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| 1 | 经腹机器人辅助腹腔镜肾部分切除术治疗T2期肾肿瘤的国际多中心临床研究显示文摘目的通过国际多中心研究探讨临床T2期肾肿瘤行经腹机器人辅助腹腔镜肾部分切除术的安全性及有效性。方法回顾性分析2012年1月至2017年12月国际19家泌尿中心378例临床T2期肾肿瘤行经腹机器人肾部分切除术和经腹机器人根治性肾切除术患者的临床资料。根据手术方式不同,分为部分切除组和根治组。部分切除组159例,男118例,女41例;年龄(59.3±13.2)岁,体重指数(28.7±5.4) kg/m^2,术前GFR (77.3±22.1)ml/min;肿瘤位于左侧72例,右侧87例;肿瘤直径(83±16)mm;R.E.N.A.L.评分(8.6±2.2)分。根治组219例,男156例,女63例;年龄(62.0±12.9)岁,体重指数(28.7±6.1) kg/m^2,术前GFR (71.4±20.3)ml/min;肿瘤位于左侧112例,右侧105例,双侧2例;肿瘤直径(92±25)mm;R.E.N.A.L.评分(9.7±1.5)分。两组患者性别、体重指数、肿瘤位置的差异均无统计学意义(P〉0.05)。部分切除组患者年龄、肿瘤直径、R.E.N.A.L.评分均低于根治组(P〈0.05),术前GFR优于根治组(P=0.012)。比较两组围手术期资料、肿瘤病理类型、随访时间、复发时间及术后GFR等。结果378例手术均顺利完成。部分切除组手术时间中位值150 min(65-353 min),短于根治组[180 min(85-361 min),P〈0.001],术中出血量中位值150 ml(40-3 000 ml),多于根治组[100 ml (10-1 100 ml),P〈0.001]。术中并发症发生率部分切除组为5.7%(9/159),根治组为3.2%(7/219),两组差异无统计学意义(P=0.240)。部分切除组术后并发症发生率高于根治组[19.5%(31/159)与10.5%(23/219),P=0.014],但≥3级并发症发生率的差异无统计学意义[4.4%(7/159)与2.3%(5/219),P=0.246]。部分切除组无复发生存率高于根治组[91.4%(117/128)与81.9%(167/204),P=0.013]。部分切除组术后GFR降低值16.9 ml/min(10.4-84.7 ml/min)明显少于根治组29.0 ml/min(14.0-54.0 ml/min),肾部分切除术更利于术后肾功能的保护(P〈0.001)。结论临床T2期肾肿瘤行机器人肾部分切除术可获得有效的肿瘤控制率,同时可以更好地保护肾功能,可作为临床T2期肾肿瘤有效的手术方式。 | 过菲 张超 王富博 王林辉 杨庆 叶华茂 吕晨 肖成武 汪洋 Giuseppe Simone Ithaar Derweesh Andrea Minervini Daniel Eun Francesco Porpiglia Sisto Perdona James Porter Matteo Ferro Alexandre Mottrie Robert Uzzo Luigi Schips Wesley White Ken Jacobsohn Prokar Dasgupta Riccardo Autorino Clayton Lau Chandru Sundaram Umberto Capitanio 孙颖浩 杨波 | 2018 | 中华泌尿外科杂志2018,39,6: | 8 |
| 2 | Perioperative and renal functional outcomes of elective robot‐assisted partial nephrectomy ( RAPN ) for renal tumours with high surgical complexity显示文摘 | Alessandro Volpe Diletta Garrou Daniele Amparore Geert De Naeyer Francesco Porpiglia Vincenzo Ficarra Alexandre Mottrie | 2014 | BJU Int2014,,: | 2 |
| 3 | Systematic Review and Meta-analysis of Studies Reporting Oncologic Outcome After Robot-assisted Radical Prostatectomy 显示文摘 | Giacomo Novara Vincenzo Ficarra Simone Mocellin Thomas E. Ahlering Peter R. Carroll Markus Graefen Giorgio Guazzoni Mani Menon Vipul R. Patel Shahrokh F. Shariat Ashutosh K. Tewari Hendrik Van Poppel Filiberto Zattoni Francesco Montorsi Alexandre Mottrie | 2012 | European Urology2012,,: | 1 |
| 4 | Systematic Review and Meta-analysis of Studies Reporting Oncologic Outcome After Robot-assisted Radical Prostatectomy <ce:link locator='eulogo1'/>显示文摘 | Giacomo Novara Vincenzo Ficarra Simone Mocellin Thomas E. Ahlering Peter R. Carroll Markus Graefen Giorgio Guazzoni Mani Menon Vipul R. Patel Shahrokh F. Shariat Ashutosh K. Tewari Hendrik Van Poppel Filiberto Zattoni Francesco Montorsi Alexandre Mottrie | 2012 | European Urology2012,,3: | 1 |
| 5 | Systematic Review and Meta-analysis of Perioperative Outcomes and Complications After Robot-assisted Radical Prostatectomy显示文摘 | Giacomo Novara Vincenzo Ficarra Raymond C. Rosen Walter Artibani Anthony Costello James A. Eastham Markus Graefen Giorgio Guazzoni Shahrokh F. Shariat Jens-Uwe Stolzenburg Hendrik Van Poppel Filiberto Zattoni Francesco Montorsi Alexandre Mottrie Timothy G | 2012 | European Urology2012,,3: | 1 |
| 6 | Robot‐assisted vs traditional laparoscopic partial nephrectomy: the time for meta‐analysis has not yet arrived显示文摘 | Vincenzo Ficarra Giacomo Novara Alessandro Volpe Alexandre Mottrie | 2013 | BJU Int2013,,4: | 1 |
| 7 | Robot-Assisted Partial Nephrectomy: An International Experience显示文摘 | Brian M. Benway Sam B. Bhayani Craig G. Rogers James R. Porter Nicolò M. Buffi Robert S. Figenshau Alexandre Mottrie | 2010 | European Urology2010,,5: | 1 |
| 8 | Expanding utilization of robotic partial nephrectomy for clinical T1b and complex T1a renal masses显示文摘 | Marco Borghesi Riccardo Schiavina Melanie Gan Giacomo Novara Alexandre Mottrie Vincenzo Ficarra | 2013 | World Journal of Urology2013,,: | 1 |
