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| 1 | Chronic obstructive pulmonary disease as a risk factor for lung cancer显示文摘The association between chronic obstructive pulmonary disease(COPD) and lung cancer has long been a subject of intense debate. The high prevalence of COPD in elderly smokers inevitably strengthens their coincidence. In addition to this contingent coincidence, recent studies have revealed a close association between the two diseases that is independent of the smoking history; that is, the existence of COPD is an independent risk factor for the development of lung cancer. Molecular-based evidence has been accumulating as a result of the efforts to explain the underlying mechanisms of this association. These mechanisms may include the following: the retention of airborne carcinogens followed by the activation of oncogenes and the suppression of tumor suppressor genes; the complex molecular mechanism associated with chronic inflammation in the distal airways of patients with COPD; the possible in-volvement of putative distal airway stem cells; and gel netic factors that are common to both COPD and lung cancer. The existence of COPD in patients with lung l cancer may potentially affect the process of diagnosis, surgical resection, radiotherapy, chemotherapy, and end-of-life care. The comprehensive management of COPD is extremely important for the appropriate treatment of lung cancer. Surgical resections with the aid of early interventions for COPD are often possible, even for patients with mild-to-moderate COPD. New challenges, such as lung cancer CT screening for individuals t at high risk, are now in the process of being implemented. Evaluating the risk of lung cancer in patients with COPD may be warranted in community-based lung cancer screening. | Yuichi Takiguchi Ikuo Sekine Shunichiro Iwasawa Ryota Kurimoto Koichiro Tatsumi | 2014 | World Journal of Clinical Oncology2014，5，4： | 21 |
| 2 | Current status of function-preserving surgery for gastric cancer显示文摘Recent advances in diagnostic techniques have allowed the diagnosis of gastric cancer(GC)at an early stage.Due to the low incidence of lymph node metastasis and favorable prognosis in early GC,function-preserving surgery which improves postoperative quality of life may be possible.Pylorus-preserving gastrectomy(PPG)is one such function-preserving procedure,which is expected to offer advantages with regards to dumping syndrome,bile reflux gastritis,and the frequency of flatus,although PPG may induce delayed gastric emptying.Proximal gastrectomy(PG)is another functionpreserving procedure,which is thought to be advantageous in terms of decreased duodenogastric reflux and good food reservoir function in the remnant stomach,although the incidence of heartburn or gastric fullness associated with this procedure is high.However,these disadvantages may be overcome by the reconstruction method used.The other important problem after PG is remnant GC,which was reported to occur in approximately 5%of patients.Therefore,the reconstruction technique used with PG should facilitate postoperativeendoscopic examinations for early detection and treatment of remnant gastric carcinoma.Oncologic safety seems to be assured in both procedures,if the preoperative diagnosis is accurate.Patient selection should be carefully considered.Although many retrospective studies have demonstrated the utility of function-preserving surgery,no consensus on whether to adopt functionpreserving surgery as the standard of care has been reached.Further prospective randomized controlled trials are necessary to evaluate survival and postoperative quality of life associated with function-preserving surgery. | Takuro Saito Yukinori Kurokawa Shuji Takiguchi Masaki Mori Yuichiro Doki | 2014 | World Journal of Gastroenterology2014，20，46： | 17 |
| 3 | High preoperative neutrophil-lymphocyte ratio predicts poor survival in patients with gastric cancer显示文摘 | Hideaki Shimada Nobuhiro Takiguchi Osamu Kainuma Hiroaki Soda Atsushi Ikeda Akihiro Cho Akinari Miyazaki Hisashi Gunji Hiroshi Yamamoto Matsuo Nagata | 2010 | Gastric Cancer2010，，3： | 4 |
| 4 | Effects of ghrelin administration during chemotherapy with advanced esophageal cancer patients显示文摘 | Yuichiro Hiura Shuji Takiguchi Kazuyoshi Yamamoto Tsuyoshi Takahashi Yukinori Kurokawa Makoto Yamasaki Kiyokazu Nakajima Hiroshi Miyata Yoshiyuki Fujiwara Masaki Mori Kenji Kangawa Yuichiro Doki | 2012 | Cancer2012，，19： | 2 |
| 5 | Genetic detection of free cancer cells in the peritoneal cavity of the patient with gastric cancer: present status and future perspectives显示文摘 | Yoshiyuki Fujiwara Yuichiro Doki Hirokazu Taniguchi Itsuro Sohma Shuji Takiguchi Hiroshi Miyata Makoto Yamasaki Morito Monden | 2007 | Gastric Cancer2007，，： | 2 |
