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| 1 | Interleukin-10 modified dendritic cells induce allo-hyporesponsiveness and prolong small intestine allograft survival显示文摘AIM: To investigate whether TL-10-transduced dendritic cells (DCs) could induce tolerogenicity and prolong allograft survival in rat intestinal transplantation.METHODS: Spleen-derived DCs were prepared and genetically modified by hTL-10 gene. The level of IL-10 expression was quantitated by ELTSA. DC function was assessed by MTT in mixed leukocyte reaction. Allogeneic T-cell apoptosis was examined by flow cytometric analysis. Seven days before heterotopic intestinal transplantation, 2x106 donor-derived IL-10-DC were injected intravenously, then transplantation was performed between SD donor and Wistar recipient.RESULTS: Compared with untransduced DC, IL-10-DC could suppress allogeneic mixed leukocyte reaction (MLR). The inhibitory effect was the most striking with the stimulator/effector (S/F) ratio of 1:10. The inhibition rate was 33.25 %,41.19 % (P<0.01) and 22.92 % with the S/E ratio of 1:1,1:10 and 1:50 respectively. At 48 hours and 72 hours by flow cytometry counting, apoptotic T cells responded to IL-10-DC in MLR were 13.8 % and 30.1%, while untransduced group did not undergo significant apoptosis (P<0.05). IL-10-DC pretreated recipients had a moderate survival prolongation with a mean allograft survival of 19.8 days (P<0.01),compared with 7.3±2.4 days in control group and 8.3±2.9days in untransduced DC group. Rejection occurred in the control group within three days. The difference between untreated DC group and control group was not significant.CONCLUSION: IL-10-DC can induce allogenic T-cell hyporesponsiveness in vitro and apoptosis may be involved in it. IL-10-DC pretreatment can prolong intestinal allograft survival in the recipient. | MinZhu Ming-FaWei FangLiu Hui-FenShi GuoWang | 2003 | World Journal of Gastroenterology2003，9，11： | 10 |
| 2 | Heart-shaped anastomosis for Hirschsprung's disease: Operative technique and long-term follow-up显示文摘AIM: To study the long-term therapeutic effect of 'heartshaped' anastomosis for Hirschsprung's disease.METHODS: From January 1986 to October 1997, we performed one-stage 'heart-shaped' anastomosis for 193 patients with Hirschsprung's disease (HD). One hundred and fiftytwo patients were followed up patients (follow-up rate 79%).The operative outcome and postoperative complications were retrospectively analyzed.RESULTS: Early complications included urine retention in 2patients, enteritis in 10, anastomotic stricture in 1, and intestinal obstruction in 2. No infection of abdominal cavity or wound and anastomotic leakage or death occurred in any patients. Late complications were present in 22 cases,including adhesive intestinal obstruction in 2, longer anal in 5, incision hernia in 2, enteritis in 6, occasional stool stains in 7 and 6 related with improper diet. No constipation or incontinence occurred in any patient.CONCLUSION: The early and late postoperative complication rates were 7.8% and 11.4% respectively in our 'heartshaped anastomosis' procedure. 'Heart-shaped'anastomosis procedure for Hirschsprung's disease provides a better therapeutic effect compared to classic procedures. | GuoWang Xiao-YiSun Ming-FaWei Yi-ZhenWeng | 2005 | World Journal of Gastroenterology2005，11，2： | 5 |
| 3 | Crashworthiness Optimization Design of Thin-Walled Tube Filled with Re-entrant Triangles Honeycombs显示文摘A novel re-entrant triangles-filled tube(RTT)is proposed through decoupling structural stiffness and energy absorption.Inner re-entrant triangles are employed to satisfy energy absorption,and outer thin wall is used to acquire high stiffness.This paper starts from establishment of theoretical models between geometric parameters of re-entrant triangles and relative density,equivalent elastic modulus and energy absorption characteristics,which are validated by experiments.On this basis,the optimal geometric parameters of unit cell are sought to maximize unit volume energy absorption and minimize relative density by adopting NSGA-II method.Subsequently,the cross-section of tube with optimal stiffness is obtained with targets for maximizing axial stiffness and lateral stiffness by employing static topology optimization method.To verify the proposed optimization method,RTT is analyzed and compared with positive Poisson’s ratio