| 9 | Robot-Assisted Partial Nephrectomy: An International Experience显示文摘 | Brian M. Benway Sam B. Bhayani Craig G. Rogers James R. Porter Nicolò M. Buffi Robert S. Figenshau Alexandre Mottrie | 2010 | European Urology2010,,5: | 1 |
| 10 | Systematic Review and Meta-analysis of Perioperative Outcomes and Complications After Robot-assisted Radical Prostatectomy显示文摘 | Giacomo Novara Vincenzo Ficarra Raymond C. Rosen Walter Artibani Anthony Costello James A. Eastham Markus Graefen Giorgio Guazzoni Shahrokh F. Shariat Jens-Uwe Stolzenburg Hendrik Van Poppel Filiberto Zattoni Francesco Montorsi Alexandre Mottrie Timothy G | 2012 | European Urology2012,,3: | 1 |
| 11 | Systematic Review and Meta-analysis of Studies Reporting Potency Rates After Robot-assisted Radical Prostatectomy 显示文摘 | Vincenzo Ficarra Giacomo Novara Thomas E. Ahlering Anthony Costello James A. Eastham Markus Graefen Giorgio Guazzoni Mani Menon Alexandre Mottrie Vipul R. Patel Henk Van der Poel Raymond C. Rosen Ashutosh K. Tewari Timothy G. Wilson Filiberto Zattoni Fran | 2012 | European Urology2012,,3: | 1 |
| 12 | Systematic Review and Meta-analysis of Perioperative Outcomes and Complications After Robot-assisted Radical Prostatectomy显示文摘 | Giacomo Novara Vincenzo Ficarra Raymond C. Rosen Walter Artibani Anthony Costello James A. Eastham Markus Graefen Giorgio Guazzoni Shahrokh F. Shariat Jens-Uwe Stolzenburg Hendrik Van Poppel Filiberto Zattoni Francesco Montorsi Alexandre Mottrie Timothy G | 2012 | European Urology2012,,3: | 1 |
| 13 | Robotic-Assisted Laparoscopic Ureteral Reimplantation with Psoas Hitch: A Multi-institutional, Multinational Evaluation显示文摘 | Nilesh N. Patil Alexandre Mottrie Bala Sundaram Vipul R. Patel | 2008 | Urology2008,,: | 1 |
| 14 | Outcomes and limitations of laparoscopic and robotic partial nephrectomy显示文摘 | Vincenzo Ficarra Marta Rossanese Michele Gnech Giacomo Novara Alexandre Mottrie | 2014 | Current Opinion in Urology2014,,5: | 1 |
| 15 | Robot-assisted adrenalectomy:Step-by-step technique and surgical outcomes at a high-volume robotic center显示文摘Objective In the last years,robotic surgery was introduced in several different settings with good perioperative results.However,its role in the management of adrenal masses is still debated.In order to provide a contribution to this field,we described our step-by-step technique for robotic adrenalectomy(RA)and related modifications according to the type of adrenal mass treated.Methods We retrospectively analyzed 27 consecutive patients who underwent RA at Onze-Lieve-Vrouw hospital(Aalst,Belgium)between January 2009 and October 2022.Demographic,intra-and post-operative,and pathological data were retrieved from our prospectively maintained institutional database.Continuous variables are summarized as median and interquartile range(IQR).Categorical variables are reported as frequencies(percentages).Results Twenty-seven patients underwent RA were included in the study.Median age,body mass index,and Charlson's comorbidity index were 61(IQR:49-71)years,26(IQR:24-29)kg/m^(2),and 2(IQR:0-3),respectively,and 16(59.3%)patients were male.Median tumor size at computed tomography scan was 6.0(IQR:3.5-8.0)cm.Median operative time and blood loss were 105(IQR:82-120)min and 175(IQR:94-250)mL,respectively.No intraoperative complications were recorded.Overall postoperative complications rate was 11.1%,with a postoperative transfusion rate of 3.7%.A total of 10(37.0%)patients harbored malignant adrenal masses.Among them,3(11.1%)had adrenocortical carcinoma,6(22.2%)secondary metastasis,and 1(3.7%)malignant pheochromocytoma on final pathological exam.Only 