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| 1 | Metal-organic framework-derived Fe/Cu-substituted Co nanoparticles embedded in CNTs-grafted carbon polyhedron for Zn-air batteries显示文摘Metal-organic frameworks(MOFs)and MOF-derived materials have attracted great attention as alternatives to noble-metal based electrocatalysts owing to their intriguing structure properties,especially for high efficiency and stable oxygen reduction reaction(ORR).Herein,we employed a one-pot reaction to make a multimetal(Fe,Co,Cu,and Zn)mixed zeolitic imidazolate framework(MM-ZIF)via adopting a simple in situ redox reaction.Further pyrolysis of the target MM-ZIF,a highly porous carbon polyhedron(FC-C@NC)grafted with abundant carbon nanotubes was obtained,in which ultrasmall Co nanoparticles with partial lattice sites substituted by Fe and Cu were embedded.The obtained FC-C@NC possessed large surface area,highly porous structure,widely-spread metal active sites,and conductive carbon frameworks,contributing to outstanding ORR activity and long-term stability.It displayed superior tolerance to methanol crossover and exceeded the commercial Pt/C catalyst and most previously reported non-noble-metal catalysts.Impressively,the as-produced FC-C@NC-based zinc-air battery afforded an open-circuit potential of 1.466 V,a large specific capacity of 659.5 mAh/g,and a high gravimetric energy density of 784.3 Wh/kgZn,significantly outperforming the Pt/C-based cathode. | Kexin Zhang Yelong Zhang Qinghua Zhang Zibin Liang Lin Gu Wenhan Guo Bingjun Zhu Shaojun Guo Ruqiang Zou | 2020 | Carbon Energy2020，2，2： | 7 |
| 2 | Super enhancer inhibitors suppress MYC driven transcriptional amplification and tumor progression in osteosarcoma显示文摘Osteosarcoma is the most common primary bone sarcoma that mostly occurs in young adults. The causes of osteosarcoma are heterogeneous and still not fully understood. Identification of novel, important oncogenic factors in osteosarcoma and development of better, effective therapeutic approaches are in urgent need for better treatment of osteosarcoma patients. In this study, we uncovered that the oncogene MYC is significantly upregulated in metastastic osteosarcoma samples. In addition, high MYC expression is associated with poor survival of osteosarcoma patients. Analysis of MYC targets in osteosarcoma revealed that most of the osteosarcoma super enhancer genes are bound by MYC. Treatment of osteosarcoma cells with super enhancer inhibitors THZ1 and JQ1 effectively suppresses the proliferation, migration, and invasion of osteosarcoma cells. Mechanistically,THZ1 treatment suppresses a large group of super enhancer containing MYC target genes including CDK6 and TGFB2. These findings revealed that the MYC-driven super enhancer signaling is crucial for the osteosarcoma tumorigenesis and targeting the MYC/super enhancer axis represents as a promising therapeutic strategy for treatment of osteosarcoma patients. | Demeng Chen Zhiqiang Zhao Zixin Huang Du-Chu Chen Xin-Xing Zhu Yi-Ze Wang Ya-Wei Yan Shaojun Tang Subha Madhavan Weiyi Ni Zhan-peng Huang Wen Li Weidong Ji Huangxuan Shen Shuibin Lin Yi-Zhou Jiang | 2018 | Bone Research2018，6，2： | 5 |
| 3 | Molecular characterization and genetic analysis of Gnrh2 and Gthβin different ploidy level fishes显示文摘释放 gonadotropin 荷尔蒙(GnRH ) 和 gonadotropin 荷尔蒙(GTH ) 在调整脊椎动物的 gonadal 发展起关键作用。在这研究, Gnrh2, Fshβ并且 LhβcDNAs 在红被克隆并且描绘鲫鱼鲤鱼, triploids 和 tetraploids,和他们的种系发生的关系比较地被分析。在不同 ploidy 鱼的所有 Gnrh2 cDNAs 编码了 86 氨基酸的蛋白质,它由信号肽, GnRH2 十肽和一个解朊的劈开地点(Gly-Lys-Arg ) 连接的联系 GnRH 的肽(差距) 组成了。GnRH2 十肽和解朊的劈开地点在在 diploids 之间的信号肽和差距在三条 ploidy 鱼,而是差别之中绝对是一致的, tetraploids 比在 diploids 和 triploids 之间的那些是少数。红鲫鱼鲤鱼是 tetraploids 的原来的母亲的父母,这被假定,因此他们有更靠近的关系。另外, Fshβ并且 Lhβ这三条鱼的 cDNAs 分别地编码了 130 和 140 氨基酸的蛋白质。与另外的 teleosts,半胱氨酸残余和 Lhβ 的潜在的 glycosylation 地点的分子相比;在这三,鱼充分被保存。然而, Fshβ 的大多数 teleosts;当这三条鱼的那些是 13,和哪个力量,形式六保存二硫化物由利用劈开地点在之间衔接中的 12 个时,有 12 半胱氨酸残余第一并且第二半胱氨酸残余。而且,在 Fshβ 的第二个 glycosylation 地点的缺乏;这三,鱼可能影响特殊结构和生物活动。在另一方面,系统发生的树分析揭示了那 Gnrh2, Fshβ并且 Lhβ在鲤科之鱼之中的有的类似的发展史关系,它显示他们在进化期间在分子的结构和功能被保存。 | Yu Long Huan Zhong Shaojun Liu Min Tao Lin Chen Jun Xiao Yun Liu | 2009 | Progress in Natural Science:Materials International2009，19，11： | 3 |
