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| 1 | 经腹机器人辅助腹腔镜肾部分切除术治疗T2期肾肿瘤的国际多中心临床研究显示文摘目的通过国际多中心研究探讨临床T2期肾肿瘤行经腹机器人辅助腹腔镜肾部分切除术的安全性及有效性。方法回顾性分析2012年1月至2017年12月国际19家泌尿中心378例临床T2期肾肿瘤行经腹机器人肾部分切除术和经腹机器人根治性肾切除术患者的临床资料。根据手术方式不同,分为部分切除组和根治组。部分切除组159例,男118例,女41例;年龄(59.3±13.2)岁,体重指数(28.7±5.4) kg/m^2,术前GFR (77.3±22.1)ml/min;肿瘤位于左侧72例,右侧87例;肿瘤直径(83±16)mm;R.E.N.A.L.评分(8.6±2.2)分。根治组219例,男156例,女63例;年龄(62.0±12.9)岁,体重指数(28.7±6.1) kg/m^2,术前GFR (71.4±20.3)ml/min;肿瘤位于左侧112例,右侧105例,双侧2例;肿瘤直径(92±25)mm;R.E.N.A.L.评分(9.7±1.5)分。两组患者性别、体重指数、肿瘤位置的差异均无统计学意义(P〉0.05)。部分切除组患者年龄、肿瘤直径、R.E.N.A.L.评分均低于根治组(P〈0.05),术前GFR优于根治组(P=0.012)。比较两组围手术期资料、肿瘤病理类型、随访时间、复发时间及术后GFR等。结果378例手术均顺利完成。部分切除组手术时间中位值150 min(65-353 min),短于根治组[180 min(85-361 min),P〈0.001],术中出血量中位值150 ml(40-3 000 ml),多于根治组[100 ml (10-1 100 ml),P〈0.001]。术中并发症发生率部分切除组为5.7%(9/159),根治组为3.2%(7/219),两组差异无统计学意义(P=0.240)。部分切除组术后并发症发生率高于根治组[19.5%(31/159)与10.5%(23/219),P=0.014],但≥3级并发症发生率的差异无统计学意义[4.4%(7/159)与2.3%(5/219),P=0.246]。部分切除组无复发生存率高于根治组[91.4%(117/128)与81.9%(167/204),P=0.013]。部分切除组术后GFR降低值16.9 ml/min(10.4-84.7 ml/min)明显少于根治组29.0 ml/min(14.0-54.0 ml/min),肾部分切除术更利于术后肾功能的保护(P〈0.001)。结论临床T2期肾肿瘤行机器人肾部分切除术可获得有效的肿瘤控制率,同时可以更好地保护肾功能,可作为临床T2期肾肿瘤有效的手术方式。 | 过菲 张超 王富博 王林辉 杨庆 叶华茂 吕晨 肖成武 汪洋 Giuseppe Simone Ithaar Derweesh Andrea Minervini Daniel Eun Francesco Porpiglia Sisto Perdona James Porter Matteo Ferro Alexandre Mottrie Robert Uzzo Luigi Schips Wesley White Ken Jacobsohn Prokar Dasgupta Riccardo Autorino Clayton Lau Chandru Sundaram Umberto Capitanio 孙颖浩 杨波 | 2018 | 中华泌尿外科杂志2018，39，6： | 8 |
| 2 | Laparoendoscopic Single-site Surgery in Urology: Worldwide Multi-institutional Analysis of 1076 Cases显示文摘 | Jihad H. Kaouk Riccardo Autorino Fernando J. Kim Deok Hyun Han Seung Wook Lee Sun Yinghao Jeffrey A. Cadeddu Ithaar H. Derweesh Lee Richstone Luca Cindolo Anibal Branco Francesco Greco Mohamad Allaf René Sotelo Evangelos Liatsikos Jens-Uwe Stolzenburg Abh | 2011 | European Urology2011，，5： | 2 |
| 3 | adrenal trauma: Elvis Presley Memorial trauma center experience 显示文摘 | Mehrazin R Derweesh IH Kincade MC | 2007 | Urology2007，70，： | 1 |
| 4 | A Systematic Approach to Minimizing Wound Problems for De Novo Sirolimus-Treated Kidney Transplant Recipients显示文摘 | Ho Yee Tiong Stuart M. Flechner Lingme Zhou Alvin Wee Barbara Mastroianni Kathy Savas David Goldfarb Ithaar Derweesh Charles Modlin | 2009 | Transplantation2009，，2： | 1 |
| 5 | Laparo- endoscopic single-site surgery for radical and cytoreductive ne- phrectomy, renal vein thrombectomy, and partial nephrectomy a prospective pilot evaluation显示文摘 | DERWEESH IH SILBERSTEIN JL BAZZI W | 2010 | Diagn Ther Endosc2010，2010，10： | 1 |
| 6 | Guideline for manage- ment of the clinical T1 renal mass显示文摘 | Campbell S C Novick A C Belldegrun A Blute M L Chow G K Derweesh I H | 2009 | J Urol2009，18，21： | 1 |
| 7 | Guideline for management of the clinical T1 renal mass显示文摘 | Campbell S C Novick A C Belldegrun A Blute M L Chow G K Derweesh I H | 2009 | J Urol2009，182，： | 1 |
| 8 | Gastrointestinal tract access for urological natural orifice transluminal endoscopic surgery显示文摘We conducted a literature review of natural orifice transluminal endoscopic surgery(NOTES),focusing on urologic procedures with gastrointestinal tract access,to update on the development of this novel surgical approach.As part of the methods,a comprehensive electronic literature search for NOTES was conducted using Pub Med and Cochrane Library from March 2002 to February 2016 for papers reporting urologic procedures performed utilizing gastrointestinal