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| 1 | A Rare Allele of GS2 Enhances Grain Size anc Grain Yield in Rice显示文摘谷物尺寸决定谷物重量并且影响谷物质量。调整谷物尺寸的几主要量的特点 loci (QTL ) 被克隆;然而,我们调整米饭谷物的尺寸的内在的机制的理解仍然保持碎片。这里,我们报导克隆和主导的 QTL 的描述,染色体 2 上的谷物尺寸(GS2 ) 编码调整生长的因素 4,一个 transcriptional 管理者。GS2 本地化到原子核并且可以充当抄写使活跃之物。影响 microRNA 的有约束力的地点的 GS2 的一个稀罕变化, OsmiR396c,原因提高了 GS2/OsGRF4 的表示。GS2 表示的增加导致更大的房间和房间的增加的数字,它因此提高谷物重量和产量。进米饭栽培变种的 GS2/OsGRF4 的这稀罕等位基因的介绍能显著地提高谷物重量和增加谷物产量,用在引起产量很高的米饭变化的可能的应用。 | Jiang Hu Yuexing Wang Yunxia Fang Longjun Zeng Jie Xu Haiping Yu Zhenyuan Shi Jiangjie Pan Dong Zhang Shujing Kang Li Zhu Guojun Dong Longbiao Guo Dali Zeng Guangheng Zhang Lihong Xie Guosheng Xiong Jiayang Li Qian Qian | 2015 | Molecular Plant2015，8，10： | 57 |
| 2 | Therapeutic potential of siRNA-mediated combined knockdown of the lAP genes (Livin, XIAP, and Survivin) on human bladder cancer T24 cells显示文摘Livin, apoptosis (XIAP ) 的 X 连接禁止者,和 Survivin 几乎是 apoptosis 的三个著名禁止者在癌症房间只过去表示并且为癌症治疗被认为有势力目标。在现在的学习,我们发现 Livin, XIAP,和 Survivin 同时在膀胱癌症房间被表示。我们推测了那 Livin, XIAP,和 Survivin 可能在房间生长和 apoptosis 上有 synergistic 效果。我们的结果证实了联合那所有这三基因击倒能 synergistically 禁止增长和高级膀胱癌症 T24 房间的转变能力并且把房间 apoptotic 敏感提升到化疗。而且,联合了 Livin, XIAP,和 Survivin 罐头击倒显著地增加许多活跃 caspase-3,活跃 caspase-7,活跃 caspase-9,和 cytosolic Smac。我们的调查结果暗示 Livin, XIAP,和 Survivin 的那联合 silencing 可以是一个有势力为膀胱癌症的多指向的基因治疗。 | Deyong Yang Xishuang Song Jianing Zhang Lin Ye Shujing Wang Xiangyu Che Jianbo Wang Zhiwei Zhang Lina Wang Wei Shi | 2010 | Acta Biochimica et Biophysica Sinica2010，42，2： | 29 |
| 3 | A Strigolactone Biosynthesis Gene Contributed to the Green Revolution in Rice显示文摘Plant architecture is a complex agronomic trait and a major factor of crop yield,which is affected by several important hormones.Strigolactones(SLs)are identified as a new class hormoneinhibiting branching in many plant species and have been shown to be involved in various developmental processes.Genetical and chemical modulation of the SL pathway is recognized as a promising approach to modify plant architecture.However,whether and how the genes involved in the SL pathway could be utilized in breeding still remain elusive.Here,we demonstrate that a partial loss-of-function allele of the SL biosynthesis gene,HIGH TILLERING AND DWARF 1/DWARF17(HTD1/D17),which encodes CAROTENOID CLEAVAGE DIOXYGENASE 7(CCD7),increases tiller number and improves grain yield in rice.We found that the HTD1 gene had been widely utilized and co-selected with Semidwarf 1(SD1),both contributing to the improvement of plant architecture in modern rice varieties since the Green Revolution in the 1960s.Understanding how phytohormone pathway genes regulate plant architecture and how they have been utilized and selected in breeding will lay the foundation for developing the rational approaches toward improving crop yield. | Yuexing Wang Lianguang Shang Hong Yu Longjun Zeng Jiang Hu Shen Ni Yuchun Rao Sanfeng Li Jinfang Chu Xiangbing Meng Lei Wang Ping Hu Jijun Yan Shujing Kang Minghao Qu Hai Lin Tao Wang Quan Wang Xingming Hu Hongqi Chen Bing Wang Zhenyu Gao Longbiao Guo Dali Zeng Xudong Zhu Guosheng Xiong Jiayang Li Qian Qian | 2020 | Molecular Plant2020，13，6： | 23 |
| 4 | Magnetic records of heavy metal pollution in urban topsoil in Lanzhou,China显示文摘This study is a systematic analysis of the magnetic characteristics and heavy metal elements in soil samples collected from Lanzhou City,China.The 117 surface soil samples were measured to study the feasibility and effectiveness of environmental magnetism for evaluating heavy metal pollution in urban soils.Results of the study indicate that low-coercivity magnetite dominates the magnetic properties in the samples.The high values of the soil magnetic mineral concentration parameters and low values of magnetic particle size parameters are distributed throughout the northern area of Xigu District,the industrial