| 4 | Natural variations in grain length 10(GL10)regulate rice grain size显示文摘Grain size is an important determinant of grain weight and yield in rice.Although several genes related to grain size have been identified,natural variations in these genes that affect grain size are poorly characterized.Here,we describe the grain length QTL GL10,encoding MADS56,which positively regulates grain length and grain weight.A natural allelic variation of NIL-gl10,containing an~1.0-kb deletion in the first exon that abolishes its transcription,results in shorter grain length,lower grain weight and delayed flowering in gl10 plants.The knockout of GL10 in the HJX74 background leads to grain phenotypes similar to that of NIL-gl10,while overexpression of GL10 results in increased grain length and weight and earlier heading date.GL10 regulates grain length by promoting greater longitudinal cell growth in the grain glume.Additionally,GL10 participates in the regulation of gibberellic acid(GA)signaling pathway genes in young panicle tissues.Analysis of GL10 haplotypes shows obvious divergence between the japonica and indica lineages.Our findings reveal an allelic variation of GL10 that may explain differences in grain length among modern cultivars and could be used to breed rice varieties with optimized grain shape. | Penglin Zhan Shuaipeng Ma Zhili Xiao Fangping Li Xin Wei Shaojun Lin Xiaoling Wang Zhe Ji Yu Fu Jiahao Pan Mi Zhou Yue Liu Zengyuan Chang Lu Li Suhong Bu Zupei Liu Haitao Zhu Guifu Liu Guiquan Zhang Shaokui Wang | 2022 | Journal of Genetics and Genomics2022，49，5： | 3 |
| 5 | Factors associated with overall survival in 1706 patients with nasopharyngeal carcinoma: Significance of intensive neoadjuvant chemotherapy and radiation break显示文摘 | Luying Xu Jianji Pan Junxin Wu Caizhu Pan Yu Zhang Shaojun Lin Ling Yang Chuanben Chen Chun Zhang Wei Zheng Senan Lin Xiaolei Ni Feng-Ming (Spring) Kong | 2010 | Radiotherapy and Oncology2010，，1： | 2 |
| 6 | EB病毒膜潜伏蛋白LMP-1筛选鼻咽癌的初步结果(英文)显示文摘Objective: Early diagnosis of nasopharyngeal carcinoma (NPC) is an important method to improve the survival rate.However,the sensitivity and specificity of the screening protocols which was widely used in clinic now are considered to be unsatisfactory.Epstein-Barr virus (EBV)-encoded latent membrane protein-1 (LMP-1) is one of the proteins that have been suggested to be a classic oncogene with transformation properties.The current study set out to discuss the clinical significance of LMP-1 on the screening of NPC.Methods: Three hundred patients who visited our institution (Department of Radiation Oncology,Fujian Provincial Cancer Hospital,Fuzhou,China) with ENT symptoms between 2007 and 2008 were involved in this study,and all of them were agreed to be involved in this investigation.Not only did they undergo nasopharyngeal swab to obtain cells for the LMP-1 polymerase chain reaction (PCR) analysis,but also nasopharyngeal biopsy were taken to identify the diagnosis.Results: An amount of DNA that was sufficient for PCR was extracted from 243 (81%) swab samples,the positive rate of LMP-1 of those with non-nasopharyngeal carcinoma was 3.85% (4/108),which was much lower than those with nasopharyngeal carcinoma (P < 0.05).By detecting LMP-1 in nasopharyngeal swabs,NPC was diagnosed with a sensitivity of 88.15% (119 of 135 patients),specificity of 96.30% (104 of 108 patients),a positive predictive value of 95.2% (119 of 123 patients),a negative predictive value of 86.67% (104 of 120 patients),accuracy of 91.77%,and Youden index of 84.45%.Conclusion: The nasopharyngeal swab coupled with PCR-based EBV LMP-1 detection have high sensitivity and specificity,and also good repeatability,it could serve as part of the screening program for high-risk populations. | Shaojun Lin Qiaojuan Guo Jin Lin Jingfeng Zong Lu Han Jianji Pan | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，1： | 2 |
