yao Naiying Mao Zhen Zhu Tianjiao Ji Qian Yang Baoying Huang Li Zhao Jianxing Yu Li Bai Shuangli Zhu Dongyan Wang Yan Zhang Yingwei Sun Mingchun Luan Yanhai Wang Haibo Sun Shihong Yang Zhijian Bo Xiang Ren Zhongjie Li George Fu Gao Wei Yao Wenqing Yao Zijian Feng Wenbo Xu | 2021 | China CDC weekly2021，3，21： | 16 |
| 2 | BMP2 and VEGF promote angiogenesis but retard terminal differentiation of osteoblasts in bone regeneration by up-regulating Idl显示文摘不适当的 vascularization 限制骨头缺点的修理。以便改进 angiogenesis 并且加速成骨,有在骨头新生的基因修正的 co 有教养的房间的协同在这研究被调查。Endothelial 祖先房间(EPC ) 和骨头髓干细胞(BMSC ) 是有脉管的 endothelial 生长因素(VEGF ) 和骨头的基因的 transfected 形态基因的蛋白质 2 (BMP2 ) 由侵入人体气管粘膜的病菌分别地。co 有教养的房间,包括 BMSC + EPC, Ad-BMP2BMSC + EPC, BMSC + Ad-VEGFEPC,和 Ad-BMP2BMSC + 指定 Ad-VEGFEPC 组织为四个组,在 alginate 胶化上被播种然后肌内地植入进老鼠在 angiogenesis 和成骨上评估效果。VEGF 和 BMP2 能导致禁止者的 overexpression DNA 有约束力 1 (Id1 ) 显著地在 vitro 和增加支持了试管形成的基因在在培植以后的 Ad-BMP2BMSC + Ad-VEGFEPC 组的血容器的数量。不过, Id1 的 overexpression 延迟了造骨细胞和骨头形成的终端区别。后来,在 transcriptional 水平,钙小瘤,和碱的磷酸酶(高山) 活动的 osteogenic 基因表示证明渐渐的减少和最新形成的成骨区域的数量在 Ad-BMP2BMSC + Ad-VEGFEPC 组展出了小增加。这发现建议在 VEGFEPC 和 BMP2BMSCs 的 Id1 表示的一条平衡规定可能对为骨头新生的基于房间、基于基因的途径批评。 | Xiaobin Song Shaohua Liu Xun Qu Yingwei Hu Xiaoying Zhang Tao Wang Fengcai Wei | 2011 | Acta Biochimica et Biophysica Sinica2011，43，10： | 13 |
| 3 | DMM:A dynamic memory mapping model for virtual machines显示文摘Memory virtualization is an important part in the design of virtual machine monitors(VMM).In this paper,we proposed dynamic memory mapping(DMM) model,a mechanism that allows the VMM to change the mapping between a virtual machine's physical memory and the underlying hardware resource while the virtual machine is running.By utilizing DMM,the VMM can implement many novel memory management policies,such as Demand Paging,Swapping,Ballooning,Memory Sharing and Copy-On-Write,while preserving compatibility with various architectures.The modular and hierarchical property of the DMM model efficiently incorporates the high-level policies and the low-level implementations,leading to a feature-adjustable VMM design.We presented the principle of the DMM model,and explained the procedures of various memory management policies under this model.Also,we implement the DMM model in KVM,an open source VMM.Our evaluation shows that the DMM model is efficient enough to provide the benefits of dynamic memory resource management with little performance impact. | CHEN HaoGang WANG XiaoLin WANG ZhenLin ZHANG BinBin LUO YingWei LI XiaoMing | 2010 | Science China(Information Sciences)2010，53，6： | 11 |
| 4 | Role of activating transcription factor 3 (ATF3) in sublytic C5b-9-induced glomerular mesangial cell apoptosis显示文摘 | Xiaoming Jiang Jing Zhang Mei Xia Wen Qiu Hui Wang Dan Zhao Yingwei Wang | 2010 | Cellular & Molecular Immunology2010，7，2： | 7 |
| 5 | Hemorrhagic Fever with Renal Syndrome — Liaoning Province, China, 1999−2018显示文摘Summary What is already known on this topic?Hemorrhagic fever with renal syndrome(HFRS)is endemic in Liaoning Province.Both Seoul and Hantaan virus are circulating in rodents,and epidemic outbreaks and sporadic cases have been recorded every year since the disease was recognized. | Cui Shang Yingwei Sun Qiangling Yin Xiaoxia Huang Xuesheng Liu Quanfu Zhang Lingling Mao Chuan Li Aqian Li Qin Wang Lina Sun Mifang Liang Shiwen Wang Dexin Li Jiandong Li | 2020 | China CDC weekly2020，2，20： | 6 |
