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| 1 | 2010年世界胃肠病学组织关于炎症性肠病诊断和治疗的实践指南显示文摘炎症性肠病(IBD)是一组特发性、慢性、炎症性肠道疾病状态,包括两种主要类型:克罗恩病(CD)和溃疡性结肠炎(UC),两者的临床和病理特征既有重叠又有区别。IBD过去常见于发达国家,近几十年,发展中国家的患病率逐步上升。本指南就IBD诊断和治疗方面提出的独特议题在当前的文献和指南中几乎从未被提及。由于各地区的IBD临床特点差异较大,因此根据患者的主诉诊断IBD或评估疾病活动度需随地区的变化而变化。同样,治疗亦应根据疾病的分类和当地医疗资源进行调整。世界胃肠病学组织根据世界各国医疗资源的差异,采用级联方法制订了IBD的诊疗指南。 | Charles N.Bernstein Michael Fried J.H.Krabshuis Henry Cohen R.Eliakim Suleiman Fedail Richard Gearry K.L.Goh Saheed Hamid Aamir Ghafor Khan A.W.LeMair Malfertheiner Qin Ouyang J.F.Rey Ajit Sood Flavio Steinwurz Ole O.Thomsen Alan Thomson Gillian Watermeyer 杨钊斌 杨川华 钱本余 | 2010 | 胃肠病学2010，15，9： | 101 |
| 2 | Accounting for Environmental Effects and Statistical Noise in Data Envelopment Analysis显示文摘 | H. O. Fried C. A. K. Lovell S. S. Schmidt S. Yaisawarng | 2002 | Journal of Productivity Analysis (-)2002，，1： | 10 |
| 3 | Clinical features and epidemiology of spondyloarthritides associated with inflammatory bowel disease显示文摘Inflammation of axial and/or peripheral joints is one of the most frequent extra-intestinal manifestations complicating the clinical course and therapeutic approach in inflammatory bowel diseases(IBD).The frequency of these complications seems to be similar for both diseases, Crohn's disease and ulcerative colitis.Arthritis associated with IBD belongs to the category of spondyloarthropathies.Axial involvement ranges from isolated inflammatory back pain to ankylosing spondylitis, whereas peripheral arthritis is noted in pauciarticular and in polyarticular disease.Asymptomatic radiological involvement of the sacroiliac joints is reported to occur in up to 50% of patients.Other musculoskeletal manifestations such as buttock pain, dactylitis, calcaneal enthesitis, and thoracic pain are frequently underdiagnosed and, consequently, are not treated appropriately.Several diagnostic approaches and criteria have been proposed over the past 40 years in an attempt to correctly classify and diagnose such manifestations.The correct recognition of spondylarthropathies needs an integrated multidisciplinary approach in order to identify common therapeutic strategies, especially in the era of the new biologic therapies. | Carlo Salvarani Walter Fries | 2009 | World Journal of Gastroenterology2009，15，20： | 9 |
| 4 | Clinical significance of NOD2/CARD15 and Toll-like receptor 4 gene single nucleotide polymorphisms in inflammatory bowel disease显示文摘AIM: To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), we investigated the single nucleotide poly- morphisms (SNPs) of NOD2/CARD15 (R702W, G908R and L1007fi nsC), and Toll-like receptor 4 (TLR4) genes (D299G and T399I) in a selected inflammatory bowel disease (IBD) population coming from Southern Italy. METHODS: Allele and genotype frequencies of NOD2/ CARD15 (R702W, G908R and L1007finsC) and TLR4 (D299G and T399I) SNPs were examined in 133 CD pa-tients, in 45 UC patients, and in 103 healthy controls. A genotype-phenotype correlation was performed. RESULTS: NOD2/CARD15 R702W mutation was sig-nificantly more frequent in CD (9.8%) than in controls (2.4%, P = 0.001) and in UC (2.3%, P = 0.03). No sig-nificant difference was found between UC patients and control group (P > 0.05). In