zones of the eastern section of Chengguan District and the districts of the narrow sections connecting Chengguan District and the other three districts;these parameters are fundamentally consistent with the distribution of the high values of the Pollution Load Index and Nemerow Pollution Index.Semi-quantitative studies which use the environmental magnetic method to monitor pollution of heavy metals(such as As,Cr,Cu,Ni,Pb,Zn,and Fe) have shown that when xlf≤35×10-8 m 3 kg-1,it is unpolluted;when 35≤xlf <150×10-8 m3 kg-1,it is moderately polluted to unpolluted;when 150≤xlf <365×10-8 m 3 kg-1,it is moderately polluted;when 365≤xlf <750×10-8 m3 kg-1,fd %<2.7 and ARM /SIRM<0.2×10-3m A-1,it is moderately to highly polluted;when xlf ≥750×10-8 m3 kg-1,xfd %<2.7 and xARM/SIRM<0.2×10-3m A-1,it is highly polluted.The region of moderately to highly polluted distribution is caused by industry and vehicles,showing that the change of pollution in Lanzhou City bears the trend of 'vehicle emission + industrial'. | WANG Bo XIA DunSheng YU Ye JIA Jia XU ShuJing | 2013 | Chinese Science Bulletin2013，58，3： | 19 |
| 5 | Study on detection of coastal water environment of China by ocean color remote sensing显示文摘Coastal water environment is essentially enhanced by ocean color which is basically decided by substances concentration in water such as chlorophyll, suspended material and yellow substance. It is very difficult, even not possible, to detect water color by expensive ship routing, because of its temporal and spatial variety of feature and scales in the very complicated dynamical system of coastal water. With the development of satellite technique in the last 20 a, space sensors can be applied to detect ocean color by measuring the spectra of water leaving radiance.It is proven that ocean color remote sensing is a powerful tool for understanding the process of oceanic biology and physics. Since the 1980s, great attention has been paid to the advanced remote sensing technique in China, especially to development of satellite programs for the coastal water environment. On 7 September 1988, China launched her first polar orbit satellite FY-1A for meteorological and oceanographic application (water color and temperature) and the second satellite FY-1B two years later. In May 1999, China launched her second generation environment satellite FY-1C with higher sensitivies, more channels and stable operation. The special ocean color satellite HY-1 is planned to be in the orbit in 2001, whose main purpose is to detect the coastal water environment of China seas. China is also developing a very advantageous sensor termed as Chinese moderate imaging spectra radiometer (CMODIS) with 91 channels, which will be a good candidate of the third generation satellite FY-3 in 2003. The technical system of ocean color remote sensing was developed by the Second Institute of Oceanography (SIO), State Oceanic Administration (SOA) in 1997. The system included data receiving, processing, distribution, calibration, validation and application units. The Hangzhou Station of SIO, SOA has the capability to receive FY-1 and AVHRR data since 1989. It was also a SeaWiFS scientific research station authorized by NASA,USA to free receive SeaWiFS data from 16 September 1997. In the recent years, the local algorithms of atmospheric correction and inversion of ocean color have been developed for FY-1C and SeaWiFS, to improve the accuracy of the measurement from satellites efficiently. The satellite data are being applied to monitor coastal water environment, such as the spatial distribution of chlorophyll, suspended material and yellow substance, red tide detection and coastal current study. The results show that the ocean color remote sensing has latent capacity in the detection of coastal water environment.In consideration of the update technique progress of ocean color remote sensing and its more important role in the detection of coastal water in the 2000s, some suggestions are set forth, which would be beneficial to the design of a cheaper but practical coastal water detection system for marine environment preservation. | Pan Delu 1,2 , Mao Tianming 1, Li Shujing 1,Huang Haiqing 11 .LaboratoryofOceanDynamicProcessesandSatelliteOceanographyofStateOceanicAdministration ,Hangzhou310 0 12 ,China 2 .LaboratoryofSubmarineGeosciencesofStateOceanicAdministration ,Hangzhou 3 | 2001 | Acta Oceanologica Sinica2001，20，1： | 16 |
