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| 1 | Gastric adenocarcinoma arising in gastritis cystica profunda presenting with selective loss of KCNE2 expression显示文摘Gastritis cystica profunda(GCP) is a rare condition caused by ectopic entrapment of gastric glands,probably secondary to the disruption of muscularis mucosae.GCP is often associated with gastric adenocarcinoma,and loss of the KCNE2 subunit from potassium channel complexes is considered a common primary target molecule leads to both GCP and malignancy.In this study,we,for the first time,analyzed the expression of KCNE2 in surgically excised tissue from human gastric cancer associated with GCP and confirmed that reduced KCNE2 expression correlates with disease formation. | Natsumi Kuwahara Riko Kitazawa Koto Fujiishi Yusa Nagai Ryuma Haraguchi Sohei Kitazawa | 2013 | World Journal of Gastroenterology2013，19，8： | 11 |
| 2 | CD13 is a therapeutic target in human liver cancer stem cells显示文摘 | Haraguchi Naotsugu Ishii Hideshi Mimori Koshi Tanaka Fumiaki Ohkuma Masahisa Kim Ho Min Akita Hirofumi Takiuchi Daisuke Hatano Hisanori Nagano Hiroaki Barnard Graham F Doki Yuichiro Mori Masaki | 2010 | Journal of Clinical Investigation2010，，9： | 7 |
| 3 | Cdx2 expression and its promoter methylation during metaplasia-dysplasia-carcinoma sequence in Barrett's esophagus显示文摘AIM:To examine how the expression of caudal type homebox transcription factor 2(Cdx2) is regulated in the development of malignancy in Barrett's esophagus.METHODS:Cdx2,mucin(MUC) series(MUC2,MUC5AC and MUC6),p53 and E-cadherin expression in Barrett's esophagus and adenocarcinoma specimens were examined by immunostaining.Isolated clusters of cells from(1) MUC2 and Cdx2-positive intestinal metaplastic mucosa;(2) MUC5AC and MUC6-positive,and MUC2 and Cdx2-negative high-grade dysplasia(HD),or intramucosal adenocarcinoma(IMC);and(3) MUC5AC,MUC6 and Cdx2-positive poorly-differentiated invasive adenocarcinoma(PDA) were analyzed by methylationspecific polymerase chain reaction using sets of primers for detecting methylation status of the Cdx2 gene.RESULTS:Most of the non-neoplastic Barrett's esophageal mucosa showing intestinal-type metaplasia with or without low-grade dysplasia was positive for E-cadherin,MUC series and Cdx2,but negative for p53.A portion of the low-grade to HD was positive for E-cadherin,MUC5AC,MUC6 and p53,but negative for MUC2 and Cdx2.The definite IMC area was strongly positive for MUC5AC,MUC6 and p53,but negative for MUC2 and Cdx2.Methylation of the Cdx2 promoter was not observed in intestinal metaplasia,while hypermethylation of part of its promoter was observed in hot dipped and IMC.Hypermethylation of a large fraction of the Cdx2 promoter was observed in PDA.CONCLUSION:Cdx2 expression is restored irrespective of the methylation status of its promoter.Apparent positive immunohistochemical results can be a molecular mark for gene silencing memory. | Kenji Makita Riko Kitazawa Shuho Semba Koto Fujiishi Miku Nakagawa Ryuma Haraguchi Sohei Kitazawa | 2013 | World Journal of Gastroenterology2013，19，4： | 5 |
| 4 | A new reduction-based LQ control for dynamic systems with a slowly time-varying delay显示文摘Time delays in the feedback control often dete-riorate the control performance or even cause the instabilityof a dynamic system.This paper presents a control strategyfor the dynamic system with a constant or a slowly time-varying input delay based on a transformation,which sim-plifies the time-delay system into a delay-free one.Firstly,the relation is discussed for two existing reduction-basedlinear quadratic controls.One is continuous and the otheris discrete.By extending the relation,a new reduction-basedcontrol is then developed with a numerical algorithm pre-sented for