| 6 | Preparation and Characterization of Waterborne Polyurethane/Cellulose Nanocrystal Composite Membrane from Recycling Waste Paper显示文摘Cellulose plays a key role in abundant organic natural materials meeting the increasing demand for green and biocompatible products.The highly crystalline nanoscale component of cellulose nanocrystals has recently attracted great attention due to the versatile performance as filler or matrix in producing functional materials.In this work,we prepared the waterborne polyurethane via a prepolymer process,and obtained cellulose and cellulose nanocrystals from waste paper via a facile acid hydrolysis process.After that,the cellulose nanocrystals were assembled into film and mixed with polyurethane to prepare flexible polyurethane/cellulose nanocrystals composite membrane with different soaking time.The correlation between the bulk structure and applied properties including thermal resistance and mechanical property was investigated by using Fourier transform infrared spectroscopy(FTIR),X-ray diffraction(XRD),X-ray photoelectron spectroscopy(XPS),scanning electron microscopy(SEM),thermogravimetric analysis(TGA),differential scanning calorimetry(DSC)and folding test.The structure analysis indicates that cellulose nanocrystals prepared from used paper have a quality similar to that of commercial cellulose.Meanwhile,the cellulose nanocrystals have been mixed with polyurethane uniformly.Polyurethane can significantly benefit to the thermal resistance and mechanical property of the cellulose nanocrystals film.The polyurethane/cellulose nanocrystals composite membrane present good flexibility and may hold a significantly potential application as visual and flexible material. | Xing Zhou Xin Zhang Dong Wang Changqing Fang Wanqing Lei Zhigang Huang Yonghua Song Xinyu He Yingwei Huang | 2020 | Journal of Renewable Materials2020，8，6： | 5 |
| 7 | IL-17-triggered downregulation of miR-497 results in high HIF-1α expression and consequent IL-1β and IL-6 production by astrocytes in EAE mice显示文摘Interleukin 17(IL-17)is increasingly recognized as a key factor that contributes to the pathogenesis of multiple sclerosis(MS)and its experimental mouse autoimmune encephalomyelitis(EAE)model.However,the roles and regulatory mechanisms of IL-17-induced pro-inflammatory cytokine production in EAE mice remain largely unclear.In this study,the expression of IL-17,hypoxia inducible factor-1α(HIF-1α),IL-1β,IL-6 and microRNA-497(miR-497),as well as their intrinsic associations,was investigated using EAE model mice and cultured astrocytes exposed to IL-17 in vitro.We observed markedly increased production of IL-17,HIF-1α,IL-1βand IL-6 in the brain tissues of EAE mice,while the expression and secretion of HIF-1α,IL-1βand IL-6 were also significantly increased when cultured primary astrocytes from mice were stimulated with IL-17.Meanwhile,the expression of miR-497 was downregulated both in vivo and in vitro.Subsequent in vitro experiments revealed that IL-17 induced the production of IL-1βand IL-6 in astrocytes through the upregulation of HIF-1αas a transcriptional factor,indicating that IL-17-mediated downregulation of miR-497 enhanced HIF-1αexpression.Furthermore,astrocytespecific knockdown of IL-17RA and HIF-1αor astrocyte-specific overexpression of miR-497 by infection with different lentiviral vectors containing an astrocyte-specific promotor markedly decreased IL-1βand IL-6 production in brain tissues and alleviated the pathological changes and score of EAE mice.Collectively,these findings indicate that decreased miR-497 expression is responsible for IL-17-triggered high HIF-1αexpression and consequent IL-1βand IL-6 production by astrocytes in EAE mice. | Kai Shan Rongrong Pang Chenhui Zhao Xiaomei Liu Wenxing Gao Jing Zhang Dan Zhao Yingwei Wang Wen Qiu | 2017 | Cellular & Molecular Immunology2017，14，11： | 5 |
