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| 1 | Evaluation of chemopreventive effect of Fumaria indica against N-nitrosodiethylamine and CCl_4-induced hepatocellular carcinoma in Wistar rats显示文摘Objective:To investigation the chemopreventive potential of Fumaria indica(F.indica) extract(FIE) on N-nitrosodiethylamine and CCl4-induced hepatocarcinogenesis in Wislar rats.Methods:The experimental animals were divided into six groups(n=6).Hepatocellular carcinoma was induced by single intraperitoneal injection of N-nitrosodiethylamine(NDEA) in normal saline at a dose of 200 mg/kg body weight followed by weekly subcutaneous injections of CCl4(3 mL/kg/week) for 6 weeks,as the promoter of carcinogenic effect.After administration of the carcinogen,200 and 400 mg/kg of FIE were administered orally once a day throughout the study.At the end of 20 weeks,the body weight,liver weight and relative liver weight were measured.The percentage of nodule incidence and liver cancer markers such as aspartate transaminase(AST),alanine transaminase(ALT),alkaline phosphatase(ALP),γ-glutamyl transferase(γ-GT),total bilirubin level(TBL),α-feto protein(AFP) and carcinoembryonic antigen were estimated along with histopathological investigation in experimental groups of rats. Results:Obtained results demonstrated that the cotreatment with FIE significantly prevented the decrease of the body weight and also increased in relative liver weight caused by NDEA. The treatment with FIE significantly reduced the nodule incidence and nodule multiplicity in the rats after NDEA administration.The levels of liver cancer markers such as AST,ALT,ALP,γ-glutamyl transferase,TBL,AFP and carcinoembryonic antigen were substantially increased by NDEA treatment.However,FIE treatment significantly reduced the liver injury and restored the entire liver cancer markers.Histological observations of liver tissues too correlated with the biochemical observations.Conclusions:These finding powerfully supports that F.indica exert chemopreventive effect by suppressing the tumor burden and restoring the activities of hepatic cancer marker enzymes on NDEA and CCl4-induced hepatocarcinogenesis in Wistar rats. | Talib Hussain Hefazat H Siddiqui Sheeba Fareed M Vijayakumar Chandana V Rao | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，8： | 3 |
| 2 | Acute and subacute oral toxicity evaluation of Tephrosia purpurea extract in rodents显示文摘 | Talib Hussain Sheeba Fareed HH Siddiqui M Vijaykumar Chandana Venkateswara Rao | 2012 | Asian Pacific Journal of Tropical Disease2012，，2： | 3 |
| 3 | Multi agent system architecture oriented prometheus methodology design to facilitate security of cloud data storage显示文摘 | TALIB A M ATAN R ABDULLAH R | 2011 | Journal of Software Engineering2011，5，3： | 1 |
| 4 | Statistical Deformable Bone Models for Robust 3D Surface Extrapolation from Sparse Data 显示文摘 | Rajamani M Styner H Talib | 2007 | Medical Image Analysis2007，，11： | 1 |
| 5 | Information filtering for ultrasound based real-time registration显示文摘 | Talib H Peterhans M Garda J | 2011 | IEEE Trans liomed Eng2011，58，3： | 1 |
| 6 | Utility of intrapleural streptokinase in management of chronic empyemas显示文摘 | Verma GR Arshad M | 2003 | J Assoc Physicians India2003，51，： | 1 |
| 7 | Nanoceria exhibit redox state-dependent catalase mimeticactivity显示文摘 | Talib Pirmohamed Janet M Dowding Sanjay Singh | 2010 | Chem Commun2010，，46： | 1 |
| 8 | Effect of flow rate on loss mechanisms in a backswept centrifugal impeller显示文摘 | Talib Z Farge M W J | 1992 | International journal of heat and fluid flow1992，13，2： | 1 |
| 9 | Vascular smooth muscle cell apoptosis induces interleukin-1-directed inflammation:effects of hyperlip-idemia-mediated inhibition of phagocytosis显示文摘 | Clarke M C Talib S Figg N L | 2010 | Circ Res2010，106，2： | 1 |