CD and UC patients, no signifi cant association with G908R variant was found. L1007f insC SNP showed an association with CD (9.8%) compared with controls (2.9%, P = 0.002) and UC patients (2.3%, P = 0.01). Moreover, in CD patients, G908R and L1007finsC mutations were significantly associated with different phenotypes compared to CD wild-type patients. No association of IBD with the TLR4 SNPs was found in either cohort (allele frequencies: D299G-controls 3.9%, CD 3.7%, UC 3.4%, P > 0.05; T399I-controls 2.9%, CD 3.0%, UC 3.4%, P > 0.05). CONCLUSION: These findings confirm that, in our IBD patients selected from Southern Italy, the NOD2/ CARD15, but not TLR4 SNPs, are associated with in-creased risk of CD. | Luciana Rigoli Claudio Romano Rosario Alberto Caruso Maria A Lo Presti Chiara Di Bella Vincenzo Procopio Giuseppina Lo Giudice Maria Amorini Giuseppe Costantino Maria D Sergi Caterina Cuppari Giovanna Elisa Calabrò Romina Gallizzi Carmelo Damiano Salpietro Walter Fries | 2008 | World Journal of Gastroenterology2008，14，28： | 8 |
| 5 | Mucosal healing in inflammatory bowel disease: Maintain orde-escalate therapy显示文摘In the past decade, thanks to the introduction of biologic therapies, a new therapeutic goal, mucosal healing(MH), has been introduced. MH is the expression of an arrest of disease progression, resulting in minor hospitalizations, surgeries, and prolonged clinical remission. MH may be achieved with several therapeutic strategies reaching success rates up to 80% for both, ulcerative colitis(UC) and Crohn's disease(CD). Various scoring systems for UC and for the transmural CD, have been proposed to standardize the definition of MH. Several attempts have been undertaken to de-escalate therapy once MH is achieved, thus, reducing the risk of adverse events. In this review, we analysed the available studies regarding the achievement of MH and the subsequent treatment de-escalation according to disease type and administered therapy, together with non-invasive markers proposed as predictors for relapse. The available data are not encouraging since de-escalation after the achievement of MH is followed by a high number of clinical relapses reaching up to 50% within one year. Unclear is also another question, in case of combination therapies, which drug is more appropriate to stop, in order to guarantee a durable remission. Predictors of unfavourable outcome such as disease extension, perianal disease, or early onset disease appear to be inadequate to foresee behaviour of disease. Further studies are warranted to investigate the role of histologic healing for the further course of disease. | Marcello Cintolo Giuseppe Costantino Socrate Pallio Walter Fries | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，1： | 6 |
