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| 1 | SPOT4-VEGETATION中国西北地区土地覆盖制图与验证显示文摘利用SPOT4 VEGETATION的遥感数据产品生成的NDVI与NDWI植被指数时间序列图像集 ,通过ISODATA非监督分类方法 ,编制中国西北地区土地覆盖图。以TM影像人工解译结果作为真实值 ,通过对西北五省共计 47个均匀分布且异质性强的 2 5km× 2 5km样本区内的土地覆盖类型及其面积进行统计分析 ,修正了SPOT4 VEGETATION的土地覆盖分类系统 ,建立了各省验证结果的样本统计直方图并计算其回归系数。结果表明SPOT4 VEGETATION中国西北地区土地覆盖图在总体上具有较高的准确性。影响遥感数据自动分类精度 ,造成土地覆盖误判的原因主要来源于两个方面 :即异物同谱和混合像元问题。对于前者通过叠加各种辅助数据如DEM等可以降低误判的机率 ; | 卢玲 李新 董庆罕 Else Swinnen Frank Veroustraete 王建华 王一谋 | 2003 | 遥感学报2003，7，3： | 27 |
| 2 | Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages显示文摘How the innate and adaptive host immune system miscommunicate to worsen COVID-19 immunopathology has not been fully elucidated.Here,we perform single-cell deep-immune profiling of bronchoalveolar lavage(BAL)samples from 5 patients with mild and 26 with critical COVID-19 in comparison to BALs from non-COVID-19 pneumonia and normal lung.We use pseudotime inference to build T-cell and monocyte-to-macrophage trajectories and model gene expression changes along them.In mild COVID-19,CD8^(+)resident-memory(TRM)and CD4^(+)T-helper-17(T_(H17))cells undergo active(presumably antigen-driven)expansion towards the end of the trajectory,and are characterized by good effector functions,while in critical COVID-19 they remain more naïve.Vice versa,CD4^(+)T-cells with T-helper-1 characteristics(TH1-like)and CD8^(+)T-cells expressing exhaustion markers(T_(EX)-like)are enriched halfway their trajectories in mild COVID-19,where they also exhibit good effector functions,while in critical COVID-19 they show evidence of inflammation-associated stress at the end of their trajectories.Monocyte-to-macrophage trajectories show that chronic hyperinflammatory monocytes are enriched in critical COVID-19,while alveolar macrophages,otherwise characterized by anti-inflammatory and antigen-presenting characteristics,are depleted.In critical COVID-19,monocytes contribute to an ATP-purinergic signaling-inflammasome footprint that could enable COVID-19 associated fibrosis and worsen disease-severity.Finally,viral RNA-tracking reveals infected lung epithelial cells,and a significant proportion of neutrophils and macrophages that are involved in viral clearance. | Els Wauters Pierre Van Mol Abhishek Dinkarnath Garg Sander Jansen Yannick Van Herck Lore Vanderbeke Ayse Bassez Bram Boeckx Bert Malengier-Devlies Anna Timmerman Thomas Van Brussel Tina Van Buyten Rogier Schepers Elisabeth Heylen Dieter Dauwe Christophe Dooms Jan Gunst Greet Hermans Philippe Meersseman Dries Testelmans Jonas Yserbyt Sabine Tejpar Walter De Wever Patrick Matthys CONTAGIOUS collaborators Johan Neyts Joost Wauters Junbin Qian Diether Lambrechts | 2021 | Cell Research2021，31，3： | 11 |
| 3 | A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling显示文摘The stromal compartment of the tumor microenvironment consists of a heterogeneous set of tissue-resident and tumor-infiltrating cells,which are profoundly moulded by cancer cells.An outstanding question is to what extent this heterogeneity is similar between cancers affecting different organs.Here,we profile 233,591 single cells from patients with lung,colorectal,ovary and breast cancer(n=36)and construct a pan-cancer blueprint of stromal cell heterogeneity using different single-cell RNA and protein-based technologies.We identify 68 stromal cell populations,of which 46 are shared between cancer types and 22 are unique.We also characterise each population phenotypically by highlighting its marker genes,transcription factors,metabolic activities and tissue-specific expression differences.Resident cell types are characterised by substantial tissue specificity,while tumor-infiltrating cell types are largely shared across cancer types.Finally,by applying the blueprint to melanoma tumors treated with checkpoint immunotherapy and identifying a naive CD4+T-cell phenotype predictive of response to checkpoint immunotherapy,we illustrate how it can serve as a guide to interpret scRNA-seq data.In conclusion,by providing a comprehensive blueprint through an interactive web server,we generate the first panoramic view on the shared complexity of stromal cells in different cancers. | Junbin Qian Siel Olbrecht Bram Boeckx Hanne Vos Damya Laoui Emre Etlioglu Els Wauters Valentina Pomella Sara Verbandt Pieter Busschaert Ayse Bassez Amelie Franken Marlies Vanden Bempt Jieyi Xiong Birgit Weynand Yannick van Herck Asier Antoranz Francesca Maria Bosisio Bernard Thienpont Giuseppe Floris Ignace Vergote Ann Smeets Sabine Tejpar Diether Lambrechts | 2020 | Cell Research2020，30，9： | 11 |
