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| 1 | Incidence of hepatocellular carcinoma in outpatients with cirrhosis in Brazil: A 10-year retrospective cohort study显示文摘AIM To determine the incidence of hepatocellular carcinoma(HCC) and the impact of HCC surveillance on early diagnosis and survival of cirrhotic outpatients. METHODS In this retrospective cohort study, cirrhotic outpatients undergoing HCC surveillance between March 2005 and March 2014 were analyzed. Exclusion criteria were HIV coinfection; previous organ transplantation; diagnosis of HCC at first consultation; missing data in the medical chart; and less than 1 year of follow-up. Surveillance was carried out every six months using ultrasound and serum alpha-fetoprotein determination. Ten-year cumulative incidence and survival were estimated through Kaplan-Meier analysis. RESULTS Four hundred and fifty-three patients were enrolled, of which 57.6% were male. Mean age was 55 years. Hepatitis C virus and heavy use of alcohol were the main etiologic agents of cirrhosis. HCC was diagnosed in 75 patients(16.6%), with an estimated cumulative incidence of 2.6% in the 1st year, 15.4% in the 5th year, and 28.8% in the 10 th year. Median survival was estimated at 17.6 mo in HCC patients compared to 234 mo in non-HCC patients(P < 0.001). Early-stage HCC was more often detected in patients who underwent surveillance every 6 mo or less(P = 0.05). However, survival was not different between patients with early stage vs non-early stage tumors [HR = 0.54(0.15-1.89), P = 0.33].CONCLUSION HCC is a frequent complication in patients with cirrhosis and adherence to surveillance programs favors early diagnosis. | Marcelo Campos Appel-da-Silva Suelen Aparecida da Silva Miozzo Isabella de Azevedo Dossin Cristiane Valle Tovo Fernanda Branco Angelo Alves de Mattos | 2016 | World Journal of Gastroenterology2016，22，46： | 7 |
| 2 | Neuroprotective measures in children with traumatic brain injury显示文摘Traumatic brain injury(TBI) is a major cause of death and disability in children. Severe TBI is a leading cause of death and often leads to life changing disabilities in survivors. The modern management of severe TBI in children on intensivecare unit focuses on preventing secondary brain injury to improve outcome. Standard neuroprotective measures are based on management of intracranial pressure(ICP) and cerebral perfusion pressure(CPP) to optimize the cerebral blood flow and oxygenation, with the intention to avoid and minimise secondary brain injury. In this article, we review the current trends in management of severe TBI in children, detailing the general and specific measures followed to achieve the desired ICP and CPP goals. We discuss the often limited evidence for these therapeutic interventions in children, extrapolation of data from adults, and current recommendation from paediatric guidelines. We also review the recent advances in understanding the intracranial physiology and neuroprotective therapies, the current research focus on advanced and multi-modal neuromonitoring, and potential new therapeutic and prognostic targets. | Shruti Agrawal Ricardo Garcia Branco | 2016 | World Journal of Critical Care Medicine2016，5，1： | 5 |
| 3 | 桡骨远端骨折——手术与非手术治疗比较显示文摘有一些证据表明外科治疗,包括开放复位内固定(ORIF)或经皮穿针固定(不包括Kapandji穿针),其功能结果优于保守治疗。不过,仍需要大规模的研究和更长的随访来证实这些结论。 | James F.Kellam Branco Kopjar Ladislav Nagy Rodrigo F.Pesantez 陈国奋 顾立强 | 2004 | 中华创伤骨科杂志2004，6，10： | 5 |
| 4 | Noninvasive imaging assessment of non-alcoholic fatty liver disease:focus on liver scintigraphy显示文摘Noninvasive diagnoses of nonalcoholic fatty-liver disease(NAFLD) involve the use of serologic markers and imaging methods, such as conventional ultrasonography(US),computed tomography, and magnetic resonance imaging. Although these methods are reliable for the noninvasive detection of moderate to severe fatty changes in the liver, they are not reliable for detecting nonalcoholic steatohepatitis(NASH) and fibrosis. New imaging technologies, such as US-based transient elastography, acoustic radiation force impulse and magnetic resonancebased elastography, can reportedly be used to determine the severity of liver fibrosis associated with NASH. In this