tract access.A total of 11 peer-reviewed studies examining utility of gastrointestinal access for NOTES urologic procedures were noted,with the first report in 2007.The procedures reported in the studies were total/radical nephrectomy,partial nephrectomy,adrenalectomy,and prostatectomy.The transgastric approach was identified in five studies examining total/radical nephrectomy(n = 2),partial nephrectomy(n = 1),partial cystectomy(n = 1),and adrenalectomy(n = 1).Six studies evaluated transrectal approach for NOTES,describing total/radical nephrectomy(n = 3),partial nephrectomy(n = 1),robotic nephrectomy with adrenalectomy(n = 1) and prostatectomy(n = 1).Feasibility was reported in all studies.Most studies were preclinical and acute,and limited by concerns regarding restricted instrumentation and infection risk.We concluded that gastrointestinal access for urologic NOTES demonstrates promise as described by outlined feasibility studies in preclinical models.Nonetheless,clinical application awaits further advancements in surgical technology and concerns regarding infectious potential. | Olga Miakicheva Zachary Hamilton Alp T Beksac Sean W Berquist Abd-elrahman Hassan Marc Holden Ithaar H Derweesh | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，19： | 1 |
| 9 | Is all chronic kidney disease created equal? 显示文摘 | Lane BR Demirjian S Derweesh IH | 2014 | Curt Opin Urol2014，24，2： | 1 |
| 10 | The predictive value of helical computed tomographyfor collecting-system en try during nephron sparing surgery 显示文摘 | Derweesh IH Herts BR Motta Ramirez GA | 2006 | BJU Int2006，98，5： | 1 |
| 11 | Guideline for management of the clinical stage T1 renal mass显示文摘 | Campbell S C Novick A C Belldegrun A Blute M L Chow G K Derweesh I H | 2009 | J Urol2009，182，： | 1 |
| 12 | Alterations in G-proteins and adrenergic responsive adenylyl cyclase in rat urinary bladder during aging显示文摘 | Derweesh IH Wheeler MA Weiss RM | 2000 | J Pharmacol Exp Ther2000，294，： | 1 |
| 13 | Laparoendoscopic single-site partial nephrectomy:a multi-institutional outcome analysis显示文摘 | Greco F Autorino R Rha K H Derweesh I Cindolo L Richstone L | 2013 | Eur Urol2013，64，： | 1 |
| 14 | Guideline for management of the clinical T1 renal mass显示文摘 | Campbell S C Novick A C Belldegrun A Blute M L Chow G K Derweesh I H | 2009 | J Urol2009，182，： | 1 |
| 15 | The impact of sirolimus,mycophenolate mofetil,cyclosporine,azathioprine,and steroids on wound healing in 513 kidney-transplant recipients显示文摘 | Flechner SM Zhou L Derweesh I | 2003 | Transplantation2003，76，12： | 1 |
| 16 | Tubeless percutaneousnephrolithotomy for complex renal stone disease: single centerexperience显示文摘 | Malcolm JB Derweesh IH Brightbill EK | 2008 | Can J Urol2008，15，3： | 1 |
| 17 | Laparo-endoscopic single-site (LESS) radical nephrectomy with renal vein thrombectomy: initial report 显示文摘 | Kopp RP Silberstein JL Derweesh IH | 2010 | BMC Urol2010，10，： | 1 |
| 18 | Second prize: Recur- rence rates after percutaneous and laparoscopic renal cryoablation of small renal masses: does the approach make a difference显示文摘 | Strom KH Derweesh I Stroup SP | 2011 | J Endourol2011，25，： | 1 |
| 19 | Superior gluteal artery pseudoaneurysm presenting as a gluteal mass: case report and ~view of litemtm'e显示文摘 | Taif S Derweesh A Talib M | 2013 | J Clin Imaging Sci2013，3，： | 1 |
| 20 | Outcomes of partial nephrecto- my for clinical Tlb and T2 renal tumors 显示文摘 | Lee HJ Liss MA Derweesh IH | 2014 | Curr Opin Urol2014，24，： | 1 |
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