| 4 | Current status of intravenous tissue plasminogen activator dosage for acute ischaemic stroke:an updated systematic review显示文摘The optimal dose of recombinant tissue plasminogen activator(rtPA)for acute ischaemic stroke(AIS)remains controversial,especially in Asian countries.We aimed to update the evidence regarding the use of low-dose versus standard-dose rtPA.We performed a systematic literature search across MEDLINE,Embase,Cochrane Central Register of Controlled Trials(CENTRAL),PsycINFO and Cumulative Index to Nursing and Allied Health Literature(CINAHL)from inception to 22 August 2016 to identify all related studies.The outcomes were death or disability(defined by modified Rankin Scale 2-6),death,and symptomatic intracerebral haemorrhage(sICH).Where possible,data were pooled for meta-analysis with ORs and corresponding 95% CIs by means of random-effects or fixed-effects meta-analysis.We included 26 observational studies and 1 randomised controlled trial with a total of 23210 patients.Variable doses of rtPA were used for thrombolysis of AIS in Asia.Meta-analysis shows that low-dose rtPA was not associated with increased risk of death or disability(OR 1.13,95% CI 0.95 to 1.33),or death(OR 0.86,95% CI 0.74 to 1.01),or decreased risk of sICH(OR 1.06,95% CI 0.65 to 1.72).The results remained consistent when sensitivity analyses were performed including only low-dose and standard-dose rtPA or only Asian studies.Our review shows small difference between the outcomes or the risk profile in the studies using low-dose and/or standard-dose rtPA for AIS.Low-dose rtPA was not associated with lower risk of death or disability,death alone,or sICH. | Xia Wang Shoujiang You Shoichiro Sato Jie Yang Cheryl Carcel Danni Zheng Sohei Yoshimura Craig S Anderson Else Charlotte Sandset Thompson Robinson John Chalmers Vijay K Sharma | 2018 | Stroke & Vascular Neurology2018，3，1： | 10 |
| 5 | Serum levels of soluble Fas, nitric oxide and cytokines in acute decompensated cirrhotic patients显示文摘AIM: To evaluate plasma levels of nitrite/nitrate (NOx), soluble Fas (sFas) antigen, tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in patients with com- pensated and acute decompensated cirrhosis and to evaluate mediators causing acute decompensation in liver cirrhosis. METHODS: This prospective study was conducted in the medical intensive care unit of an academic tertiary center. Fifty-five patients with acute decompensation (gastrointestinal hemorrhage, encephalopathy, hydropic decompensation) and twenty-five patients with compen- sated liver cirrhosis were included. Blood samples were taken for analyses of sFas, Nox, IL-6, TNF-α. Liver en- zymes and kidney functions were also tested. RESULTS: In patients with acute decompensation, plas- ma sFas levels were higher than in non-decompensated patients (15 305 ±4646 vs 12 458 ±4322 pg/mL,, P < 0.05). This was also true for the subgroup of patients with alcoholic liver cirrhosis (P < 0.05). The other media- tors were not different and none of the parameters pre- dicted survival, except for ALT (alanine-aminotransfer- ase). In patients with portal-hypertension-induced acute hemorrhage, NOx levels were significantly lower than in patients with other forms of decompensation (70.8 ± 48.3 vs 112.9 ± 74.9 pg/mL, P < 0.05). When NOx lev- els were normalized to creatinine levels, the difference disappeared. IL-6, TNF-α and