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| 1 | 钢筋的局部和整体粘结特性显示文摘难以建立精确的钢筋局部粘结应力-滑移关系有两个原因:一是由于钢筋被包在内部,很难用应变仪量化给定钢筋长度的应变变化从而直接测定局部应力-滑移关系。另一方面是钢筋的屈服,它一般发生在剥离之前并显著影响钢筋的性能。为了克服定量测量局部应力-滑移关系的困难,通过纤维增强聚合物包裹钢筋混凝土结构的整体荷载滑移响应来获取理论上的局部粘结应力-滑移关系,研究对钢筋嵌入长度的影响。首次提出钢筋整体荷载滑移响应与局部粘结应力-滑移关系之间的联系与钢筋嵌入长度无关。此外,采用新的理论从试验结果中得到局部粘结应力-滑移关系以及显示腐蚀对局部粘结应力-滑移关系的影响,其中,量化了引起钢筋混凝土梁中钢筋剥离腐蚀的数量。 | Matthew Haskett Deric John Oehlers1s M.S. Mohamed Ali | 2008 | 钢结构2008，23，8： | 3 |
| 2 | A systematic review of follow-up biopsies reveals disease progression in patients with non-alcoholic fatty liver显示文摘 | Raluca Pais Fréderic Charlotte Larissa Fedchuk Pierre Bedossa Pascal Lebray Thierry Poynard Vlad Ratziu | 2013 | Journal of Hepatology2013，，： | 2 |
| 3 | A systematic review of follow-up biopsies reveals disease progression in patients with non-alcoholic fatty liver<!-- Doctopic: GMD -->显示文摘 | Raluca Pais Fréderic Charlotte Larissa Fedchuk Pierre Bedossa Pascal Lebray Thierry Poynard Vlad Ratziu | 2013 | Journal of Hepatology2013，，： | 2 |
| 4 | Pathophysiology of urticaria显示文摘 | Ana Hennino Fréderic Bérard Isabelle Guillot Nathalie Saad Auore Rozières Jean-Fran?ois Nicolas | 2006 | Clinical Reviews in Allergy & Immunology2006，，1： | 1 |
| 5 | Prognostic model for predicting hearing recovery in idiopathic sudden sensorineural hearing loss显示文摘 | Cvorovic L Deric D Probst R | 2008 | Otol Neurotol2008，29，4： | 1 |
| 6 | Interseismic strain accumulation and anthropogenic mo- tion in metropolitan Los Angeles 显示文摘 | Donald F Argus Michael B Heflin Fre'deric Crampe' | 2005 | Journal of Geophysi- cal Research2005，110，04401： | 1 |
| 7 | Rosiglitazone for Nonalcoholic Steatohepatitis: One-Year Results of the Randomized Placebo-Controlled Fatty Liver Improvement With Rosiglitazone Therapy (FLIRT) Trial显示文摘 | Vlad Ratziu Philippe Giral Sophie Jacqueminet Fréderic Charlotte Agnès Hartemann–Heurtier Lawrence Serfaty Philippe Podevin Jean–Marc Lacorte Carole Bernhardt Eric Bruckert André Grimaldi Thierry Poynard | 2008 | Gastroenterology2008，，1： | 1 |
| 8 | Molecular mechanisms of tumor vascularization显示文摘 | Patrick A Sylvie L Fre deric | 2005 | Critical Reviews in Oncology/Hematology2005，54，1： | 1 |
| 9 | Influence of fibrinolitic potential reduction in ischemic brain disease development 显示文摘 | VUCKOVIC B DERIC M ZARKOV M | 2008 | Med Pregl2008，61，56： | 1 |
| 10 | DNA methylation inhibitors in cancer: Recent and future approaches显示文摘 | Christina Gros Jacques Fahy Ludovic Halby Isabelle Dufau Alexandre Erdmann Jean-Marc Gregoire Fréderic Ausseil Stéphane Vispé Paola B. Arimondo | 2012 | Biochimie2012，，11： | 1 |
| 11 | Targeting γ-secretase triggers the selective enrichment of oligomeric APP-CTFs in brain extracellular vesicles from Alzheimer cell and mouse models显示文摘Background:We recently demonstrated an endolysosomal accumulation of theβ-secretase-derived APP C-terminal fragment(CTF)C99 in brains of Alzheimer disease(AD)mouse models.Moreover,we showed that the treatment with theγ-secretase inhibitor(D6)led to further increased endolysosomal APP-CTF levels,but also revealed extracellular APP-CTF-associated immunostaining.We here hypothesized that this latter staining could reflect extracellular vesicle(EV)-associated APP-CTFs and aimed to characterize theseγ-secretase inhibitor-induced APPCTFs.Methods:EVs were purified from cell media or mouse brains from vehicle-or D6-treated C99 or APPswedish expressing cells/mice and analyzed for APP-CTFs by immunoblot.Combined pharmacological,immunological and genetic approaches(presenilin invalidation and C99 dimerization mutants(GXXXG))were used to characterize vesicle-containing APP-CTFs.Subcellular APP-CTF localization was determined by immunocytochemistry.Results:Purified EVs from both AD cell or mouse models were enriched in APP-CTFs as compared to EVs from control cells/brains.Surprisingly,EVs from D6-treated cells not only displayed increased C99 and C99-derived C83 levels but also