| 10 | An overview of Malaysian food industry: the opportunity and quality aspects显示文摘 | TALIB H H A ALI K A M | 2009 | Pakistan Journal of Nutrition2009，8，5： | 1 |
| 11 | 查看详情显示文摘 | Abu Talib A R Ali A Badie M A | | 0，，01： | 1 |
| 12 | Facile synthesis of gold nanohexagons on graphene templates in Raman spectroscopy for biosensing cancer and cancer stem cells显示文摘 | MANIKANDAN M NASSER ABDELHAMID H TALIB A | 2014 | Biosensors and Bioelectronics2014，55，： | 1 |
| 13 | Vascular smooth muscle cell apop-tosis induces interleukin-1 directed inflammation:effects of hyperlipi-demia mediated inhibition of phagocytosis显示文摘 | Clarke M C Talib S Figg N L | 2010 | Circ Res2010，106，2： | 1 |
| 14 | Predicting web user' s behavior patterns 显示文摘 | TALIB M R HIDAYAT S U SARWAR M U | 2014 | International Journal of Comput- er Science & Mobile Computing2014，3，8： | 1 |
| 15 | Film thickness effects on calibrations of a narrowband thermochromic liquid crystal显示文摘 | ABDULLAH N TALIB A R A SAIAH H R M | 2009 | Experimental Thermal and Fluid Science2009，33，4： | 1 |
| 16 | Facile Synthesis of Gold Nanohexagons on Graphene Templates in Raman Spectroscopy for Biosensing Cancer and Cancer Stem Gells 显示文摘 | Manikandan M Abdelhamid H N Talib A | 2014 | Biosensors & Bioelectronics2014，55，5663： | 1 |
| 17 | Drift tube studies of SF3+and SF5+Ions in SF6gas显示文摘 | TALIB Z A SAPOROSCHENKO M | 1992 | International Journal of Spectrometry and Ion Processes1992，116，1： | 1 |
| 18 | Nephroprotective activity of Solanum xanthocarpum fruit extract against gentamicin-induced nephrotoxicity and renal dysfunction in experimental rodents显示文摘Objective:To evaluate nephroprotective potential of Solarium xanthocarpum(S.xanthocarpum) fruit extract(SXE) against gentamicin(GM) induced nephrotoxicity) and renal dysfunction. Methods:Twenty-four Wistar rats were divided into four groups(n=6).Control rats that received normal saline(i.p.) and 0.5%carboxymethyl cellulose(p.o.) per day lor 8 d.Nephrotoxicity was induced in rats by intraperitoneal administration of GM(100 mg/kg/d for 8 d) and were treated with SXE(200 and 400 mg/kg/d(p.o.) for 8 d).Plasma and urine urea and creatinine,kidney weight,urine output,blood urea nitrogen,renal enzymatic and non-enzymatic antioxidants and lipid peroxidation was evaluated along with histopathological investigation in various experimental groupsof rats.Results:It was observed that the GM treatment induced significant elevation(P<0.001) in plasma and urine urea,creatinine,kidney weight,blood urea nitrogen, renal lipid peroxidation along with significant decrement(P<0.001) in urine output,renal enzymatic and non-enzymatic antioxidants.SXE 200 and 400 mg/kg treatment to GM treated rats recorded significant decrement(up to P<0.001) in plasma and mine urea and creatinine, renal lipid peroxidation along with significanl increment(up to P<0.001) in renal enzymatic and non-enzvmatic antioxidants.Histological obsenatioiis of kidney tissues too correlated with the biochemical obsenatioiis.Conclusions:These finding powerfully supports that S,xanthocarpum fruit extract acts in the kidney as a potent scavenger of free radicals to prevent the toxic effects of GM both in the biochemical and histopathological parameters and thus validates its elhnomedicinal use. | Talib Hussain Ramesh K Gupta K Sweety Bavani Eswaran M Vijayakumar Chandana Venkateswara Rao | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，9： | 1 |
| 19 | Utility of intrapleural streptokinase in management of chronic empyemas显示文摘 | Talib SH Verma GR Arshad M | 2003 | J Assoc Physicians India2003，51，4： | 1 |
| 20 | Learning Process Enhancement for Robot Behavior显示文摘 | Baneamoon S M Salam R A Talib A Hj | 2007 | International Journal of intel- ligent Teehnology2007，2，3： | 1 |
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