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| 1 | Ageing affects chondroitin sulfates and their synthetic enzymes in the intervertebral disc显示文摘The depletion of chondroitin sulfates(CSs)within the intervertebral disc(IVD)during degenerative disc disease(DDD)results in a decrease in tissue hydration,a loss of fluid movement,cell apoptosis,a loss of nerve growth inhibition and ultimately,the loss of disc function.To date,little is known with regards to the structure and content of chondroitin sulfates(CSs)during IVD ageing.The behavior of glycosaminoglycans(GAGs),specifically CSs,as well as xylosyltransferase I(XT-I)and glucuronyltransferase I(GT-I),two key enzymes involved in CS synthesis as a primer of glycosaminoglycan(GAG)chain elongation and GAG synthesis in the nucleus pulposus(NP),respectively,were evaluated in a bovine ageing IVD model.Here,we showed significant changes in the composition of GAGs during the disc ageing process(6-month-old,2-year-old and 8-year-old IVDs representing the immature to mature skeleton).The CS quantity and composition of annulus fibrosus(AF)and NP were determined.The expression of both XT-I and GT-I was detected using immunohistochemistry.A significant decrease in GAGs was observed during the ageing process.CSs are affected at both the structural and quantitative levels with important changes in sulfation observed upon maturity,which correlated with a decrease in the expression of both XT-I and GT-I.A progressive switch of the sulfation profile was noted in both NP and AF tissues from 6 months to 8 years.These changes give an appreciation of the potential impact of CSs on the disc biology and the development of therapeutic approaches for disc regeneration and repair. | Estelle C Collin Oliver Carroll Michelle Kilcoyne Marianna Peroglio Eugene See Doris Hendig Mauro Alini Sibylle Grad Abhay Pandit | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 2 |
| 2 | A collagen-glycosaminoglycan co-culture model for heart valve tissue engineering applications显示文摘 | Thomas C. Flanagan Brendan Wilkins Alexander Black Stefan Jockenhoevel Terence J. Smith Abhay S. Pandit | 2005 | Biomaterials2005，，10： | 1 |
| 3 | The influence of size and charge of chitosan/polyglutamic acid hollow spheres on cellular internalization, viability and blood compatibility显示文摘 | Biraja C. Dash Gildas Réthoré Michael Monaghan Kathleen Fitzgerald William Gallagher Abhay Pandit | 2010 | Biomaterials2010，，32： | 1 |
| 4 | Liposomal gene delivery mediated by tissue-engineered scaffolds显示文摘 | Mangesh Kulkarni Udo Greiser Timothy O’Brien Abhay Pandit | 2009 | Trends in Biotechnology2009，，1： | 1 |
| 5 | Recovery of cardiac function mediated by MSC and interleukin-10 plasmid functionalised scaffold显示文摘 | Carolyn A. Holladay Aoife M. Duffy Xizhe Chen Michael V. Sefton Timothy D. O’Brien Abhay S. Pandit | 2011 | Biomaterials2011，，5： | 1 |
| 6 | Fabrication methods of porous metals for use in orthopaedic applications显示文摘 | Garrett Ryan Abhay Pandit Dimitrios Panagiotis Apatsidis | 2005 | Biomaterials2005，，13： | 1 |
| 7 | An injectable cross-linked scaffold for nucleus pulposus regeneration显示文摘 | Damien O. Halloran Sibylle Grad Martin Stoddart Peter Dockery Mauro Alini Abhay S. Pandit | 2007 | Biomaterials2007，，4： | 1 |
| 8 | Using computed tomography scans to develop an ex-vivo gastric model显示文摘The objective of this research was to use abdominal computed tomography (CT) scans to non-invasively quantify anthropometrical data of the human stomach and to concomitantly create an anatomically correct and distensible ex-vivo gastric model. Thirty-three abdominal CT scans of human subjects were obtained and were imported into reconstruction software to generate 3D models of the stomachs. Anthropometrical data such as gastric wall thickness, gastric surface area and gastric volume were subsequently quantified. A representative 3D computer model was exported into a selective laser sintering (SLS) rapid prototyping machine to create an anatomically correct solid gastric model. Subsequently, a replica wax template of the SLS model was created. A negative mould was offset around the wax template such that the offset distance was equivalent to that of the gastric wall thickness. A silicone with similar mechanical properties to the human stomach was poured into the offset. The lost wax manufacturing technique was employed to create a hollow distensible stomach model. 3D computer gastric models were generated from the CT scans. A hollow distensible silicone ex-vivo gastric model with similar compliance to that of the human stomach was created. The anthropometrical data indicated that there is no significant relationship between BMI and gastric surface area or gastric volume. There were inter- and intra-group differences between groups with respect to gastric wall thickness. This study demonstrates that abdominal CT scans can be used to both non-invasively determine gastric anthropometrical data as well as create realistic ex-vivo stomach models. | Jerome A Henry Gerard O’Sullivan Abhay S Pandit | 2007 | World Journal of Gastroenterology2007，13，9： | 0 |