| 6 | Feruloylated Arabinoxylans Are Oxidatively Cross- Linked by Extracellular Maize Peroxidase but Not by Horseradish Peroxidase显示文摘在生活玉米文化的可溶的细胞外的 arabinoxylans 的共有原子价 cross-linking,为墙界限 arabinoxylans 的 cross-linking 建模,由于到 oligoferuloyl 酉旨和醚的 feruloyl 酉旨的氧化。氧化系统负责 H2O2/peroxidase, O2/laccase,或反应的氧种类能 non-enzymically 正在行动。区分这些可能性,我们在 vivo 并且在 vitro 学习了 arabinoxylan cross-linking。在生活文化,外长,可溶,细胞外, feruloylated [pentosyl-3H ] arabinoxylans 经历了 cross-linking,突然地开始 8 ? 在再次培养以后的 d。Cross-linking 被碘化物压制, H2O2 scavenger,在内长的 H2O2 上显示依赖。然而,外长的 H2O2 没引起早熟的 cross-linking,尽管有内长的 peroxidases 的经常的存在,建议更年轻的文化包含了自然 cross-linking 禁止者。渗析的文化过滤 cross-linked [3H ] 在 vitro 的 arabinoxylans 仅当 H2O2 也被增加,显示一个 peroxidase 要求。这 cross-linking 是高度 ionic-strength-dependent。peroxidases 负责是热易变的,尽管相对热马厩 peroxidases (o-dianisidine 上的 assayed ) 也是现在。令人惊讶地,补充说甚至在热变性作用以后,山葵 peroxidase 堵住了玉米 peroxidases 的交叉结合 arabinoxylan 行动,建议山葵蛋白质是竞争底层为[3H ] 联合的 arabinoxylan。在结论,我们第一次证明在生活玉米文化的细胞外的 arabinoxylan 的 cross-linking 是 apoplastic peroxidases 的一个行动,我们报导其不平常的性质的一些。 | Sally J. Burr Stephen C. Fry | 2009 | Molecular Plant2009，2，5： | 6 |
| 7 | 可逆热致变色油墨的色度学特性研究显示文摘本文研究了活化温度为31℃的3种含隐色染料基的热致变色油墨的色度学特性。这3种油墨具有相似的颜料粒径分布和同等厚度且对氧等离子体腐蚀相对稳定的微胶囊壳。油墨颜色与温度、引起颜色滞后的样品热史两个因素有关。比较脱色和着色过程,在CIELAB色空间中所观测的滞后环面积决定了样品上色差的大小。同一样品所能达到的最大色差是由样品不同的热史和温度决定。4个特征温度描述了引起颜色滞后的2个化学反应。当冷却到低于活化温度时,脱色状态的稳定性超过10h。热致变色效应的可逆性随着最高加热温度约呈线性降低。 | Rahela Kular Moja Frikovec Nina Hauptman Alenka Vesel Marta Klanjek Gunde 柳玲 | 2010 | 中国印刷与包装研究2010，2，3： | 6 |
| 8 | Late biliary complications in human alveolar echinococcosis are associated with high mortality显示文摘AIM:To evaluate the incidence of late biliary complications in non-resectable alveolar echinococcosis(AE)under long-term chemotherapy with benzimidazoles.METHODS:Retrospective analysis of AE patients with biliary complications occurring more than three years after the diagnosis of AE.We compared characteristics of patients with and without biliary complications,analyzed potential risk factor for biliary complications and performed survival analyses.RESULTS:Ninety four of 148 patients with AE in Zurich had non-resectable AE requiring long-term benzimidazole chemotherapy,of which 26(28%)patients developed late biliary complications.These patients had a median age of 55.5(35.5-65)years at diagnosis of AE and developed biliary complications after 15(8.25-19)years of chemotherapy.The most common biliary complications during long-term chemotherapy were late-onset cholangitis(n=14),sclerosing cholangitis-like lesions(n=8),hepatolithiasis(n=5),affection of the common bile duct(n=7)and secondary biliary cirrhosis(n=7).Thirteen of the 26 patients had undergone surgery(including 12 resections)before chemotherapy.Previous surgery was a risk factor for late biliary complications in linear regression analysis(P=0.012).CONCLUSION:Late biliary complications can be observed in nearly one third of patients with non-resectable AE,with previous surgery being a potential risk factor.After the occurrence of late biliary complications,the median survival is only 3 years,suggesting that late biliary complications indicate a poor prognostic outcome. | Pascal Frei Benjamin Misselwitz Meher K Prakash Alain M Schoepfer Bettina M Prinz Vavricka Beat Müllhaupt Michael Fried Kuno Lehmann Rudolf W Ammann Stephan R Vavricka | 2014 | World Journal of Gastroenterology2014，20，19： | 5 |
| 9 | Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection显示文摘 | Fried MW Shiffman ML Reddy KR | | New England Journal of Medicine0，，： | 4 |
