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| 1 | Neuroinflammation and oxidative stress act in concert to promote neurodegeneration in the diabetic retina and optic nerve:galectin-3 participation显示文摘Diabetes is a lifelong disease characterized by glucose metabolic imbalance,in which low insulin levels or impaired insulin signaling lead to hyperglycemic state.Within 20 years of diabetes progression,95%of patients will have diabetic retinopathy,the leading cause of visual defects in working-age people worldwide.Although diabetes is considered a microvascular disease,recent studies have shown that neurodegeneration precedes vascular changes within the diabetic visual system,albeit its mechanisms are still under investigation.Neuroinflammation and oxidative stress are intrinsically related phenomena,since macrophage/microglia and astrocytes are the main sources of reactive oxygen species during central nervous system chronic degenerative diseases,and both pathological processes are increased in the visual system during diabetes.The present review will focus on recent findings of the contribution of oxidative stress derived from neuroinflammation in the early neurodegenerative aspects of the diabetic visual system and their relationship with galectin-3. | Henrique Rocha Mendonca Raul Carpi-Santos Karin da Costa Calaza Ana Maria Blanco Martinez | 2020 | Neural Regeneration Research2020，15，4： | 16 |
| 2 | Injection of bone marrow mesenchymal stem cells by intravenous or intraperitoneal routes is a viable alternative to spinal cord injury treatment in mice显示文摘In spite of advances in surgical care and rehabilitation,the consequences of spinal cord injury(SCI)ar still challenging.Several experimental therapeutic strategies have been studied in the SCI field,and recen advances have led to the development of therapies that may act on the inhibitory microenvironment.As sorted lineages of stem cells are considered a good treatment for SCI.This study investigated the effect o systemic transplantation of mesenchymal stem cells(MSCs)in a compressive SCI model.Here we presen results of the intraperitoneal route,which has not been used previously for MSC administration after comveI.WeafC57BL/6nt lmy atb spinal cord compression for 1 minute with a 30-g vascular clip.The animals were divided into five groups DMEM at 7 days after SCI),DMEM i.v.(intravenous injection of 500μL of DMEM at 7 days after SCI)The effects of MSCs transplantation in white matter sparing were analyzed by luxol fast blue staining.Th number of preserved fibers was counted in semithin sections stained with toluidine blue and the presenc of trophic factors was analyzed by immunohistochemistry.In addition,we analyzed the locomotor perfor mance with Basso Mouse Scale and Global Mobility Test.Our results showed white matter preservation and a larger number of preserved fibers in the MSC groups than in the DMEM groups.Furthermore,th MSC groups had higher levels of trophic factors(brain-derived neurotrophic factor,nerve growth factor neurotrophin-3 and neurotrophin-4)in the spinal cord and improved locomotor performance.Our result indicate that injection of MSCs by either intraperitoneal or intravenous routes results in beneficial out comes and can be elected as a choice for SCI treatment. | Bruna dos Santos Ramalho FernANDa Martins de Almeida Conrado Mendonca Sales Silmara de Lima Ana Maria Blanco Martinez | 2018 | Neural Regeneration Research2018，13，6： | 12 |
