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| 1 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 3 |
| 2 | Ageing affects chondroitin sulfates and their synthetic enzymes in the intervertebral disc显示文摘The depletion of chondroitin sulfates(CSs)within the intervertebral disc(IVD)during degenerative disc disease(DDD)results in a decrease in tissue hydration,a loss of fluid movement,cell apoptosis,a loss of nerve growth inhibition and ultimately,the loss of disc function.To date,little is known with regards to the structure and content of chondroitin sulfates(CSs)during IVD ageing.The behavior of glycosaminoglycans(GAGs),specifically CSs,as well as xylosyltransferase I(XT-I)and glucuronyltransferase I(GT-I),two key enzymes involved in CS synthesis as a primer of glycosaminoglycan(GAG)chain elongation and GAG synthesis in the nucleus pulposus(NP),respectively,were evaluated in a bovine ageing IVD model.Here,we showed significant changes in the composition of GAGs during the disc ageing process(6-month-old,2-year-old and 8-year-old IVDs representing the immature to mature skeleton).The CS quantity and composition of annulus fibrosus(AF)and NP were determined.The expression of both XT-I and GT-I was detected using immunohistochemistry.A significant decrease in GAGs was observed during the ageing process.CSs are affected at both the structural and quantitative levels with important changes in sulfation observed upon maturity,which correlated with a decrease in the expression of both XT-I and GT-I.A progressive switch of the sulfation profile was noted in both NP and AF tissues from 6 months to 8 years.These changes give an appreciation of the potential impact of CSs on the disc biology and the development of therapeutic approaches for disc regeneration and repair. | Estelle C Collin Oliver Carroll Michelle Kilcoyne Marianna Peroglio Eugene See Doris Hendig Mauro Alini Sibylle Grad Abhay Pandit | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 2 |
| 3 | Trabecular Bone Score: A Noninvasive Analytical Method Based Upon the DXA Image显示文摘 | Barbara C Silva William D Leslie Heinrich Resch Olivier Lamy Olga Lesnyak Neil Binkley Eugene V McCloskey John A Kanis John P Bilezikian | 2014 | J Bone Miner Res2014，，3： | 2 |
| 4 | Five-year follow-up of unilateral posteroventral pallidotomy in Parkinson 's disease显示文摘 | Adriana M Eugene C Joseph | 2009 | Surgical Neurology2009，71，5： | 1 |
| 5 | Separation of ownership and control显示文摘 | Fama Eugene F Michael C Jensen | 1983 | Journal of Law and Economics1983，26，： | 1 |
| 6 | Chemokine receptors CCR6 and CXCR3 are necessary for CD4 + T cell mediated ocular surface disease in experimen- tal dry eye disease显示文摘 | TERRY G NIRAL B EUGENE A STEPHEN C CINTIA S | 2013 | PLoS One2013，8，78： | 1 |
| 7 | Isolation and sequencing of the Epstein-Barr virus BNLF-1 gene(LMP1)from a Chinese nasopharyngeal cancer显示文摘 | Hu LF Eugene RZ Fu C | 1991 | J Gen Virol1991，72，： | 1 |
| 8 | Separation of Ownership and Control 显示文摘 | Fama Eugene F Jensen Michael C | 1983 | Joumal of Law and Economics1983，26，2： | 1 |
| 9 | Manage- ment of tumors arising in the parapharyngeal space 显示文摘 | Ricardo L C Eugene N M Jonas T J | 1990 | Laryngoscope1990，100，6： | 1 |
| 10 | Separation of ownership and control显示文摘 | Fama Eugene F Jensen Michael C | 1983 | Journal of Law and Economics1983，26，2： | 1 |
| 11 | Effects of Resuscitation Fluid on Neurologic Physiology After Cerebral Trauma and Hemorrhage显示文摘 | Baker Andrew J Park Eugene Mazer David C | 2008 | Journal of Trauma-Injury Infection&Critical Care2008，64，2： | 1 |
| 12 | Design and performance of Sandia's contactless coilgun for 50 rnm projectiles显示文摘 | Kaye R J Eugene C Cowan M | 1993 | IEEE Transac- tions on Magnetics1993，29，1： | 1 |
| 13 | Separation of Ownership and Control 显示文摘 | Fama Eugene F Jensen Michael C | 1983 | Journal of Law and Economics1983，26，2： | 1 |
| 14 | The Adjustment of Stock Price to New Information 显示文摘 | Eugene F Fama Lawrence Fisher Michael C Jensen Richard Roll | 1969 | International Economic Review1969，10，： | 1 |
| 15 | A brief overview of evidence-informed management of chronic low back pain with surgery显示文摘 | Angus SD Eugene C | | 0，，01： | 1 |
| 16 | Cyclic multiple-robot scheduling with time-window constraints using a critical path approach显示文摘 | David A Chengbin C Vladimir K Eugene L | 2007 | European Journal of Operational Research2007，177，： | 1 |
| 17 | Evolution and nature of US higher edu- cation显示文摘 | C Eugene Allen | 2004 | Journal of university of Minnesota2004，，6： | 1 |
| 18 | Tacrolimus for the treatment of fistulas in patients with crohn’s disease: a randomized, placebo-controlled trial显示文摘 | William J Sandborn Daniel H Present Kim L Isaacs Douglas C Wolf Eugene Greenberg Stephen B Hanauer Brian G Feagan Lloyd Mayer Therese Johnson Joseph Galanko Christopher Martin Robert S Sandler | 2003 | Gastroenterology2003，，2： | 1 |
| 19 | Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans显示文摘 | Rhee Eugene P Cheng Susan Larson Martin G Walford Geoffrey A Lewis Gregory D McCabe Elizabeth Yang Elaine Farrell Laurie Fox Caroline S O’Donnell Christopher J Carr Steven A Vasan Ramachandran S Florez Jose C Clish Clary B Wang Thomas J Ger | 2011 | Journal of Clinical Investigation2011，，4： | 1 |
| 20 | Influenza-associated myoglobinuric renal failure显示文摘 | EUGENE C ROMECH K ROCCO C V | 1979 | JAMA1979，242，22： | 1 |
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