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| 1 | Studies on classification,criteria and control of rockbursts显示文摘This paper attempts to present the findings involving rockbursts classification,rockburst failure criteria,and related control measures.Experimental investigations were performed using the strainburst testing machine and impact-induced rockburst testing machine.According to the stress paths and experimental methods,rockbursts were classified into two major groups,i.e.the strainbursts and impact-induced bursts.The mechanisms and criteria of rockburst obtained from experimental investigations were discussed.Then,the developments of constant-resistance and large-deformation bolt(CRLDB),which can adapt itself to the external loading at a constant resistance by elongating continually,were introduced.The deformation energy of country rocks with large deformation can be absorbed by CRLDBs.Finally,the principles and the experimental results for control and prevention of rockburst using the CRLDBs were presented. | Manchao He Hongman Xia Xuena Jia Weili Gong Fei Zhao Kangyuan Liang | 2012 | Journal of Rock Mechanics and Geotechnical Engineering2012，4，2： | 21 |
| 2 | Chinese Society of Clinical Oncology(CSCO) diagnosis and treatment guidelines for malignant lymphoma 2021(English version)显示文摘1. General guidelines2. Diagnosis3. Staging4. Treatment4.1 Diffuse large B-cell lymphoma(DLBCL)4.2 Follicular lymphoma(FL)4.3 Mantle cell lymphoma(MCL)4.4 Marginal zone lymphoma(MZL)4.5 Burkitt lymphoma(BL)4.6 CLL/Small lymphocytic lymphoma(SLL)4.7 Extra-nodal natural killer/T-cell lymphoma(ENKTCL), nasal type4.8 Peripheral T-cell lymphoma(PTCL)4.9 HL4.10 Primary central nervous system lymphoma5. Prognosis Lymphomas are a group of heterogeneous diseases. | Jun Zhu Jun Ma Union for China Lymphoma Investigators of Chinese Society of Clinical Oncology Zhixiang Shen Zifen Gao Huiqiang Huang Xiaoqiu Li Yexiong Li Lugui Qiu Weili Zhao Qingyuan Zhang | 2021 | Chinese Journal of Cancer Research2021，33，3： | 18 |
| 3 | Beclin 1 cleavage by caspase-3 inactivates autophagy and promotes apoptosis显示文摘Autophagy and apoptosis are both highly regulated biological processes that play essential roles in tissue homeostasis,development and diseases.Autophagy is also described as a mechanism of death pathways,however,the precise mechanism of how autophagy links to cell death remains to be fully understood.Beclin 1 is a dual regulator for both autophagy and apoptosis.In this study we found that Beclin 1 was a substrate of caspase-3 with two cleavage sites at positions 124 and 149,respectively.Furthermore,the autophagosome formation occurred,followed by the appearance of morphological hallmarks of apoptosis after staurosporine treatment.The cleavage products of Beclin 1 reduced autophagy and promoted apoptosis in HeLa cells and the cells in which Beclin 1 was stably knocked down by specific shRNA.In addition,the cleavage of Beclin 1 resulted in abrogating the interaction between Bcl-2 with Beclin 1,which could be blocked by z-VAD-fmk.Thus,our results suggest that the cleavage of Beclin 1 by caspase-3 may contribute to inactivate autophagy leading towards augmented apoptosis. | Yushan Zhu Lixia Zhao Lei Liu Ping Gao Weili Tian Xiaohui Wang Haijing Jin Haidong Xu Quan Chen | 2010 | Protein & Cell2010，1，5： | 17 |