| 6 | MdGSTF6,activated by MdMYB1,plays an essential role in anthocyanin accumulation in apple显示文摘Anthocyanins are biosynthesized on the cytosolic surface of the endoplasmic reticulum and then transported into the vacuole for storage.Glutathione S-transferases(GSTs)are considered to be responsible for the transport of anthocyanins into the vacuole.However,the regulatory mechanisms of GSTs in plants are still unclear.Here,we performed a genome-wide analysis and identified 69 GST genes in apple.The expression of MdGSTF6 was positively correlated with the anthocyanin content(r=0.949)during‘Yanfu 8’fruit development.The overexpression of MdGSTF6 in the Arabidopsis thaliana tt19 mutant resulted in seedlings of 35S::MdGSTF6-GFP/tt19 that could accumulate anthocyanin and rescue its phenotype,suggesting that MdGSTF6 was an anthocyanin transporter.The silencing of MdGSTF6 affected anthocyanin accumulation in apple fruit.Moreover,the knockdown of MdGSTF6 by RNA interference in cultured‘Gala’seedlings inhibited anthocyanin accumulation.The interaction experiments showed that MdMYB1 could bind directly to the MdGSTF6 promoter to transcriptionally activate its expression.Collectively,our results demonstrate that MdGSTF6 encodes an important GST transporter of anthocyanins in apple fruit and provide evidence for the associated regulatory mechanisms.Therefore,MdMYB1 can not only regulate anthocyanin synthesis,but also control the transport of anthocyanin in apples.This information may be useful for further clarifying the regulation of anthocyanin transport in apple. | Shenghui Jiang Min Chen Naibo He Xiaoliu Chen Nan Wang Qingguo Sun Tianliang Zhang Haifeng Xu Hongcheng Fang Yicheng Wang Zongying Zhang Shujing Wu Xuesen Chen | 2019 | Horticulture Research2019，6，1： | 16 |
| 7 | Genetic Variation of the VP1 Gene of the Virulent Duck Hepatitis A Virus Type 1(DHAV-1) Isolates in Shandong Province of China显示文摘To investigate the relationship of the variation of virulence and the external capsid proteins of the pandemic duck hepatitis A virus type 1(DHAV-1) isolates,the virulence,cross neutralization assays and the complete sequence of the virion protein 1(VP1) gene of nine virulent DHAV-1 strains,which were isolated from infected ducklings with clinical symptoms in Shandong province of China in 2007-2008,were tested.The fifth generation duck embryo allantoic liquids of the 9 isolates were tested on 12-day-old duck embryos and on 7-day-old ducklings for the median embryonal lethal doses(ELD 50 s) and the median lethal doses(LD 50 s),respectively.The results showed that the ELD 50 s of embryonic duck eggs of the 9 DHAV-1 isolates were between 1.9 × 10 6 /mL to 1.44 × 10 7 /mL,while the LD 50 s were 2.39 × 10 5 /mL to 6.15 × 10 6 /mL.Cross-neutralization tests revealed that the 9 DHAV-1 isolates were completely neutralized by the standard serum and the hyperimmune sera against the 9 DHAV-1 isolates,respectively.Compared with other virulent,moderate virulent,attenuated vaccine and mild strains,the VP1 genes of the 9 strains shared 89.8%-99.7% similarity at the nucleotide level and 92.4%-99.6% at amino acid level with other DHAV-1 strains.There were three hypervariable regions at the C-terminus(aa 158-160,180-193 and 205-219) and other variable points in VP1 protein,but which didn't cause virulence of DHAV-1 change. | Jiming Gao Junhao Chen Xingkui Si Zhijing Xie Yanli Zhu Xingxiao Zhang Shujing Wang Shijin Jiang | 2012 | Virologica Sinica2012，27，4： | 10 |