| 8 | A model for predicting bubble rise velocity in a pulsed gas solid fluidized bed显示文摘Bed stability, and especially the bed density distribution, is affected by the behavior of bubbles in a gas solid fluidized bed. Bubble rise velocity in a pulsed gas-solid fluidized bed was studied using photographic and computational fluid dynamics methods. The variation in bubble rise velocity was investigated as a function of the periodic pulsed air flow. A predictive model of bubble rise velocity was derived: ub=ψ(Ut+Up-Umf)+kp(gdb)(1/2). The software of Origin was used to fit the empirical coefficients to give ψ = 0.4807 and kp = 0.1305. Experimental verification of the simulations shows that the regular change in bubble rise velocity is accurately described by the model. The correlation coefficient was 0.9905 for the simulations and 0.9706 for the experiments. | Dong Liang Zhao Yuemin Luo Zhenfu Duan Chenlong Wang Yingwei Yang Xuliang Zhang Bo | 2013 | International Journal of Mining Science and Technology2013，23，2： | 4 |
| 9 | RATIONAL SPECTRAL COLLOCATION METHOD FOR A COUPLED SYSTEM OF SINGULARLY PERTURBED BOUNDARY VALUE PROBLEMS显示文摘为不可思议地使不安的线性方程的 a coupled 系统的一个新奇搭配方法被介绍。这个方法基于合理光谱在有 sinh 的 barycentric 形式的搭配方法变换。由 sinh 变换,原来的 Chebyshev 点被印射进在答案的单个点附近聚类的转变的。从关于奇特答案的 asymptotic 分析的结果被采用在这 sinh 变换决定参数。数字实验被执行表明我们的方法的高精确性和效率。[从作者抽象] | Suqin Chen Yingwei Wang Xionghua Wu | 2011 | Journal of Computational Mathematics2011，29，4： | 4 |
| 10 | Dynamic memory paravirtualization transparent to guest OS显示文摘This paper introduces dynamic paravirtualization, which imitates paravirtualization and aims at reducing VM exits of full virtualization with hardware support. In dynamic paravirtualization, VMM (virtual machine monitor) dynamically monitors and replaces the hot instructions, which cause most VM exits. It is transparent to the guest OS such that the legacy OSes can benefit from this optimization. Our study focuses on reducing the overhead of memory virtualization-dynamic memory paravirtualization (DMP). We implant a new memory management mechanism in VMM such that all user-mode page faults can be handled by the guest OS directly without VM exits. We implement a prototype of dynamic memory paravirtulization based on a version of KVM using Intel VT. Our experimental results show that our technique essentially eliminates the overhead of VM exits caused by page faults. Dynamic memory paravirtualization can achieve the effectiveness of paravirtualization without changing the source code of guest OS. | WANG XiaoLin SUN YiFeng LUO YingWei WANG ZhenLin LI Yu ZHANG BinBin CHEN HaoGang LI XiaoMing | 2010 | Science China(Information Sciences)2010，53，1： | 4 |
| 11 | Two-dimensional noble transition-metal dichalcogenides for nanophotonics and optoelectronics:Status and prospects显示文摘An emerging subclass of transition-metal dichalcogenides(TMDs),noble-transition-metal dichalcogenides(NMDs),has led to an increase in nanoscientific research in two-dimensional(2D)materials.NMDs feature a unique structure and several useful properties.2D NMDs are promising candidates for a broad range of applications in areas such as photodetectors,phototransistors,saturable absorbers,and meta optics.In this review,the state of the art of 2D NMDs research,their structures,properties,synthesis,and potential applications are discussed,and a perspective of expected future developments is provided. | Yingwei Wang Li Zhou Mianzeng Zhong Yanping Liu Si Xiao Jun He | 2022 | Nano Research2022，15，4： | 3 |