| 7 | Comparative analysis and evolutionary significance of the HMG1 gene in crucian carp,blunt snout bream,and their polyploid progeny显示文摘高活动性组蛋白质的全身的 mRNA 1 个编码基因(HMG1 ) 被 RACE-PCR 从红鲫鱼鲤鱼(Carassius auratus 红 var ) 获得,钝猪嘴鲷(Megalobrama amblycephala ) ,并且他们的三倍性并且 tetraploid 子孙。顺序包含了为 193 氨基酸编码的 579 核苷酸的一个开的读物框架。HMG1 的核苷酸身份比在 tetraploid 混血儿和父亲的钝猪嘴鲷(97%) 之间在 tetraploid 混血儿和母亲的红鲫鱼鲤鱼(99%) 之间是更高的。在三倍性的混血儿和每个父母(95%) 之间的核苷酸身份在父母(98%) 之间是比那低的。在 tetraploid 混血儿和每个父母(100%) 之间的蛋白质身份在三倍性的混血儿和每个父母(97%) 之间比那高。我们的结果建议种间的杂交在三倍性的混血儿产生震动到 HMG1 基因,引起核苷酸的分叉。tetraploid 混血儿的 HMG1 蛋白质与它的父母的一致,它减少了在等位基因之间的生气不兼容的障碍,提供形成在自然的新多倍体种的两性的肥沃的 tetraploid 混血儿的基础。HMG1 蛋白质的第二等、第三级的结构包含八他 lices,三个开关,在 N 终点的二个 DNA 有约束力的领域,和在 C 终点的一条长酸的尾巴。一起,这些数据建议 HMG1 蛋白质起蛋白质 DNA 相互作用的一个作用,在原子核便于各种各样的 DNA 依赖的活动。我们也调查了鱼,两栖动物,爬虫,鸟,和哺乳动物的 HMG1 蛋白质的发展史。我们的结果建议 HMG1 是高度被保存了的祖先的蛋白质。这些数据提供种间的杂交怎么可以形成多倍体混血儿的线索。 | Dong Liu Zhen Liu Shaojun Liu Liangguo Liu Cuiping You Lin Chen Huan Zhong Yun Liu | 2009 | Progress in Natural Science:Materials International2009，19，12： | 1 |
| 8 | Current situation and advances in postharvest storage and transportation technology of longan fruit显示文摘 | Lin Hetong Chen Shaojun Chen Jinquan | 2001 | Acta Horticuhurae2001，558，： | 1 |
| 9 | Nasopharyngeal Carcinoma Treated With Reduced-Volume Intensity-Modulated Radiation Therapy: Report on the 3-Year Outcome of a Prospective Series显示文摘 | Shaojun Lin Jianji Pan Lu Han Xiuchun Zhang Xiyi Liao Jiade J. Lu | 2009 | International Journal of Radiation Oncology, Biology, Physics2009，，： | 1 |
| 10 | GL9 from Oryza glumaepatula controls grain size and chalkiness in rice显示文摘Grain size is a key factor influencing grain yield and appearance quality in rice.We identified twelve quantitative trait loci(QTL)for grain length(GL),nine for grain width(GW),and nine for 1000-kernel weight(TKW)using GLU-SSSLs,which are single-segment substitution lines with Oryza glumaepatula as donor parent and Huajingxian 74(HJX74)as recipient parent.Among the QTL,qGL1-2,qGL1-4,qGL9-2,qGW2-2,qGW9-1 and qTKW9-2 contributed to high grain yield.GL9 was identified as a candidate gene for qGL9-2 by map-based cloning and sequencing,and is a novel allele of GS9.The kernel of NIL-gl9was slenderer and longer than that of HJX74,and the TKW and grain yield per plant of NIL-gl9 were higher than those of HJX74.The proportion of grain chalkiness of NIL-gl9 was much lower than that of HJX74.Thus,gl9 increased grain yield and appearance quality simultaneously.Three pyramid lines,NIL-gs3/gl9,NIL-GW7/gl9 and NIL-gw8/gl9,were developed and the kernel of each was longer than that of the corresponding recipient parent lines.The gl9 allele may be beneficial for breeding rice varieties with high grain yield and good appearance quality. | Shaojun Lin Zupei Liu Kui Zhang Weifeng Yang Penglin Zhan Quanya Tan Yajun Gou Shuaipeng Ma Xin Luan Chubing Huang Zhili Xiao Yuanyuan Liu Bihuang Zhu Ruiqing Liang Wenqi Zhou Haitao Zhu Suhong Bu Guifu Liu Guiquan Zhang Shaokui Wang | 2023 | The Crop Journal2023，11，1： | 1 |
| 11 | Nasopharyngeal Carcinoma Treated With Reduced-Volume Intensity-Modulated Radiation Therapy: Report on the 3-Year Outcome of a Prospective Series显示文摘 | Shaojun Lin Jianji Pan Lu Han Xiuchun Zhang Xiyi Liao Jiade J. Lu | 2009 | International Journal of Radiation Oncology Biology Physics2009，，4： | 1 |