| 4 | Characteristics and recent trends of sulfur dioxide at urban,rural,and background sites in North China:Effectiveness of control measures显示文摘SO 2 measurements made in recent years at sites in Beijing and its surrounding areas are performed to study the variations and trends of surface SO 2 at different types of sites in Northern China.The overall average concentrations of SO 2 are (16.8±13.1) ppb,(14.8±9.4) ppb,and (7.5±4.0) ppb at China Meteorological Administration (CMA,Beijing urban area),Gucheng (GCH,relatively polluted rural area,110 km to the southwest of Beijing urban area),and Shangdianzi (SDZ,clean background area,100 km to the northeast of Beijing urban area),respectively.The SO 2 levels in winter (heating season) are 4-6 folds higher than those in summer.There are highly significant correlations among the daily means of SO 2 at different sites,indicating regional characteristics of SO 2 pollution.Diurnal patterns of surface SO 2 at all sites have a common feature with a daytime peak,which is probably caused by the downward mixing and/or the advection transport of SO 2 -richer air over the North China Plain.The concentrations of SO 2 at CMA and GCH show highly significant downward trends (-4.4 ppb/yr for CMA and -2.4 ppb/yr for GCH),while a less significant trend (-0.3 ppb/yr) is identified in the data from SDZ,reflecting the character of SDZ as a regional atmospheric background site in North China.The SO 2 concentrations of all three sites show a significant decrease from period before to after the control measures for the 2008 Olympic Games,suggesting that the SO 2 pollution control has long-term effectiveness and benefits.In the post-Olympics period,the mean concentrations of SO 2 at CMA,GCH,and SDZ are (14.3±11.0) ppb,(12.1±7.7) ppb,and (7.5±4.0) ppb,respectively,with reductions of 26%,36%,and 13%,respectively,compared to the levels before.Detailed analysis shows that the differences of temperature,relative humidity,wind speed,and wind direction were not the dominant factors for the significant differences of SO 2 between the pre-Olympics and post-Olympics periods.By extracting the data being more representative of local or regional characteristics,a reduction of up to 40% for SO 2 in polluted areas and a reduction of 20% for regional SO 2 are obtained for the effect of control measures implemented for the Olympic Games. | Weili Lin Xiaobin XU Zhiqiang Ma Huarong Zhao Xiwen Liu Ying Wang | 2012 | Journal of Environmental Sciences2012，24，1： | 15 |
| 5 | Highly Stretchable,Elastic,and Sensitive MXene-Based Hydrogel for Flexible Strain and Pressure Sensors显示文摘Electronic skin is driving the next generation of cutting-edge wearable electronic products due to its good wearability and high accuracy of information acquisition.However,it remains a challenge to fulfill the requirements on detecting full-range human activities with existing flexible strain sensors.Herein,highly stretchable,sensitive,and multifunctional flexible strain sensors based on MXene-(Ti_(3)C_(2)T_(x)-)composited poly(vinyl alcohol)/polyvinyl pyrrolidone double-network hydrogels were prepared.The uniformly distributed hydrophilic MXene nanosheets formed a three-dimensional conductive network throughout the hydrogel,endowing the flexible sensor with high sensitivity.The strong interaction between the double-network hydrogel matrix and MXene greatly improved the mechanical properties of the hydrogels.The resulting nanocomposited hydrogels featured great tensile performance(2400%),toughness,and resilience.Particularly,the as-prepared flexible pressure sensor revealed ultrahigh sensitivity(10.75 kPa^(-1))with a wide response range(0-61.5 kPa),fast response(33.5 ms),and low limit of detection(0.87 Pa).Moreover,the hydrogel-based flexible sensors,with high sensitivity and durability,could be employed to monitor fullrange human motions and assembled into some aligned devices for subtle pressure detection,providing enormous potential in facial expression and phonation recognition,handwriting verification,healthy diagnosis,and wearable electronics. | Yao Lu Xinyu Qu Wen Zhao Yanfang Ren Weili Si Wenjun Wang Qian Wang Wei Huang Xiaochen Dong | 2020 | Research2020，，1： | 14 |
