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| 1 | Inflammatory bowel diseases and spondyloarthropathies: From pathogenesis to treatment显示文摘Spondyloarthropathies(SpA) include many different forms of inflammatory arthritis and can affect the spine(axial SpA) and/or peripheral joints(peripheral SpA) with Ankylosing spondylitis(AS) being the prototype of the former. Extraarticular manifestations, like uveitis, psoriasis and inflammatory bowel disease(IBD) are frequently observed in the setting of SpA and are, in fact, part of the SpA classification criteria. Bowel involvement seems to be the most common of these manifestations. Clinically evident IBD is observed in 6%-14% of AS patients, which is significantly more frequent compared to the general population. Besides, it seems that silent microscopic gut inflammation, is evident in around 60% in AS patients. Interestingly, occurrence of IBD has been associated with AS disease activity. For peripheral SpA, two different forms have been proposed with diverse characteristics. Of note, SpA(axial or peripheral) is more commonly observed in Crohn's disease than in ulcerative colitis. The common pathogenetic mechanisms that explain the link between IBD and SpA are still ill-defined. The role of dysregulated microbiome along with migration of T lymphocytes and other cells from gut to the joint('gut-joint' axis) has been recognized, in the context of a genetic background including associations with alleles inside or outside the human leukocyte antigen system. Various therapeutic modalities are available with monoclonal antibodies against tumour necrosis factor, interleukin-23 and interleukin-17, being the most effective. Both gastroenterologists and rheumatologists should be alert to identify the coexistence of these conditions and ideally follow-up these patients in combined clinics. | George E Fragoulis Christina Liava Dimitrios Daoussis Euangelos Akriviadis Alexandros Garyfallos Theodoros Dimitroulas | 2019 | World Journal of Gastroenterology2019，25，18： | 13 |