1(10.0%)patient had positive surgical margins.Conclusion We described our step-by-step technique for RA,which can be safely performed even in case of high challenging settings as malignant tumors,pheochromocytoma,and large masses.The standardization of perioperative protocol should be encouraged to maximize the outcomes of this complex surgical procedure. | Federico Piramide Carlo Andrea Bravi Marco Paciotti Luca Sarchi Luigi Nocera Adele Piro Maria Peraire Lores Eleonora Balestrazzi Angelo Mottaran Rui Farinha Hubert Nicolas Pieter De Backer Frederiek D'hondt Peter Schatteman Ruben De Groote Geert De Naeyer Alexandre Mottrie | 2023 | Asian Journal of Urology2023,10,4: | 0 |
| 16 | New imaging technologies for robotic kidney cancer surgery显示文摘Objective:Kidney cancers account for approximately 2%of all newly diagnosed cancer in 2020.Among the primary treatment options for kidney cancer,urologist may choose between radical or partial nephrectomy,or ablative therapies.Nowadays,robotic-assisted partial nephrectomy(RAPN)for the management of renal cancers has gained popularity,up to being considered the gold standard.However,RAPN is a challenging procedure with a steep learning curve.Methods:In this narrative review,different imaging technologies used to guide and aid RAPN are discussed.Results:Three-dimensional visualization technology has been extensively discussed in RAPN,showing its value in enhancing robotic-surgery training,patient counseling,surgical planning,and intraoperative guidance.Intraoperative imaging technologies such as intracorporeal ultrasound,near-infrared fluorescent imaging,and intraoperative pathological examination can also be used to improve the outcomes following RAPN.Finally,artificial intelligence may play a role in the field of RAPN soon.Conclusion:RAPN is a complex surgery;however,many imaging technologies may play an important role in facilitating it. | Stefano Puliatti Ahmed Eissa Enrico Checcucci Pietro Piazza Marco Amato Stefania Ferretti Simone Scarcella Juan Gomez Rivas Mark Taratkin Jose Marenco Ines Belenchon Rivero Karl-Friedrich Kowalewski Giovanni Cacciamani Ahmed El-Sherbiny Ahmed Zoeir Abdelhamid MEl-Bahnasy Ruben De Groote Alexandre Mottrie Salvatore Micali | 2022 | Asian Journal of Urology2022,9,3: | 0 |
| 17 | New insights into the pathogenesis of Peyronie’s disease:A narrative review显示文摘Peyronie’s disease(PD)is a benign,progressive fibrotic disorder characterized by scar or plaques within the tunica albuginea(TA)of the penis.This study provides new insights into the pathogenesis of PD based on data from different studies regarding the roles of cytokines,cell signaling pathways,biochemical mechanisms,genetic factors responsible for fibrogenesis.A growing body of literature has shown that PD is a chronically impaired,localized,wound healing process within the TA and the Smith space.It is caused by the influence of different pathological stimuli,most often the effects of mechanical stress during sexual intercourse in genetically sensitive individuals with unusual anatomical TA features,imbalanced matrix metalloproteinase/tissue inhibitor of metalloproteinase(MMP/TIMP),and suppressed antioxidant systems during chronic inflammation.Other intracellular signal cascades are activated during fibrosis along with low expression levels of their negative regulators and transforming growth factor-β1 signaling.The development of multikinase agents with minimal side effects that can block several signal cell pathways would significantly improve fibrosis in PD tissues by acting on common downstream mediators. | Denis V.Krakhotkin Volodymyr A.Chernylovskyi Alexandre Mottrie Francesco Greco Ruslan A.Bugaev | 2020 | Chronic Diseases and Translational Medicine2020,6,3: | 0 |