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| 1 | Development of Oryza rufipogon and O. sativa Introgression Lines and Assessment for Yield-related Quantitative Trait Loci显示文摘基因渗入线人口有效地在印射量的特点 loci (QTL ) 被使用,识别有利基因,发现隐藏的遗传变异,评估处于多重条件的 QTL 的行动或相互作用并且提供为植物繁殖和基因研究的有利试验性的材料。在这研究,先进回交和连续 selfing 策略被用来开发基因渗入线(IL ) ,它源于 Oryza rufipogon Griff 的就职。从 Yuanjiang 县镇定,中国的云南省,著名计算机生产厂商他施主,和精英 indica 栽培变种 Teqing (O。sativa L.) ,接受者。从 O 的 Introgressionsegments。rufipogon 用 179 次多态的简单顺序重复(SSR ) 被屏蔽在每 IL 的染色体的标记。基因渗入线人口带的 Introgressed 片断包含了盖住整个 O 的 120 IL。rufipogon 染色体。同型结合的 O 的吝啬的数字。rufipogonsegments 每基因渗入线是大约 3.88。introgressed 片断的平均长度是近似的 25.5 厘米,并且有的大约 20.8% 这些片断缩放不到 10 厘米。eachIL 的染色体怀有 O 的 chromosomal 碎片。rufipogon 从 0.54% ~ 23.7%,与 5.79% 的全面一般水准。在每个地点, O 的替换的比率。rufipogon 等位基因有范围 of1.67-9.33,与 5.50 的一般水准。大量改变在词法并且 yield-relatedtraits 也在基因渗入线人口被发现。用单个点的分析,为产量和产量构成因素的 37 通常认为的 QTL 的一个总数与解释 phenotypic 的 7%-20% 在二个地点被检测。十九 QTL (51.4%) 在两个地点被检测,并且从在十五 loci (40.5%) 的 O.rufipogon 的等位基因在 Teging 背景改进了收益和产量构成因素。这些 O。rufipogon-O。sativa 基因渗入线将为从普通野米饭识别并且使用有利基因用作遗传物质…… | Lubin Tan | 2007 | Journal of Integrative Plant Biology2007，49，6： | 28 |
| 2 | Estrogen and insulin synergistically promote endometrial cancer progression via crosstalk between their receptor signaling pathways显示文摘Objective: Despite evidence that estrogens and insulin are involved in the development and progression of many cancers, their synergistic role in endometrial carcinoma(EC) has not been analyzed yet.Methods: Here, we investigated how estrogens act synergistically with insulin to promote EC progression. Cell growth in vitro and in vivo, effects of estradiol and insulin on apoptosis and cell cycle distribution, and expression and activation of estrogen receptor(ER), insulin receptor(InsR), and key proteins in the PI3K and MAPK pathways were examined after combined stimulation with estradiol and insulin.Results: Compared to EC cells treated with estradiol or insulin alone, those treated with both estradiol and insulin exhibited stronger stimulation. Estradiol significantly induced phosphorylation of InsR-β and IRS-1, whereas insulin significantly induced phosphorylation of ER-α. In addition, treatment with both insulin and estradiol together significantly increased the expression and phosphorylation of Akt, MAPK, and ERK. Notably, InsR-β inhibition had a limited effect on estradiol-dependent proliferation,cell cycle, and apoptosis, whereas ER-α inhibition had a limited insulin-dependent effect, in EC cell lines. Insulin and estradiol individually and synergistically promoted EC xenograft growth in mice.Conclusions: Estrogen and insulin play synergistic roles in EC carcinogenesis and progression by activating InsR-β and ER-α,promoting a crosstalk between them, and thereby resulting in the activation of downstream PI3K/Akt and MAPK/ERK signaling pathways. | Wenyan Tian Fei Teng Jinping Gao Chao Gao Guoyan Liu Yanfang Zhang Shizhu Yu Wei Zhang Yingmei Wang Fengxia Xue | 2019 | Cancer Biology & Medicine2019，16，1： | 6 |
| 3 | miR-506: a regulator of chemo-sensitivity through suppression of the RAD51-homologous recombination axis显示文摘Ovarian carcinoma is the most lethal gynecologic malignancy. Resistance to platinum is considered the major problem afecting prognosis. Our recent study established that micro RNA-506(mi R-506) expression was closely associated with progression-free survival and overall survival in two independent patient cohorts totaling 598 epithelial ovarian cancer cases. Further functional study demonstrated that mi R-506 could augment the response to cisplatin and olaparib through targeting RAD51 and suppressing homologous recombination in a panel of ovarian cancer cell lines. Systemic delivery of mi R-506 in an orthotopic ovarian cancer mouse model signiicantly augmented the cisplatin response, thus recapitulating the clinical observation. Therefore, mi R-506 plays a functionally important role in homologous recombination and has important therapeutic value for sensitizing cancer cells to chemotherapy, especially in chemo-resistant patients with attenuated expression of mi R-506. | Guoyan Liu Fengxia Xue Wei Zhang | 2015 | Chinese Journal of Cancer2015，34，11： | 4 |
