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| 1 | Integrated lipidomics and proteomics network analysis highlights lipid and immunity pathways associated with Alzheimer's disease显示文摘Background:There is an urgent need to understand the pathways and processes underlying Alzheimer's disease(AD)for early diagnosis and development of effective treatments.This study was aimed to investigate Alzheimer's dementia using an unsupervised lipid,protein and gene multi-omics integrative approach.Methods:A lipidomics dataset comprising 185 AD patients,40 mild cognitive impairment(MCI)individuals and 185 controls,and two proteomics datasets(295 AD,159 MCI and 197 controls)were used for weighted gene CO-expression network analyses(WGCNA).Correlations of modules created within each modality with clinical AD diagnosis,brain atrophy measures and disease progression,as well as their correlations with each other,were analyzed.Gene ontology enrichment analysis was employed to examine the biological processes and molecular and cellular functions of protein modules associated with AD phenotypes.Lipid species were annotated in the lipid modules associated with AD phenotypes.The associations between established AD risk loci and the lipid/protein modules that showed high correlation with AD phenotypes were also explored.Results:Five of the 20 identified lipid modules and five of the 17 identified protein modules were correlated with clinical AD diagnosis,brain atrophy measures and disease progression.The lipid modules comprising phospholipids,triglycerides,sphingolipids and cholesterol esters were correlated with AD risk loci involved in immune response and lipid metabolism.The five protein modules involved in positive regulation of cytokine production,neutrophil-mediated immunity,and humoral immune responses were correlated with AD risk loci involved in immune and complement systems and in lipid metabolism(the APOE ε4 genotype).Conclusions:Modules of tightly regulated lipids and proteins,drivers in lipid homeostasis and innate immunity,are strongly associated with AD phenotypes. | Jin Xu Giulia Bankov Min Kim Asger Wretlind Jodie Lord Rebecca Green Angela Hodges Abdul Hye Dag Aarsland Latha Velayudhan Richard J.B.Dobson Petroula Proitsi Cristina Legido-Quigley on behalf of the AddNeuroMed Consortium | 2020 | Translational Neurodegeneration2020，9，3： | 3 |
| 2 | Graphene-plasmon polaritons: From fundamental properties to potential applications显示文摘 | Sanshui Xiao Xiaolong Zhu Bo-Hong Li N. Asger Mortensen | 2016 | Frontiers of physics2016，11，2： | 2 |
| 3 | Reduction and carburization of iron oxides for Fischer–Tropsch synthesis显示文摘The activation of iron oxide Fischer–Tropsch Synthesis(FTS) catalysts was investigated during pretreatment: reduction in hydrogen followed by carburization in either CO or syngas mixture, or simultaneously reduction and carburization in syngas. A combination of different complementary in situ techniques was used to gain insight into the behavior of Fe-based FTS catalysts during activation. In situ XRD was used to identify the crystalline structures present during both reduction in hydrogen and carburization. An increase in reduction rate was established when increasing the temperature. A complete reduction was demonstrated in the ETEM and a grain size dependency was proven, i.e. bigger grains need higher temperature in order to reduce. XPS and XAS both indicate the formation of a small amount of carbonaceous species at the surface of the bulk metallic iron during carburization. | Monia Runge Nielsen Asger Barkholt Moss Anton Simon Bjrnlund Xi Liu Axel Knop-Gericke Alexander YuKlyushin Jan-Dierk Grunwaldt Thomas LSheppard Dmitry EDoronkin Anna Zimina Thomas Eric Lyck Smitshuysen Christian Danvad Damsgaard Jakob Birkedal Wagner Thomas Willum Hansen | 2020 | Journal of Energy Chemistry2020，29，12： | 2 |