| 3 | Endoscopic stenting for inoperable malignant biliary obstruction: A systematic review and meta-analysis显示文摘AIM: To analyze through meta-analyses the benefits of two types of stents in the inoperable malignant biliary obstruction.METHODS: A systematic review of randomized clinical trials(RCT) was conducted, with the last update on March 2015, using EMBASE, CINAHL(EBSCO), MEDLINE, LILACS/CENTRAL(BVS), SCOPUS, CAPES(Brazil), and gray literature. Information of the selected studies was extracted in sight of six outcomes: primarily regarding dysfunction, complication and reintervention rates; and secondarily costs, survival, and patency time. The data about characteristics of trial participants, inclusion and exclusion criteria and types of stents were also extracted. The bias was mainly assessed through the JADAD scale. This meta-analysis was registered in the PROSPERO database by the number CRD42014015078. The analysis of the absolute risk of the outcomes was performed using the software Rev Man, by computing risk differences(RD) of dichotomous variables and mean differences(MD) of continuous variables. Data on RD and MD for each primary outcome were calculated using the MantelHaenszel test and inconsistency was qualified and reported in χ2 and the Higgins method(I2). Sensitivity analysis was performed when heterogeneity was higher than 50%, a subsequent assay was done and other findings were compiled. Student's t-test was used for the comparison of weighted arithmetic means regarding secondary outcomes.RESULTS: Initial searching identified 3660 studies; 3539 were excluded through title, repetition, and/or abstract, while 121 studies were fully assessed and were excluded mainly because they did not compare self-expanding metal stents(SEMS) and plastic stents(PS), leading to thirteen RCT selected, with 13 articles and 1133 subjects meta-analyzed. The mean age was 69.5 years old, that were affected mostly by bile duct(proximal) and pancreatic tumors(distal). The preferred SEMS diameter used was the 10 mm(30 Fr) and the preferred PS diameter used was 10 Fr. In the metaanalysis, SEMS had lower overall stent dysfunction compared to PS(21.6% vs 46.8%, P < 0.00001) and fewer re-interventions(21.6% vs 56.6%, P < 0.00001), with no difference in complications(13.7% vs 15.9%, P = 0.16). In the secondary analysis, the mean survival rate was higher in the SEMS group(182 d vs 150 d, P < 0.0001), with a higher patency period(250 d vs 124 d, P < 0.0001) and a lower cost per patient(4193.98 vs 4728.65 Euros, P < 0.0985).CONCLUSION: SEMS are associated with lower stent dysfunction, lower re-intervention rates, better survival, and higher patency time. Complications and costs showed no difference. | Leonardo Zorrón Pu Eduardo Guimaraes Hourneaux de Moura Wanderley Marques Bernardo Felipe Iankelevich Baracat Ernesto Quaresma Mendonca AndréKondo Gustavo Oliveira Luz Carlos Kiyoshi Furuya Júnior Everson Luiz de Almeida Artifon | 2015 | World Journal of Gastroenterology2015，21，47： | 10 |
| 4 | Role of pancreatography in the endoscopic management of encapsulated pancreatic collections-review and new proposed classification显示文摘Pancreatic fluids collections are local complications related to acute or chronic pancreatitis and may require intervention when symptomatic and/or complicated.Within the last decade,endoscopic management of these collections via endoscopic ultrasound-guided transmural drainage has become the gold standard treatment for encapsulated pancreatic collections with high clinical success and lower morbidity compared to traditional surgery and percutaneous drainage.Proper understanding of anatomic landmarks,including assessment of the main pancreatic duct and any associated lesions–such as disruptions and strictures-are key to achieving clinical success,reducing the