sFas were not different between bleeders and non-bleeders. In decompensated patients sFas, IL-6 and NOx levels correlated positively with creatinine levels, while IL-6 levels were dependent on Child class. CONCLUSION: In acute decompensated cirrhotic pa- tients sFas is increased, suggesting a role of apoptosis in this process and patients with acute bleeding have lower NOx levels. However, in this acute complex clinical situa-tion, kidney function seems to have a predominant influ- ence on mediator levels. | Christoph Elsing Sabine Harenberg Wolfgang Stremmel Thomas Herrmann | 2007 | World Journal of Gastroenterology2007，13，3： | 10 |
| 6 | Anti-HIV Ⅰ/Ⅱ Activity and Molecular Cloning of a Novel Mannose/Sialic Acidbinding Lectin from Rhizome of Polygonatum cyrtonema Hua显示文摘 | Jie AN Jin-Zhi LIU Chuan-Fang WU Jian LI Lei DAI Els Van DAMME Jan BALZARINI Erik De CLERCQ Fang CHEN Jin-Ku BAO | 2006 | Acta Biochimica et Biophysica Sinica2006，38，2： | 8 |
| 7 | Purification and Characterization of a Mannose-binding Lectin from the Rhizomes of Aspidistra elatior Blume with Antiproliferative Activity显示文摘有一个新奇 N 终端氨基酸序列的凝集素被硫酸铵降水,离子交换层析 ondiethylaminoethyl-Sepharose 和 carboxymethyl-Sepharose 和凝胶过滤层析 onSephacryl S-100 从蜘蛛抱蛋 elatior 布鲁坶的根茎净化。A。elatior 布鲁坶凝集素(AEL ) 是有 56kDa 的一个分子的团的 heterotetramer 并且一起由 13.5 kDa 和 14.5 kDaheld 的二不同多肽组成由的二 homodimers 创作非共有原子价相互作用。Hapten 抑制试金显示向兔子红血球的 AEL 的那项 hemagglutinating 活动能被 D 甘露糖禁止,甘露聚糖, thyroglobulinand ovomucoid。凝集素是稳定的直到 70 ° C,并且在 7.0-8.0 的一个狭窄的 pH 范围显示出最大的活动。化学修正和光谱分析显示色氨酸,精氨酸,半胱氨酸和 carboxyl 组织残余为它的 hemagglutinating 活动是必要的。然而,他们可能不在活跃中心是在场的,除了一些 carboxyl 组残余。AEL 也出现了在向 Bre-04 (66%) 的 antiproliferative 活动, Lu-04 (60%) 和人的癌症房间的 HepG2 (56%) 衬里的 vitro 重要。 | Xiaochao XU Chuanfang WU Chao LIU Yongting LUO Jian LI Xinping ZHAO Els Van DAMME Jinku BAO | 2007 | Acta Biochimica et Biophysica Sinica2007，39，7： | 8 |
| 8 | Trefoil factors in inflammatory bowel disease显示文摘Inflammatory bowel disease(IBD),which comprises ulcerative colitis and Crohn’s disease,is characterized by inflammation of the gastrointestinal tract.The trefoil factors 1,2,and 3(TFF1-3)are a family of peptides that play important roles in the protection and repair of epithelial surfaces,including the gastrointestinal tract.TFFs may be involved in IBD pathogenesis and are a potential treatment option.In the present review,we describe the TFF family and their potential role in IBD by summarizing the current knowledge of their expression,possible function and pharmacological role in IBD. | Luise Aamann Else Marie Vestergaard Henning Grφnbk | 2014 | World Journal of Gastroenterology2014，20，12： | 6 |
| 9 | 中国—中新世湖泊的古生态:根据山旺盆地植硅体的初步解释显示文摘山东山旺中新世山旺组湖相沉积中富含保存精美的古生物化石。对于湖相沉积中的昆虫、植物和哺乳动物化石,前人已经做了大量的研究工作。其中植物大化石和孢粉的研究结果表明,中新世山旺组在沉积期间,山旺湖周围的植被处于湿润的暖温带到亚热带的古生态环境下。哺乳动物蝙蝠和貘化石的研究结果也支持这个结论。然而,迄今为止,还没有关于草本植物的种类组成及含量的研究报道。本文首次对山旺组样品中的植硅体进行了研究,为山旺中新世植被的研究提供了新的证据。对从6块山旺组样品中分析出的植硅体进行研究的结果表明,山旺中新世植硅体组合含有丰富的保存极好的草本植物植硅体,代表森林成分的双子叶植物植硅体,以及偶尔出现的棕榈科植硅体。草本植物的植硅体主要来自于C_3/C_4禾本科的PACCAD类群和早熟禾亚科的植物,少数可能来自于在林下封闭生活环境中生长的草本植物。山旺中新世植硅体组合显示,在湖边森林生活环境下,伴生大量的适合沼生到中生环境的草本植物,在较干旱的地区生长着早熟禾(和PACCAD)的草本植物。本文的研究结果进一步支持山旺中新世气候比现在更加湿润而且变动较小的观点。山旺中新世植硅体组合与土耳其和北美大平原中新世湖相沉积中的植硅体组合不同,后者的植硅体组合主要是由多种C_3早熟禾亚科草本和不同种类的PACCAD类群草本植物组成。今后的研究工作将进一步揭示这种差异是否反映了草本植物群落在大尺度的生物地理上的差异,或者是由于地区性的局部气候不同所导致。 | Caroline A.E.STRoMBERG Else Marie FRIIS 梁明媚 Lars WERDELIN 张玉亮 | 2007 | 古脊椎动物学报2007，45，2： | 6 |
| 10 | 加兰他敏治疗轻至中度阿尔茨海默病人的有效性及安全性:多中心随机对照试验显示文摘 | Gordon K Wilcock Sean Lilienfeld Els Gaens 殷剑 | 2001 | 英国医学杂志中文版2001，4，4： | 5 |
| 11 | Metformin in patients with non-alcoholic fatty liver disease: A randomized, controlled trial显示文摘 | John Willy Haukeland Zbigniew Konopski Heidi Beate Eggesb? Hilde L?land von Volkmann Gabriele Raschpichler Kristian Bj?ro Terese Haaland Else Marit L?berg K?re Birkeland | 2009 | Scandinavian Journal of Gastroenterology2009，，7： | 3 |
| 12 | Nondestructive measurement of fruit and vegetable quality by means of NIR spectroscopy: A review显示文摘 | Bart M. Nicola? Katrien Beullens Els Bobelyn Ann Peirs Wouter Saeys Karen I. Theron Jeroen Lammertyn | 2007 | Postharvest Biology and Technology2007，，2： | 3 |