| 2 | HLA-B27与强直性脊柱炎的相关性研究显示文摘目的探讨应用流式细胞术检测人类白细胞抗原B27(HLA-B27)在临床上对强直性脊柱炎(AS)的诊断价值。方法应用流式细胞术,选择来本院就诊的门诊、住院的AS患者(AS组)561例及健康体检者(健康对照组)1 000例,进行HLA-B27检测。结果两组间HLA-B27阳性率比较:AS组为88.95%,健康对照组为6.90%,两组比较差异有显著性(P〈0.01)。两组不同性别间HLA-B27检测阳性率比较:临床确诊的AS组561名患者中,HLA-B27表达阳性患者499名(88.95%),其中男性364名(64.88%),女性135名(24.07%),AS组男女比例约为2.7∶1,阳性率差异有显著性(P〈0.01);健康对照组1 000例中HLA-B27表达阳性患者69名(6.9%),其中男性39名(3.9%),女性30名(3.0%),健康对照组男女比例约为1.3∶1,阳性率差异无显著性(P〉0.05)。两组不同年龄段间HLA-B27检测阳性率比较:临床确诊的AS组561名患者,HLA-B27表达阳性患者中21~40年龄段298名(52.46%),21~40年龄段阳性率差异有显著性(P〈0.01),其他年龄段的阳性率无显著性差异(P〉0.05);健康体检组HLA-B27表达阳性患者各年龄段的阳性率无显著性差异(P〉0.05)。结论 HLA-B27与AS具有高度相关性,检测HLA-B27有助于早期发现AS患者,以实现早期诊断,早期治疗。 | 张小芳 张运刚 李守霞 张海丽 冯丽娟 孙彩霞 | 2013 | 中国现代医学杂志2013，23，36： | 12 |
| 3 | HLA-B27检测对强直性脊柱炎诊断的临床意义显示文摘目的探讨人类白细胞抗原(HLA)-B27对强直性脊柱炎(AS)的诊断价值。方法选择2 768例疑诊AS患者作为研究对象,其中600例为确诊AS患者。采用流式细胞术进行血HLA-B27检测。结果 2 768例疑诊AS的患者中,HLA-B27阳性598例(21.6%),阴性2 170例(78.4%)。男、女性患者HLA-B27阳性率的差异有统计学意义(P〈0.05);20~〈40岁的AS疑诊患者HLA-B27阳性率显著高于其他年龄段的阳性率(P〈0.05)。600例AS确诊患者中,HLA-B27阳性536例(89.3%)。结论 HLA-B27检测结合临床表现有助于AS的早期诊断。 | 刘永杰 张小芳 张运刚 李海新 李守霞 | 2014 | 国际检验医学杂志2014，35，10： | 11 |
| 4 | 强直性脊柱炎患者检测骨代谢指标潜在的临床价值显示文摘目的:探讨骨代谢指标和人类白细胞抗原B27(HLA-B27)在检测强直性脊柱炎(AS)患者的临床意义,并分析其诊断价值。方法:研究对象为94例AS患者、239例其他病种对照和80例健康对照组,并对其结果进行回顾性分析。结果:AS组β-胶原特殊序列(β-CTX)高于对照组,而骨钙素(OC)、25羟基维生素D[25-(OH)D]和甲状旁腺素(PTH)低于对照组(P<0.05);AS组C反应蛋白(CRP)和β-CTX呈明显的正相关(P<0.01),25-(OH)D呈负相关(P<0.05),其他骨代谢指标和CRP无相关性;AS组HLA-B27阳性率明显高于其他组(P<0.05),且HLA-B27在诊断AS时具有很高的敏感性和特异性;AS组25-(OH)D检测的敏感性高于β-CTX,但特异性低于β-CTX。结论:骨代谢指标对AS早期筛查,临床诊断有着重要价值,尤其是β-CTX和25-(OH)D的诊断价值更为明显。 | 谭立明 冯晓晶 焦安君 陈娟娟 谭福燕 何思齐 徐镠粤 蒋永清 罗姮 李华 吴洋 田永建 曾婷婷 余建林 曹莉萍 郑剑峰 | 2017 | 中国免疫学杂志2017，33，10： | 9 |
| 5 | HLA-B27^+的强直性脊柱炎与非强直性脊柱炎患者外周血T淋巴细胞亚群及免疫炎症指标分析显示文摘目的探讨HLA-B27^+的不同研究对象T淋巴细胞亚群以及免疫炎症指标的相关性与差异性,从而辅助AS和非AS疾病的早期鉴别。方法本研究以HLA-B27^+的AS患者、HLA-B27^+的非AS患者、HLA-B27^+的未发病者为研究对象,以HLA-B27-的健康人群为对照组。通过流式细胞术观察HLA-B27 MFI和T淋巴细胞亚群分布、速率散射比浊法检测ASO、RF、ESR、CRP指标。结果 HLA-B27~^+AS患者、非AS患者与未发病者的HLA-B27 MFI差异无统计学意义(P>0.05),ASO和RF阳性率差异无统计学意义(P>0.05)。HLA-B27^+AS患者、HLA-B27^+非AS患者的ESR、CRP、CD4^+和CD8^+T细胞百分率、CD4^+T/CD8^+T比值与健康人群组相比,差异均有统计学意义(P<0.05)。HLA-B27^+AS患者的ESR、CRP水平高于HLA-B27^+非AS患者,差异有统计学意义(P<0.05)。HLA-B27^+AS患者CD8^+T细胞百分率高于HLA-B27^+非AS患者,CD4^+T/CD8^+T比值低于HLA-B27^+非AS患者,差异均有统计学意义(P<0.05)。结论 HLA-B27^+AS患者与HLA-B27^+非AS患者早期可以通过ESR、CRP、CD8^+T细胞百分率、CD4^+T/CD8^+T比值加以鉴别。 | 尤金彪 毛向红 董浙清 邵笑 祝骥 方揆 | 2016 | 中国卫生检验杂志2016，26，14： | 6 |
| 6 | 炎症性肠病患者脊柱关节炎的表现特点显示文摘目的探讨炎症性肠病(IBD)患者的肠外表现—脊柱关节炎的发生情况,为后续炎症性肠病患者的诊断治疗提供借鉴。方法分析2016年9月至2020年9月本院收治的210例炎症性肠病患者(其中溃疡性结肠炎/UC组138人,克罗恩病/CD组72人)肠道病变分布情况,并分析UC组及CD组患者脊柱关节炎各种分型的发生率及两组之间表达的差异。结果UC患者的临床表现以直肠炎,左半结肠炎及全结肠炎为主。CD患者的临床表现以回结肠炎,末端回肠炎及结肠炎为主。IBD患者肠外脊柱关节炎总发生率为UC:20.3%,CD:36.1%;两组中轴型关节炎发病率较低,且在UC与CD患者之间没有差异;外周型关节炎CD组的发生率均高于UC组,差异有统计学意义(P=0.013),外周型发病率由高到低依次为:关节炎,肌腱炎,指/趾炎;本研究中,中轴型+外周型关节炎在UC和CD患者中的发病率相同。结论炎症性肠病患者脊柱关节炎发生率较高,临床医生在诊治过程中应提高对炎症性肠病肠外关节表现的认识,根据患者的临床表现和医学检查结果对患者进行综合诊断,合理地选择治疗方法和药物,有效地提高治疗效果,改善患者的症状。 | 王慧玲 赵静 李刚 | 2021 | 分子诊断与治疗杂志2021，13，1： | 6 |