| 8 | Anelasticity of twinned CuO nanowires显示文摘CuO nanowires (NW ) 的机械行为被调查由在 situ 传播电子显微镜学。在压缩期间, NW 展出了与高机械的应力联系的高弯曲的能力。有趣地,滞弹性一致地在压力版本以后被观察。进一步的调查显示滞弹性对 CuO NW 内在,尽管 electronbeam 照耀加速形状恢复被证明有能力。机制基于联系双胞胎的原子的合作运动被建议说明这现象。结果提供卓见进 CuO NW 的机械性质,它是为抑制系统的 nanoscale 的有希望的材料。 | Huaping Sheng He Zheng Fan Cao Shujing Wu Lei Li Chun Liu Dongshan Zhao Jianbo Wang | 2015 | Nano Research2015，8，11： | 9 |
| 9 | An approach to quick and easy evaluation of the dam breach flood显示文摘In the context of an impending dam failure, quick evaluation of dam breach flood is necessary. Previous studies provided an approach to calculate the dam breach hydrograph using an Excel spreadsheet based on the improved soil erosion model and numerical algorithm. However, calculation of the breach lateral enlargement requires the modeling of the successive collapse of the breach banks. It is time-consuming with special training, which is difficult to provide during an emergency. This study proposes that the lateral enlargement process can be modeled using a hyperbolic relationship with sufficient accuracy. Consequently, field engineers can perform the dam breach analysis along with the sensitive study for a target case within 1 h in an Excel spreadsheet which is self-tutorial. This paper presents this easy and quick approach based on only fifteen input parameters that can be determined based on the experience. This approach can also be used for the preliminary study when a dam safety planning work is undertaken. | CHEN ZuYu PING ZiYi WANG NaiXin YU Shu CHEN ShuJing | 2019 | Science China(Technological Sciences)2019，62，10： | 9 |
| 10 | Gold nanoprisms as a hybrid in vivo cancer theranostic platform for in situ photoacoustic imaging, angiography, and localized hyperthermia显示文摘高分辨率的 nanosized photoacoustic 对比代理人的发展是令人激动的还挑战性的工艺的进展。此处,抗体(胸联系癌症的抗原 1 (Brcaa1 ) monoclonal 抗体)- 并且肽(RGD )-functionalized 金牌 nanoprisms (AuNprs ) 被用作组合方法论为在使用的 situ photoacoustic 成像, angiography,和局部性的过高热, orthotopic 和下的鼠科的胃的癌当模特儿。结合 RGD 的 PEGylated AuNprs 为结合抗体的 PEGylated AuNprs 被用于指向的肿瘤 angiography,和 Brcaa1 monoclonal 并且为是可得到的在在 orthotopic 的胃的癌的 situ 成像,肿瘤当模特儿。在 situ photoacoustic 成像允许在肿瘤地点的解剖、功能的成像。在 vivo 肿瘤 angiography,成像以一种时间依赖者方式显示出 photoacoustic 信号的改进。而且, photoacoustic 成像证明肿瘤容器清楚地在局部性的过高热以后被损坏。这作为高度敏感的对比和治疗学的代理人是用二根 AuNprs 探针的第一 proof-of-concept 为在 situ 肿瘤察觉和抑制。这些聪明的抗体 / 肽 AuNprs 能被用作一个有效 nanotheranostic 平台为在局部性的过高热处理以后在有高敏感的 vivo 肿瘤察觉,以及为指向治疗,与单个剂量的注射,它导致肿瘤的肿瘤缩放减小和增加老鼠幸存。 | Chenchen Bao Joao Conde Fei Pan Chao Li Chunlei Zhang Furong Tian Shujing Liang Jesus M. de la Fuente Daxiang Cui | 2016 | Nano Research2016，9，4： | 9 |
| 11 | Progress in the mechanism and targeted drug therapy for COPD显示文摘Chronic obstructive pulmonary disease(COPD)is emphysema and/or chronic bronchitis characterised by long-term breathing problems and poor airflow.The prevalence of COPD has increased over the last decade and the drugs most commonly used to treat it,such as glucocorticoids and bronchodilators,have significant therapeutic effects;however,they also cause side effects,including infection and immunosuppression.Here we reviewed the pathogenesis and progression of COPD and elaborated on the effects and mechanisms of newly developed molecular targeted COPD therapeutic drugs.Among these new drugs,we focussed on thioredoxin(Trx).Trx effectively prevents the progression of COPD by regulating redox status and protease/anti-protease balance,blocking the NF-κB and MAPK signalling pathways,suppressing the activation and migration of inflammatory cells and the production of cytokines,inhibiting the synthesis and the activation of adhesion factors and growth factors,and controlling the cAMP-PKA and PI3K/Akt signalling pathways.The mechanism by which Trx affects COPD is different from glucocorticoid-based mechanisms which regulate the inflammatory reaction in association with suppressing immune responses.In addition,Trx also improves the insensitivity of COPD to steroids by inhibiting the production and internalisation of macrophage migration inhibitory factor(MIF).Taken together,these findings suggest that Trx may be the ideal drug for treating COPD. | Cuixue Wang Jiedong Zhou Jinquan Wang Shujing Li Atsushi Fukunaga Junji Yodoi Hai Tian | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 8 |