| 4 | Sex-determining region Y box-containing genes: regulators and biomarkers in gynecological cancers显示文摘Sex-determining region Y box-containing genes are transcription factors with roles in multiple biological processes, including cell differentiation, proliferation, and apoptosis.Sex-determining region Y box-containing genes have also been shown to act as regulators and biomarkers in the progression of many different cancers, including gynecological cancers such as ovarian, cervical,and endometrial cancer.In this review, we summarize the contrasting regulatory roles of Sex-determining region Y box-containing genes in different gynecological cancers, as promotors with high expression levels or as suppressors with low expression levels.Expression levels of Sex-determining region Y box-containing genes were also identified as biomarkers of clinical features, including International Federation of Gynecology and Obstetrics stage, histopathologic grade together with disease-free survival, and treatment efficacy in patients with gynecological cancers.An understanding of the mechanisms whereby Sex-determining region Y box-containing genes regulate the progression of gynecological cancers will aid in the development of novel diagnostic and therapeutic strategies, while analysis of Sex-determining region Y box-containing expression levels will help to predict the prognosis of patients with gynecological cancers. | Jiali Hu Ke Li Zhanghuan Li Chao Gao Fei Guo Yingmei Wang Fengxia Xue | 2019 | Cancer Biology & Medicine2019，16，3： | 4 |
| 5 | Clinicopathological Features of Endometrial Carcinoma Associated with Lynch Syndrome in China显示文摘 | Yingmei WANG Fengxia XUE Russell R. BROADDUS Xia TAO Susu XIE Yanbin ZHU | 2009 | 中国肺癌杂志2009，12，6： | 3 |
| 6 | The pathogens of pelvic inflammatory disease 显示文摘 | LEI Ying WANG Chen XUE Fengxia | 2013 | J Pract Obstet Gynecol2013，29，10： | 1 |
| 7 | Optimization of Synthetic Conditions for the Preparation of Dihomo-γ-Linolenic Acid from γ-Linolenic Acid显示文摘 | Gang Xue Fengxia Liu Ying Wang Kaixun Huang | 2009 | Journal of the American Oil Chemists’ Society2009，，1： | 1 |
| 8 | Characterization and subunit composition of collagen from the body wall of sea cucumber Stichopusjaponicus显示文摘 | CUI Fengxia XUE Changhu LI Zhaojie | 2007 | Food Chemistry2007，100，3： | 1 |
| 9 | Optimization of Synthetic Conditions for the Preparation of Dihomo-γ-Linolenic Acid from γ-Linolenic Acid显示文摘 | Gang Xue Fengxia Liu Ying Wang Kaixun Huang | 2009 | Journal of the American Oil Chemists’ Society2009，，1： | 1 |
| 10 | Establishment and Application of Heminested RT-PCR Assay for Detection of Mosquito-Borne Flavivirus—Guizhou Province,China,2018显示文摘Introduction:Mosquito-borne flavivirus can lead to serious infectious diseases worldwide and cause high mortality and disability.In order to strengthen epidemiological investigation of flavivirus and meet the needs of early warning of diseases,a simple,rapid,and sensitive detection method needs to be established to prevent and control mosquito-borne diseases.Methods:Using the NS5 gene of flavivirus in GenBank,3 universal primers targeting the conserved regions were designed.The complementary DNAs(cDNAs)of Japanese encephalitis virus(JEV),dengue virus(DENV),West Nile virus(WNV),and yellow fever virus(YFV)were used as the template to optimize the reaction conditions.A heminested reversetranscriptase polymerase chain reaction(hnRT-PCR)was established to verify the sensitivity and specificity of this method and to detect field-caught mosquitoes.Results:Our results showed that this method exhibited better specificity,higher sensitivity,and the ability to detect multiple viruses simultaneously.The lowest detection limit of JEV,DENV-2,YFV,and WNV was 3×10^(4),3×10^(6),3×10^(5),and 3×10^(4)copies/μL,respectively.Mosquito-borne flavivirus was successfully detected in the field-caught mosquito samples using the method established in this study.Discussion:The hnRT-PCR method established in this study can be employed for the rapid detection of flavivirus and provide technical support for early and rapid diagnosis of mosquito-borne flavivirus. | Zhijing Xue Ning Zhao Jun Wang Xiuping Song Fengxia Meng Wenqin Liang Jingzhu Zhou Dan Wang Zhong Zhang Qiyong Liu | 2021 | China CDC weekly2021，3，1： | 1 |
| 11 | Clinicopathological Features in Endometrial Carcinoma Associated With Lynch Syndrome in China显示文摘 | Yingmei Wang Fengxia Xue Russell R. Broaddus Xia Tao Su-su Xie Yanbin Zhu | 2009 | International Journal of Gynecological Cancer2009，，4： | 1 |
| 12 | Interpretation of “2010 US CDC ondiagnosis and treatment of pelvic inflammatory disease norms' 显示文摘 | AipingFan Fengxia Xue | 2011 | Journal Of International Obstetrics And Gynecology2011，38，6： | 1 |
| 13 | Characterization and subunit composition of collagen from the body wall of sea cucumber Stichopus japonicus 显示文摘 | CUI Fengxia XUE Changhu LI Zhaojie | 2007 | Food Chemistry2007，100，3： | 1 |
| 14 | Diagnostic and therapeutic advancements for aerobic vaginitis显示文摘 | Cha Han Wenjuan Wu Aiping Fan Yingmei Wang Huiying Zhang Zanjun Chu Chen Wang Fengxia Xue | 2015 | Archives of Gynecology and Obstetrics2015，，2： | 1 |