context, the field of nuclear medicine through liver scintigraphy has recently been proposed, and is being explored for use in the diagnosis of NASH. More importantly, nuclear medicine may contribute to the distinction between simple steatosis and NASH. For example, the enhanced release of cytokines and the decrease in the phagocytic activity of Kupffer cells play important roles in the pathogenesis of NASH. Removal of technetium-99 m colloid from circulation by Kupffer cell phagocytosis therefore provides a valuable imaging technique. Thus, nuclear medicine is poised to provide useful tools for the evaluation of patients with NAFLD. However, the evidence is still scarce, and more studies with larger samples are needed to identify their role before they are used in clinical practice. | Cristiane Valle Tovo Angelo Zambam de Mattos Gabriela Perdomo Coral Fernanda Schild Branco Eiji Suwa Angelo Alves de Mattos | 2015 | World Journal of Gastroenterology2015，21，15： | 5 |
| 5 | Hyperbaric oxygen therapy as a complementary treatment for radiation proctitis:Useless or useful?-A literature review显示文摘Radiotherapy(RT)is the backbone of multimodality treatment of more than half of cancer cases.Despite new modern RT techniques,late complications may occur such as radiation proctitis(RP).The natural history of RP is unpredictable.Minor symptoms may resolve spontaneously or require conservative treatment.On the other hand,for similar and uncomplicated clinical contexts,symptoms may persist and can even be refractory to the progressive increase in treatment measures.Over the last decades,an enormous therapeutic armamentarium has been considered in RP,including hyperbaric oxygen therapy(HBOT).Currently,the evidence regarding the impact of HBOT on RP and its benefits is conflicting.Additional prospective and randomised studies are necessary to validate HBOT’s effectiveness in the‘real world’clinical practice.This article reviewed the relevant literature on pathophysiology,clinical presentation,different classifications and discuss RP management including a proposal for a therapeutic algorithm with a focus on HBOT. | Diogo Alpuim Costa Carla Espiney Amaro Ana Nunes Joana Santos Cardoso Pedro Modas Daniel Isabel Rosa João Vieira Branco | 2021 | World Journal of Gastroenterology2021，27，27： | 4 |
| 6 | Mercury in sediments and vegetation in a moderately contaminated salt marsh (Tagus Estuary, Portugal)显示文摘Depth variations of total mercury (Hg) and methylmercury (MeHg) concentrations were studied in cores from non-colonized sediments, sediments colonized by Halimione portulacoides, Sarcocornia fruticosa and Spartina maritima and belowground biomass, in a moderately contaminated salt marsh (Tagus Estuary, Portugal). Concentrations in belowground biomass exceeded up to 3 (Hg) and 15 (MeHg) times the levels in sediments, and up to 198 (Hg) and 308 (MeHg) times those found in aboveground parts. Methylmercury in colonized sediments reached 3% of the total Hg, 50 times above the maximum values found in non-colonized sediments. The absence of correlations between total Hg concentrations in sediments and the corresponding MeHg levels suggested that methylation was only dependent on the environmental and microbiological factors. The analysis of belowground biomass at high-depth resolution (2 cm) provided evidence that Hg and MeHg were actively absorbed from sediments, with higher enrichment factors at layers where higher microbial activity was probably occurring. The results obtained in this study indicated that the biotransformation of Hg to the toxic MeHg could increase the toxicity of plant-colonized sediments. | Joao Canário Carlos Vale Laurier Poissant Marta Nogueira Martin Pilote Vasco Branco | 2010 | Journal of Environmental Sciences2010，22，8： | 4 |
