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| 1 | 氢燃料内燃机技术现状与发展展望显示文摘介绍了氢气及氢燃料内燃机的特点及氢燃料内燃机的技术现状。通过对比分析指出氢燃料内燃机既可以采用清洁可再生能源,又可以充分利用现有的庞大工业体系,是实现氢气经济的现实途径。 | 刘福水 郝利君 Heitz Peter Berg | 2006 | 汽车工程2006，28，7： | 31 |
| 2 | Seed selections for crystallization of calcium phosphate for phosphorus recovery显示文摘种子导致并且支持恢复的磷(P) .In 顺序的钙磷酸盐,和 actsas 搬运人的结晶化为 P 恢复 fromwastewater 选择合适的种子,三粒种子包括磷灰石( AP ), Juraperle ( JP )和 weretested 和 compared.Batch 和改正床列 calciumphosphate 的播种结晶化试验的修改磷酸盐的 Juraperle ( M-JP )被使用合成废水, 10 mgP/L.It 出现了承担那 AP 在结晶化过程有 badenduring 性质, | SONG Yong-hui Dietfried DONNERT Ute BERG Peter G. WEIDLER Rolf NUEESCH | 2007 | Journal of Environmental Sciences2007，19，5： | 16 |
| 3 | Design and dynamic simulation of hydraulic system of a new automatic transmission显示文摘A new hydraulic system of a novel automatic transmission (AT) was designed. The dimension and structure of valves and cylinders were designed by theoretical calculation. The dynamic simulation model of hydraulic system of AT was established by ITI-SimulationX. Simulation results and theoretical design results were compared to confirm the simulation model. Based on the confirmed simulation model, the simulation results of pressure and flow of the hydraulic system were analyzed. The dynamic simulation method is very helpful for designing and analyzing the performance of hydraulic system and further optimization design. The theoretical design method and dynamic simulation model are feasible for the real industrial applications. The research results can be used in hydraulic system design and optimization. | 王书翰 徐向阳 刘艳芳 戴振坤 TEN BERGE P 曲巍 | 2009 | Journal of Central South University2009，16，4： | 15 |
| 4 | Computed tomography-guided percutaneous core needle biopsy in pancreatic tumor diagnosis显示文摘AIM: To evaluate the techniques, results, and complications related to computed tomography(CT)-guided percutaneous core needle biopsies of solid pancreatic lesions.METHODS: CT-guided percutaneous biopsies of solid pancreatic lesions performed at a cancer reference center between January 2012 and September 2013 were retrospectively analyzed. Biopsy material was collected with a 16-20 G Tru-Core needle(10-15 cm; Angiotech, Vancouver, CA) using a coaxial system and automatic biopsy gun. When direct access to the lesion was not possible, indirect(transgastric or transhepatic) access or hydrodissection and/or pneumodissection maneuvers were used. Characteristics of the patients, lesions, procedures, and histologic results were recorded using a standardized form. RESULTS: A total of 103 procedures included in the study were performed on patients with a mean age of 64.8 year(range: 39-94 year). The mean size of the pancreatic lesions was 45.5 mm(range: 15-195 mm). Most(75/103, 72.8%) procedures were performed via direct access, though hydrodissection and/or pneumodissection were used in 22.2%(23/103) of cases and indirect transhepatic or transgastric access was used in 4.8%(5/103) of cases. Histologic analysis was performed on all biopsies, and diagnoses were conclusive in 98.1%(101/103) of cases, confirming3.9%(4/103) of tumors were benign and 94.2%(97/103) were malignant; results were atypical in 1.9%(2/103) of cases, requiring a repeat biopsy to diagnose a neuroendocrine tumor, and surgical resection to confirm a primary