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| 1 | Modeling sustainability:population,inequality,consumption,and bidirectional coupling of the Earth and Human Systems显示文摘Over the last two centuries,the impact of the Human System has grown dramatically,becoming strongly dominant within the Earth System in many diferent ways.Consumption,inequality,and population have increased extremely fast,especially since about 1950,threatening to overwhelm the many critical functions and ecosystems of the Earth System.Changes in the Earth System,in turn,have important feedback efects on the Human System,with costly and potentially serious consequences.However,current models do not incorporate these critical feedbacks.We argue that in order to understand the dynamics of either system,Earth System Models must be coupled with Human System Models through bidirectional couplings representing the positive,negative,and delayed feedbacks that exist in the real systems.In particular,key Human System variables,such as demographics,inequality,economic growth,and migration,are not coupled with the Earth System but are instead driven by exogenous estimates,such as United Nations population projections.his makes current models likely to miss important feedbacks in the real Earth–Human system,especially those that may result in unexpected or counterintuitive outcomes,and thus requiring diferent policy interventions from current models.he importance and imminence of sustainability challenges,the dominant role of the Human System in the Earth System,and the essential roles the Earth System plays for the Human System,all call for collaboration of natural scientists,social scientists,and engineers in multidisciplinary research and modeling to develop coupled Earth–Human system models for devising efective science-based policies and measures to beneit current and future generations. | Safa Motesharrei Jorge Rivas Eugenia Kalnay Ghassem R.Asrar Antonio J.Busalacchi Robert F.Cahalan Mark A.Cane Rita R.Colwell Kuishuang Feng Rachel S.Franklin Klaus Hubacek Fernando Miralles-Wilhelm Takemasa Miyoshi Matthias Ruth Roald Sagdeev Adel Shirmohammadi Jagadish Shukla Jelena Srebric Victor M.Yakovenko Ning Zeng | 2016 | National Science Review2016，3，4： | 34 |
| 2 | Clinical impact of endoscopy position detecting unit(UPD-3) for a non-sedated colonoscopy显示文摘AIM:To evaluate whether an endoscopy position detecting unit(UPD-3) can improve cecal intubation rates, cecal intubation times and visual analog scale(VAS) pain scores, regardless of the colonoscopist's level of experience.METHODS:A total of 260 patients(170 men and 90women)who underwent a colonoscopy were divided into the UPD-3-guided group or the conventional group(no UPD-3 guidance).Colonoscopies were performed by experts(experience of more than 1000colonoscopies)or trainees(experience of less than 100colonoscopies).Cecal intubation rates,cecal intubation times,insertion methods(straight insertion:shortening the colonic fold through the bending technique;roping insertion:right turn shortening technique)and patient discomfort were assessed.Patient discomfort during the endoscope insertion was scored by the VAS that was divided into 6 degrees of pain.RESULTS:The cecum intubation rates,cecal intubation times,number of cecal intubations that were performed in<15 min and insertion methods were not significantly different between the conventional group and the UPD-3-guided group.The number of patients who experienced pain during the insertion was markedly less in the UPD-3-guided group than in the conventional group.Univariate and multivariate analysis showed that the following factors were associated with lower VAS pain scores during endoscope insertion:insertion method(straight insertion)and UPD-3guidance in the trainee group.For the experts group,univariate analysis showed that only the insertion method(straight insertion)was associated with lower VAS pain scores.CONCLUSION:Although UPD-3 guidance did not shorten intubation times,it resulted in less patient painduring endoscope insertion compared with conventional endoscopy for the procedures performed by trainees. | Masakatsu Fukuzawa Junichi Uematsu Shin Kono Sho Suzuki Takemasa Sato Naoko Yagi Yuichiro Tsuji Kenji Yagi Chika Kusano Takuji Gotoda Takashi Kawai Fuminori Moriyasu | 2015 | World Journal of Gastroenterology2015，21，16： | 5 |