| 13 | Pentetration of carboplatin and cisplatin into rat peritoneal tumor nodules after intraperitoneal chemotherapy显示文摘 | Gerrit Los Els M. E. Verdegaal Peter H. A. Mutsaers J. Gordon McVie | 1991 | Cancer Chemotherapy and Pharmacology1991，，3： | 3 |
| 14 | Risk factors for colonic diverticular bleeding:A Westernized community based hospital study显示文摘AIM:To evaluate the risk factors-other than nonsteroidal anti-inflammatory drugs-for colonic diverticular bleeding in a westernized population. METHODS:One hundred and forty patients,treated for symptomatic diverticular disease in a community based hospital,were included.Thirty(21%) had signs of diverticular bleeding.Age,gender,and the results of colonoscopy were collected and compared to a group of patients with nonbleeding symptomatic diverticulosis.Records were reviewed for comorbidities,such as obesity,alcohol consumption,smoking habits and metabolic diseases.Special emphasis was put on arterial hypertension,cardiovascular events,diabetes mellitus,hyperuricemia and hypercholesterinemia. RESULTS:There was no difference between patients with diverticular hemorrhage and those with nonbleeding symptomatic diverticulosis regarding gender ratio(male/female 9/21 vs 47/63) and diverticular localisation.Bleeding patients differed in respect to age(73.4±9.9 vs 67.8±13.0,P<0.013) . Significant differences were found between both groups regarding the presence of hyperuricemia and use of steroids and nonsteroidal anti-inflammatory drugs.Patients with three concomitant metabolic diseases were also identified as being at risk of bleeding.A forward stepwise logistic regression analysis revealed steroids,hyperuricemia and the use of calcium-channel blockers as independent risk factors of bleeding.CONCLUSION:Beside nonsteroidal anti-inflammatory steroid drug use,antihypertensive medication and concomitant arteriosclerotic diseases are risk factors for colonic diverticular hemorrhage.Our results support the hypothesis of an altered arteriosclerotic vessel as the source of bleeding. | Antje Jansen Sabine Harenberg Uwe Grenda Christoph Elsing | 2009 | World Journal of Gastroenterology2009，15，4： | 3 |
| 15 | Alcohol binging causes peliosis hepatis during azathioprine therapy in Crohn's disease显示文摘Patients with inflammatory bowel disease have normal life expectancy and, due to modern immunosuppressive therapies, also a normal quality of life. Since mostly young people are affected, their social behaviour suits this environment. Alcohol binging is an increasingly disturbing factor among young people. We describe a patient with Crohn's disease, treated with azathioprine, who developed peliosis hepatis after three epsiodes of alcohol binging. Liver toxicity was not observed previously during the course of the treatment. Azathioprine-induced peliosis hepatis is thought to be idiosyncratic in humans. From animal studies, however, it is clear that hepatic depletion of glutathione leads to azathioprine toxicity to the sinusoidal endothelial cells. Damage of these cells causes peliosis hepatis. Since alcohol binging leads to hepatic glutathione depletion, we conclude that in our patient the episodes of binging have reduced liver gluathione content and therefore this has increased azathioprine toxicity causing peliosis hepatis. The problem of alcohol binging has not yet been addressed in IBD patients undertaking immunosuppressive therapy. This should be reviewed in future considerations regarding patients advice. | Christoph Elsing Joerg Placke Thomas Herrmann | 2007 | World Journal of Gastroenterology2007，13，34： | 3 |