| 6 | Outcomes in refractory diffuse large B-cell lymphoma:results fromamulticenter real-world study in China显示文摘Background:Diffuse large B-cell lymphoma(DLBCL)patients refractory to rituximab-based immunochemotherapy have a dismal prognosis.However,the definition of refractory DLBCL remains inconsistent and no large cohort study data is available from Asian countries.To validate the definition and outcomes of refractory DLBCL in China,we conducted a multicenter,retrospective cohort study.Methods:The REtrospective AnaLysis of Treatment REspoNse of refractory DLBCL(REAL-TREND)study was performed using real-world data from 8 centers in China.DLBCL patients with curative intent were included in the REAL-TREND dataset.Overall survival(OS)was estimated using the Kaplan-Meier method and compared by the log-rank test.Due to heterogeneity in response rates among different centers,the response rates of refractory patients were pooled using random-effect models.Multivariate survival analysis was performed using the Cox regression model.Results:A total of 2778 DLBCL patients diagnosed between January,2010 and December,2015 were enrolled to this study.After validating previous definitions,the SCHOLAR-1 study was most suitable to define refractory DLBCL.The estimated 5-year cumulative incidence of refractory patients was 20%(95% confidence Interval[CI]=18%-22%).After the determination of refractory disease,overall response rate and complete remission rate were 30%(95%CI=22%-38%)and 9%(95%CI=4%-15%),respectively.Patients with either no response to immunochemotherapy or relapse within 12 months after stem-cell transplantation had inferior survival with a median OS of 5.9 months(95%CI=5.5-7.1 months)and 2-year OS rate of 16%(95%CI=12%-20%).International prognostic index score 4-5(hazard ratio[HR]=2.22;95%CI=1.47-3.35),central nervous systemrelapse(HR=1.43;95%CI=1.04-1.97),and best response status(HR=2.68;95%CI=1.42-5.03 for partial remission.HR=5.97,95%CI=3.21-11.11 for stable disease/progressive disease)were independent unfavorable prognostic factors.Conclusions:This is the first large-scale Asian cohort study focusing on outcomes of refractory DLBCL.The definition of the SCHOLAR-1 study identifies patients with homogenously inferior survival,thus is appropriate to select refractory DLBCL.Due to poor clinical outcomes in the rituximab era,patients with refractory DLBCL may be potential candidates for novel treatment modalities. | Shuo Wang Li Wang Jianda Hu Wenbin Qian Xi Zhang Yu Hu Qi Zhu Bobin Chen Depei Wu Chung-Chou H.Chang Pengpeng Xu Xiaoyun Zheng Juying Wei Yao Liu Guohui Cui Yong Tang Yan Ma Haiwen Huang Hongmei Yi Weili Zhao | 2021 | Cancer Communications2021，41，3： | 10 |
| 7 | Recommended psychological crisis intervention response to the 2019 novel coronavirus pneumonia outbreak in China:a model of West China Hospital显示文摘The novel coronavirus pneumonia(COVID-19)epidemic has brought serious social psychological impact to the Chinese people,especially those quarantined and thus with limited access to face-to-face communication and traditional social psychological interventions.To better deal with the urgent psychological problems of people involved in the COVID-19 epidemic,we developed a new psychological crisis intervention model by utilizing internet technology.This new model,one of West China Hospital,integrates physicians,psychiatrists,psychologists and social workers into Internet platforms to carry out psychological intervention to patients,their families and medical staff.We hope this model will make a sound basis for developing a more comprehensive psychological crisis intervention response system that is applicable for urgent social and psychological problems. | Jun Zhang Weili Wu Xin Zhao Wei Zhang | 2020 | Precision Clinical Medicine2020，3，1： | 10 |