| 12 | A Tailored High-Efficiency Sample Pretreatment Method for Simultaneous Quantification of 10 Classes of Known Endogenous Phytohormones显示文摘One of the hottest topics in plant hormone biology is the crosstalk mechanisms,whereby multiple classes of phytohormones interplay with each other through signaling networks.To better understand the roles of hormonal crosstalks in their complex regulatory networks,it is of high significance to investigate the spatial and temporal distributions of multiple-phytohormones simultaneously from one plant tissue sample.In this study,we develop a high-sensitivity and high-throughput method for the simultaneous quantitative analysis of 44 phytohormone compounds,covering currently known 10 major classes of phytohormones(strigolactones,brassinosteroids,gibberellins,auxin,abscisic acid,jasmonic acid,salicylic acid,cytokinins,ethylene,and polypeptide hormones[e.g.,phytosulfokine])from only 100 mg of plant sample.These compounds were grouped and purified separately with a tailored solid-phase extraction procedure based on their physicochemical properties and then analyzed by LC–MS/MS.The recoveries of our method ranged from 49.6%to 99.9%and the matrix effects from 61.8%to 102.5%,indicating that the overall sample pretreatment design resulted in good purification.The limits of quantitation(LOQs)of our method ranged from 0.06 to 1.29 pg/100 mg fresh weight and its precision was less than 13.4%,indicating high sensitivity and good reproducibility of the method.Tests of our method in different plant matrices demonstrated its wide applicability.Collectively,these advantages will make our method helpful in clarifying the crosstalk networks of phytohormones. | Peiyong Xin Qiuhuan Guo Bingbing Li Shujing Cheng Jijun Yan Jinfang Chu | 2020 | Plant Communications2020，1，3： | 7 |
| 13 | Multi-channel micro neural probe fabricated with SOI显示文摘Silicon-on-insulator(SOI) substrate is widely used in micro-electro-mechanical systems(MEMS).With the buried oxide layer of SOI acting as an etching stop,silicon based micro neural probe can be fabri-cated with improved uniformity and manufacturability.A seven-record-site neural probe was formed by inductive-coupled plasma(ICP) dry etching of an SOI substrate.The thickness of the probe is 15 μm.The shaft of the probe has dimensions of 3 mm×100 μm×15 μm with typical area of the record site of 78.5 μm2.The impedance of the record site was measured in-vitro.The typical impedance characteris-tics of the record sites are around 2 MΩ at 1 kHz.The performance of the neural probe in-vivo was tested on anesthetic rat.The recorded neural spike was typically around 140 μV.Spike from individual site could exceed 700 μV.The average signal noise ratio was 7 or more. | PEI WeiHua ZHU Lin WANG ShuJing GUO Kai TANG Jun ZHANG Xu LU Lin GAO ShangKai CHEN HongDa | 2009 | Science China(Technological Sciences)2009，52，5： | 6 |
| 14 | Intranasal and oral vaccination with protein-based antigens: advantages, challenges and formulation strategies显示文摘大多数病原体在人的 mucosal 表面开始他们的感染。因此, mucosal 种痘,通过特别口头或 intranasal 管理线路,高度为传染疾病被需要。同时,基于蛋白质的抗原提供一种更安全的选择给基于的整个病原体或 DNA 在疫苗的开发的。然而,在他们到达指向,相对低的 immunogenicity ,以及蛋白质抗原的低稳定性的地点以前, intranasally 或口头上地交付了蛋白质疫苗的唯一的 biopharmaceutical 障碍需要克服,要求有头脑、调整的 mucosal 疫苗明确的表达包括 immunostimulants 的选择,合适的疫苗的交货系统的鉴定,和准确作文和生产条件的决心。这评论试图提供蛋白质的新调查基于抗原的疫苗的明确的表达开发,包括 immunostimulants 和为 intranasal 和口头的政府的疫苗的交货系统的优化的用法。 | Shujing Wang Huiqin Liu Xinyi Zhang Feng Qian | 2015 | Protein & Cell2015，6，7： | 6 |