| 7 | HLA-B27、HLA-Cw、KIRs与强直性脊柱炎显示文摘强直性脊柱炎(AS)是一种慢性进行性炎症性关节炎,具有明显的家族倾向。虽然,人类白细胞抗原B27(HLA-B27)被认为与AS的发病密切相关,但是由于AS发病机制复杂,HLA-B27仅为导致AS易感的主要基因之一。近年来研究发现,自然杀伤细胞免疫球蛋白样受体(KIRs)和HLA-Cw基因与AS的发生发展也有一定的相关性,且HLA-Cw与活化性/抑制性KIRs之间的失衡可能是影响AS发病机制的关键因素。 | 张谷香 赵福涛 | 2012 | 医学综述2012，18，4： | 2 |
| 8 | Sudden blindness in a child with Crohn's disease显示文摘Inflammatory bowel disease(IBD) is often associated with extraintestinal manifestations(EIMs) such as optic neuritis(ON),although this has been described in only a few adult patients so far,all of whom were affected with Crohn's disease(CD).Furthermore,ON and demyelinating diseases have been demonstrated to be more frequent in IBD patients than in control populations.In our current case report,we describe a child with active CD who developed sudden blindness due to bilateral ON that was not related to any known cause,and that promptly responded to a high dose of steroids.Investigations and a clinical follow-up have so far ruled out the development of demyelinating diseases in this patient.To our knowledge,this is the first report of ON in a pediatric patient with CD.Possible explanations for this case include an episodic EIM of an active bowel disease,an associated autoimmune disorder such as a recurrent isolated ON,the first manifestation of multiple sclerosis,or another demyelinating disease that could appear in a later follow-up. | Arrigo Vittorio Barabino Paolo Gandullia Angela Calvi Silvia Vignola Serena Arrigo Riccardo De Marco | 2011 | World Journal of Gastroenterology2011，17，38： | 1 |
| 9 | Inflammatory bowel disease-associated spondyloarthropathies显示文摘This issue presents a symposium held in Messina talking about inflammatory bowel disease(IBD) and associated spondyloarthropathies.The topic covers epidemiology and clinical manifestations of IBD-related arthropathies, common genetic and immunologic features, combined therapies for gut and joint inflammation, and future biologic therapies etc.I believe this series of articles will deeply facilitate understanding of and the approach to IBD and associated arthropathies. | Walter Fries | 2009 | World Journal of Gastroenterology2009，15，20： | 0 |
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