| 8 | Calcium carbonate-methylene blue nanohybrids for photodynamic therapy and ultrasound imaging显示文摘Photodynamic therapy plays an important role in cancer treatment.In this work,methylene blue(MB)-embedded calcium carbonate nanorods(CaCO_3-MB NRs)have been synthesized for p H-responsive photodynamic therapy and ultrasound imaging.The morphology of CaCO_3-MB NRs can be controlled by modulating the concentration of Na_2CO_3 aqueous solution.The generation of effective reactive oxygen species(ROS)were confirmed by 1,3-diphenylisobenzofuran(DPBF)probe.Both photodynamic therapy performance and echogenic performance of CaCO_3-MB NRs were investigated to confirm the feasibility of CaCO_3-MB nanohybrids for ultrasound image-guided photodynamic therapy. | Weili Fan Yu Qi Ranran Wang Chen Xu Nana Zhao Fu-Jian Xu | 2018 | Science China(Life Sciences)2018，61，4： | 8 |
| 9 | Biomimetic thiamine- and niacin-decorated liposomes for enhanced oral delivery of insulin显示文摘Biomimetic nanocarriers are emerging as efficient vehicles to facilitate dietary absorption of biomacromolecules. In this study, two vitamins, thiamine and niacin, are employed to decorate liposomes loaded with insulin, thus facilitating oral absorption via vitamin ligand–receptor interactions. Both vitamins are conjugated with stearamine, which works to anchor the ligands to the surface of liposomes.Liposomes prepared under optimum conditions have a mean particle size of 125–150 nm and an insulin entrapment efficiency of approximately 30%–36%. Encapsulation into liposomes helps to stabilize insulin due to improved resistance against enzymatic disruption, with 60% and 80% of the insulin left after 4 h when incubated in simulated gastric and intestinal fluids, respectively, whereas non-encapsulated insulin is broken down completely at 0.5 h. Preservation of insulin bioactivity against preparative stresses is validated by intra-peritoneal injection of insulin after release from various liposomes using the surfactant Triton X-100. In a diabetic rat model chemically induced by streptozotocin, both thiamine-and niacindecorated liposomes showed a comparable and sustained mild hypoglycemic effect. The superiority of decorated liposomes over conventional liposomes highlights the contribution of vitamin ligands. It is concluded that decoration of liposomes with thiamine or niacin facilitates interactions with gastrointestinal vitamin receptors and thereby facilitates oral absorption of insulin-loaded liposomes. | Haisheng He Yi Lu Jianping Qi Weili Zhao Xiaochun Dong Wei Wu | 2018 | Acta Pharmaceutica Sinica B2018，8，1： | 8 |
| 10 | Microstructure and corrosion behavior of Mg-Zn-Y-Al alloys with long-period stacking ordered structures显示文摘Mg97−xZn1Y2Alx alloys with long-period stacking ordered(LPSO)structures were prepared by conventional casting method.The optical microscopy(OM),X-ray diffraction(XRD)and the scanning electron microscope(SEM)equipped with energy dispersive X-ray spectroscopy(EDS)were used to analyze the microstructure of the alloys with different compositions.Immersion test and electrochemical measurement were used to evaluate the corrosion behavior of the alloys at room temperature,and the corrosive medium is 3.5%NaCl aqueous solution.The results showed that,with the increasing aluminum(Al)addition,exceptα-Mg and LPSO phases,new phases also emerged on the grain boundaries.At the same time,the zigzag part of LPSO phases disappeared,and the boundaries between LPSO phases andα-Mg became smooth.Furthermore,the addition of Al to Mg-Zn-Y alloys could hinder the activity of cathodic hydrogen evolution reaction and improve the uniformity and compactness of the protective surface film,thus,enhanced the corrosion resistance of Mg-Zn-Y alloys. | Dan Wang Jinshan Zhang Jidong Xu Zilong Zhao Weili Cheng Chunxiang Xu | 2014 | Journal of Magnesium and Alloys2014，2，1： | 6 |
