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| 1 | Pediatric gastrointestinal bleeding: Perspectives from the Italian Society of Pediatric Gastroenterology显示文摘There are many causes of gastrointestinal bleeding(GIB) in children, and this condition is not rare, having a reported incidence of 6.4%. Causes vary with age, but show considerable overlap; moreover, while many of the causes in the pediatric population are similar to those in adults, some lesions are unique to children. The diagnostic approach for pediatric GIB includes definition of the etiology, localization of the bleeding site and determination of the severity of bleeding; timely and accurate diagnosis is necessary to reduce morbidity and mortality. To assist medical care providers in the evaluation and management of children with GIB, the 'Gastro-Ped Bleed Team' of the Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition(SIGENP) carried out a systematic search on MEDLINE via Pub Med(http://gffzz16a62c593b5540cehxwuqb6b50v6p6fcn.ffgz.tsg.suse.edu.cn/pubmed/) to identify all articles published in English from January 1990 to 2016; the following key words were used to conduct the electronic search: 'upper GIB' and 'pediatric' [all fields]; 'lower GIB' and 'pediatric' [all fields]; 'obscure GIB' and 'pediatric' [all fields]; 'GIB' and 'endoscopy' [all fields]; 'GIB' and 'therapy' [all fields]. The identified publications included articles describing randomized controlled trials, reviews, case reports, cohort studies, casecontrol studies and observational studies. References from the pertinent articles were also reviewed. This paper expresses a position statement of SIGENP that can have an immediate impact on clinical practice and for which sufficient evidence is not available in literature. The experts participating in this effort were selected according to their expertise and professional qualifications. | Claudio Romano Salvatore Oliva Stefano Martellossi Erasmo Miele Serena Arrigo Maria Giovanna Graziani Sabrina Cardile Federica Gaiani Gian Luigi de'Angelis Filippo Torroni | 2017 | World Journal of Gastroenterology2017，23，8： | 12 |
| 2 | Synergistic effect of interleukin-10-receptor variants in a case of early-onset ulcerative colitis显示文摘AIM:To investigated the molecular cause of very early-onset ulcerative colitis(UC)in an 18-mo-old affected child.METHODS:We analysed the interleukin-10(IL10)receptor genes at the DNA and RNA level in the proband and his relatives.Beta catenin and tumor necrosis factor-α(TNFα)receptors were analysed in the proteins extracted from peripheral blood cells of the proband,his relatives and familial adenomatous polyposis(FAP)and PTEN hamartoma tumor syndrome(PHTS)patients.Samples were also collected from the proband’s inflamed colorectal mucosa and compared to healthy and tumour mucosa collected from a FAP patient and patients affected by sporadic colorectal cancer(CRC).Finally,we examined mesalazine and azathioprine effects on primary fibroblasts stabilised from UC and FAP patients.RESULTS:Our patient was a compound heterozygote for the IL10RB E47K polymorphism,inherited from his father,and for a novel point mutation within the IL10RA promoter(the-413G->T),inherited from his mother.Beta catenin and tumour necrosis factorαreceptors-Ⅰ(TNFRI)protein were both over-expressed in peripheral blood cells of the proband’s relatives more than the proband.However,TNFRII was over-expressed only in the proband.Finally,both TNFα-receptors were shown to be under-expressed in the inflamed colon mucosa and colorectal cancer tissue compared to healthy colon mucosa.Consistent with this observation,mesalazine and azathioprine induced,in primary fibroblasts,IL10RB and TNFRII over-expression and TNFRI and TNFαunder-expression.We suggest thatβ-catenin and TNFRI protein expression in peripheral blood cells could represent molecular markers of sub-clinical disease in apparently healthy relatives of patients with early-onset UC.CONCLUSION:A synergistic effect of several variant alleles of the IL10 receptor genes,inherited in a Mende-lian manner,is involved in UC onset in this young child. | Martina Galatola Erasmo Miele Caterina Strisciuglio Lorella Paparo Daniela Rega Paolo Delrio Francesca Duraturo Massimo Martinelli Giovanni Battista Rossi Annamaria Staiano Paola Izzo Marina De Rosa | 2013 | World Journal of Gastroenterology2013，19，46： | 7 |
| 3 | Italian survey on non-steroidal anti-inflammatory drugsand gastrointestinal bleeding in children显示文摘AIM: To investigate gastrointestinal complications associated with non-steroidal anti-inflammatory drug(NSAIDs) use in children.METHODS: A retrospective, multicenter study was conducted between January 2005 and January 2013, with the participation of 8 Italian pediatric gastroenterology centers. We collected all the cases of patients who refer to emergency room for suspected gastrointestinal bleeding following NSAIDs consumption, and underwent endoscopic evaluation. Previous medical history, associated risk factors, symptoms and signs at presentation, diagnostic procedures, severity of bleeding and management of gastrointestinal bleeding were collected. In addition, data