| 6 | Seismic proof test of a reinforced concrete containment vessel (RCCV)显示文摘 | Toshihiko Hirama Masashi Goto Keiji Shiba Toshio Kobayashi Ryozo Tanaka Shizuo Tsurumaki Katsuki Takiguchi Hiroshi Akiyama | 2005 | Nuclear Engineering and Design2005，，13： | 2 |
| 7 | Phase I/II study of S-1 plus cisplatin combined with peptide vaccinesfor human vascular endothelial growth factor receptor 1 and 2 in patients withadvanced gastric cancer显示文摘 | Toru Masuzawa Yoshiyuki Fujiwara Kaoru Okada Ayumu Nakamura Shuji Takiguchi Kiyokazu Nakajima Hiroshi Miyata Makoto Yamasaki Yukinori Kurokawa Ryuji Osawa Kazuyoshi Takeda Koji Yoshida Takuya Tsunoda Yusuke Nakamura Masaki Mori Yuichiro Doki | 2012 | International Journal of Oncology2012，，4： | 2 |
| 8 | Feasibility of laparoscopy-assisted total gastrectomy in patients with clinical stage I gastric cancer显示文摘 | Noriko Wada Yukinori Kurokawa Shuji Takiguchi Tsuyoshi Takahashi Makoto Yamasaki Hiroshi Miyata Kiyokazu Nakajima Masaki Mori Yuichiro Doki | 2014 | Gastric Cancer2014，，1： | 2 |
| 9 | Overexpression of Forkhead Box M1 Transcription Factor (FOXM1) is a Potential Prognostic Marker and Enhances Chemoresistance for Docetaxel in Gastric Cancer显示文摘 | Kaoru Okada Yoshiyuki Fujiwara Tsuyoshi Takahashi Yurika Nakamura Shuji Takiguchi Kiyokazu Nakajima Hiroshi Miyata Makoto Yamasaki Yukinori Kurokawa Masaki Mori Yuichiro Doki | 2013 | Annals of Surgical Oncology2013，，3： | 2 |
| 10 | Comparison of Perioperative and Long-term Outcomes of Total and Proximal Gastrectomy for Early Gastric Cancer: A Multi-institutional Retrospective Study显示文摘 | Toru Masuzawa Shuji Takiguchi Motohiro Hirao Hiroshi Imamura Yutaka Kimura Junya Fujita Isao Miyashiro Shigeyuki Tamura Masahiro Hiratsuka Kenji Kobayashi Yoshiyuki Fujiwara Masaki Mori Yuichiro Doki | 2014 | World Journal of Surgery2014，，5： | 2 |
| 11 | A comparison of postoperative quality of life and dysfunction after Billroth I and Roux-en-Y reconstruction following distal gastrectomy for gastric cancer: results from a multi-institutional RCT显示文摘 | Shuji Takiguchi Kazuyoshi Yamamoto Motohiro Hirao Hiroshi Imamura Junya Fujita Masahiko Yano Kenji Kobayashi Yutaka Kimura Yukinori Kurokawa Masaki Mori Yuichiro Doki | 2012 | Gastric Cancer2012，，2： | 2 |
| 12 | Survival benefit of bursectomy in patients with resectable gastric cancer: interim analysis results of a randomized controlled trial显示文摘 | Junya Fujita Yukinori Kurokawa Tomoyuki Sugimoto Isao Miyashiro Shohei Iijima Yutaka Kimura Shuji Takiguchi Yoshiyuki Fujiwara Masaki Mori Yuichiro Doki | 2012 | Gastric Cancer2012，，1： | 2 |
| 13 | Circulating miR-200c Levels Significantly Predict Response to Chemotherapy and Prognosis of Patients Undergoing Neoadjuvant Chemotherapy for Esophageal Cancer显示文摘 | Koji Tanaka Hiroshi Miyata Makoto Yamasaki Keijiro Sugimura Tsuyoshi Takahashi Yukinori Kurokawa Kiyokazu Nakajima Shuji Takiguchi Masaki Mori Yuichiro Doki | 2013 | Annals of Surgical Oncology2013，，3： | 2 |
| 14 | Lack of Cholecystokinin-A Receptor Enhanced Gallstone Formation: A Study in CCK-A Receptor Gene Knockout Mice显示文摘 | Norikazu Sato Kyoko Miyasaka Shinji Suzuki Setsuko Kanai Minoru Ohta Takako Kawanami Yuki Yoshida Soichi Takiguchi Tetsuo Noda Yutaka Takata Akihiro Funakoshi | 2003 | Digestive Diseases and Sciences2003，，10： | 2 |
| 15 | Increased level of polyploidyl, a conserved repressor of CYCLINA2 transcription, controls endoreduplication in Arabidopsis显示文摘 | Yoshizumi T Tsumoto Y Takiguchi T | 2006 | Plant Cell2006，18，： | 1 |
| 16 | A new family of macrolide antibodies: fermentation,isolation and physico-chemical properties显示文摘 | Takiguchi Y Mishima H Okuda M | 1980 | J Antibiot1980，33，： | 1 |
| 17 | Effect of rikkunshito, a Japanese herbal medicine, on gastroin testinal symptoms and ghrelin levels in gastric cancer patients after gastrectomy显示文摘 | Takiguchi S Hiura Y Takahashi T | 2013 | Gastric Cancer2013，16，2： | 1 |
| 18 | Adaptation of HIV-1to human leukocyte antigen class I显示文摘 | Kawashima Y Pfafferott K Frater J Matthews P Payne R Addo M Gatanaga H Fujiwara M Hachiya A Koizumi H Kuse N Oka S Duda A Prendergast A Crawford H Leslie A Brumme Z Brumme C Allen T Brander C Kaslow R Tang J Hunter E Allen S Mulenga J Branch S Roach T John M Mallal S Ogwu A Shapiro R Prado J G Fidler S Weber J Pybus O G Klenerman P Ndung'u T Phillips R Heckerman D Harrigan P R Walker B D Takiguchi M Goulder P | 2009 | Nature2009，458，7238： | 1 |
| 19 | Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway显示文摘 | Oyadomari S Takeda K Takiguchi M | 2001 | Proc Natl Acad Sci USA2001，98，10： | 1 |
| 20 | A simple method to release polyphosphate from activated sludge for phosphorus reuse and recycling 显示文摘 | KURODA A TAKIGUCHI N GOTANDA T | 2002 | Biotechnology and Bioengineering2002，78，3： | 1 |
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