| 11 | Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia显示文摘好攻击的 NK 房间白血病(ANKL ) 是在从亚洲的人之中是更流行的 NK 房间瘤的一种稀罕形式并且中央并且南美洲。病人们通常在天以内死到月,甚至在收到迅速的治疗学的管理以后。这里,我们由集成整个染色体执行了 ANKL 的第一全面研究, transcriptome 并且定序指向,象功能的试金一样的 cytokine 数组。在 JAK-STAT 小径的变化在 48% 被识别(14/29 ) ANKL 病人,当细胞外的 STAT3 激发器 IL10 被 56 褶层的一般水准提高时(P < 0.0001 ) 在检查的所有病人的血浆。另外的经常变异的基因包括的 TP53 (34%) , TET2 (28%) , CREBBP (21%) 和 MLL2 (21%) 。耐心的 NK 白血病房间在多重新陈代谢的小径显示出 STAT3 phosphorylation, MYC 表示和 transcriptional 活动的突出的激活。机能上地, STAT3 激活和 MYC 表示为 ANKL 房间的增长和幸存是批评的。发信号的 STAT 调整了发信号的 MYC 抄写节目,和两 STAT, MYC 抄写被要求维持核苷酸合成和 glycolysis 的激活。一起, JAK-STAT 小径在 ANKL 为 genomic 改变和 IL10 刺激代表一个主要目标。这最新发现的 JAK/STAT-MYC-biosynthesis 轴可以在对待白血病的这种子类型为新奇治疗学的策略的发展提供机会。 | Liang Huang Dan Liu Na Wang Shaoping Ling Yuting Tang Jun Wu Lingtong Hao Hui Luo Xuelian Hu Lingshuang Sheng Lijun Zhu Di Wang Yi Luo Zhen Shang Min Xiao Xia Mao Kuangguo Zhou Lihua Cao Lili Dong Xinchang Zheng Pinpin Sui Jianlin He Shanlan Mo Jin Yan Qilin Ao Lugui Qiu Hongsheng Zhou Qifa Liu Hongyu Zhang Jianyong Li Jie Jin Li Fu Weili Zhao Jieping Chen Xin Du Guoliang Qing Hudan Liu Xin Liu Gang Huang Ding Ma Jianfeng Zhou Qian-fei Wang | 2018 | Cell Research2018，28，2： | 5 |
| 12 | Effectiveness of ZiYin Xiehuo granules and Zishen Qinggan granules on partial precocious puberty in girls: a multicenter, randomized, single-blind, controlled trial显示文摘OBJECTIVE: To evaluate the effect of ZiYin Xiehuo granules(ZYXH) and Zishen Qinggan granules(ZSQG) on partial precocious puberty(PPP).METHODS: This was a multicenter, randomized, single-blind, positive-controlled trial. A total of 143 pa-tients were assigned to either the ZYXH group or the ZSQG group using a random number table. The ZYXH group received ZYXH three times daily for 6 months and the ZSQG group received ZSQG three times daily for 6 months. Mammary nucleus diameter; the results of uterus, ovarian, and maximum follicle measures; and Chinese medicine symptom pattern scores were compared at baseline and after 3 months and 6 months of treatment.RESULTS: After 3 months' treatment, there were no significant differences between the two groups in mammary nucleus index changes(left 3.4 ± 3.1 vs3.5 ± 3.1, P = 0.790; right 3.0 ± 2.9 vs 3.6 ± 3.0, P =0.719). The uterine volume in the ZYXH group was smaller than that in the ZSQG group(2.1 ± 1.6 vs2.6 ± 2.2, P = 0.006). There were no significant between-group differences in ovarian volume and maximum follicular diameter on either side(ovarian volume: left 1.2 ± 0.7 vs 1.3 ± 0.6, P = 0.8; right1.2 ± 0.7 vs 1.4 ± 1.1, P = 0.984; maximum follicular diameter: left 3.9 ± 1.7 vs 3.5 ± 2.2, P = 0.158; right3.5 ± 1.7 vs 3.9 ± 2.1, P = 0.314).CONCLUSION: ZYXH granules and ZSQG granules both affected the size of the mammary nucleus in girls with PPP, and improved Chinese medicine symptom patterns. ZYXH granules showed slight advantages over ZSQG granules in terms of the decrease in the size of the uterus, ovaries, and ovarian follicles. | Sun Wen Han Xinghui Wang Yonghong Yu Jian Yan Weili Zhao Jun Chen Weibin Xue Zheng | 2018 | Journal of Traditional Chinese Medicine2018，38，5： | 5 |
| 13 | Synthesis and in vivo nematocidal evaluation of novel 3-(trifluoromethyl)-lH-pyrazole-4-carboxamide derivatives显示文摘 | Wen Zhao Jiahua Xing Tianming Xu Weili Peng Xinghai Liu | 2017 | Frontiers of Chemical Science and Engineering2017，11，3： | 5 |
