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| 1 | Inflammatory pathways of importance for management of inflammatory bowel disease显示文摘Inflammatory bowel disease(IBD)is a group of chronic disorders of the gastrointestinal tract comprising Crohn’s disease(CD)and ulcerative colitis(UC).Their etiologies are unknown,but they are characterised by an imbalanced production of pro-inflammatory mediators,e.g.,tumor necrosis factor(TNF)-α,as well as increased recruitment of leukocytes to the site of inflammation.Advantages in understanding the role of the inflammatory pathways in IBD and an inadequate response to conventional therapy in a large portion of patients,has over the last two decades lead to new therapies which includes the TNF inhibitors(TNFi),designed to target and neutralise the effect of TNF-α.TNFi have shown to be efficient in treating moderate to severe CD and UC.However,convenient alternative therapeutics targeting other immune pathways are needed for patients with IBD refractory to conventional therapy including TNFi.Indeed,several therapeutics are currently under development,and have shown success in clinical trials.These include antibodies targeting and neutralising interleukin-12/23,small pharmacologic Janus kinase inhibitors designed to block intracellular signaling of several pro-inflammatory cytokines,antibodies targeting integrins,and small anti-adhesion molecules that block adhesion between leukocytes and the intestinal vascular endothelium,reducing their infiltration into the inflamed mucosa.In this review we have elucidated the major signaling pathways of clinical importance for IBD therapy and highlighted the new promising therapies available.As stated in this paper several new treatment options are under development for the treatment of CD and UC,however,no drug fits all patients.Hence,optimisations of treatment regimens are warranted for the benefit of the patients either through biomarker establishment or other rationales to maximise the effect of the broad range of mode-of-actions of the present and future drugs in IBD. | Jannie Pedersen Mehmet Coskun Christoffer Soendergaard Mohammad Salem Ole Haagen Nielsen | 2014 | World Journal of Gastroenterology2014，20，1： | 28 |
| 2 | Bariatric surgery in patients with non-alcoholic fatty liver disease-from pathophysiology to clinical effects显示文摘Non-alcoholic fatty liver disease(NAFLD) is increasingly recognized as a significant liver disease,and it covers the disease spectrum from simple steatosis with a risk of development of non-alcoholic steatohepatitis(NASH) to fibrosis,subsequent cirrhosis,end-stage liver failure,and liver cancer with a potential need for liver transplantation.NAFLD and NASH are closely related to obesity,metabolic syndrome,and type 2 diabetes(T2 D).The role of gut hormones,especially glucagon-like peptide 1(GLP-1),is important in NAFLD.Bariatric surgery has the potential for inducing great weight loss and may improve the symptoms of metabolic syndrome and T2 D.Recent data demonstrated significant effects of bariatric surgery on GLP-1 and other gut hormones and important lipid metabolic and inflammatory abnormalities in the pathophysiology of NAFLD.Therefore,bariatric surgery may reverse the pathological liver changes in NAFLD and NASH patients.In the present review,we describe NAFLD and NASH pathophysiology and the primary effects of bariatric surgery on metabolic pathways.We performed a systematic review of the beneficial and harmful effects and focused on changes in liver disease severity in NAFLD and NASH patients.The specific focus was liver histopathology as assessed by the invasive liver biopsy.Additionally,we reviewed several non-invasive methods used for the assessment of liver disease severity following bariatric surgery. | Tea L Laursen Christoffer A Hagemann Chunshan Wei Konstantin Kazankov Karen L Thomsen Filip K Knop Henning Grønbæk | 2019 | World Journal of Hepatology2019，11，2： | 11 |
| 3 | A sensitivity study of the WRF model in offshore wind modeling over the Baltic Sea显示文摘Accurate wind modeling is important for wind resources assessment and wind power forecasting. To improve the WRF model configuration for the offshore wind modeling over the Baltic Sea, this study performed a sensitivity study of the WRF model to multiple model configurations, including domain setup,grid resolution, sea surface temperature, land surface data, and atmosphere-wave coupling. The simulated offshore wind was evaluated against LiDAR observations under different wind directions, atmospheric stabilities, and sea status. Generally, the simulated wind profiles matched observations, despite systematic