practical control implementation.The controllersuggested by the proposed method has such a promisingproperty that it can be used for the cases of different values ofan input time delay without redesign of controller.This prop-erty provides the potential for stabilizing the dynamic systemwith a time-varying input delay.Consequently,the applica-tion of the proposed method to the dynamic system with aslowly time-varying delay is discussed.Finally,numericalsimulations are given to show the efficacy and the applica-bility of the method. | Masakazu Haraguchi | 2009 | Acta Mechanica Sinica2009，25，4： | 5 |
| 5 | Hepcidin/ferroportin expression levels involve efficacy of pegylated-interferon plus ribavirin in hepatitis C virusinfected liver显示文摘AIM:To investigate the relationship between the ironmetabolism-related gene expression profiles and efficacy of antiviral therapy in chronic hepatitis C patients.METHODS:The hepatic expression profile of ironmetabolism-related genes was analyzed and its association with virological response to pegylated-interferon plus ribavirin combination therapy was evaluated.A hundred patients with chronic hepatitis C(genotype1b,n = 50; genotype 2,n = 50) were enrolled and retrospectively analyzed.Liver biopsy samples were subjected to quantitative polymerase chain reaction for iron-metabolismrelated genes and protein expression(Western blotting analysis) for ferroportin.As a control,normal liver tissue was obtained from 18 living donors of liver transplantation.Serum hepcidin level was measured by sensitive liquid chromatography/electrospray ionization tandem mass spectrometry.RESULTS:Iron overload is associated with liver damage by increasing oxidative stress and hepatitis C virus(HCV)is reported to induce iron accumulation in hepatocytes in vivo.Conversely,iron administration suppresses HCV replication in vitro.Therefore,the association between HCV infection and iron metabolism remains unclear.Compared with controls,patients had significantly higher gene expression for transferrin,iron-regulatoryproteins 1 and 2,divalent metal transporter 1,and ferroportin,but similar for transferrin receptors 1 and2,and hepcidin.When the expression profiles were compared between sustained virological response(SVR)and non-SVR patients,the former showed significantly lower transcription and protein expression of hepcidin and ferroportin.Expression of hepcidin-regulating genes,BMPR1,BMPR2,and hemojuvelin,was significantly increased,whereas BMP2 was decreased in HCV-infected liver.BMPR2 and hemojuvelin expression was significantly lower in the SVR than non-SVR group.HCV infection affects the expression of iron-metabolism-related genes,leading to iron accumulation in hepatocytes.CONCLUSION:Decreased expression of hepcidin and ferroportin in SVR patients indicates the importance of hepatocytic iron retention for viral response during pegylated-interferon plus ribavirin treatment. | Motoyuki Kohjima Tsuyoshi Yoshimoto Munechika Enjoji Nobuyoshi Fukushima Kunitaka Fukuizumi Tsukasa Nakamura Miho Kurokawa Nao Fujimori Yusuke Sasaki Yasushi Shimonaka Yusuke Murata Susumu Koyama Ken Kawabe Kazuhiro Haraguchi Yorinobu Sumida Naohiko Harada Masaki Kato Kazuhiro Kotoh Makoto Nakamuta | 2015 | World Journal of Gastroenterology2015，21，11： | 4 |
| 6 | 抗反射疏水红外窗口的制备研究显示文摘本研究利用纳秒激光两次双光束干涉无掩模烧蚀、快速制备硫化锌(ZnS)微纳结构抗反射疏水表面,使其红外透过率由原来的75%增加到92%,解决了表面淀积抗反射镀层膜层附着力、抗蚀性、热胀失配等问题.此方法加工过程快速简单,可实现大面积制作,且微纳结构使基底具有疏水性能,疏水角可达145fi.使其在光电子、太阳能、航空航天及红外制导等领域具有广泛的应用前景. | 张然 曹小文 徐微微 Haraguchi Masanobu 高炳荣 | 2014 | 物理学报2014，63，5： | 3 |