| 16 | Heterogeneity across the murine small and large intestine显示文摘The small and large intestine of the gastrointestinal tract(GIT) have evolved to have discrete functions with distinct anatomies and immune cell composition.The importance of these differences is underlined when considering that different pathogens have uniquely adapted to live in each region of the gut.Furthermore,different regions of the GIT are also associated with differences in susceptibility to diseases such as cancer and chronic inflammation.The large and small intestine,given their anatomical and functional differences,should be seen as two separate immunological sites.However,this distinction is often ignored with findings from one area of the GIT being inappropriately extrapolated to the other.Focussing largely on the murine small and large intestine,this review addresses the literature relating to the immunology and biology of the two sites,drawing comparisons between them and clarifying similarities and differences.We also highlight the gaps in our understanding and where further research is needed. | Rowann Bowcutt Ruth Forman Maria Glymenaki Simon Richard Carding Kathryn Jane Else Sheena Margaret Cruickshank | 2014 | World Journal of Gastroenterology2014，20，41： | 2 |
| 17 | Fatigue in children and adolescents with inflammatory bowel disease显示文摘AIM To identify factors other than active disease and anemia that contribute to fatigue in pediatric inflammatory bowel disease(IBD).METHODS We performed an electronic search in Medline and EMBASE from their inception to May 2017 using the search term 'fatigue' or the related keywords 'physical impairment' and 'inflammatory bowel disease' with the filter 'child'(age 0-18 years). Cross-sectional and case-control studies were included. We restricted our search to studies published in English. We used the PRISMA checklist and flow diagram. Duplicate articles were manually deleted in End Note. To identify further relevant studies, we checked the reference lists of the selected articles.RESULTS We identified 149 papers, of which 19 were retrieved for full text review. Eleven studies were subsequently excluded because fatigue was not evaluated as an outcome measure. Eight papers focused on the desired topic and were discussed in the final analysis. A lack of uniformity of outcome measures made the pooling of data impossible. In all but one study, questionnaires were used to evaluate fatigue. In the remaining study, an accelerometer was used to measure daily activities, sleeping time and their relationships with fatigue in a more quantifiable manner. Adolescents with IBD are significantly more fatigued than healthy controls. In addition to active disease, increased anxiety or depression and disturbed family relationships were frequently reported predictors of fatigue. Quantitative measurement of physical activity in patients with Crohn's disease showed a reduction in the number of steps per day, and patients with ulcerative colitis had a shorter duration of physical activity during the day.CONCLUSION Fatigue in pediatric IBD is related to a combination of biological, functional and behavioral factors, which should all be taken into account when managing fatigue. | Els Van de Vijver Ann Van Gils Laura Beckers Yannick Van Driessche Nicolette Dorien Moes Patrick Ferry van Rheenen | 2019 | World Journal of Gastroenterology2019，25，5： | 2 |
| 18 | Combining transient elastography with FIB4 enhances sensitivity in detecting advanced fibrosis of the liver显示文摘 | Hans Lannerstedt Zbigniew Konopski Leiv Sandvik Terese Haaland Else Marit Lø berg John Willy Haukeland | 2013 | Scandinavian Journal of Gastroenterology2013，，1： | 2 |
| 19 | Targeting Dexamethasone to Macrophages in a Porcine Endotoxemic Model显示文摘 | Asger Granfeldt Christine Lodberg Hvas Jonas Heilskov Graversen Peter Astrup Christensen Mikkel Due Petersen Gabriela Anton Pia Svendsen Christoffer S?lling Anders Etzerodt Else T?nnesen S?ren Kragh Moestrup Holger Jon M?ller | 2013 | Critical Care Medicine2013，，11： | 2 |
| 20 | Mitochondrial Reactive Oxygen Species and Risk of Atherosclerosis显示文摘 | Maarten Hulsmans Els Dooren Paul Holvoet | 2012 | Current Atherosclerosis Reports2012，，3： | 2 |
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