| 12 | Identification and Expression Analysis of Genes Involved in Early Ovary Development in Diploid Gynogenetic Hybrids of Red Crucian Carp × Common Carp显示文摘 | Dong Liu Shaojun Liu Cuiping You Lin Chen Zhen Liu Liangguo Liu Jing Wang Yun Liu | 2010 | Marine Biotechnology2010，，2： | 1 |
| 13 | Current situation and advances in postharvest storage and trans- portation technology of longan fruit 显示文摘 | Lin Hetong Chen Shaojun Chen Jinquan | 2001 | Acta Horticuhu- rae2001，558，： | 1 |
| 14 | Zeolite-mediated hybrid Cu^(+)/Cu~0 interface for electrochemical nitrate reduction to ammonia显示文摘The electrocatalytic conversion of reactive nitrogen species to ammonia is a promising strategy for efficient NH_(3) synthesis.In this study,we reveal that the hybrid Cu^(+)/Cu~0 interface is catalytically active for electrochemical ammonia synthesis from nitrate reduction.To maintain the hybrid Cu^(+)/Cu~0 state at negative reaction potentials,hydrophilic zeolite is used to modify Cu/Cu_(2)O electrocatalyst,which demonstrates an impressive NH_(3) production rate of 41.65 mg h^(-1) cm^(-2)with ~100% Faradaic efficiency of ammonia synthesis at-0.6 V vs.RHE.In-situ Raman spectroscopy unveil the high activity originates from the zeolite reconstruction at the electrode–electrolyte interface,which protects the valence state of Cu~0/Cu^(+) site under negative potential and promotes electrochemical activity towards NH_(3) synthesis. | Jiabao Lv Angjian Wu Liang Wang Yunhao Zhong Zhihao Zeng Qunxing Huang Xiaoqing Lin Hao Zhang Shaojun Liu Qian Liu Songqiang Zhu Xiaodong Li Jianhua Yan Zhifu Qi Hao Bin Wu | 2023 | Journal of Energy Chemistry2023，，12： | 0 |
| 15 | Synergetic roadmap of carbon neutrality and clean air for China显示文摘It is well recognized that carbon dioxide and air pollutants share similar emission sources so that synergetic policies on climate change mitigation and air pollution control can lead to remarkable co-benefits on greenhouse gas reduction,air quality improvement,and improved health.In the context of carbon peak,carbon neutrality,and clean air policies,this perspective tracks and analyzes the process of the synergetic governance of air pollution and climate change in China by developing and monitoring 18 indicators.The 18 indicators cover the following five aspects:air pollution and associated weather-climate conditions,progress in structural transition,sources,inks,and mitigation pathway of atmospheric composition,health impacts and benefits of coordinated control,and synergetic governance system and practices.By tracking the progress in each indicator,this perspective presents the major accomplishment of coordinated control,identifies the emerging challenges toward the synergetic governance,and provides policy recommendations for designing a synergetic roadmap of Carbon Neutrality and Clean Air for China. | Qiang Zhang Zhicong Yin Xi Lu Jicheng Gong Yu Lei Bofeng Cai Cilan Cai Qimin Chai Huopo Chen Hancheng Dai Zhanfeng Dong Guannan Geng Dabo Guan Jianlin Hu Cunrui Huang Jianing Kang Tiantian Li Wei Li Yongsheng Lin Jun Liu Xin Liu Zhu Liu Jinghui Ma Guofeng Shen Dan Tong Xuhui Wang Xuying Wang Zhili Wang Yang Xie Honglei Xu Tao Xue Bing Zhang Da Zhang Shaohui Zhang Shaojun Zhang Xian Zhang Bo Zheng Yixuan Zheng Tong Zhu Jinnan Wang Kebin He | 2023 | Environmental Science and Ecotechnology2023，，4： | 0 |
| 16 | Cell type-specific proteomics uncovers a RAF15-SnRK2.6/OST1 kinase cascade in guard cells显示文摘Multicellular organisms such as plants contain various cell types with specialized functions.Analyzing the characteristics of each cell type reveals specific cell functions and enhances our understanding of organization and function at the organismal level.Guard cells(GCs)are specialized epidermal cells that regulate the movement of the stomata and gaseous exchange,and provide a model genetic system for analyzing cell fate,signaling,and function.Several proteomics analyses of GC are available,but