| 15 | Prevalence of Reproductive Tract Infections and Association with Human Papillomavirus Infection Among Reproductive-Age Women—Six Tertiary Hospitals,China,June 2021-December 2022显示文摘Summary What is already known about this topic?Previous studies have indicated a possible association between reproductive tract infections(RTIs)and highrisk human papillomavirus(HPV)infection,but the evidence is still inconclusive.What is added by this report?This multicenter study found significantly higher positive rates of HPV,including general HPV,highrisk HPV. | Di Gao Jiayue Li Gengli Zhao Zhaohui Liu Hui Bi Dai Zhang Fengxia Xue Chen Liu Hongtao Ma Bei Lin Xu Wang Xiaosong Zhang Linhong Wang | 2024 | China CDC weekly2024，6，10： | 0 |
| 16 | Mitogenic and Anti-apoptotic Effects of Insulin in Endometrial Cancer Cells Are Phosphatidylinositol 3-kinase/Akt Dependent显示文摘 | Shaofang HUA Fengxia XUE Jing ZHAO | 2009 | 中国肺癌杂志2009，12，6： | 0 |
| 17 | Construction of QIAN Xuesen's Meta-Synthetic Wisdom System and Aerospace Hall for Workshop for Meta-Synthetic Engineering显示文摘China's aerospace industry is facing a major task of increasing the reform of aerospace management system and speeding up civil-military integration, which leads to an urgent demand for new aerospace think tank products. Thankfully, with 'information space' as the carrier, the 'systems science' as the guidance, and QIAN Xuesen's 'metasynthetic wisdom system' as the core, QIAN Xuesen think tank provides the decision support for China to develop an aerospace knowledge economy and to continuously enhance the 'space soft power'. In this paper, the framework of the meta-synthetic wisdom system guided by systems science is presented, the relationship between basic ideas of QIAN Xuesen think tank and meta-synthetic wisdom system is explained and the construction items of aerospace hall of the workshop for meta-synthetic engineering(aerospace HWMSE) are analyzed. | ZHANG Wenyu XUE Yu YANG Fengxia YU Qi | 2017 | Aerospace China2017，18，2： | 0 |
| 18 | Ovarian cancer presenting with hypercalcemia:two cases with similar manifestations but different mechanisms显示文摘Hypercalcemia presenting in ovarian cancer is uncommon in the clinic.Here,two cases of ovarian epithelial carcinoma that presented with severe hypercalcemia were reported,with a review of the literature.The laboratory findings and stepwise clinical investigations of these two cases differed,indicating distinct underlying causes of hypercalcemia.In case one,the serum levels and immunostaining for parathyroid hormone-related protein(PTHr P)verified humoral hypercalcemia of malignancy(HHM).In case two,the high level of parathyroid hormone(PTH)and the scintigraphy scan showing parathyroid gland adenoma confirmed primary hyperparathyroidism-induced hypercalcemia.Both patients received optimal cytoreductive operation and adjuvant chemotherapy but showed different outcomes respectively.This article focused on differential diagnosis of ovarian cancerassociated hypercalcemia,by stepwise imaging and laboratory investigation,and the appropriate therapy should be considered based on the different etiologies. | Xuegong Ma Yingmei Wang Xuhong Zhang Mengting Dong Wen Yang Fengxia Xue | 2018 | Cancer Biology & Medicine2018，15，2： | 0 |
| 19 | Study on Air-Purifying Performance of Semi-Flexible Asphalt Samples Coated with Titanium Dioxide Using Different Methods显示文摘Titanium dioxide(TiO_(2))was recently employed to apply onto road surfaces to degrade the harmful compounds from vehicle emissions.However,it remains a challenging task to find a highly compatible pavement type for TiO_(2)application to achieve durable and efficient air-purifying performance.This study proposed to coat TiO_(2)particles onto semi-flexible pavement surface and tried to investigate an optimum coating method.Three coating methods,including direct mixing TiO_(2)(MT)with asphalt mixture,spraying dry TiO_(2)(ST)coating and watersolution-based TiO_(2)(WT)coating on semi-flexible pavement surface.To achieve this objective,semi-flexible samples were prepared to evaluate and compare the performances of three coating methods by employing resistance to wearing,NO removal efficiency tests and residual texture depth tests.It was found that the ST method not only provided better NO degrading efficiency but also improved the resistance to wearing than the other two methods. | Shoujing Yan Yangyang Wang Fengxia Chi Xue Luo Tianjie Zhang Chenchen Xi | 2022 | Journal of Renewable Materials2022，10，5： | 0 |
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