underestimations. Strengthening the forcing from the reanalysis data through reducing the number of nested domains played the largest role in improving wind modeling. Atmosphere-wave coupling further improved the simulated wind, especially under the growing and mature sea conditions.Increasing the vertical resolution, and updating the sea surface temperature and the land surface information only had a slight impact, mainly visible during very stable conditions. Increasing the horizontal resolution also only had a slight impact, most visible during unstable conditions. Our study can help to improve the wind resources assessment and wind power forecasting over the Baltic Sea. | Huidong Li Björn Claremar Lichuan Wu Christoffer Hallgren Heiner Körnich Stefan Ivanell Erik Sahlée | 2021 | Geoscience Frontiers2021，12，6： | 2 |
| 4 | Targeting Dexamethasone to Macrophages in a Porcine Endotoxemic Model显示文摘 | Asger Granfeldt Christine Lodberg Hvas Jonas Heilskov Graversen Peter Astrup Christensen Mikkel Due Petersen Gabriela Anton Pia Svendsen Christoffer S?lling Anders Etzerodt Else T?nnesen S?ren Kragh Moestrup Holger Jon M?ller | 2013 | Critical Care Medicine2013，，11： | 2 |
| 5 | Insecticidal activity and mode of action of novel nicotinoids synthesized by new acylpyridinium salt chemistry and directed lithiation pesticide显示文摘 | ChristofF S Daniel L C Thomas C S | 2007 | Biochemistry and Physiology2007，87，： | 1 |
| 6 | Photolytic transformation of polychlorinated dioxins and dibenzofurans in fly ash显示文摘 | MATS TYSKLIND CHRISTOFFER RAPPE | 1991 | Chemosphere1991，23，： | 1 |
| 7 | Proteomic analysis of a multi-resistant clinical Escherichia coli isolate of unknown genomic background显示文摘 | Gisele G. Tomazella Kine Risberg Haima Mylvaganam Paul Christoffer Lindemann Bernd Thiede Gustavo A. de Souza Harald G. Wiker | 2011 | Journal of Proteomics2011，，6： | 1 |
| 8 | Extremely low-frequency magnetic fields and heart disease显示文摘 | Leeka K Anders A Christoffer J | 2007 | Scand J Work Environ Health2007，33，1： | 1 |
| 9 | Stereoselective construction of quaternary stereocenters advanced synthesis & catalysis 显示文摘 | Christoffers J Baro A | 2005 | Adv Synth Cata12005，347，： | 1 |
| 10 | Effect of low-level GaA1As laser irradiation on the proliferation rate of human periodontal ligament fibro-blasts:An in vitro study显示文摘 | Kreisler M Christoffers AB Wiliershausen B | 2003 | J ClinPeriodontol2003，30，4： | 1 |
| 11 | Effect of low-level GaA1As laser irradiation on the proliferation rate of human periodontal ligament fibroblasts : An in vitro study 显示文摘 | Kreisler M Christoffers AB Willershausen B | 2003 | J Clin Periodontol2003，30，4： | 1 |
| 12 | Ecological Modernization, Ecological Modernities 显示文摘 | Christoff P | 1996 | Environmental Politics1996，5，3： | 1 |
| 13 | α-Hydroxylation of β-Dicarbonyl Compounds显示文摘 | Christoffers J Baro A Werner T | 2004 | Adv Synth Catal2004，346，2： | 1 |
| 14 | The INTERPHONE study: design, epidemiological methods, and description of the study population显示文摘 | Elisabeth Cardis Lesley Richardson Isabelle Deltour Bruce Armstrong Maria Feychting Christoffer Johansen Monique Kilkenny Patricia McKinney Baruch Modan Siegal Sadetzki Joachim Schüz Anthony Swerdlow Martine Vrijheid Anssi Auvinen Gabriele Berg Maria Blet | 2007 | European Journal of Epidemiology2007，，9： | 1 |
| 15 | Synthesis of tetra- hydropyran-4-ones and thiopyran-4-ones from donor- substituted c~-bromostyrene derivatives 显示文摘 | Rosiak A Frey W Christoffers J | 2006 | Eur J Org Chem2006，，17： | 1 |
| 16 | High susceptibility of neural stem cells to methylmercury toxicity:effects on cell survival and neuronal differentiation显示文摘 | Joshua D Ola H | 2006 | J Neurochem2006，97，1： | 1 |
| 17 | Four genes,morphology and ecology:distinguishing a new species of Acesta(Mollusca;Bivalvia)from the Gulf of Mexico显示文摘 | Johanna J Christoffer S Jon-Arne S | 2007 | Mar Biol2007，，152： | 1 |
| 18 | Low-level 809 nm GaAIAs laser irradiation increases the proliferation rate of human laryngeal carcinoma cells in vitro显示文摘 | Kreisler M Christoffers AB Willershaasen B | 2003 | Lasers Med Sci2003，18，1： | 1 |
| 19 | Survival of patients with BRCAl-assoeiated breast cancer diagnosed in an MRI-based surveillance program显示文摘 | Stormorken Christoffer Jonsrud Marit Muri Holmen Anne Irene Hagen Neal Clark Anita Sun Steven A Narod Lovise | 2013 | Breast cancer research and treatment2013，139，1： | 1 |
| 20 | Crohn’s disease and cancer risk (Denmark)显示文摘 | Lene Mellemkj?r Christoffer Johansen Gloria Gridley Martha S. Linet Susanne Krüger Kj?r J?rgen H. Olsen | 2000 | Cancer Causes and Control2000，，2： | 1 |
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