adenocarcinoma. Only mild/moderate complications were observed in 9/103 patients(8.7%),and they were more commonly associated with biopsies of lesions located in the head/uncinate process(n =8), than of those located in the body/tail(n = 1) of the pancreas, but this difference was not significant.CONCLUSION: CT-guided biopsy of a pancreatic lesion is a safe procedure with a high success rate, and is an excellent option for minimally invasive diagnosis. | Chiang J Tyng Maria Fernanda A Almeida Paula NV Barbosa Almir GV Bitencourt José Augusto AG Berg Macello S Maciel Felipe JF Coimbra Luiz Henrique O Schiavon Maria Dirlei Begnami Marcos D Guimares Charles E Zurstrassen Rubens Chojniak | 2015 | World Journal of Gastroenterology2015，21，12： | 14 |
| 5 | A CASE FOR SERVICE SYSTEMS ENGINEERING显示文摘A case is made for further developing a branch of systems engineering that focuses on problemsand issues which arise in the service sector. We promulgate this special focus not only because of thesize and importance of the service sector but also because of the unique opportunities that systemsengineering can exploit in the design and joint production and delivery of services. We begin byconsidering the economic, technological and demographic contexts within which the service sectorhas flourished; we then address both services, especially emerging services, and systems engineering,followed by a discussion of how to advance the field of service systems engineering, and concludingwith several remarks. In particular, a number of service systems engineering methods are identified toenhance the design and production/delivery of services, especially taking advantage of the uniquefeatures that characterize services - namely, services, especially emerging services, are information-driven, customer-centric, e-oriented, and productivity-focused. | James M.TIEN Daniel BERG | 2003 | Systems Science and Systems Engineering2003，12，1： | 13 |
| 6 | Catalytic domain of PDC-E2 contains epitopes recognized by antimitochondrial antibodies in primary biliary cirrhosis显示文摘AIM:To search for further immunodominant peptides of the pyruvate dehydrogenase complex E2-component (PDC-E2) recognized by antimitochondrial antibodies (AMA) in primary biliary cirrhosis (PBC). METHODS:Sera from 95 patients with PBC were tested by enzyme-linked immunosorbent assay against 33 synthetic overlapping peptides (25 amino acids; aa) covering the entire length of the E2-subunit of PDC-E2. Furthermore,the inner lipoyl peptide 167-184 was used in an unlip oylated and a lipoylated form as well as coupled to ovalbumin. Sera from 11 AMA negative/ANA posit ive PBC patients,63 patients with other liver disorders and 22 healthy blood donors served as controls.RESULTS:Of the 95 PBC-sera,74% reacted with the peptide 475-499 and 58% with the pept ide 407-431 located within the catalytic domain of PDC-E2. Patients with other disorders or healthy controls were positive in only up to 18%. Antibodies to the unlipoylatedand lip oylated pept ide 167-184 within the inner lipoyl domain were found in only 5% and 11% of the PBC sera,respectively; using ovalbumin-coupled peptides,the incidence increased up to 57% (unlipoylated form). CONCLUSION:Peptides within the catalytic site of PDC-E2 rather than the previously reported lipoyl binding peptide 167-184 may represent major immunodomin ant epitopes recognized by AMA in PBC. | Sandra Braun Christoph Berg Sandra Buck Michael Gregor Reinhild Klein | 2010 | World Journal of Gastroenterology2010，16，8： | 13 |