| 9 | Bioactive potential of natural biomaterials: identification, retention and assessment of biological properties显示文摘Biomaterials have had an increasingly important role in recent decades,in biomedical device design and the development of tissue engineering solutions for cell delivery,drug delivery,device integration,tissue replacement,and more.There is an increasing trend in tissue engineering to use natural substrates,such as macromolecules native to plants and animals to improve the biocompatibility and biodegradability of delivered materials.At the same time,these materials have favourable mechanical properties and often considered to be biologically inert.More importantly,these macromolecules possess innate functions and properties due to their unique chemical composition and structure,which increase their bioactivity and therapeutic potential in a wide range of applications.While much focus has been on integrating these materials into these devices via a spectrum of cross-linking mechanisms,little attention is drawn to residual bioactivity that is often hampered during isolation,purification,and production processes.Herein,we discuss methods of initial material characterisation to determine innate bioactivity,means of material processing including cross-linking,decellularisation,and purification techniques and finally,a biological assessment of retained bioactivity of a final product.This review aims to address considerations for biomaterials design from natural polymers,through the optimisation and preservation of bioactive components that maximise the inherent bioactive potency of the substrate to promote tissue regeneration. | Kieran Joyce Georgina Targa Fabra Yagmur Bozkurt Abhay Pandit | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 0 |
| 10 | Adhesive hydrogels in osteoarthritis:from design to application显示文摘Osteoarthritis(OA)is the most common type of degenerative joint disease which affects 7%of the global population and more than 500 million people worldwide.One research frontier is the development of hydrogels for OA treatment,which operate either as functional scaffolds of tissue engineering or as delivery vehicles of functional additives.Both approaches address the big challenge:establishing stable integration of such delivery systems or implants.Adhesive hydrogels provide possible solutions to this challenge.However,few studies have described the current advances in using adhesive hydrogel for OA treatment.This review summarizes the commonly used hydrogels with their adhesion mechanisms and components.Additionally,recognizing that OA is a complex disease involving different biological mechanisms,the bioactive therapeutic strategies are also presented.By presenting the adhesive hydrogels in an interdisciplinary way,including both the fields of chemistry and biology,this review will attempt to provide a comprehensive insight for designing novel bioadhesive systems for OA therapy. | Wang-Lin Duan Li-Ning Zhang Raghvendra Bohara Sergio Martin-Saldana Fei Yang Yi-Yang Zhao Yong Xie Ya-Zhong Bu Abhay Pandit | 2023 | Military Medical Research2023，10，5： | 0 |
| 11 | Cohesion mechanisms for bioadhesives显示文摘Due to the nature of non-invasive wound closure,the ability to close different forms of leaks,and the potential to immobilize various devices,bioadhesives are altering clinical practices.As one of the vital factors,bioadhesives’strength is determined by adhesion and cohesion mechanisms.As well as being essential for adhesion strength,the cohesion mechanism also influences their bulk functions and the way the adhesives can be applied.Although there are many published reports on various adhesion mechanisms,cohesion mechanisms have rarely been addressed.In this review,we have summarized the most used cohesion mechanisms.Furthermore,the relationship of cohesion strategies and adhesion strategies has been discussed,including employing the same functional groups harnessed for adhesion,using combinational approaches,and exploiting different strategies for cohesion mechanism.By providing a comprehensive insight into cohesion strategies,the paper has been integrated to offer a roadmap to facilitate the commercialization of bioadhesives. | Yazhong Bu Abhay Pandit | 2022 | Bioactive Materials2022，7，7： | 0 |
| 12 | Correction to: Bioactive potential of natural biomaterials: identification, retention and assessment of biological properties显示文摘Since the publication of this review article,1 the authors recognise a misinterpretation of a cited article in the text.It was previously stated on page 2,column 2,line 54 that:'Silk fibroin binds to receptor activation of nuclear factor kB ligand(RANKL)causing ERK1/2 signalling and expression of NF-κBp65,which promotes induction of osteoclastogenesis.' | Kieran Joyce Georgina Targa Fabra Yagmur Bozkurt Abhay Pandit | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 0 |
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