| 15 | Bio-Functional Cu Containing Biomaterials: a New Way to Enhance Bio-Adaption of Biomaterials显示文摘Although being an essential trace element required for human body health, Cu has long been seriously considered toxic when its amount exceeds certain limitation, which significantly limited the wide application of Cu in biomaterials. However, more and more bio-functions and benefits of Cu were found and confirmed, attracting the attention from biomaterials researchers in recent years. People have tried to immobilize Cu into biomaterials by various ways, in order to develop novel bio-functional Cu containing biomaterials with better bio-adaptions, and several different bio-functions of them have been demonstrated. This paper makes a review of the development of novel bio-functional Cu containing biomaterials, and focuses on their unique roles in enhancing bio-adaption of biomedical materials, including antibacterial performance, stimulating angiogenesis, promoting osteogenesis and inhibition of in-stent restenosis, aiming at proposing a prospective development direction for biomedical materials with better bio-adaptions. | Shujing Jin Ling Ren Ke Yang | 2016 | Journal of Materials Science & Technology2016，32，9： | 6 |
| 16 | Dual quaternion based virtual hand interaction modeling显示文摘Virtual hands play key roles in three-dimensional interaction in various virtual reality applications.However,their visual realism has seldom been seriously discussed in the community of human computer interaction,not to mention the challenging balance between their visual/motion realism and real-time performance.In this paper,a novel approach for virtual hand interaction modeling based on dual quaternion is proposed.Specifically,dual quaternion blending(DQB) is introduced as pseudo muscular layer of our virtual hand model instead of traditional linear blending(LB) and quaternion blending(QB) due to its advantages in muscular deformation.A framework for virtual hand interaction is proposed which supports both gesture interactions and 3D manipulations.Experimental results show that our proposed virtual hand interaction model is suitable for most virtual reality applications and achieves good visual/motion realism while maintains real-time performance. | CHEN WenFeng ZHU ShuJing WAN HuaGen FENG JieQing | 2013 | Science China(Information Sciences)2013，56，3： | 6 |
| 17 | Nanocrystalline TiO_(2) thin film electrodes prepared by common pressure hydrothermal method at low temperature显示文摘Nanocrystalline TiO2 thin film electrodes have been prepared from mixed pastes of tetrabutyl titanate and nanocrystalline TiO2 particles by common pressure hydro- thermal method at low temperature. The tetrabutyl titanate was hydrolyzed and crystallized into anatase TiO2 to inter- connect nanocrystalline TiO2 particles and adhere them to conductive substrates, obtaining highly porous and me- chanically stable TiO2 nanocrystalline film. The conversion efficiencies of the dye-sensitized solar cells based on prepared electrodes on conductive glass substrates and flexible sub- strates were 4.8% and 1.9% under illumination of 100 mW/cm2, respectively. | LI Chengyu LIN Yuan LI Xueping WANG Zhengping MA Yutao ZHOU Xiaowen FENG Shujing XIAO Xurui | 2005 | Chinese Science Bulletin2005，50，14： | 5 |