| 7 | 《汉语语气词“了”:汉语的语篇构造和语用标记》介绍显示文摘 | M.van den Berg Wu Guo 杨素英(译) 黄月圆(译) | 2009 | 当代语言学2009，11，1： | 11 |
| 8 | 多环芳烃污染区域氧化多环芳烃的来源、迁移转化和毒性危害显示文摘本文阐明了在对高浓度多环芳烃污染区域进行风险评估和修复过程中,氧化多环芳烃是不容忽视的重要污染物。我们通过对自己的研究成果和公开发表资料的综合分析,发现在这些地方氧化多环芳烃的量较大,但并未受到足够重视。这些氧化多环芳烃是通过多环芳烃转化而来的,滞留时间也较长。许多修复方法会加速多环芳烃的降解,从而导致在环境中的氧化多环芳烃浓度升高。此外,我们发现尽管氧化多环芳烃与通过诱变和致癌等多环芳烃常见的毒害有区别的方式产生毒性,但他们对人类和环境也是有害的。我们还有数据支持以下假说:在环境中,具有极性的氧化多环芳烃比多环芳烃稳定性差,更易通过受污染地区的地表水和地下水扩散。因此在受多环芳烃污染区域,氧化多环芳烃应该纳入监测项目当中,而其它毒性相关成分如带硝基的多环芳烃和氮杂环芳烃等则不必纳入监洲项目当中。因为氧化多环芳烃有可能在多环芳烃发生降解的时候形成,而且它们的环境行为是完全不同的,也很难通过多环芳烃浓度来预测氧化多环芳烃的含量。 | Staffan Lundstedt Paul A.White Christine L.Lemieux Krista D.Lynes Iain B.Lambert Larsberg Peter Haglund Mats Tysklind 王丽平 | 2007 | AMBIO-人类环境杂志2007，36，6： | 11 |
| 9 | Arabidopsis Extra Large G-Protein 2 (XLG2) Interacts with the Gβ Subunit of Heterotrimeric G Protein and Functions in Disease Resistance显示文摘Heterotrimeric GTP 有约束力的蛋白质,由 G, G,和 G 子单元组成,在细胞外的信号由房间表面受体察觉了进细胞内部的生理的回答的 transducing 起重要作用。除了单个原型的 G 蛋白质(GPA1 ) , Arabidopsis 有三唯一的象 G 一样蛋白质,作为 XLG1, XLG2,和 XLG3 知道,那被发现了在原子核局部性,尽管他们行动的功能和模式仍然保持大部分未知。通过 transcriptomic 分析,我们发现 XLG2 和 XLG3 被感染很快与细菌的病原体 Pseudomonas syringae 导致,而 XLG1 抄本水平没被病原体感染影响。一幅反向的基因屏幕表明 xlg2 loss-of-function 变化原因提高了危险性到 P。syringae。介绍的 Transcriptome 表明 xlg2 变化影响防卫相关的基因的一个小集合的被触发病原体的正式就职。然而, xlg1 和 xlg3 异种没在抵抗从野类型的植物显示出差别到 P。syringae。另外, xlg2 xlg3 两倍异种和 xlg1 xlg2 xlg3 三元组异种不与在疾病抵抗显型的 xlg2 单身者异种显著地不同,建议如果有的话,在防卫的 XLG1 和 XLG3 的角色不比为 XLG2 重要。XLG2 的组成的 overexpression 从多重防卫相关的基因导致反常抄本的累积。通过 co-immunoprecipitation 试金, XLG2 被发现与 AGB1 交往,在 Arabidopsis 的唯一的 G 子单元,它以前被发现了是在到 necrotrophic 的抵抗的一个积极管理者真菌的病原体。然而,没有重要差别在三 xlg 单身者异种之间被发现, xlg2 xlg3 在到 necrotrophic 的抵抗的两倍异种, xlg 三元组异种,和野类型的植物真菌的病原体 Botrytis cinerea 或 Alternaria brassicicola。这些结果建议 XLG2 和 AGB1 是与原型的 heterotrimeric G 蛋白质不同的 G 蛋白质建筑群的部件并且可以在 modulating 防卫回答有不同功能。 | Huifen Zhu Guo-Jing Li Lei Ding Xiangqin Cui Howard Berg Sarah M. Assmann Yiji Xia | 2009 | Molecular Plant2009，2，3： | 8 |
| 10 | Collagen/hyaluronan based hydrogels releasing sulfated hyaluronan improve dermal wound healing in diabetic mice via reducing inflammatory macrophage activity显示文摘Sustained inflammation associated with dysregulated macrophage activation prevents tissue formation and healing of chronic wounds.Control of inflammation and immune cell functions thus represents a promising approach in the development of advanced therapeutic strategies.Here we describe immunomodulatory hyaluronan/collagen(HA-AC/coll)-based hydrogels containing high-sulfated hyaluronan(sHA)as immunoregulatory component for the modulation of inflammatory macrophage activities in disturbed wound healing.Solute sHA downregulates inflammatory activities of bone marrow-derived and tissue-resident macrophages in vitro.This further affects macrophage-mediated pro-inflammatory activation of skin cells as shown in skin ex-vivo cultures.In a mouse model of acute skin inflammation,intradermal injection of sHA downregulates the inflammatory processes in the skin.This is associated with the promotion of an anti-inflammatory gene signature in skin macrophages indicating a shift of their activation profile.For