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| 1 | Current status of intravenous tissue plasminogen activator dosage for acute ischaemic stroke:an updated systematic review显示文摘The optimal dose of recombinant tissue plasminogen activator(rtPA)for acute ischaemic stroke(AIS)remains controversial,especially in Asian countries.We aimed to update the evidence regarding the use of low-dose versus standard-dose rtPA.We performed a systematic literature search across MEDLINE,Embase,Cochrane Central Register of Controlled Trials(CENTRAL),PsycINFO and Cumulative Index to Nursing and Allied Health Literature(CINAHL)from inception to 22 August 2016 to identify all related studies.The outcomes were death or disability(defined by modified Rankin Scale 2-6),death,and symptomatic intracerebral haemorrhage(sICH).Where possible,data were pooled for meta-analysis with ORs and corresponding 95% CIs by means of random-effects or fixed-effects meta-analysis.We included 26 observational studies and 1 randomised controlled trial with a total of 23210 patients.Variable doses of rtPA were used for thrombolysis of AIS in Asia.Meta-analysis shows that low-dose rtPA was not associated with increased risk of death or disability(OR 1.13,95% CI 0.95 to 1.33),or death(OR 0.86,95% CI 0.74 to 1.01),or decreased risk of sICH(OR 1.06,95% CI 0.65 to 1.72).The results remained consistent when sensitivity analyses were performed including only low-dose and standard-dose rtPA or only Asian studies.Our review shows small difference between the outcomes or the risk profile in the studies using low-dose and/or standard-dose rtPA for AIS.Low-dose rtPA was not associated with lower risk of death or disability,death alone,or sICH. | Xia Wang Shoujiang You Shoichiro Sato Jie Yang Cheryl Carcel Danni Zheng Sohei Yoshimura Craig S Anderson Else Charlotte Sandset Thompson Robinson John Chalmers Vijay K Sharma | 2018 | Stroke & Vascular Neurology2018，3，1： | 10 |
| 2 | Occurrence of Vitamin D Deficiency in Pediatric Patients at High Risk in West Virginia显示文摘 | Christy Robinson Myra Chiang Stephanie N. Thompson Stephen B. Sondike | 2012 | Southern Medical Journal2012，，10： | 1 |
| 3 | Characteristics,management and response to alteplase in China versus non-China participants of the ENCHANTED trial显示文摘Background The characteristics of patients with acute ischaemic stroke(AIS)and their management vary across regions,which may influence outcomes.We examined for differential patterns of outcome between China and non-China participants of the ENhanced Control of Hypertension And Thrombolysis strokE stuDy(ENCHANTED),which tested different alteplase doses in AIS.Methods ENCHANTED was an international,multicentre,open,blinded-endpoint trial of the effects of low-dose(0.6 mg/kg)versus standard-dose(0.9 mg/kg)intravenous alteplase on 90-day disability outcomes and symptomatic intracerebral haemorrhage(sICH)in 3310 patients with AIS.Results Participants(n=1419,48%)in China were younger,and more often male,hypertensive and with prior stroke and coronary artery disease,but less likely to have atrial fibrillation and use antihypertensive,antithrombotic and lipid-lowering agents,compared with non-China patients with AIS.Although China participants had more AIS due to large artery occlusion,were treated later and had differing ancillary management,there was no significant difference in 90-day modified Rankin scale scores 2–6(55.6% vs 47.8%;OR,adjusted for baseline and management factors 0.87(95%CI 0.71 to 1.07;p=0.20))and risk of sICH(Safe Implementation of Thrombolysis in Stroke-Monitoring Study criteria:1.4% vs 1.8%;p=0.12)compared with non-China participants.There was no heterogeneity in the treatment effects of low-dose versus standard-dose alteplase between China and non-China participants.Conclusion Patients with AIS recruited to the ENCHANTED trial in China had similar outcomes in response to thrombolysis treatment despite significantly differing demographic,clinical and management factors to patients with AIS in other regions. | Lily Song Xia Wang Thompson Robinson Richard I Lindley Hisatomi Arima Pablo M Lavados Xiaoying Chen John Chalmers Craig S Anderson | 2017 | Stroke & Vascular Neurology2017，2，2： | 1 |
| 4 | A meta-analysis of cognitive deficits in euthymic patients with bipolar disorder显示文摘 | Robinson LJ Thompson JM Gallagher P | 2006 | J Affect Disord2006，93，13： | 1 |
| 5 | A meta- analysis of cognitive deficits in euthymic patients with bipolar disorder显示文摘 | Robinson LJ Thompson JM Gallagher P | 2006 | J Afect Disord2006，93，13： | 1 |
