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您的检索式：作者名="Birgit Weynand"
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| 1 | A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling显示文摘The stromal compartment of the tumor microenvironment consists of a heterogeneous set of tissue-resident and tumor-infiltrating cells,which are profoundly moulded by cancer cells.An outstanding question is to what extent this heterogeneity is similar between cancers affecting different organs.Here,we profile 233,591 single cells from patients with lung,colorectal,ovary and breast cancer(n=36)and construct a pan-cancer blueprint of stromal cell heterogeneity using different single-cell RNA and protein-based technologies.We identify 68 stromal cell populations,of which 46 are shared between cancer types and 22 are unique.We also characterise each population phenotypically by highlighting its marker genes,transcription factors,metabolic activities and tissue-specific expression differences.Resident cell types are characterised by substantial tissue specificity,while tumor-infiltrating cell types are largely shared across cancer types.Finally,by applying the blueprint to melanoma tumors treated with checkpoint immunotherapy and identifying a naive CD4+T-cell phenotype predictive of response to checkpoint immunotherapy,we illustrate how it can serve as a guide to interpret scRNA-seq data.In conclusion,by providing a comprehensive blueprint through an interactive web server,we generate the first panoramic view on the shared complexity of stromal cells in different cancers. | Junbin Qian Siel Olbrecht Bram Boeckx Hanne Vos Damya Laoui Emre Etlioglu Els Wauters Valentina Pomella Sara Verbandt Pieter Busschaert Ayse Bassez Amelie Franken Marlies Vanden Bempt Jieyi Xiong Birgit Weynand Yannick van Herck Asier Antoranz Francesca Maria Bosisio Bernard Thienpont Giuseppe Floris Ignace Vergote Ann Smeets Sabine Tejpar Diether Lambrechts | 2020 | Cell Research2020，30，9： | 11 |
| 2 | Contrast EUS Versus EUS Sono-Elastography in the Differentiation of Atypical Pancreatic Masses显示文摘 | Pierre H. Deprez Chun-Ping R. Yeung Birgit Weynand Cedric Gillain Jean-Fran?ois Gigot Catherine Hubert Yves Horsmans Ivan Borbath | 2007 | Gastrointestinal Endoscopy2007，，5： | 1 |
| 3 | Results of selective neck dissection in the primary management of head and neck squamous cell carcinoma显示文摘 | Sandra Schmitz Jean-Pascal Machiels Birgit Weynand Vincent Gregoire Marc Hamoir | 2009 | European Archives of Oto - Rhino - Laryngology2009，，3： | 1 |
| 4 | Pneumoproteins as markers of paraquat lung injury: A clinical case显示文摘 | Philippe Hantson Birgit Weynand Ian Doyle Alfred Bernand Cedric Hermans | 2006 | Journal of Forensic and Legal Medicine2006，，： | 1 |
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