in vivo translation,we designed HA-AC/coll hydrogels allowing delivery of sHA into wounds over a period of at least one week.Their immunoregulatory capacity was analyzed in a translational experimental approach in skin wounds of diabetic db/db mice,an established model for disturbed wound healing.The sHA-releasing hydrogels improved defective tissue repair with reduced inflammation,augmented pro-regenerative macrophage activation,increased vascularization,and accelerated new tissue formation and wound closure. | Sophia Hauck Paula Zager Norbert Halfter Elke Wandel Marta Torregrossa Ainur Kakpenova Sandra Rother Michelle Ordieres Susann Räthel Albrecht Berg Stephanie Möller Matthias Schnabelrauch Jan C.Simon Vera Hintze Sandra Franz | 2021 | Bioactive Materials2021，6，12： | 7 |
| 11 | 6B1细胞的低频弱电磁场效应研究显示文摘以小鼠 6B1骨髓瘤细胞为效应靶细胞 ,采用细胞化学 ( MTT) ,免疫酶标 ( ELISA)等方法 ,研究了低频弱电磁场对 6B1细胞代谢的影响 .结果表明 :( 1 ) 1 m V/ cm的低频电场 ( 1 0~ 1 0 0 Hz)对 6B1细胞的增殖无明显作用 ,而 1 m V/ cm,50 Hz电场对 6B1细胞乙肝表面抗体的分泌有显著促进 ,提示在此条件下电场对 6B1细胞膜的外侧存在某种特异性作用 ;( 2 ) 0 .8m T、3 0 Hz的弱磁场对 6B1细胞的增殖有明显的抑制作用 ,其它频率下则效应不明显 . | 刘曼 王星 周爱华 于海鹰 庞利君 朱明尧 王磊光 Hermann Berg | 2000 | 南开大学学报(自然科学版)2000，33，1： | 7 |
| 12 | The effects of trained peer response on ESL students’ revision types and writing quality显示文摘 | E.Cathrine Berg | 1999 | Journal of Second Language Writing1999，，3： | 6 |
| 13 | Percutaneous closure of secundum type atrial septal defects:More than 5-year follow-up显示文摘AIM: To investigate long-term efficacy of two different devices more than five years after percutaneous atrial septal defect(ASD) closure in adults.METHODS: All patients who underwent percutaneous closure of an ASD in the St. Antonius Hospital, Nieuwegein, The Netherlands, between February 1998 and December 2006 were included. Percutaneous closure took place under general anaesthesia and transesophageal echocardiographic moni toring. Transthoracic echocardiography(TTE) was performed 24 h post-procedure to visualize the device position and to look for residual shunting using color Doppler. All complications were registered. All patients were invited for an outpatient visit and contrast TTE more than 5-years after closure. Efficacy was based on the presence of a residual right-to-left shunt(RLS), graded as minimal, moderate or severe. The presence of a residual left-to-right shunt(LRS) was diagnosed using color Doppler, and was not graded. Descriptive statistics were used for patients' characteristics. Univariate analysis was used to identify predictors for residual shunting.RESULTS: In total, 104 patients(mean age 45.5 ± 17.1 years) underwent percutaneous ASD closure using an Amplatzer device(ASO) in 76 patients and a Cardioseal/Starflex device(CS/SF) in 28 patients. The mean follow-up was 6.4 ± 3.4 years. Device migration occurred in 4 patients of whom two cases occurred during the index hospitalization(1 ASO, 1 CS/SF). The other 2 cases of device migration occurred during the first 6 mo of follow-up(2 CS/SF). The recurrent thrombo-embolic event rate was similar in both groups: 0.4% per follow-up year. More than 12 mo post-ASD closure and latest follow-up, new-onset supraventricular tachyarrhythmia's occurred in 3.9% and 0% for the ASO and CS/SF group, respectively. The RLS rate at latest follow-up was 17.4%(minimal 10.9%, moderate 2.2%, severe 4.3%) and 45.5%(minimal 27.3%, moderate 18.2%, severe 0%) for the ASO- and CS/SF groups, respectively. There was no residual LRS in both groups.CONCLUSION: Percutaneous ASD closure has good long-term safety and efficacy profiles. The residual RLS rate seems to be high more than 5 years after closure, especially in the CS/SF. Residual LRS was not observed. | Roel JR Snijder Maarten J Suttorp Jurrien M Ten Berg Martijn C Post | 2015 | World Journal of Cardiology2015，7，3： | 6 |