these are limited in depth.Here we used enzymatic isolation and flow cytometry to enrich GC and mesophyll cell protoplasts and perform in-depth proteomics in these two major cell types in Arabidopsis leaves.We identified approximately 3,000 proteins not previously found in the GC proteome and more than600 proteins that may be specific to GC.The depth of our proteomics enabled us to uncover a guard cell-specific kinase cascade whereby Raf15and Snf1-related kinase2.6(SnRK2.6)/OST1(open stomata 1)mediate abscisic acid(ABA)-induced stomatal closure.RAF15 directly phosphorylated SnRK2.6/OST1 at the conserved Ser175 residue in its activation loop and was sufficient to reactivate the inactive form of SnRK2.6/OST1.ABAtriggered SnRK2.6/OST1 activation and stomatal closure was impaired in raf15 mutants.We also showed enrichment of enzymes and flavone metabolism in GC,and consistent,dramatic accumulation of flavone metabolites.Our study answers the long-standing question of how ABA activates SnRK2.6/OST1 in GCs and represents a resource potentially providing further insights into the molecular basis of GC and mesophyll cell development,metabolism,structure,and function. | Hongliang Wang Yubei Wang Tian Sang Zhen Lin Rongxia Li Weiwei Ren Xin Shen Bing Zhao Xiao Wang Xuebin Zhang Shaoqun Zhou Shaojun Dai Honghong Hu Chun-Peng Song Pengcheng Wang | 2023 | Journal of Integrative Plant Biology2023，65，9： | 0 |
| 17 | Bound states in the continuum in all-dielectric metasurfaces with scaled lattice constants显示文摘Bound states in the continuum(BICs)have emerged as an efficient tool for trapping light at the nanoscale,promising several exciting applications in photonics.Breaking the structural symmetry has been proposed as an effective way of exciting quasiBICs(QBICs)and generating high-Q resonances.Herein,we demonstrate that QBICs can be excited in an all-dielectric metasurface by scaling the lattice of the metasurface,causing translational symmetry breaking.The corresponding BICs arise from band folding from the band edge to the Γ point in the first Brillouin zone.Multipole analysis reveals that the toroidal dipole dominates these QBICs.Furthermore,scaling the lattice along different directions provides additional freedom for tailoring QBICs,enabling polarization-dependent or-independent QBICs.In addition,this allows the realization of two QBICs at different wavelengths using plane-wave illumination with different polarizations on the metasurface.We experimentally demonstrated the existence of these BICs by fabricating silicon metasurfaces with scaled lattices and measuring their transmission spectra.The vanished resonant linewidth identifies BICs in the transmission spectrum,and the QBICs are characterized by highQ Fano resonances with the Q-factor reaching 2000.Our results have potential applications in enhancing light-matter interaction,such as laser,nonlinear harmonic generation,and strong coupling. | Mimi Zhou Shaojun You Lei Xu Menghui Fan Jing Huang Wenbin Ma Mingzhe Hu Shengyun Luo Mohsen Rahmani Ya Cheng Lin Li Chaobiao Zhou Lujun Huang Andrey E.Miroshnichenko | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，12： | 0 |
| 18 | Ar-plasma enhanced copper-nickel alloy catalysis for ammonia synthesis显示文摘Ammonia(NH_(3))synthesis via electrocatalytic nitrogen reduction generally suffers from low NH_(3)yield and faradaic efficiency.Compared with activating stable,low-solubility N_(2),the electrochemical conversion of nitrates to ammonia provides a more reasonable route for NH_(3)production.Herein,we introduce Ar-plasma to enhance the interaction between copper-nickel alloys and carbon substrate to improve the performance of NH_(3)production.The NH_(3)faradaic efficiency from nitrate is nearly 100%and the yield rate is over 6000μgNH_(3)cm^(−2)h^(−1).DFT(density functional theory)calculation reveals the high performance of Cu_(50)Ni_(50)originates from the lower energy barrier on the reaction path and the closer position to the Fermi level of the d-band center.This work offers a promising strategy for plasma-modified electrocatalyst to promote ammonia synthesis via nitrate reduction. | Zhou Yimeng Lv Jiabao Peng Yaqi Lin Xiaoqing Lv Xingjie Ye Qiulin Liu Shaojun Wu Angjian Li Xiaodong | 2022 | Waste Disposal and Sustainable Energy2022，4，2： | 0 |