| 10 | Changes in Cinnamic Acid Derivatives Associated with the Habituation of Maize Cells to Dichlobenil显示文摘到象 dichlobenil (DCB ) 那样的纤维素生合成禁止者的房间文化的使习惯表示改进我们机制的知识的一个珍贵工具在植物房间墙中包含了结构的粘性。玉米房间线使熟习到 DCB 的致命的集中能通过在哪个纤维素被 arabinoxylans 的一个更广泛的网络部分代替的一面修改房间墙的获得成长。这个工作的目的是调查非使熟习、使熟习 DCB 的玉米房间文化的酉分的新陈代谢。玉米房间文化被喂[14C ] cinnamate 和在在整个文化周期的不同 intra 原形质、墙局部性的部分的放射性的命运被 autoradiography 并且焕发数分析。非使熟习、使熟习的文化显著地没处于他们举起的能力不同外长[14C ] 苯乙烯的酸。然而,有趣的差别在 radiolabeling 被发现低 -- 先生和高度 -- 先生代谢物。使熟习的文化显示了 radiolabeled 的一个更高的数字和数量低 -- 先生加重,它能充当以后为多糖 feruloylation 使用的储备。使熟习 DCB 的文化高度在 esterified 被充实[14C ] dehydrodiferulates 和更大的联合产品。在结论, hydroxycinnamates 的广泛、早的 cross-linking 在使熟习 DCB 的文化被观察,可能加强他们的纤维素缺乏的墙。 | Hugo Melida Jesus Alvarez Jose Luis Acebes Antonio Encina Stephen C. Fry | 2011 | Molecular Plant2011，4，5： | 4 |
| 11 | 固相微萃取/气相色谱-质谱联用技术在有机磷酸三酯阻燃剂土壤吸附分析中的应用显示文摘以3种常用且极性相差较大的有机磷酸三酯阻燃剂(OPFRs)作为研究对象,采用固相微萃取/气相色谱-质谱(SPME/GC-MS)联用技术建立了一种适用于研究OPFRs土壤吸附的分析方法:优化固相微萃取的萃取条件——取样体积为7mL,萃取时间为30min,解吸温度和时间分别为270℃和5min;分析测定过程中导致空白值升高的干扰因素;针对不同类型的土壤分别绘制标准曲线。利用已建立的SPME/GC-MS法对3种OPFRs在不同类型土壤中的吸附程度进行了初步评估,结果表明:3种OPFRs在试验土壤中的吸附率为27%~69%,吸附程度随着OPFRs极性的减弱以及土壤有机质含量的增加而增加。该方法具有操作简单,分析速度快,准确度、灵敏度和精密度均能满足定量测试要求,空白干扰小以及易于普及等特点。 | 郑春莉 冯珊珊 杜苗苗 齐月 Elke FRIES | 2015 | 西安交通大学学报2015，49，11： | 4 |
| 12 | Accounting for Environmental Effects and Statistical Noise in Data Envelopment Analysis显示文摘 | H. O. Fried C. A. K. Lovell S. S. Schmidt S. Yaisawarng | 2002 | Journal of Productivity Analysis (-)2002，，12： | 4 |
| 13 | Four-sample lactose hydrogen breath test for diagnosis of lactose malabsorption in irritable bowel syndrome patients with diarrhea显示文摘AIM: To validate 4-sample lactose hydrogen breath testing(4SLHBT) compared to standard 13-sample LHBT in the clinical setting.METHODS: Irritable bowel syndrome patients with diarrhea(IBS-D) and healthy volunteers(HVs) were enrolled and received a 10 g, 20 g, or 40 g doselactose hydrogen breath test(LHBT) in a randomized, double-blinded, controlled trial. The lactase gene promoter region was sequenced. Breath samples and symptoms were acquired at baseline and every 15 min for 3 h(13 measurements). The detection rates of lactose malabsorption(LM) and lactose intolerance(LI) for a 4SLHBT that acquired four measurements at 0, 90, 120, and 180 min from the same data set were compared with the results of standard LHBT.RESULTS: Sixty IBS-D patients and 60 HVs were studied. The genotype in all participants was C/C-13910. LM and LI detection rates increased with lactose dose from 10 g, 20 g to 40 g in both groups(P < 0.001). 4SLHBT showed excellent diagnostic concordance with standard LHBT(97%-100%, Kappa 0.815-0.942) with high sensitivity(90%-100%) and specificity(100%) at all three lactose doses in both groups.CONCLUSION: Reducing the number of measurements from 13 to 4 samples did not significantly impact on the accuracy of LHBT in health and IBS-D. 4SLHBT is a valid test for assessment of LM and LI in clinical practice. | Jian-Feng Yang Mark Fox Hua Chu Xia Zheng Yan-Qin Long Daniel Pohl Michael Fried Ning Dai | 2015 | World Journal of Gastroenterology2015，21，24： | 4 |