| 14 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 15 | 肾移植:应用磁化准备稳态自由进动技术行肾血管非增强MRA检查显示文摘机构审查委员会批准本项符合HIPAA标准的研究,具有知情同意豁免权。目的是研究反转恢复稳态自由进动(steady—state free precession,SSFP)非增强MRA技术在评估肾移植病人肾动脉中的价值。13例接受肾移植者于对比增强MRA检查前行SSFP MRA检查。SSFP MRA提示3处狭窄(2处轻度狭窄,1处重度狭窄),与对比增强MRA一致。2种成像方法的影像质量差异无统计学意义。结果提示SSFP MRA在肾移植动脉成像质量及检测动脉狭窄方面, | X. Liu N. Berg J. Sheehan X. Bi P. Weale R. Jerecic 刘丽华(译) 季倩(校) | 2009 | 国际医学放射学杂志2009，32，4： | 6 |
| 16 | Strategies to obtain pattern fidelity in nanowire growth from large-area surfaces patterned using nanoimprint lithography显示文摘位置控制 nanowire 生长为依靠轻排放或轻吸收的基于 nanowire 的 optoelectronic 部件是重要的。为收获应用程序的太阳能, nanowires 的稠密的数组被需要;然而,到获得稠密的 nanowire 数组的一个主要障碍是种子粒子排水量并且在 nanowire 生长以前在退火的舞台期间联合。这里,我们探索三不同策略改进 nanoimprint 平版印刷术为 nanowire 生长定义的大区域的催化剂粒子数组的模式保藏。首先,我们看到在 nanoimprint 平版印刷术以前对待生长底层的热改进模式保藏。第二,我们探索由在由修改生长过程退火以前在地方修理种子粒子改进模式保藏的可能性。并且第三,我们证明一个罪恶 x 生长面具罐头充分阻止种子粒子排水量。我们显示出这些策略怎么允许我们极大地与对太阳能电池应用合适的尺寸改进成年 InP nanowire 数组的模式忠实,在取样的区域上的最终完成的 100% 模式保藏。这些策略的通用性质通过 GaAs 和差距 nanowires 的合成被支持。 | Gaute Otnes Magnus Heurlin Mariusz Graczyk Jesper Wallentin Daniel Jacobsson Alexander Berg Ivan Maximov Magnus T. Borgstrom | 2016 | Nano Research2016，9，10： | 6 |
| 17 | ON SERVICES RESEARCH AND EDUCATION显示文摘The importance of the services sector can not be overstated; it employs 82.1 percent of the U. S. workforce and 69 percent of graduates from an example technological university. Yet, university research and education have not followed suit. Clearly, services research and education deserve our critical attention and support since services – and services innovation – serve as an indispensable engine for global economic growth. The theme of this paper is that we can and should build services research and education on what has occurred in manufacturing research (especially in regard to customization and intellectual property) and education; indeed, services and manufactured goods become indistinguishable as they are jointly co-produced in real-time. Fortunately, inasmuch as manufacturing concepts, methodologies and technologies have been developed and refined over a long period of time (i.e., since the 1800s), the complementary set of concepts, methodologies and technologies for services are more obvious. However, while new technologies (e.g., the Internet) and globalization trends have served to enable, if not facilitate, services innovation, the same technologies (e.g., the Internet) and 21st Century realities (e.g., terrorism) are making services innovation a far more complex problem and, in fact, may be undermining previous innovations in both services and manufacturing. Finally, there is a need to define a “knowledge-adjusted” GDP metric that can more adequately measure the growing knowledge economy, one driven by intangible ideas and services innovation. | James M.TIEN Daniel BERG | 2006 | Journal of Systems Science and Systems Engineering2006，15，3： | 5 |