| 7 | Usefulness and limitations of taste sensors in the evaluation of palatability and taste-masking in oral dosage forms显示文摘The purpose of this review is to discuss the advantages and limitations of taste sensors in the evaluation of the taste of palatability of different oral dosage forms. First, we consider some ways in which the palatability of various pharmaceutical formulations including orally disintegrating tablets(ODTs) are tested using two different taste sensors. Second, we focus on the evaluation of palatability of ODTs. We compare the usefulness of three pieces of apparatus for estimating the disintegration time of ODTs. Finally, we compare the characteristics of the two taste sensors in the evaluation of palatability of various kinds of drug formulations. | Tamami Haraguchi Miyako Yoshida Honami Kojima Takahiro Uchida | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，4： | 2 |
| 8 | Iodide uptake and experimental 131 I therapy in transplanted undifferentiated thyroid cancer cells expressing the Na/I symporter gene显示文摘 | Shimura H Haraguchi K Miyazaki A | 1997 | Endocrinology1997，138，： | 2 |
| 9 | Is Manipulative Therapy Clinically Necessary for Relief of Neck Pain?A Systematic Review and Meta-Analysis显示文摘Objective:To summarize and critically assess the efficacy of Eastern and Western manipulative therapies for the treatment of neck pain in adults. Methods:A search of Pub Med/MEDLINE, the Cochrane Central Register of Controlled Trials, Clinical Trials.gov, EMBASE, etc. from their inception date to January 2014 with Chinese, Japanese, and Korean databases. Two reviewers independently selected randomized controlled trials(RCTs) with negative control or blank control, extracted data and assessed methodological quality. Meta-analysis and levels of evidence were performed by Revman5.1 and Grades of Recommendations Assessment, Development and Evaluation(GRADE) approach. Results:Nineteen clinical trials with adequate randomization were included in this review, 11 of them had a low risk of bias. The primary outcome for shortterm pain had no significant differences, however, the secondary outcome, only the Numerical Pain Rating Scale(NPRS) score of intermediate-term [n=916, pooled mean differences(MD) =–0.29, P=0.02], the Neck Disability Index(NDI) score of short-term(n=1,145, pooled MD=–2.10, P<0.01), and intermediate-term(n=987, pooled MD=–1.45, P=0.01) were significantly reduced with moderate quality evidence. However, it supported the minimally clinically important difference(MCID) of the Visual Analogue Scale and NPRS pain score to be 13 mm, while NDI was 3.5 points. The meta-analysis only suggested a trend in favor of manipulative therapy rather than clinical significance. Conclusions:The results do not support the existing evidences for the clinical value of Eastern or Western manipulative therapy for neck pain of short-term follow-up according to MCIDs. The limitations of our review related to blinding, allocation concealment and small sample size. | YAO Min SUN Yue-li DUN Rong-liang LAN Tian-ying LI Jin-long Hyo Jin Lee Noriko Haraguchi WANG Yong-jun CUI Xue-jun | 2017 | Chinese Journal of Integrative Medicine2017，23，7： | 2 |
| 10 | Endoscopic mucosal resection vs endoscopic submucosal dissection for superficial non-ampullary duodenal tumors显示文摘BACKGROUND The selection of endoscopic treatments for superficial non-ampullary duodenal epithelial tumors(SNADETs)is controversial.AIM To compare the efficacy and safety of endoscopic mucosal resection(EMR)and endoscopic submucosal dissection(ESD)for SNADETs.METHODS We retrospectively analyzed the data of patients with SNADETs from a database of endoscopic treatment for SNADETs,which included eight hospitals in Fukuoka,Japan,between April 2001 and October 2017.A total of 142 patients with SNADETs treated with EMR or ESD were analyzed.Propensity score matching was performed to adjust for the differences in the patient characteristics between the two groups.We