| 14 | Cryo-self-assembled silk fibroin sponge as a biodegradable platform for enzyme-responsive delivery of exosomes显示文摘Although advances in protein assembly preparation have provided a new platform for drug delivery during tissue engineering,achieving long-term controlled exosome delivery remains a significant challenge.Diffusion-dominated exosome release using protein hydrogels results in burst release of exosomes.Here,a fibroin-based cryo-sponge was developed to provide controlled exosome release.Fibroin chains can self-assemble into silk I structures under ice-cold conditions when annealed above the glass transition temperature.Exosome release is enzyme-responsive,with rates primarily determined by enzymatic degradation of the scaffolds.In vivo experiments have demonstrated that exosomes remain in undigested sponge material for two months,superior to their retention in fibrin glue,a commonly used biomaterial in clinical practice.Fibroin cryo-sponges were implanted subcutaneously in nude mice.The exosome-containing sponge group exhibited better neovascularization and tissue ingrowth effects,demonstrating the efficacy of this exosome-encapsulating strategy by realizing sustained release and maintaining exosome bioactivity.These silk fibroin cryo-sponges containing exosomes provide a new platform for future studies of exosome therapy. | Muyang Sun Qi Li Huilei Yu Jin Cheng Nier Wu Weili Shi Fengyuan Zhao Zhenxing Shao Qingyang Meng Haifeng Chen Xiaoqing Hu Yingfang Ao | 2022 | Bioactive Materials2022，7，2： | 4 |
| 15 | Chinese expert consensus on the management of chimeric antigen receptor T cell therapy-associated coagulopathy显示文摘Chimeric antigen receptor T-cell(CAR-T)therapy has greatly improved the disease remission rate and long-term survival rate of patients with relapsed/refractory hematological malignancies.[1-3]Currently,several commercial CAR-T products are available in the market and numerous CAR-T clinical trials have been conducted.Attention should be paid to the safety of CAR-T therapy.The main adverse effects of CAR-T therapy are cytokine release syndrome(CRS)and immune effector cell-associated neurotoxicity syndrome(ICANS).[4] | Heng Mei Fangping Chen Yue Han Ming Hou He Huang Xiaojun Huang Yuhua Li Aibin Liang Qifa Liu Ting Niu Jun Peng Wenbin Qian Yongping Song Jianxiang Wang Ying Wang Depei Wu Kailin Xu Linhua Yang Renchi Yang Lei Zhang Liansheng Zhang Xi Zhang Xiaohui Zhang Weili Zhao Weidong Han Yu Hu | 2022 | Chinese Medical Journal2022，，14： | 4 |
| 16 | Mechanism and effect of Shijueming (Concha Haliotidis) on serum calcium in spontaneously hypertensive rats显示文摘OBJECTIVE: To observe the impact of Shijueming (Concha Haliotidis) on spontaneously hypertensive rats via blood pressure, serum calcium, vascular smooth muscle membrane L-type calcium channel α1 C subunit (CaL-α1C), plasma membrane calcium-ATPase (PMCA) mRNA expression, and the L-type calcium channel in vascular smooth muscle cells. METHODS:Twelve-week-old male rats with spontaneous hypertension were divided into three groups: a Shijueming (Concha Haliotidis) group (group 1), a nifedipine group (group 2), and a distilled water group (group 3). All were given a four-week treatment. Blood pressure and dissociative serum calcium were examined before treatment. Blood pressure was taken every week during treatment. Atomic absorption spectrometry was used to examine dissociative serum calcium. Re-verse transcription-polymerase chain reaction was used to examine the expression of CaL-α1C and PM-CA1 mRNA. The patch clamp technique was used to examine the electrophysiological characteristics of the vascular smooth muscle cell calcium channels. RESULTS: After treatment, blood pressure of the Shijueming (Concha Haliotidis) group lowered but not significantly (P>0.05). Blood pressure of the nifedipine group lowered significantly (P<0.05). Blood pressure of the distilled water group remained high. The concentration of serum calcium in the Shijueming (Concha Haliotidis) and the distilled water groups lowered (P<0.05). Expression of CaL-α1C mRNA in the nifedipine group decreased compared