| 3 | Endocytoscopic narrow-band imaging efficiency for evaluation of inflammatory activity in ulcerative colitis显示文摘AIM:To assess the efficacy of endocytoscopic narrowband imaging(EC-NBI)for evaluating the severity of inflammation in ulcerative colitis(UC).METHODS:This retrospective study was conducted at a single tertiary care referral center.We included UC patients who underwent colonoscopy with endocytoscopy from July 2010 to December 2013.ECNBI was performed,and the images were evaluated by assessing visibility,increased vascularization,and the increased calibers of capillaries and were classified as Obscure,Visible or Dilated.Obscure was indicative of inactive disease,while Visible and Dilated were indicative of acute inflammation.This study received Institutional Review Board approval.The primary outcome measures included the diagnostic ability of EC-NBI to distinguish between active and inactive UC on the basis of histological activity.The conventional endoscopic images were classified according to the Mayo endoscopic score.A score of 0 or 1 indicated inactive disease,whereas a score of 2 indicated active disease.RESULTS:Fifty-two patients were enrolled.There was a strong correlation between the EC-NBI findings and the histological assessment(r=0.871,P<0.01).The sensitivity,specificity,positive predictive value,negative predictive value,and accuracy of EC-NBI for diagnosing acute inflammation were 84.0%,100%,87.1%,100%,and 92.3%,respectively,while those for the Mayo endoscopic score were 100%,40.7%,100%,61.0%,and 69.2%,respectively.Compared with conventional endoscopy,EC-NBI was superior in diagnostic specificity,negative predictive value,and accuracy(P<0.001,P=0.001 and P=0.047,respectively).CONCLUSION:The EC-NBI finding of capillaries in the rectal mucosa was strongly correlated with histological inflammation and aided in the differential diagnosis between active and inactive UC. | Yasuharu Maeda Kazuo Ohtsuka Shin-ei Kudo Kunihiko Wakamura Yuichi Mori Noriyuki Ogata Yoshiki Wada Masashi Misawa Akihiro Yamauchi Seiko Hayashi Toyoki Kudo Takemasa Hayashi Hideyuki Miyachi Fuyuhiko Yamamura Fumio Ishida Haruhiro Inoue Shigeharu Hamatani | 2015 | World Journal of Gastroenterology2015，21，7： | 4 |
| 4 | Circulating microRNA-21 as a novel biomarker for hepatocellular carcinoma显示文摘 | Yoshito Tomimaru Hidetoshi Eguchi Hiroaki Nagano Hiroshi Wada Shogo Kobayashi Shigeru Marubashi Masahiro Tanemura Akira Tomokuni Ichiro Takemasa Koji Umeshita Tatsuya Kanto Yuichiro Doki Masaki Mori | 2011 | Journal of Hepatology2011，，1： | 3 |
| 5 | Efficiency of endocytoscopy in differentiating types of serrated polyps显示文摘 | Makoto Kutsukawa Shin-ei Kudo Nobunao Ikehara Yushi Ogawa Kunihiko Wakamura Yuichi Mori Katsuro Ichimasa Masashi Misawa Toyoki Kudo Yoshiki Wada Takemasa Hayashi Hideyuki Miyachi Haruhiro Inoue Shigeharu Hamatani | 2014 | Gastrointestinal Endoscopy2014，，4： | 3 |
| 6 | 金属V-带推块型CVT的研究(I)——传递转矩和带轮推力间关系显示文摘本文在金属V-带推块型CVT上,测出了主、从动带轮的传递转矩和推力以及两带轮间的轴向力。绘出了不同速比下主、从动带轮间相对于转矩比的推力比线图并作相互比较。发现推力比与速比几乎和带轮转速及正常转矩下的最大可传递的转矩无关,该推力比是速比的函数,它和转矩比及推块与带轮间的摩擦系数有关。还导出了带轮推力经验平衡方程式,该式以显函数形式表示。它可以简化并可适用于电控CVT。 | Doshisha Univ. Toru Fujii and Takemasa kurokawa Honda R&D Co.Ltd.Shigeru Kanehara | 2000 | 传动技术2000，14，1： | 2 |
| 7 | Coexistence of hERG current block and disruption of protein trafficking in ketoconazole-induced long QT syndrome显示文摘 | Takemasa H Nagatomo T Abe H | 2008 | Br J Pharmacol2008，153，3： | 1 |
| 8 | Feasibility of sin- gle-site laparoseopic colectomy with complete mesocolic exci- sion for colon cancer: a prospective case-control comparison显示文摘 | Takemasa I Uemura M Nishimnra J | 2014 | Surg Eudosc2014，28，4： | 1 |