analyzed the treatment outcomes,including the rates of en bloc/complete resection,procedure time,adverse event rate,hospital stay,and local or metastatic recurrence.RESULTS Twenty-eight pairs of patients were created.The characteristics of patients between the two groups were similar after matching.The EMR group had a significantly shorter procedure time and hospital stay than those of the ESD group[median procedure time(interquartile range):6(3-10.75)min vs 87.5(68.5-136.5)min,P<0.001,hospital stay:8(6-10.75)d vs 11(8.25-14.75)d,P=0.006].Other outcomes were not significantly different between the two groups(en bloc resection rate:82.1%vs 92.9%,P=0.42;complete resection rate:71.4%vs 89.3%,P=0.18;and adverse event rate:3.6%vs 17.9%,P=0.19,local recurrence rate:3.6%vs 0%,P=1;metastatic recurrence rate:0%in both).Only one patient in the ESD group underwent emergency surgery owing to intraoperative perforation.CONCLUSION EMR has significantly shorter procedure time and hospital stay than ESD,and provides acceptable curability and safety compared to ESD.Accordingly,EMR for SNADETs is associated with lower medical costs. | Mitsuru Esaki Kazuhiro Haraguchi Kazuya Akahoshi Naru Tomoeda Akira Aso Soichi Itaba Haruei Ogino Yusuke Kitagawa Hiroyuki Fujii Kazuhiko Nakamura Masaru Kubokawa Naohiko Harada Yosuke Minoda Sho Suzuki Eikichi Ihara Yoshihiro Ogawa | 2020 | World Journal of Gastrointestinal Oncology2020，12，8： | 2 |
| 11 | Utilization of silkworm cocoon waste as a sorbent for the removal of oil from water显示文摘 | Hiroshi Moriwaki Shiori Kitajima Masahiro Kurashima Ayaka Hagiwara Kazuma Haraguchi Koji Shirai Rensuke Kanekatsu Kenji Kiguchi | 2008 | Journal of Hazardous Materials2008，，1： | 2 |
| 12 | Preparation of Large-area Controllable Patterned Silver Nanocrystals for High Sensitive and Stable Surface-enhanced Raman Spectroscopy显示文摘 | XU Weiwei OKAMOTO Toshihiro LI Aiwu WANG Jiping HARAGUCHI Masanobu | 2016 | Chemical Research in Chinese Universities2016，32，3： | 2 |
| 13 | Effect of coagulation conditions on crystal modification of poly (p-phenylene terephthalamide) 显示文摘 | HARAGUCHI K KAJIYAMA T TAKAYANAGI M | 1979 | Journal of Applied Polymer Science1979，23，： | 1 |
| 14 | Comparison of changes in hemodynamics between unilateral and bilateral lung volume reduction for pulmonary emphysema显示文摘 | Koizumi K Haraguchi S Akiyama H | 2001 | Ann Thorac Cardiovasc Surg2001，7，5： | 1 |
| 15 | Biological and genetic characteristics of tumor-initiating cells in colon cancer显示文摘 | Ieta K Tanaka F Haraguchi N | | 0，，： | 1 |
| 16 | Sensitive assessment of activ- ity of Takayasug arteritis by pentraxin3, a new biomarker显示文摘 | Ishihara T Haraguchi G Kamiishi T | 2011 | J Am Coll Cardiol2011，57，16： | 1 |
| 17 | Determination of rare earth elements in human blood serum by inductively coupled plasma mass spectrometry after chelating resin preconcentration显示文摘 | INAGAKI K HARAGUCHI H | 2000 | T- he Analyst2000，125，1： | 1 |
| 18 | Synchronous Double Cancer of the Stomach and Rectum With Situs Inversus Totalis and Polysplenia Syndrome显示文摘 | Takeshi Iwamura Naoya Shibata Yasuaki Haraguchi Yosuke Hisashi Takushi Nishikawa Hiroki Yamada Toru Hayashi Kiyokazu Toyoda | 2001 | Journal of Clinical Gastroenterology2001，，2： | 1 |
| 19 | Novel polymer-supported organocatalyst via ion exchange reaction:facile im mobilizationof chiral im idazolidin本one and its application to D iels-A lder reaction显示文摘 | Haraguchi N Takem ura Y Itsu n o S | 2010 | Tetrahedron L e tt2010，51，： | 1 |
| 20 | Potential role of dendritic cell vaccination with MAGE peptides in gastrointestinalcarcinomas显示文摘 | Fumiaki Tanaka Naotsugu Haraguchi Kenji Isikawa Hiroshi Inoue Masaki Mori | 2008 | Oncology Reports2008，，5： | 1 |
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