regarding type of drug used, indication, dose, duration of treatment and prescriber(physician or selfmedication) were examined. RESULTS: Fifty-one patients, including 34 males, were enrolled(median age: 7.8 years). Ibuprofen was the most used NSAID [35/51 patients(68.6%)]. Pain was the most frequent indication for NSAIDs use [29/51 patients(56.9%)]. Seven patients had positive family history of Helicobacter pylori(H. pylori) infection or peptic ulcer, and 12 had associated comorbidities. Twenty-four(47%) out of 51 patients used medication inappropriately. Hematemesis was the most frequent symptom(33.3%). Upper gastrointestinal endoscopy revealed gastric lesions in 32/51(62%) patients, duodenal lesions in 17(33%) and esophageal lesions in 8(15%). In 10/51(19.6%) patients, a diagnosis of H. pylori gastritis was made. Forty-eight(94%) patients underwent medical therapy, with spontaneous bleeding resolution, while in 3/51(6%) patients, an endoscopic hemostasis was needed.CONCLUSION: The data collected in this study confirms that adverse events with the involvement of the gastrointestinal tract secondary to NSAID use are also common in | Sabrina Cardile Massimo Martinelli Arrigo Barabino Paolo Gandullia Salvatore Oliva Giovanni Di Nardo Luigi Dall'Oglio Francesca Rea Gian Luigi de'Angelis Barbara Bizzarri Graziella Guariso Enzo Masci Annamaria Staiano Erasmo Miele Claudio Romano | 2016 | World Journal of Gastroenterology2016，22，5： | 7 |
| 4 | Recurrent and novel LDL receptor gene mutations causing heterozygous familial hypercholesterolemia in La Habana显示文摘 | Erasmo Pereira Raoul Ferreira Brigitte Hermelin Ginette Thomas Chantal Bernard Véronique Bertrand Hadad Nassiff Dora Mendez Castillo Gilbert Bereziat Pascale Benlian | 1995 | Human Genetics1995，，3： | 1 |
| 5 | Efficacy of repeated cycles of chemo-immunotherapy with Thymosin α1 and interleukin-2 after intraperitoneal 5-fluorouracil delivery显示文摘 | Gianfranco Silecchia Enrico Guarino Paola Sinibaldi-Vallebona Pasquale Pierimarchi Angelo Restuccia Erasmo Spaziani Paola Bernard Cynthia Tuthill Enrico Garaci Guido Rasi | 1999 | Cancer Immunology, Immunotherapy1999，，4： | 1 |
| 6 | R&D and the Growth of Firms: Empirical Analysis of a Panal of Italian Firms 显示文摘 | Alfredo Del Monte Erasmo Papagni | 2003 | Research Poli- cy2003，，32： | 1 |
| 7 | Vasospasm in response to repeated subarachnoid hemorrhages in the monkey显示文摘 | Erasmo R Miller J | 1970 | J Neurosurg1970，33，： | 1 |
| 8 | Wind Speed Forecasting in Three Different Regions of Mexico Using a Hybrid ARIMA-ANN Model 显示文摘 | Erasmo C Wilfrido R | 2010 | Re- newable Energy2010，35，12： | 1 |
| 9 | Fiber (Glucomannan) is beneficial in the treatment of childhood constipation 显示文摘 | Vera L B Erasmo M Staiano A | 2004 | Pediatrics2004，113，3： | 1 |
| 10 | Antibacterial activity, inflammatory response, coagulation and cytotoxicity effects of silver nanoparticles显示文摘 | Fidel Martínez-Gutierrez Emily P. Thi Judith M. Silverman Carolina Camargo de Oliveira Sarah L. Svensson Amanda Vanden Hoek Elpidio Morales Sánchez Neil E. Reiner Erin C. Gaynor Edward L.G. Pryzdial Edward M. Conway Erasmo Orrantia Facundo Ruiz Yossef Av- | 2012 | Nanomedicine: Nanotechnology Biology and Medicine2012，，3： | 1 |
| 11 | Serum albumin level at admission:mortality and clinical outcome in geriatric patients显示文摘 | D'Erasmo E Pisani D Ragno A | 1997 | Am J Med Sci1997，314，1： | 1 |
| 12 | Platelet count, MPV and their relation to prognosis in cerebral infarction显示文摘 | D~Erasmo | 1990 | J Inter Med1990，227，： | 1 |
| 13 | Probability current in the tight-binding model 显示文摘 | Erasmo A de Andrada e Silva | 1992 | America Journal of Physics1992，60，： | 1 |
| 14 | Short term wind speed forecasting in La Venta, Oaxaca, Mexico, using artificial neural networks显示文摘 | Erasmo Cadenas Wilfrido Rivera | 2009 | Renewable Energy2009，34，1： | 1 |
| 15 | Short Term Wind Speed Forecasting in La Venta, Oaxaca, Mexico, Using Artificial Neural Networks显示文摘 | Erasmo Cadenas Wilfrido Rivera | 2009 | Renew- able Energy2009，34，1： | 1 |
| 16 | Synthesis, characterization, and evaluation of antimicrobial and cytotoxic effect of silver and titanium nanoparticles显示文摘 | Fidel Martinez-Gutierrez Peggy L. Olive Adriana Banuelos Erasmo Orrantia Nereyda Nino Elpidio Morales Sanchez Facundo Ruiz Horacio Bach Yossef Av-Gay | 2010 | Nanomedicine: Nanotechnology Biology and Medicine2010，，5： | 1 |
| 17 | Platelet count,MPV and their relation to prognosis in cerebral infarction显示文摘 | D′Erasmo E A liberti G Celi F S | 1990 | J Intern Med1990，227，： | 1 |
| 18 | Modeling wave propagation in damped waveguides of arbitrary cross-section显示文摘 | Ivan Bartoli Alessandro Marzani Francesco Lanza di Scalea Erasmo Viola | 2006 | Journal of Sound and Vibration2006，，3： | 1 |
| 19 | Short term wind speed forecas- ting inLa Venta, Oaxaca, Mexico, using artificial neural networks 显示文摘 | ErasmO Cadenas Wilfrido Rivera | 2009 | Renewable Energy2009，34，1： | 1 |
| 20 | Wind speed forecasting in three different regions ofiVIexico, using a hybrid ARIMA-ANN model 显示文摘 | Erasmo Cadenas Wilfrido Rivera | 2010 | Renewable Energy2010，35，12： | 1 |
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