| 18 | An adaptive turbo-shaft engine modeling method based on PS and MRR-LSSVR algorithms显示文摘In order to establish an adaptive turbo-shaft engine model with high accuracy, a new modeling method based on parameter selection (PS) algorithm and multi-input multi-output recursive reduced least square support vector regression (MRR-LSSVR) machine is proposed. Firstly, the PS algorithm is designed to choose the most reasonable inputs of the adaptive module. During this process, a wrapper criterion based on least square support vector regression (LSSVR) machine is adopted, which can not only reduce computational complexity but also enhance generalization performance. Secondly, with the input variables determined by the PS algorithm, a mapping model of engine parameter estimation is trained off-line using MRR-LSSVR, which has a satisfying accuracy within 5&. Finally, based on a numerical simulation platform of an integrated helicopter/ turbo-shaft engine system, an adaptive turbo-shaft engine model is developed and tested in a certain flight envelope. Under the condition of single or multiple engine components being degraded, many simulation experiments are carried out, and the simulation results show the effectiveness and validity of the proposed adaptive modeling method. | Wang Jiankang Zhang Haibo Yan Changkai Duan Shujing Huang Xianghua | 2013 | Chinese Journal of Aeronautics2013，26，1： | 5 |
| 19 | Spatial-temporal Variation of Extreme Precipitation Events in Northwest China During 1961-2010显示文摘Using the daily precipitation data of 118 meteorological stations in Northwest China from January 1,1961 to December 31,2010,we analyzed extreme precipitation events from prime precipitation data by applying R-language Climate Index( RClimDex).The spatial-temporal change characteristics in the past 50 years have been examined using the method of trend analysis,Mann-Kendall and the spatial analysis module of Arcgis9.2.The results show that the spatial distribution of the indices for extreme precipitation in Northwest China is greatly influenced by geographic location,atmospheric circulation and topography,and the spatial difference of extreme precipitation events is very evident,while the indices reduce from the southeast to the northwest except Consecutive Dry Days( CDD).In Xinjiang region,high values appear in Tianshan Mountains and decrease towards the south and north respectively.In the past 50 years,the temporal variation tendency of the indices for extreme precipitation in Northwest China has a great spatial distinction.It shows that the variation tendency is opposite between the east( decrease) and the west( increase),and CDD has a decreasing tendency while other indices increase.For each region,it is found that the indices for extreme precipitation in Xinjiang and Qinghai Province shows an increasing trend,and it is remarkable in Tianshan Mountains,the north of Xinjiang and the northeast of Qinghai Province.The temporal variation tendency of the indices for extreme precipitation in Ningxia,Shaanxi and Gansu has a large spatial distinction.The stations which have an increasing tend are mainly found in the north of Ningxia,south of Shaanxi and Hexi Corridor of Gansu.However,the south of Ningxia,north of Shaanxi and Longnan of Gansu Province mainly present a decreasing trend.The temporal variation tendency of the indices for extreme precipitation in Inner Mongolia is not obvious.Overall,the east part of Northwest China has a dry tendency,while the west part has an opposite trend. | Lian Lishu Xu Shujing Li Zhifu Sun Xiaoyin | 2014 | Meteorological and Environmental Research2014，5，1： | 5 |
| 20 | Medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors显示文摘Novel therapies are urgently needed to improve global treatment of SARS-CoV-2 infection.Herein,we briefly provide a concise report on the medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors with representative examples in different strategies from the medicinal chemistry perspective. | Shenghua Gao Tianguang Huang Letian Song Shujing Xu Yusen Cheng Srinivasulu Cherukupalli Dongwei Kang Tong Zhao Lin Sun Jian Zhang Peng Zhan Xinyong Liu | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 5 |
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