| 12 | The deubiquitinase OTUD1 inhibits colonic inflammation by suppressing RIPK1-mediated NF-κB signaling显示文摘The E3 ubiquitin ligase(E3)-mediated ubiquitination and deubiquitinase(DUB)-mediated deubiquitination processes are closely associated with the occurrence and development of colonic inflammation.Ovarian tumor deubiquitinase 1(OTUD1)is involved in immunoregulatory functions linked to infectious diseases.However,the effect of OTUD1 on intestinal immune responses during colonic inflammatory disorders such as inflammatory bowel disease(IBD)remains unclear.Here,we show that loss of OTUD1 in mice contributes to the pathogenesis of dextran sulfate sodium(DSS)-induced colitis via excessive release of proinflammatory cytokines.In addition,bone marrow transplantation experiments revealed that OTUD1 in hematopoietic cells plays a dominant role in protection against colitis.Mechanistically,OTUD1 physically interacts with receptor-interacting serine/threonine-protein kinase 1(RIPK1)and selectively cleaves K63-linked polyubiquitin chains from RIPK1 to inhibit the recruitment of NF-κB essential modulator(NEMO).Moreover,the expression of OTUD1 in mucosa samples from ulcerative colitis(UC)patients was lower than that in mucosa samples from healthy controls.Furthermore,we demonstrate that the UC-associated OTUD1 G430V mutation abolishes the ability of OTUD1 to inhibit RIPK1-mediated NF-κB activation and intestinal inflammation.Taken together,our study unveils a previously unexplored role of OTUD1 in moderating intestinal inflammation by inhibiting RIPK1-mediated NF-κB activation,suggesting that the OTUD1-RIPK1 axis could be a potential target for the treatment of IBD. | Bo Wu Lihua Qiang Yong Zhang Yesheng Fu Mengyuan Zhao Zehui Lei Zhe Lu Yan-Ge Wei Hongmiao Dai Yingwei Ge Mingqiu Liu Xuemei Zhou Zhiqiang Peng Hongchang Li Chun-Ping Cui Jing Wang Hui Zheng Cui Hua Liu Lingqiang Zhang | 2022 | Cellular & Molecular Immunology2022，19，2： | 3 |
| 13 | Contextual and selective attention networks for image captioning显示文摘The steady momentum of innovations has convincingly demonstrated the high capability of attention mechanisms for the sequence to sequence learning.Nevertheless,the computation of attention across a sequence is often independent in either hard or soft mode,thereby resulting in undesired effects such as repeated modeling.In this paper,we introduce a new design to holistically explore the interdependencies between attention histories and locally emphasize the strong focus of each attention on image captioning.Specifically,we present a contextual and selective attention network(namely Co SA-Net)that novelly memorizes contextual attention and brings out the principal components from each attention.Technically,Co SA-Net writes/updates the attended image region features into memory and reads from memory when measuring attention in the next time step to leverage contextual knowledge.Only the regions with the top-k highest attention scores are selected,and each region feature is individually employed to compute an output distribution.The final output is an attention-weighted mixture of all k distributions.In turn,the attention is then upgraded by the posterior distribution conditioned on the output.Our Co SA-Net is appealing given that it is pluggable to the sentence decoder in any neural captioning model.Extensive experiments on the COCO image captioning dataset demonstrate the superiority of Co SA-Net.More remarkably,integrating Co SA-Net to a one-layer long short-term memory(LSTM)decoder increases CIDEr-D performance from 125.2%to 128.5%on the COCO Karpathy test split.When further endowing a two-layer LSTM decoder with Co SA-Net,the CIDEr-D score is boosted to 129.5%. | Jing WANG Yehao LI Yingwei PAN Ting YAO Jinhui TANG Tao MEI | 2022 | Science China(Information Sciences)2022，65，12： | 2 |