foam-filled tube(PFT),non-filled traditionally optimized tube(NTT)and pre-optimized square tube(PST).The results show that the novel RTT can improve stiffness and energy absorption performance simultaneously.Compared with the positive Poisson’s ratio material,re-entrant triangles honeycomb shows superior advantages in energy absorption.In comparison with the PFT,energy absorption of the RTT increases by 17.23%,and the peak crush force reduces by 5.04%.Therefore,the proposed decoupling design method demonstrates superiority in satisfying various performance requirements simultaneously. | Fangwu Ma Ying Zhao Guowang Wang Liang Wu Yongfeng Pu | 2019 | Automotive Innovation2019，2，1： | 3 |
| 4 | Metabolic Characterization of Hepatocellular Carcinoma Using Nontargeted Tissue Metabolomics显示文摘 | Qiang Huang Yexiong Tan Peiyuan Yin Guozhu Ye Peng Gao Xin Lu Hongyang Wang Guowang Xu | 2013 | Cancer Research2013，，16： | 2 |
| 5 | Serum metabolomics reveals the deregulation of fatty acids metabolism in hepatocellular carcinoma and chronic liver diseases显示文摘 | Lina Zhou Quancai Wang Peiyuan Yin Wenbin Xing Zeming Wu Shili Chen Xin Lu Yong Zhang Xiaohui Lin Guowang Xu | 2012 | Analytical and Bioanalytical Chemistry2012，，1： | 2 |
| 6 | The Effect of Helicobacter pylori Infection on hMSH2 and P53 Proteins in Gastric Carcinogenesis显示文摘 | Kai Fan Jianmei Ma Zhaohui Wang Min Liu Mei Li Shen Lue Lina Liu Guowang Xu | 2005 | Chinese Journal of Clinical Oncology2005，2，5： | 1 |
| 7 | The Cauehy problem for the generalized IMBq equation in W,P(Rn)显示文摘 | Wang shubin Chen guowang | 2002 | J Math Anal Appl2002，266，1： | 1 |
| 8 | Small amplitude solutions of the generahzed IMBq equation显示文摘 | Wang Shubin Chen Guowang | 2002 | Math Anal Appl2002，274，2： | 1 |
| 9 | Energy- efficient link adaptation in frequency-selective channels 显示文摘 | Miao Guowang Himayat N Li Geoffrey Ye | 2010 | IEEE Trans Commun2010，58，2： | 1 |
| 10 | Cauchy problem for generalized IMBq Equation with several variables显示文摘 | Guowang Chen Jiasheng Xing Zhijian Yang | 1996 | Nonlinear Analysis Theory Methods Applications1996，26，： | 1 |
| 11 | Energy-efficient link adaptation in frequency-selective channels显示文摘 | MIAO Guowang HIMAYAT N LI G Y | | 0，，02： | 1 |
| 12 | Characterization of flavor compounds in Chinese liquor Moutai by comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry显示文摘 | Shukui Zhu Xin Lu Keliang Ji Kunliang Guo Yanli Li Caiying Wu Guowang Xu | 2007 | Analytica Chimica Acta2007，，2： | 1 |
| 13 | Empirical Likelihood Inference for the Semiparametric Varying-Coefficient Spatial Autoregressive Model显示文摘In this paper empirical likelihood(EL)-based inference for a semiparametric varyingcoefficient spatial autoregressive model is investigated.The maximum EL estimators for the parametric component and the nonparametric component are established.Furthermore,asymptotic properties of the proposed estimators and EL ratios are derived,and the corresponding confidence regions/bands are constructed.Their finite sample performances are studied via simulation and an example. | LUO Guowang WU Mixia PANG Zhen | 2021 | Journal of Systems Science & Complexity2021，34，6： | 1 |
| 14 | Strategy for metabonomics research based on high-performance liquid chromatography and liquid chromatography coupled with tandem mass spectrometry 显示文摘 | Yang Jun Xu Guowang Zheng Yufang | 2005 | J Chromatogr A2005，1084，： | 1 |
| 15 | Distributed interference- Aware energy-efficient power optimization 显示文摘 | Guowang M Himayat N L | 2011 | Wireless Communications2011，10，4： | 1 |
| 16 | Existence and nonexistence of global Solutions for the generalized IMBq equation 显示文摘 | Chen Guowang and Wang Shubin | 1999 | Nonlinear Analysis1999，36，： | 1 |
| 17 | Cauehy problem for generalized IMBq equation with several variables 显示文摘 | Chen Guowang Xing Jiasheng Yang Zhijian | 1996 | Nonlinear Analysis TMA1996，26，7： | 1 |
| 18 | Vibration analysis and optimal design for cab's isolation system of vibratory roller显示文摘 | Le Van Quynh Jianrun zhang Guowang Jiao | 2011 | Advanced Material Research2011，，199200： | 1 |
| 19 | 显示文摘 | WENG Qianfeng XU Guowang YUAN Kailong | 2006 | J Chromatogr: B2006，835，： | 1 |
| 20 | Energy-efficient link ad- aptation in frequency-selective channels 显示文摘 | Miao Guowang Himayat N Li G Y | 2010 | IEEE Transac- tions on Communications2010，58，2： | 1 |
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