need for reintervention or recurrence,especially in cases with suspected disconnected pancreatic duct syndrome.Additionally,proper review of imaging and anatomic landmarks,including collection location,are pivotal to determine type and size of pancreatic stenting as well as approach using long-term transmural indwelling plastic stents.Pancreatography to adequately assess the main pancreatic duct may be performed by two methods:Either non-invasively using magnetic resonance cholangiopancreatography or endoscopically via retrograde cholangiopancreatography.Despite the critical need to understand anatomy via pancrea tography and assess the main pancreatic duct,a standardized approach or uniform assessment strategy has not been described in the literature.Therefore,the aim of this review was to clarify the role of pancreatography in the endoscopic management of encapsulated pancreatic collections and to propose a new classification system to aid in proper assessment and endoscopic treatment. | Igor Mendonca Proença Marcos Eduardo Lera dos Santos Diogo Turiani Hourneaux de Moura Igor Braga Ribeiro Sergio Eiji Matuguma Spencer Cheng Thomas R McCarty Epifanio Silvino do Monte Junior Paulo Sakai Eduardo Guimaraes Hourneaux de Moura | 2020 | World Journal of Gastroenterology2020，26，45： | 3 |
| 5 | WONCA研究论文摘要汇编——罕见癌症患者转诊前的全科医生问诊:研究报告数据显示文摘——罕见癌症患者转诊前的全科医生问诊:研究报告数据【摘要】背景部分癌症患者在初级医疗中经历多次诊断前问诊,导致专科医生调查和诊断延后。罕见癌症患者更有可能面临这种情况,但是缺乏具体证据。目的探讨罕见癌症患者接受全科医生重复问诊的频率和预测因子。 | Mendonca SC Abel GA Lyratzopoulos G 本刊编辑部 | 2016 | 中国全科医学2016，19，12： | 2 |
| 6 | Experimental and Theoretical Analysis of an Optical Current Sensor for High Power Systems显示文摘一个磁电机光的传感器,用双照测定偏振的处理计划,在高电压线为当前的 metering 和保护应用被评估。传感器刻度和分辨率在 1550-nm 乐队用照明处于不同运作的条件被获得。获得的结果显示了经由连接在标准高力量格子安装了的光地面电线(OPGW ) 讯问如此的传感器的可行性。测定偏振的体积光当前的传感器理论上也被学习,并且就实际推广而言的错误的不同来源的效果被评估。特别地,从在一个树阶段系统的外部磁场的干扰被分析。 | A. C. S. BRIGIDA I. M. NASCIMENTO S. MENDONCA J. C. W. A. COSTA M. A. G. MARTINEZ, J. M. BAPTISTA,P. A. S. JORGE J. C. W. A. COSTA, M. A. G. MARTINEZ, J. M. BAPTISTA J. M. BAPTISTA P.A.S. JORGE | 2013 | Photonic Sensors2013，3，1： | 2 |
| 7 | Neutrophile-to-lymphocyte,lymphocyte-to-monocyte,and platelet-tolymphocyte ratios as prognostic and response biomarkers for resectable locally advanced gastric cancer显示文摘BACKGROUND Perioperative fluorouracil plus leucovorin,oxaliplatin,and docetaxel(FLOT)improves prognosis in locally advanced gastric cancer(LAGC).Neutrophil-to-lymphocyte(NLR),lymphocyte-tomonocyte(LMR),and platelet-to-lymphocyte(PLR)ratios are prognostic biomarkers but not predictive factors.AIM To assess blood ratios’(NLR,LMR and PLR)potential predictive response to FLOT and survival outcomes in resectable LAGC patients.METHODS This was a multicentric retrospective study investigating the clinical potential of NLR,LMR,and PLR in resectable LAGC patients,treated with at least one preoperative FLOT cycle,from 12 Portuguese hospitals.Means were compared through non-parametric Mann-Whitney tests.Receiver operating characteristic curve analysis defined the cut-off values as:High PLR>141 for progression and>144 for mortality;high LMR>3.56 for T stage regression(TSR).Poisson and Cox regression models the calculated relative risks/hazard ratios,using NLR,pathologic complete response,TSR,and tumor regression grade(TRG)as independent variables,and overall survival(OS)as the dependent variable.RESULTS This study included 295 patients(mean age,63.7 years;59.7% males).NLR was correlated with survival time(r=0.143,P=0.014).PLR was associated with systemic progression during FLOT(P=0.022)and mortality(P=0.013),with high PLR patients having a 2.2-times higher risk of