higher molecular weight(HMW)APP-CTF-immunoreactivities that were hardly detectable in whole cell extracts.Accordingly,the intracellular levels of HMW APP-CTFs were amplified by the exosomal inhibitor GW4869.By combined pharmacological,immunological and genetic approaches,we established that these HMW APP-CTFs correspond to oligomeric APP-CTFs composed of C99 and/or C83.Immunocytochemical analysis showed that monomers were localized mainly to the trans-Golgi network,whereas oligomers were confined to endosomes and lysosomes,thus providing an anatomical support for the selective recovery of HMW APP-CTFs in EVs.The D6-induced APP-CTF oligomerization and subcellular mislocalization was indeed due toγ-secretase blockade,since it similarly occurred in presenilin-deficient fibroblasts.Further,our data proposed that besides favoring APP-CTF oligomerization by preventing C99 proteolysis,γ-secretase inhibiton also led to a defective SorLA-mediated retrograde transport of HMW APP-CTFs from endosomal compartments to the TGN.Conclusions:This is the first study to demonstrate the presence of oligomeric APP-CTFs in AD mouse models,the levels of which are selectively enriched in endolysosomal compartments including exosomes and amplified byγ-secretase inhibition.Future studies should evaluate the putative contribution of these exosome-associated APP-CTFs in AD onset,progression and spreading. | Inger Lauritzen Anaïs Bécot Alexandre Bourgeois Raphaëlle Pardossi-Piquard Maria-Grazia Biferi Martine Barkats Fréderic Checler | 2019 | Translational Neurodegeneration2019，8，1： | 1 |
| 12 | Results of Two Bi-Institutional Prospective Studies Using Intraperitoneal Oxaliplatin With or Without Irinotecan During HIPEC After Cytoreductive Surgery for Colorectal Carcinomatosis显示文摘 | Fran?ois Quenet Diane Goéré Sanket Sharad Mehta Lise Roca Fréderic Dumont Mehdi Hessissen Bernard Saint-Aubert Dominique Elias | 2011 | Annals of Surgery2011，，2： | 1 |
| 13 | Noise-predictive decision-feedback detection for multiple-input multiple-output channels显示文摘 | Deric W Waters John R Barry | 2005 | IEEE Transactions on Signal Processing2005，53，5： | 1 |
| 14 | The Role of Natural Killer Cells in Sepsis显示文摘 | Laurent Chiche Jean-Marie Forel Guillemette Thomas Catherine Farnarier Fréderic Vely Mathieu Bléry Laurent Papazian Eric Vivier Lorenzo Moretta | 2011 | Journal of Biomedicine and Biotechnology2011，，： | 1 |
| 15 | Ventilatory and hemodynamic effects of continuous positive airway pressure in left heart failure显示文摘 | Florent Lenique Michel Habis Fréderic Lofaso | 1997 | Am J Respir Crit Care Med1997，155，： | 1 |
| 16 | Combinations of ketamine and atropine are neuroprotective and reduce neuroinflammation after a toxic status epilepticus in mice显示文摘 | Franck Dhote Pierre Carpentier Laure Barbier André Peinnequin Valérie Baille Fabien Pernot Guy Testylier Claire Beaup Annie Foquin Fréderic Dorandeu | 2012 | Toxicology and Applied Pharmacology2012，，2： | 1 |
| 17 | Prognostic model for predicting hearing recovery in idiopathic sudden sensorineural hearing loss显示文摘 | Cvorovic L Deric D Probst R | 2008 | Otol Neurotol2008，29，4： | 1 |
| 18 | Differential expression of the integrins α6Aβ4 and α6Bβ4 along the crypt–villus axis in the human small intestine显示文摘 | Anders Bondo Dydensborg Inga C. Teller Nuria Basora Jean-Fran?ois Groulx Jo?lle Auclair Caroline Francoeur Fabrice Escaffit Fréderic Paré Elizabeth Herring Daniel Ménard Jean-Fran?ois Beaulieu | 2009 | Histochemistry and Cell Biology2009，，4： | 1 |
| 19 | A comparison of the fibrotic potential of nonalcoholic fatty liver disease and chronic hepatitis C显示文摘 | Fréderic Charlotte Gilles Le Naour Carole Bernhardt Thierry Poynard Vlad Ratziu | 2010 | Human Pathology2010，，8： | 1 |
| 20 | Composite Beams with Limited-Slip-Capacity Shear Connectors显示文摘 | Deric John Oehlers George Sved | 1995 | Journal of Structural Engineering1995，，6： | 1 |
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