| 14 | 2D-ultrathin MXene/DOXjade platform for iron chelation chemo-photothermal therapy显示文摘An increased demand for iron is a hallmark of cancer cells and is thought necessary to promote high cell proliferation,tumor progression and metastasis.This makes iron metabolism an attractive therapeutic target.Unfortunately,current iron-based therapeutic strategies often lack effectiveness and can elicit off-target toxicities.We report here a dual-therapeutic prodrug,DOXjade,that allows for iron chelation chemo-photothermal cancer therapy.This prodrug takes advantage of the clinically approved iron chelator deferasirox(ExJade®)and the topoisomerase 2 inhibitor,doxorubicin(DOX).Loading DOXjade onto ultrathin 2D Ti_(3)C_(2) MXene nanosheets produces a construct,Ti_(3)C_(2)-PVP@DOXjade,that allows the iron chelation and chemotherapeutic functions of DOXjade to be photo-activated at the tumor sites,while potentiating a robust photothermal effect with photothermal conversion efficiencies of up to 40%.Antitumor mechanistic investigations reveal that upon activation,Ti_(3)C_(2)-PVP@DOXjade serves to promote apoptotic cell death and downregulate the iron depletion-induced iron transferrin receptor(TfR).A tumor pH-responsive iron chelation/photothermal/chemotherapy antitumor effect was achieved both in vitro and in vivo.The results of this study highlight what may constitute a promising iron chelation-based phototherapeutic approach to cancer therapy. | Yunjie Xu Yingwei Wang Jusung An Adam C.Sedgwick Mingle Li Jianlei Xie Weibin Hu Jianlong Kang Sajal Sen Axel Steinbrueck Bin Zhang Lijun Qiao Swelm Wageh Jonathan F.Arambula Liping Liu Han Zhang Jonathan L.Sessler Jong Seung Kim | 2022 | Bioactive Materials2022，7，8： | 2 |
| 15 | Effect of preparation methods of aluminum emulsions on catalytic performance of copper-based catalysts for methanol synthesis from syngas显示文摘Various Cu/ZnO/Al2O3 catalysts have been synthesized by different aluminum emulsions as aluminum sources and their performances for methanol synthesis from syngas have been investigated. The influences of preparation methods of aluminum emulsions on physicochemical and catalytic properties of catalysts were studied by XRD, SEM, XPS,N2 adsorption-desorption techniques and methanol synthesis from syngas. The preparation methods of aluminum emulsions were found to influence the catalytic activity, CuO crystallite size, surface area and Cu0 surface area and reduction process. The results show that the catalyst CN using the aluminum source prepared by addition the ammonia into the aluminum nitrate (NP) exhibited the best catalytic performance for methanol synthesis from syngas. | Lili Wang Wen Ding Yingwei Liu Weiping Fang Yiquan Yang | 2010 | Journal of Natural Gas Chemistry2010，19，5： | 2 |
| 16 | Ulinastatin improves survival of septic mice by suppressing inflammatory response and lymphocyte apoptosis显示文摘 | Na Huang Fei Wang Yingwei Wang Jiong Hou Jinbao Li Xiaoming Deng | 2013 | Journal of Surgical Research2013，，2： | 2 |