| 18 | 儿童前庭性偏头痛和儿童复发性眩晕:Bárány协会前庭疾病分类委员会和国际头痛协会诊断标准共识文件显示文摘本文介绍了Bárány协会国际前庭疾病分类(International Classification of Vestibular Disorders,ICVD)委员会和国际头痛协会偏头痛分类小组所提出的'儿童前庭性偏头痛'(vestibular migraine of childhood,VMC)、'很可能的儿童前庭性偏头痛'(probable VMC,pVMC)和'儿童复发性眩晕'(recurrent vertigo of childhood,RVC)的诊断标准。偏头痛在儿童期不同复发性眩晕亚型中起着重要作用。在此分类文件中,VMC、p VMC和RVC这3种与偏头痛相关的一组谱系疾病分类,上述诊断标准中的偏头痛成分为确定、很可能及可能不存在。VMC的诊断标准:(A)至少5次中度或重度前庭症状发作,持续时间5分钟~72小时;(B)当前或既往有伴或不伴先兆的偏头痛病史;(C)至少50%的发作与至少1种偏头痛样症状相关。pVMC的诊断标准:至少3次中度或重度前庭症状发作,持续时间5分钟~72小时,符合VMC诊断标准B或C中的1项。RVC的诊断标准:至少3次中度或重度前庭症状发作,持续时间为1分钟~72小时,VMC诊断标准中的B和C均不符合。对于以上3种疾病,患者的年龄必须<18岁。建议将来的研究应特别关注RVC,以研究和确定其可能的亚型及其与偏头痛的关系。 | 凌霞(译) 张赛(译) 申博(译) 隋汝波(审校) 杨旭(审校) Raymond van de Berg Josine Widdershoven Alexandre Bisdorff Stefan Evers Sylvette Wiener-Vacher Sharon LCushing Kenneth JMack Ji Soo Kim Klaus Jahn Michael Strupp Thomas Lempert | 2021 | 神经损伤与功能重建2021，16，8： | 5 |
| 19 | Relationship between HER-2 overexpression and brain metastasis in esophageal cancer patients显示文摘AIM:To study if HER-2 overexpression by locally advanced esophageal cancers increase the chance of brain metastasis following esophagectomy.METHODS:We retrospectively reviewed the medical records of esophageal cancer patients who underwent esophagectomy at University of Iowa Hospitals and Clinics between 2000 and 2010.Data analyzed consisted of demographic and clinical variables.The brain metastasis tissue was assayed for HER-2 overexpression utilizing the FDA approved DAKO Hercept Test.RESULTS:One hundred and forty two patients were reviewed.Median age was 64 years(36-86 years).Eighty eight patients(62%) received neoadjuvant chemoradiotherapy.Pathological complete and partial responses were achieved in 17(19%) and 71(81%) patients.Cancer relapsed in 43/142(30%) patients.The brain was the first site of relapse in 9/43 patients(21%,95% CI:10%-36%).HER-2 immunohistochemistry testing of the brain metastasis tissue showed that 5/9(56%) cases overexpressed HER-2(3+ staining).CONCLUSION:HER-2 overexpression might be associated with increased risk of brain metastasis in esophageal cancer patients following esophagectomy.Further studies will be required to validate this observation. | Taher Abu Hejleh Barry R DeYoung Eric Engelman Jeremy M Deutsch Bridget Zimmerman Thorvardur R Halfdanarson Daniel J Berg Kalpaj R Parekh William R Lynch Mark D Iannettoni Sudershan Bhatia Gerald Clamon | 2012 | World Journal of Gastrointestinal Oncology2012，4，5： | 5 |
| 20 | A CALCULUS FOR SERVICES INNOVATION显示文摘在服务区的革新 - 特别在电子服务(电子服务) 领域 - 能被首先认为战略司机是 andfoci 系统地开发,然后战术的原则和 enablers,并且最后,运作的决定归因,所有哪个组成服务革新的一个过程或演算。更明确地,有四位顾客司机(即,合作,定制,集成和改编),三企业 foci (即,集中创造、集中答案、集中比赛),六个企业原则(即,重建市场边界,大图画的焦点不数,在存在需求以外的活动范围,得到战略顺序权利,克服组织上的障碍并且造进策略的执行),八技术 enablers (即,软件算法,自动化,电信,合作,标准化,定制,组织,和全球化),并且决定信息科学的六个属性(即,决定驱动,基于信息,即时,连续地适应、顾客中央、computationally集中)。四个顾客驱动程序都针对授权个人,这应该被注意 - 分别地,也就是说处于一种合作状况在认识到个人装作出贡献,收到设定或个性化的注意,存取一个综合系统或进程,并且获得适应即时或即时的输入。Thedeveloped 过程或演算服务为革新识别潜在的空白或蓝海洋。除了在服务和相关经验阐述当前的革新,白空格为可能的未来革新被识别;他们包括能减轻更早的革新的未预见到的后果或弊病的那些,保卫我们的权利到隐私,保护我们免受在总是上的伤害,互连的世界,向我们提供一个权威的搜索引擎,并且产生能足够地测量成长知识经济的一个 GDP 度量标准,无形的想法和服务革新驾驶的。 | James M. TIEN Daniel BERG | 2007 | Journal of Systems Science and Systems Engineering2007，16，2： | 4 |
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