| 6 | Loss of cation - chloride cotransporter expression in preterm infants with white matter lesions:Im- plications for the pathogenesis of epilepsy显示文摘 | Robinson S Mikolaenko I Thompson I | 2010 | J Neuropathol Exp Neu- rol2010，69，： | 1 |
| 7 | A meta- analysis of cognitive deficits in euthymic patients with bipolar disorder 显示文摘 | Robinson LJ Thompson JM Gallagher P | 2006 | J Affect Disord2006，93，123： | 1 |
| 8 | The rela- tion between accounting goodwill numbers and equity values显示文摘 | Jennings R J Robinson R Thompson | 1996 | Journal of Business Finance & Accounting1996，23，： | 1 |
| 9 | Ovarian cancer cell-derived migration inhibitory factor enhances tumor growth grogression and angiogenesis显示文摘 | Hagemann T Robinson SC Thompson RG | 2007 | Mol Cancer Ther2007，6，7： | 1 |
| 10 | A meta-analysis of cognitive deficits in euthymic patients with bipolar disorder显示文摘 | ROBINSON L J THOMPSON J M GALLAGHER P | 2006 | Journal of Affective Disorders2006，93，13： | 1 |
| 11 | Smoking influences outcome in patients who had thrombolysed ischaemic stroke:the ENCHANTED study显示文摘Background and purpose As studies vary in defining the prognostic significance of smoking in acute ischaemic stroke(AIS),we aimed to determine the relation of smoking and key outcomes in patient participants who had thrombolysed AIS of the international quasi-factorial randomised Enhanced Control of Hypertension and Thrombolysis Stroke Study(ENCHANTED).Methods Post-hoc analyses of ENCHANTED,an international quasi-factorial randomised evaluation of intravenous alteplase-dose comparison and levels of blood pressure control in patients who had thrombolysed AIS.Multivariable logistic regression models with inverse probability of treatment weighting(IPTW)propensity scores were used to determine associations of self-reported smoking status and clinical outcomes,according to 90-day modified Rankin Scale(mRS)scores and symptomatic intracerebral haemorrhage(sICH).Results Of 4540 patients who had an AIS,there were 1008(22.2%)current smokers who were younger and predominantly male,with more comorbidities of hypertension,coronary artery disease,atrial fibrillation and diabetes mellitus,and greater baseline neurological impairment,compared with non-smokers.In univariate analysis,current smokers had a higher likelihood of a favourable shift in mRS scores(OR 0.88,95%CI 0.77 to 0.99;p=0.038)but this association reversed in a fully adjusted model with IPTW(adjusted OR 1.15,95%CI 1.04 to 1.28;p=0.009).A similar trend was also apparent for dichotomised poor outcome(mRS scores 2–6:OR 1.18,95%CI 1.05 to 1.33;p=0.007),but not with the risk of sICH across standard criteria.Conclusion Smoking predicts poor functional recovery in patients who had thrombolysed AIS.Trial registration number NCT01422616. | Lingli Sun Lili Song Jie Yang Richard I Lindley Thompson Robinson Pablo M Lavados Candice Delcourt Hisatomi Arima Bruce Ovbiagele John Chalmers Craig S Anderson Xia Wang | 2021 | Stroke & Vascular Neurology2021，6，3： | 1 |
| 12 | A meta-analysis of cognitivedefieits in euthymic patients with bipolar disorder显示文摘 | Robinson L Thompson J Gallagher P | 2006 | Journal of Affective Disorders2006，93，13： | 1 |
| 13 | Ovarian cancer cell-derived migration inhibitory factor enhances tumor growth,progression,and angiogenesis显示文摘 | Hagemann T Robinson SC Thompson RG | | 0，，07： | 1 |
| 14 | Breast feeding and intelligence of preschool children显示文摘 | Slykerman RF Thompson JMD Becroft DMO Robinson E Pryor JE Clark PM | 2005 | Acta Paediatrica2005，94，7： | 1 |
| 15 | Ovarian caneer cell- derived migration inhibitory factor enhances tumor growth, progres- sion, and angiogenesis 显示文摘 | Hagemann T Robinson SC Thompson RG | 2007 | Mol Cancer Ther2007，6，7： | 1 |
| 16 | Regional forest frag- mentation and the nesting success of migratory birds显示文摘 | Robinson S K Thompson F R Donovan T M | 1995 | Science1995，267，5206： | 1 |
| 17 | Prognostic significance of electrocardiographic site of infarction after correction for enzymatic size of infarction显示文摘 | MARK E. HANDS BRIAN L. LLOYD JAMES S. ROBINSON NICHOLAS DE KLERK PETER L. THOMPSON | 1986 | Circulation1986，，5： | 1 |
| 18 | Risk factors for small-for-gestational-age babies: the Auckland birthweight collaborative study显示文摘 | Thompson JMD Clark PM Robinson E | 2001 | J Paediatr Child Health2001，37，： | 1 |
| 19 | A meta- analysis of cognitive deficits in euthymic patients with bipolar disorder显示文摘 | Robinson LJ Thompson JM Gallagher P | 2006 | J Affect Disord2006，93，13： | 1 |
| 20 | Ovarian cancer cell-derived migration inhibitory factor enhances tumor growth,progression,and angiogenesis显示文摘 | Hagemann T Robinson SC Thompson RG | | 0，，： | 1 |
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