| 7 | Review of anticancer mechanisms of isoquercitin显示文摘This review was based on a literature search of PubM ed and Scielo databases using the keywords 'quercetin,rutin,isoquercitrin,isoquercitin(IQ),quercetin-3-glucoside,bioavailability,flavonols and favonoids,and cancer' and combinations of all the words.We collected relevant scientific publications from 1990 to 2015 about the absorption,bioavailability,chemoprevention activity,and treatment effects as well as the underlying anticancer mechanisms of isoquercitin.Flavonoids are a group of polyphenolic compounds widely distributed throughout the plant kingdom.The subclass of flavonols receives special attention owing to their health benefits.The main components of this class are quercetin,rutin,and IQ,which is a flavonoid and although mostly found as a glycoside,is an aglycone(lacks a glycoside side chain).This compound presents similar therapeutic profiles to quercetin but with superior bioavailability,resulting in increased efficacy compared to the aglycone form.IQ has therapeutic applications owing to its wide range of pharmacological effects including antioxidant,antiproliferative,anti-inflammatory,anti-hypertensive,and anti-diabetic.The protective effects of IQ in cancer may be due to actions on lipid peroxidation.In addition,the antitumor effect of IQ and its underlying mechanism are related to interactions with Wnt signaling pathway,mixed-lineage protein kinase 3,mitogen-activated protein kinase,apoptotic pathways,as well proinflammatory protein signaling.This review contributed to clarifying the mechanisms of absorption,metabolism,and actions of IQ and isoquercitrin in cancer. | Guilherme di Camillo Orfali Ana Carolina Duarte Vivien Bonadio Natalia Peres Martinez Maria Elisa Melo Branco de Araújo Fernanda Bruschi Marinho Priviero Patricia Oliveira Carvalho Denise Gon?alves Priolli | 2016 | World Journal of Clinical Oncology2016，7，2： | 4 |
| 8 | Corporate Social Responsibility and Resource-Based Perspectives显示文摘 | Manuel Castelo Branco Lúcia Lima Rodrigues | 2006 | Journal of Business Ethics2006，，2： | 3 |
| 9 | Natural Orifice Translumenal Endoscopic Surgery (NOTES) Transvaginal Cholecystectomy in a Morbidly Obese Patient显示文摘 | Luis DeCarli Ricardo Zorron Alcides Branco Fernando Cirme Lima Marcos Tang Sergio Ricardo Pioneer Idilio Zanin Alfredo Augusto Schulte André Vicente Bigolin Michel Gagner | 2008 | Obesity Surgery2008，，7： | 2 |
| 10 | Laparoendoscopic Single-site Surgery in Urology: Worldwide Multi-institutional Analysis of 1076 Cases显示文摘 | Jihad H. Kaouk Riccardo Autorino Fernando J. Kim Deok Hyun Han Seung Wook Lee Sun Yinghao Jeffrey A. Cadeddu Ithaar H. Derweesh Lee Richstone Luca Cindolo Anibal Branco Francesco Greco Mohamad Allaf René Sotelo Evangelos Liatsikos Jens-Uwe Stolzenburg Abh | 2011 | European Urology2011，，5： | 2 |
| 11 | The design of multidimensional auctions 显示文摘 | Branco F | 1997 | The Rand Journal of Economics1997，28，1： | 1 |
| 12 | Fuzzy Logic Torque Ripple Reduction by Turn-off Angle Compensation for Switched Reluctance Motors显示文摘 | Rodrigues M Costa Branco PJ Suemitsu W | 2001 | IEEE Transactions on Industrial Electronics2001，48，3： | 1 |
| 13 | Physiology of tempera- ture regulation:comparative aspects显示文摘 | Bicego KC Barros RC Branco LG | 2007 | Comp Biochem Phy- siol A Mol Integr Physiol2007，147，3： | 1 |
| 14 | Neural substrate of cold- seeking behavior in endotoxin shock显示文摘 | Almeida MC Steiner AA Branco LG | 2006 | PLoS One2006，1，： | 1 |
| 15 | Probiotic DairyProducts as Functional Foods显示文摘 | GRANATO D BRANCO G F CRUZ A G | 2010 | Comprehensive Reviews in FoodScience and Food Safety2010，9，5： | 1 |
| 16 | Carbon monoxide is the heme oxygenase product with a pyretic action: evidence for acGMP signaling pathway显示文摘 | Steiner AA Branco LG | 2001 | Am J Physiol Regul Integr Comp Physiol2001，280，2： | 1 |
| 17 | Prevention of postop-erative peritonealadhesions: a review of the literature 显示文摘 | Schnuriger B Barmparas G Branco BC | 2011 | Am J Surg2011，201，1： | 1 |
| 18 | The incidence and risk factors of post-laparotomy adhesive small bowel ob-struction显示文摘 | Barmparas G Branco BC Schnuriger B | 2010 | J Gastrointest Surg2010，14，10： | 1 |
| 19 | Statistical analysis of thermal actions for concrete bridge design 显示文摘 | SILVEIRA A P BRANCO F A CASTANHETA M | 2000 | Journal of the International Association for Bridge and Structural Engineering2000，10，1： | 1 |
| 20 | Flexural behaviour of GFRP-eoncrete hybrid beams with interconnection slip 显示文摘 | Correia J R Branco F A Ferreira J G | 2007 | Composite Structures2007，77，1： | 1 |
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