| 9 | Overexpres-sion of CDC25B phosphatase as a novel marker of poor prognosis human colorectal carcinoma显示文摘 | Takemasa I Yamamoto H Sekimoto M | 2000 | Cancer Res2000，60，11： | 1 |
| 10 | Factors affecting quaity of life of the hornebound elderly hemiparetic stroke patients 显示文摘 | Takemasa S Nakagoshi R Murakami M | 2014 | J Phys Ther Sci2014，26，2： | 1 |
| 11 | A Bayesian missing value estimation method显示文摘 | Oba S Sato M Takemasa I | 2003 | Bioinformatics2003，19，： | 1 |
| 12 | Adaptation of macrophages to exercise training improves innated immunity显示文摘 | Takako Kizaki Tohru Takemasa Takuya Sakurai | 2008 | Biochem Biophys Res Commun2008，372，1： | 1 |
| 13 | Coexistence of HERG current block and disruption of protein trafficking in ketoconazole-induced long QT syndrome显示文摘 | Takemasa H Nagatomo T Abe H | 2008 | Br J Pharmacol2008，153，3： | 1 |
| 14 | Overexpression of CDC25B phosphatase as a novel marker of poor prognosis of human colorectal carcinoma 显示文摘 | TAKEMASA I YAMAMOTO H SEKIMOTO M | | Cancer Res0，60，11： | 1 |
| 15 | A neutrophil elastaseinhibitor prevents bleomycin- induced pulmonary fibrosis inmice显示文摘 | Takemasa A Ishii Y Fukuda T | 2012 | Eur Respir J2012，40，6： | 1 |
| 16 | Construction of preferential cDNA Mieroarray specialized for human colorectal carcinoma : molecular sketch of colorectal cancer 显示文摘 | Takemasa I Higuchi H Yamamoto H | 2001 | Biochem Biophys Res Commun2001，285，： | 1 |
| 17 | A Bayesian missing value estimation method for gene expression profile data显示文摘 | SHIGEYUKI OBA MASA-AKI SATO ICHIRO TAKEMASA | 2003 | Bioinformatics2003，19，16： | 1 |
| 18 | Clinicopathological features of small T1 colorectal cancers显示文摘BACKGROUND Although small colorectal neoplasms(<10 mm)are often easily resected endoscopically and are considered to have less malignant potential compared with large neoplasms(≥10 mm),some are invasive to the submucosa.AIM To clarify the clinicopathological features of small T1 colorectal cancers.METHODS Of 32025 colorectal lesions between April 2001 and March 2018,a total of 1152 T1 colorectal cancers resected endoscopically or surgically were included in this study and were divided into two groups by tumor size:a small group(<10 mm)and a large group(≥10 mm).We compared clinicopathological factors including lymph node metastasis(LNM)between the two groups.RESULTS The incidence of small T1 cancers was 10.1%(116/1152).The percentage of initial endoscopic treatment in small group was significantly higher than in large group(<10 mm 74.1%vs≥10 mm 60.2%,P<0.01).In the surgical resection cohort(n=798),the rate of LNM did not significantly differ between the two groups(small 12.3%vs large 10.9%,P=0.70).In addition,there were also no significant differences between the two groups in pathological factors such as histological grade,vascular invasion,or lymphatic invasion.CONCLUSION Because there was no significant difference in the rate of LNM between small and large T1 colorectal cancers,the requirement for additional surgical resection should be determined according to pathological findings,regardless of tumor size. | Yuki Takashina Shin-Ei Kudo Katsuro Ichimasa Yuta Kouyama Kenichi Mochizuki Yoshika Akimoto Yasuharu Maeda Yuichi Mori Masashi Misawa Noriyuki Ogata Toyoki Kudo Tomokazu Hisayuki Takemasa Hayashi Kunihiko Wakamura Naruhiko Sawada Toshiyuki Baba Fumio Ishida Kazunori Yokoyama Mitsuru Daita Tetsuo Nemoto Hideyuki Miyachi | 2021 | World Journal of Clinical Cases2021，9，33： | 1 |
| 19 | Feasibility of single-site laparoseopic colectomy with complete mesocolic exci-sion for colon cancer:a prospective case control comparison显示文摘 | Takemasa I Uemura M Nishimura J | 2014 | Surgical endoscopy2014，28，4： | 1 |
| 20 | Effect of dietary taurine on egg weight显示文摘 | Yamazaki M Takemasa M | 1998 | Poult Sci1998，77，： | 1 |
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