| 17 | TSP-1 promotes glomerular mesangial cell proliferation and extracellular matrix secretion in Thy-1 nephritis rats显示文摘The proliferation of glomerular mesangial cells (GMC) and secretion of the extracellular matrix (ECM) in rat with Thy-1 nephritis (Thy-1N) resembling human mesangioproliferative glomerulonephritis have been explored for many years; however, the molecular mechanisms of GMC proliferation and ECM production remain unclear. Our previous studies have demonstrated that the thrombospondin-1 (TSP-1) gene was involved in mediating rat GMC proliferation and ECM synthesis induced by sublytic C5b-9 in vitro. In the present study, the roles of the TSP-1 gene in GMC proliferation, ECM production, and urinary protein secretion in Thy-1N rats were determined by using TSP-1 small hairpin RNA, and the results revealed that silencing of the TSP-1 gene in rat renal tissues could diminish GMC proliferation (P < 0.01) and ECM secretion (P < 0.01) as well as urinary protein secretion (P < 0.05) in Thy-1N rats. Together, the current findings suggested that TSP-1 gene expression was required for GMC proliferation and ECM production in Thy-1N rats. | Wen Qiu Yan Li Jianbo Zhou Chenhui Zhao Jing Zhang Kai Shan Dan Zha Yingwei Wang | 2011 | The Journal of Biomedical Research2011，25，6： | 2 |
| 18 | Dynamic cache partitioning based on hot page migration显示文摘静态的缓存划分能减少内部申请的缓存干扰并且当他们在在一样的多核心处理器分享最后水平缓存的核心上运行时,改进一个弄脏缓存的应用程序和一个缓存敏感的应用程序的合成性能。在一个虚拟化的系统,自从不同应用程序可能在不同时间在不同虚拟机(VM ) 上运行,预先静态地划分缓存是不适用的。这份报纸建议划分使用热页察觉和页移植根据缓存敏感的应用程序的优先的知识动态地改进共同招待的虚拟机的合成表演的计划的动态缓存。,试验性的结果在大多数情况中证明我们的页移植计划的开销是低的,合成性能是在免费作文上的改进。 | Xiaolin WANG Xiang WEN Yechen LI Zhenlin WANG Yingwei LUO Xiaoming LI | 2012 | Frontiers of Computer Science2012，6，4： | 2 |
| 19 | A novel recombinant DNA vaccine encodingMycobacterium tuberculosis ESAT-6 and FL protects againstMycobacterium tuberculosis challenge in mice显示文摘Mycobacterium tuberculosis 6-kDa early secretory antigenic target(ESAT-6)is a dominant target antigen for cell-mediated immunity in the early phase of tuberculosis.The fms-like tyrosine kinase 3 ligand(FL)that induces potent immune response has been used as an adjuvant in vaccine development.In this study,a new recombinant plasmid(pIRES-epitope-peptides-FL)encoding three T cell epitopes of ESAT-6 and FL was constructed,and the immunogenicity of the DNA vaccine was assessed in C57BL/6 mice immunized with the plasmid DNA vaccine.Additionally,a strategy of intramuscular injection with the DNA vaccine(prime)and intranasal administration of the epitope peptides(boost)was employed to induce higher immune reaction of the mice.The results showed that mice vaccinated with the recombinant plasmid DNA vaccine and boosted with the peptides not only increased the levels of Th1 cytokines(IFN-γand IL-12),the number of IFN-γ+T cells and activities of cytotoxic T lymphocytes as well as IgG,but also enhanced protection against Mycobacterium tuberculosis challenge.In conclusion,these data indicate that the novel recombinant pIRES-epitope-peptides-FL plasmid is a useful DNA vaccine for preventing Mycobacterium tuberculosis infection. | Qingtao Jiang Jing Zhang Xia Chen Mei Xia Yanlai Lu Wen Qiu Ganzhu Feng Dan Zhao Yan Li Fengxia He Guangyong Peng Yingwei Wang | 2013 | The Journal of Biomedical Research2013，27，5： | 2 |
| 20 | Design and testing of a high temperature superconducting pulsed pow- er transformer 显示文摘 | Haitao Li Yu Wang Yingwei Zhu | 2012 | IEEE Transactions on Applied Super- conductivity2012，22，55： | 1 |
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