with the distilled water group (P<0.01). There was the decreasing trend in the Shijueming (Concha Haliotidis) group, but it was not statistically significant. Shijueming (Concha Haliotidis) also had effects on the expression of PMCA1 mRNA but with- out statistical significance. However, there was a significant decreasing effect on vascular smooth muscle cell I Ca-L flow. CONCLUSION: This study indicated that Shijueming (Concha Haliotidis) could increase serum calcium and decrease blood pressure. It may work by influencing calcium channels, expression of PMCA1 mRNA, and regulating ion calcium channels and calcium-ATPase. | Chao Chen Changlin Zhao Xuejun Wang Weili Li Xiaoyin Chen | 2013 | Journal of Traditional Chinese Medicine2013，33，3： | 4 |
| 17 | Permeation into but not across the cornea:Bioimaging of intact nanoemulsions and nanosuspensions using aggregation-caused quenching probes显示文摘Nanoemulsions(NEs) and nanosuspensions(NSs) show great potential in enhancing the ocular bioavailability of therapeutics through topical delivery. However, transocular fate of intact NEs and NSs is still inconclusive. In this study, an aggregation-caused quenching fluorescent probe is used to track precorneal retention and transocular transportation of intact NEs and NSs, while coumarin 6 is used to mimick the cargo. NEs show superior precorneal retention to NSs. Both the two types of nanocarriers can permeate into but not across the cornea. The smaller NEs(100 nm) permeate better into the cornea than the bigger ones(210 nm). Nanocarriers in the cornea serves as depots. The released cargo molecules can penetrate across the cornea and diffuse into the lens. Moreover, the conjunctiva-scleral route may be potential to deliver drugs to the back of the eye, In conclusion, the study provides useful tools and information in the field of transocular transportation of nanoparticles. | Dailei Liu Bo Wan Jianping Qi Xiaochun Dong Weili Zhao Wei Wu Yikang Dai Yi Lu Zhongjian Chen | 2018 | Chinese Chemical Letters2018，29，12： | 4 |
| 18 | Methodology for credibility assessment of historical global LUCC datasets显示文摘Land use-induced land cover change(LUCC)is an important anthropogenic driving force of global change that has influenced,and is still influencing,many aspects of regional and global environments.Accurate historical global land use/cover datasets are essential for a better understanding of the impacts of LUCC on global change.However,there are not only evident inconsistencies in current historical global land use/cover datasets,but inaccuracies in the data in these global dataset revealed by historical record-based reconstructed regional data throughout the world.A focus in historical LUCC and global change research relates to how the accuracy of historical global land cover datasets can be improved.A methodology for assessing the credibility of existing historical global land cover datasets that addresses temporal as well as spatial changes in the amount and distribution of land cover is therefore needed.Theoretically,the credibility of a global land cover dataset could be assessed by comparing similarities or differences in the data according to actual land cover data(the'true value').However,it is extremely difficult to obtain historical evidence for assessing the credibility of historical global land cover datasets,which cannot be verified through field sampling like contemporary global land cover datasets.We proposed a methodological framework for assessing the credibility of global land cover datasets.Considering the types and characteristics of the available evidence used for assessments,we outlined four methodological approaches:(1)accuracy assessment based on regional quantitative reconstructed land cover data,(2)rationality assessment based on regional historical facts,(3)rationality assessment based on expertise,and(4)likelihood assessment based on the consistency of multiple datasets.These methods were illustrated through five case studies of credibility assessments of historical cropland cover data.This framework can also be applied in assessments of other land cover types,such as forest and grassland. | Xiuqi FANG Wanyi ZHAO Chengpeng ZHANG Diyang ZHANG Xueqiong WEI Weili QIU Yu YE | 2020 | Science China Earth Sciences2020，63，7： | 4 |