| 19 | An in-situ NH_(4)^(+)-etched strategy for anchoring atomic Mo site on ZnIn_(2)S_(4) hierarchical nanotubes for superior hydrogen photocatalysis显示文摘Atomic sites co-catalyst (ASC) on photocatalytic materials possesses an attractive prospect to promote charge carrier separation and tune surface reaction kinetics,yet the synthesis of earth-abundant ASC under low temperature remains a great challenge.Here,a novel in-situ NH_(4)^(+)-etched strategy to anchor atomic Mo sites on ZnIn_(2)S_(4)hierarchical nanotubes (HNTs) with abundant mesopores under mild conditions for promoting charge carrier separation and enhancing light multi-reflections is developed for efficient photocatalytic H_(2) evolution.Density functional theory calculations and linear sweep voltammetry demonstrate that the well-defined Mo-S_(2)O_(1) sites with distinctive coordination configuration and electronic property contribute to the enhanced separation of photo-generated charge carriers and reduced Gibbs free energy for H_(2) evolution.Consequently,the well-defined MoSA-ZIS HNTs present an excellent photocatalytic activity with a rate of 29.9μmol h^(-1)(5.98 mmol g^(-1)h^(-1)),which is 7.3 times higher than that of ZnIn_(2)S_(4)nanosheets (NSs),to be among the best ZnIn_(2)S_(4)-based photocatalysts.The present strategy breaks the high-temperature limitation of conventional top-down thermal dissociation/emitting approach for anchoring non-noble metal atomic sites on catalyst support. | Yuguang Chao Weiyu Zhang Peng Zhou Hui Chen Shiyu Lu Menggang Li Qinghua Zhang Lin Gu Shaojun Guo | 2021 | Science China Chemistry2021，64，10： | 0 |
| 20 | Photostimulation of lymphatic clearance ofβ‑amyloid from mouse brain:a new strategy for the therapy of Alzheimer’s disease显示文摘Alzheimer’s disease(AD)is an age-related neurodegenerative disorder that poses a signifcant burden on socio-economic and healthcare systems worldwide.However,the currently available therapy of AD is limited,and new strategies are needed to enhance the clearance ofβ-amyloid(Aβ)protein and improve cognitive function.Photobiomodulation(PBM)is a noninvasive and efective therapeutic method that has shown promise in treating various brain diseases.Here,we demonstrate that 1267-nm PBM signifcantly alleviates cognitive decline in the 5xFAD mouse model of AD and is safe as it does not induce a signifcant increase in cortical temperature.Moreover,with the combination of 3D tissue optical clearing imaging and automatic brain region segmentation,we show that PBM-mediated reductions of Aβplaques in diferent subregions of prefrontal cortex and the hippocampus are diferent.The PBM-induced lymphatic clearance of Aβfrom the brain is associated with improvement of memory and cognitive functions in 5xFAD mice.Our results suggest that the modulation of meningeal lymphatic vessels(MLVs)should play an important role in promoting Aβclearance.Collectively,this pilot study demonstrates that PBM can safely accelerate lymphatic clearance of Aβfrom the brain of 5xFAD mice,promoting improvement of neurocognitive status of AD animals suggesting that PBM can be an efective and bedside therapy for AD. | Dongyu Li Hao Lin Silin Sun Shaojun Liu Zhang Liu Yuening He Jingtan Zhu Jianyi Xu Oxana Semyachkina‑Glushkovskaya Tingting Yu Dan Zhu | 2023 | Frontiers of Optoelectronics2023，16，4： | 0 |
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