| 4 | Targeting Dexamethasone to Macrophages in a Porcine Endotoxemic Model显示文摘 | Asger Granfeldt Christine Lodberg Hvas Jonas Heilskov Graversen Peter Astrup Christensen Mikkel Due Petersen Gabriela Anton Pia Svendsen Christoffer S?lling Anders Etzerodt Else T?nnesen S?ren Kragh Moestrup Holger Jon M?ller | 2013 | Critical Care Medicine2013，，11： | 2 |
| 5 | A new approach to maximum likelihood estimation for stochastic differential equations based on discrete observations显示文摘 | Pedersen Asger | 1995 | Scandinavian Journal of Statistics1995，22，1： | 1 |
| 6 | Combined Shape and Topology Opti- mization of 3D structures显示文摘 | Asger Nyman Christiansen J Andreas Barentzen Nobel-JoRgensen Morten | 2015 | Computers & Graphics2015，，46： | 1 |
| 7 | Fe和钢在O_2、SO_2和碱金属氯化物体系中的腐蚀及低熔点盐混合物的形成显示文摘含50~500ppmSO_2,8%~10%O_2和1~2g/m^2的碱金属氯化物尘埃的烟道气在300~500℃时会造成Fe合金的严重腐蚀.实验证明,在含Fe_2O_3、碱金属氯化物、SO_2和O_2系统中可能存在一种容点低至310℃的液相.这种液相也几乎以相同的速度腐蚀不锈钢和低合金钢,腐蚀性极强. | ASGER KARLSSON PREBEN J.M.LLER VAGN JOHANSEN 尹德才 | 1991 | 石油化工腐蚀与防护1991，8，3： | 1 |
| 8 | 港域波动的数值模型及其与物理模型和现场观测的比较显示文摘 | 余广明 Morten Rugbjerg Asger Kej | 1987 | 水利水运科学研究1987，，04： | 1 |
| 9 | Modeling of realistic cladding structures for air-core photonic bandgap fibers显示文摘 | NIELS ASGEr Mortensen MARTIN Dybendal Nielsen | 2004 | Optics Letters2004，29，4： | 1 |
| 10 | A new approach to maximum likelihood estimation for stochastic differential equations based on discrete observations显示文摘 | Asger P | 1995 | Scandinavian Journal of Statistics1995，22，1： | 1 |
| 11 | Effective area of photonic crystal fibers显示文摘 | Niels Asger Mortensen | 2002 | Opt Express2002，10，： | 1 |
| 12 | Effective area ofphotonic crystal fibers 显示文摘 | Niels Asger Mortensen | 2002 | Opt Express2002，10，7： | 1 |
| 13 | Persistent high incidence of tuberculosis in immigrants in low-incidence country 显示文摘 | Troels L Ase B A Asger D | 2002 | Emerging Infectious Diseases J2002，8，： | 1 |
| 14 | Uterine receptivity and implantation:The regulation and action of insulin- like growth factor binding protein-I (IGFBP-I), HOXA10 and forkhead transcription factor-I (FOX()- I) in the baboon endometrium 显示文摘 | Kim J J Asgerally T Fazleabas | 2004 | Reproductive Biol- ogy and Endocrinology2004，2，： | 1 |
| 15 | Scientific co-authorship socialnetworks ? a case study of computer science scenario in India显示文摘 | ARIF T ALI R ASGER M | 2012 | International Journal of Computer Applications2012，52，12： | 1 |
| 16 | Subsampling realised kernels显示文摘 | Ole E. Barndorff-Nielsen Peter Reinhard Hansen Asger Lunde Neil Shephard | 2010 | Journal of Econometrics2010，，1： | 1 |
| 17 | Benzene exposure and the effect of traffic pollution in Copenhagen, Denmark显示文摘 | Henrik Skov Asger B. Hansen Gitte Lorenzen Helle Vibeke Andersen Per L?fstr?m Carsten S. Christensen | 2001 | Atmospheric Environment2001，，14： | 1 |
| 18 | Characterization andmatching of oil samples using fluorescence spectroscopy andparallel factor analysis显示文摘 | JAN H C ASGER B H JOHN M | 2005 | Analytical Chemistry2005，77，7： | 1 |
| 19 | Modal cutoff and the V parameter in photonic crystal fiber显示文摘 | Mortensen Niels Asger Folkenberg Jacob Riis | 2003 | Optics Letters2003，28，20： | 1 |
| 20 | Characterization and matching of oil samples using fluorescence spectroscopy and parallel factor analysis显示文摘 | Asger B Hansen John Mortensen | 2005 | Analytica Chemica2005，77，： | 1 |
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