| 19 | Gastrointestinal lipolysis and trans-epithelial transport of SMEDDS via oral route显示文摘Self-microemulsifying drug delivery systems(SMEDDSs)have recently returned to the limelight of academia and industry due to their enormous potential in oral delivery of biomacromolecules.However,information on gastrointestinal lipolysis and trans-epithelial transport of SMEDDS is rare.Aggregation-caused quenching(ACQ)fuorescent probes are utilized to visualize the in vivo behaviors of SMEDDSs,because the released probes during lipolysis are quenched upon contacting water.Two SMEDDSs composed of medium chain triglyceride and different ratios of Tween-80 and PEG-400 are set as models,meanwhile Neoral?was used as a control.The SMEDDS droplets reside in the digestive tract for as long as 24 h and obey frst order kinetic law of lipolysis.The increased chain length of the triglyceride decreases the lipolysis of the SMEDDSs.Ex vivo imaging of main tissues and histological examination confrm the trans-epithelial transportation of the SMEDDS droplets.Approximately 2%-4%of the given SMEDDSs are transported via the lymph route following epithelial uptake,while liver is the main termination.Caco-2 cell lines confrm the cellular uptake and trans-epithelial transport.In conclusion,a fraction of SMEDDSs can survive the lipolysis in the gastrointestinal tract,permeate across the epithelia,translocate via the lymph,and accumulate mainly in the liver. | Fei Xia Zhongjian Chen Quangang Zhu Jianping Qi Xiaochun Dong Weili Zhao Wei Wu Yi Lu | 2021 | Acta Pharmaceutica Sinica B2021，11，4： | 4 |
| 20 | In vivo dissolution of poorly water-soluble drugs:Proof of concept based on fluorescence bioimaging显示文摘In vitro-in vivo correlation(IVIVC)of solid dosage forms should be established basically between in vitro and in vivo dissolution of active pharmaceutical ingredients.Nevertheless,in vivo dissolution profles have never been accurately portrayed.The current practice of IVIVC has to resort to in vivo absorption fractions(Fa).In this proof-of-concept study,in vivo dissolution of a model poorly watersoluble drug fenofbrate(FNB)was investigated by fuorescence bioimaging.FNB crystals were frst labeled by near-infrared fuorophores with aggregation-caused quenching properties.The dyes illuminated FNB crystals but quenched immediately and absolutely once been released into aqueous media,enabling accurate monitoring of residual drug crystals.The linearity established between fuorescence and crystal concentration justifed reliable quantifcation of FNB crystals.In vitro dissolution was frst measured following pharmacopoeia monograph protocols with well-documented IVIVC.The synchronicity between fuorescence and in vitro dissolution of FNB supported using fuorescence as a measure for determination of dissolution.In vitro dissolution correlated well with in vivo dissolution,acquired by either live or ex vivo imaging.The newly established IVIVC was further validated by correlating both in vitro and in vivo dissolution with Faobtained from pharmacokinetic data. | Yinqian Yang Yongjiu Lv Chengying Shen Tingting Shi Haisheng He Jianping Qi Xiaochun Dong Weili Zhao Yi Lu Wei Wu | 2021 | Acta Pharmaceutica Sinica B2021，11，4： | 3 |
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