progression[95% confidence interval(CI):0.89-5.26]and 1.5-times higher risk of mortality(95%CI:0.92-2.55).LMR was associated with TSR,and high LMR patients had a 1.4-times higher risk of achieving TSR(95%CI:1.01-1.99).OS benefit was found with TSR(P=0.015)and partial/complete TRG(P<0.001).Patients without TSR and with no evidence of pathological response had 2.1-times(95%CI:1.14-3.96)and 2.8-times(95%CI:1.6-5)higher risk of death.CONCLUSION Higher NLR is correlated with longer survival time.High LMR patients have a higher risk of decreasing T stage,whereas high PLR patients have higher odds of progressing under FLOT and dying.Patients with TSR and a pathological response have better OS and lower risk of dying. | Tiago Cruz Tomás Ines Eiriz Marina Vitorino Rodrigo Vicente Joao Gramaca Alicia Guadalupe Oliveira Paulo Luz Mafalda Baleiras Ana Sofia Spencer Luísa Leal Costa Patrícia Liu Joana Mendonca Magno Dinis Teresa Padrao Marisol Correia Goncalo Atalaia Michelle Silva Teresa Fiúza | 2022 | World Journal of Gastrointestinal Oncology2022，14，7： | 2 |
| 8 | Long-term potentiation observed upon blockade of adenosine A1 in rat hippocampus is NMDAR-dependent显示文摘 | Ribeiro JA | 2000 | Neurosci Lett2000，291，2： | 1 |
| 9 | Mesenteric venous t-hrombosis:still a lethal disease in the 1990s显示文摘 | Rhee RY Gloviczki P Mendonca CT | 1994 | J Vasc Surg1994，20，： | 1 |
| 10 | Ge- netic identification of lamniform and earcharhiniform sharks using multiplex - PCR 显示文摘 | Mendonca F F Hashimoto D T De - Franco B | 2010 | Conser- Genet Re- sour2010，2，1： | 1 |
| 11 | Bioconversion ofapple pomace into a nutritionally enriched substrate by Candida utilis andPleurotus ostreatus显示文摘 | VILLAS-BOAS S G ESPOSITO E MENDONCA M M | 2003 | World Journal of Microbiology&Biotechnology2003，19，： | 1 |
| 12 | Palm- CIS: A wireless handheld application for satisfying clinician infor- mation needs显示文摘 | Chen Elizabeth S Mendonca E A McKnight L K | 2004 | Journal of the American Medical Informatics As- sociation2004，11，1： | 1 |
| 13 | Robust Ck/C0 generalized FEM approximations for higher-order conformity requirements:Appfication to Reddy's HSDT model for anisotropic laminated plates thoery显示文摘 | Mendonca P T R Barcellos C S Torres DAF | 2013 | Compos Struct2013，，96： | 1 |
| 14 | CYP1A1, GSTM1, and GSTrl polymorphisms and breast cancer risk in Brazilian women 显示文摘 | Fonte A Rossini A Mendonca G | 2002 | Cancer2002，181，： | 1 |
| 15 | Steroid hormones affect limbic afterdischarge thresholds and kindling rates in adult female rats显示文摘 | Edwards HE Burnham WM Mendonca A | 1999 | Brain Res1999，838，12： | 1 |
| 16 | Human papillo- mavirus cervical infection: viral genotyping and risk factors for high - grade squamous intraepithelial lesion and cervix cancer 显示文摘 | de Mendonca VG Guimarges MJ de Lima Filho JL | 2010 | Rev Bras Ginecol Obstet2010，32，10： | 1 |
| 17 | Er: YAG laser, ultrasonic system, and curette produce different profiles on dentine root surfaces: an in vitro study显示文摘 | de Mendonca AC Maximo MB RodriguesJA | 2008 | Photomed Laser Surg2008，26，2： | 1 |
| 18 | Expression of VEGF and Flk-1 and Flt-1 receptors during blood-brain barrier (BBB) impairment following Phoneutria nigriventer spider venom exposure 显示文摘 | Mendonca MC Soares ES Stdvale LM | 2013 | Toxins (Basel)2013，5，12： | 1 |
| 19 | Pierre Robin Sequence显示文摘 | Noopur Gangopadhyay Derick Mendonca Albert Woo | 2012 | Seminars in Plastic Surgery2012，，02： | 1 |
| 20 | Creatine supplementation improves muscular perform- ance in older women 显示文摘 | Gotshalk LA Kraemer W J Mendonca MA | 2008 | Eur J Appl Physiol2008，102，： | 1 |
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