| 14 | Product design based on discrete particle modeling of a fluidized bed granulator显示文摘Fluidized bed agglomeration is a process commonly used to construct powdered food or pharmaceutical products to improve their instant properties. This works analyzes the influence of a wide range of operating parameters(i.e., fluidization air flow rate, temperature, and liquid injection rate) on growth rate, process stability, and product particle structure. Different granulator configurations(i.e., top spray,Wurster coater, spouted bed) are compared using identical process parameters. The impacts of both process variables and granulator geometry on the fluidization regime, the particle and collision dynamics, and the resulting product structure and corresponding properties are studied in detailed simulations using a discrete particle model(DPM) and lab-scale agglomeration experiments with amorphous dextrose syrup(DE21). The combination of numerical and experimental results allows to correlate the kinetics of microscale particle interactions and the final product properties(i.e., agglomerate structure and strength). In conclusion, detailed DPM simulations are proven as a valuable tool for knowledge-based product design. | Lennart Fries Sergiy Antonyuk Stefan Heinrich Gerhard Niederreiter Stefan Palzer | 2014 | Particuology2014，12，1： | 4 |
| 15 | Nosema ceranae n. sp. (Microspora, Nosematidae), morphological and molecular characterization of a microsporidian parasite of the Asian honey bee Apis cerana (Hymenoptera, Apidae)显示文摘 | Ingemar Fries Feng Feng Alexandre da Silva Susan B. Slemenda Norman J. Pieniazek | 1996 | European Journal of Protistology1996，，3： | 3 |
| 16 | 超高效液相色谱法测定山楂原料、提取物和相关食品中金丝桃苷和异槲皮苷的含量显示文摘目的建立超高效液相色谱法测定山楂原料、提取物和相关食品中金丝桃苷和异槲皮苷的分析方法。方法采用ACQUITY UPLC BEH C_(18)柱(100 mm×2.1 mm,1.7μm),以甲酸乙腈-甲酸水为流动相进行梯度洗脱分离金丝桃苷和异槲皮苷,在紫外检测波长360 nm下进行检测,外标法定量。结果金丝桃苷和异槲皮苷的检出限(S/N=3)均为2 mg/kg,定量限(S/N=10)均为5 mg/kg;在0.5~10.0 mg/L的范围内线性关系良好,相关系数均为0.999;在原料、提取物和相关食品中,金丝桃苷和异槲皮苷的平均回收率分别为85.0%~108.0%和86.2%~105.0%,相对标准偏差(relative standard deviations,RSDs)分别为1.6%~5.7%和1.1%~3.9%。结论本方法操作简便、快速、分离度和准确度高,可用于山楂原料、提取物和相关食品的质量控制。 | 周凌 朱吟吟 许生霞 廖勇诚 石欢 续斐 FRIES Lennart | 2021 | 食品安全质量检测学报2021，12，20： | 3 |
| 17 | Management of severe perioperative bleeding: Guidelines from the European Society of Anaesthesiology显示文摘 | Sibylle A. Kozek-Langenecker Arash Afshari Pierre Albaladejo Cesar Aldecoa Alvarez Santullano Edoardo De Robertis Daniela C. Filipescu Dietmar Fries Klaus G?rlinger Thorsten Haas Georgina Imberger Matthias Jacob Marcus Lancé Juan Llau Sue Mallett Jens Mei | 2013 | European Journal of Anaesthesiology2013，，6： | 3 |
| 18 | Retinol Binding Protein 4 Expression in Humans: Relationship to Insulin Resistance, Inflammation, and Response to Pioglitazone显示文摘 | Aiwei Yao-Borengasser Vijayalakshmi Varma Angela M. Bodles Neda Rasouli Bounleut Phanavanh Mi-Jeong Lee Tasha Starks Leslie M. Kern Horace J. Spencer Amir Adel Rashidi Robert E. McGehee Susan K. Fried Philip A. Kern | 2007 | The Journal of Clinical Endocrinology & Metabolism2007，，7： | 3 |
| 19 | Randomized clinical trial on enhanced recovery versus standard care following open liver resection显示文摘 | C. Jones L. Kelliher M. Dickinson A. Riga T. Worthington M. J. Scott T. Vandrevala C. H. Fry N. Karanjia N. Quiney | 2013 | Br J Surg2013，，8： | 3 |
| 20 | Sepsis, Systemic Inflammatory Response, and Multiple Organ Dysfunction: The Mystery Continues显示文摘 | Fry Donald E | 2012 | The American Surgeon2012，，： | 2 |
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