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| 1 | 肽酰基精氨酸脱亚氨酶4和中性粒细胞胞外诱捕网形成在实验性动脉粥样硬化和动脉损伤中的作用:浅表糜烂的影响显示文摘中性粒细胞可能促进人类动脉粥样硬化的血栓并发症的发生。特别是中性粒细胞胞外诱捕网(neutrophil extracellular traps,NETs)可加剧局部炎症,并放大和加剧动脉内膜损伤和血栓形成。肽酰基精氨酸脱亚氨酶4(peptidyl arginine deiminase 4,PAD4)参与NET的形成,但对该酶在动脉粥样硬化血栓形成中的作用的认识仍然不足。 | 刘青 叶鹏 Franck G Mawson TL Folco EJ Molinaro R Ruvkun V Engelbertsen D Liu X Tesmenitsky Y Shvartz F Sukhova GK Michel JB Nicoletti A Lichtman AH Wagner DD Croce KJ Libby P | 2018 | 中华高血压杂志2018，26，5： | 13 |
| 2 | Early precut sphincterotomy and the risk of endoscopic retrograde cholangiopancreatography related complications: An updated meta-analysis显示文摘AIM: To study the cannulation and complication rates of early pre-cut sphincterotomy vs persistent attempts at cannulation by standard approach.METHODS: Systematic search of PubMed, EMBASE, Web of Science, and the Cochrane Library for relevant studies published up to February 2013. The main outcome measurements were cannulation rates and postendoscopic retrograde cholangiopancreatography(ERCP) complications. A comprehensive systematic search of the Cochrane library, PubMed, Google scholar, Scopus, National Institutes of Health, meta-register of controlled trials and published proceedings from major Gastroenterology journals and meetings until February 2013 was conducted using keywords. All Prospective randomized controlled trials(RCT) studies whichmet our inclusion criteria were included in the analysis. Prospective non-randomized studies and retrospective studies were excluded from our meta-analysis. The main outcomes of interest were post-ERCP pancreatitis, overall complication rates including cholangitis, ERCPrelated bleeding, perforation and cannulation success rates. RESULTS: Seven RCTs with a total of 1039 patients were included in the meta-analysis based on selection criteria. The overall cannulation rate was 90% in the pre-cut sphincterotomy vs 86.3% in the persistent attempts group(OR = 1.98; 95%CI: 0.70-5.65). The risk of post-ERCP pancreatitis(PEP) was not different between the two groups(3.9% in the pre-cut sphincterotomy vs 6.1% in the persistent attempts group, OR = 0.58, 95%CI: 0.32-1.05). Similarly, there was no statistically significant difference between the groups for overall complication rate including PEP, cholangitis, bleeding, and perforation(6.2% vs 6.9%, OR = 0.85, 95%CI: 0.51-1.41). CONCLUSION: This meta-analysis suggests that precut sphincterotomy and persistent attempts at cannulation are comparable in terms of overall complication rates. Early pre-cut implementation does not increase PEP complications. | Udayakumar Navaneethan Rajesh Konjeti Preethi GK Venkatesh Madhusudhan R Sanaka Mansour A Parsi | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，5： | 12 |
| 3 | Clostridium difficile infection and inflammatory bowel disease:Understanding the evolving relationship显示文摘Clostridium difficile(C.difficile)infection(CDI)is the leading identifiable cause of antibiotic-associated diarrhea.While there is an alarming trend of increasing incidence and severity of CDI in the United States and Europe,superimposed CDI in patients with inflammatory bowel disease(IBD)has drawn considerable attention in the gastrointestinal community.The majority of IBD patients appear to contract CDI as outpatients.C.difficile affects disease course of IBD in several ways,including triggering disease flares,sustaining activity,and in some cases,acting as an'innocent'bystander.Despite its wide spectrum of presentations,CDI has been reported to be associated with a longer duration of hospitalization and a higher mortality in IBD patients.IBD patients with restorative proctocolectomy or with diverting ileostomy are not immune to CDI of the small bowel or ileal pouch.Whether immunomodulator or corticosteroid therapy for IBD should be continued in patients with superimposed CDI is controversial.It appears that more adverse outcomes was observed among patients treated by a combination of immunomodulators and antibiotics than those treated by antibiotics alone.The use of biologic agents does not appear to increase the risk of acquisition of CDI.For CDI in the setting of underlying IBD,vancomycin appears to be more efficacious than metronidazole.Randomized controlled trials are required to clearly define the appropriate management for CDI in patients with IBD. | Udayakumar Navaneethan Preethi GK Venkatesh Bo Shen | 2010 | World Journal of Gastroenterology2010，16，39： | 12 |
| 4 | A long-term follow-up study on hepatitis B surface antigen-positive patients undergoing allogeneic hematopoietic stem cell transplantation显示文摘 | Hui CK Lie A Au WY Leung YH Ma SY Cheung WW Zhang HY Chim CS Kwong YL Liang R Lau GK | 2006 | 中国生物学文摘2006，20，5： | 10 |
| 5 | Surgical considerations for ‘intrinsic' brainstem gliomas: proposal of a modification in classification显示文摘 | Mehta VS Chandra PS Singh PK Garg A Rath GK | 2009 | 中国神经肿瘤杂志2009，7，3： | 9 |
| 6 | 离子液体作为溶剂/催化剂用于卤代烃对胺的选择性烷基化反应显示文摘在三乙胺存在下,在离子液体([bmim]I和[bmim]PF6)中进行了各种卤代烃对胺类化合物中氨基的选择性烷基化反应.反应在相对温和的条件下进行,转化率和选择性优异.离子液体可以回收并重复使用. | Yetkin GK smail ZDEMR Engin ETNKAYA | 2007 | 催化学报2007，28，6： | 7 |
| 7 | Factors predicting adverse short-term outcomes in patients with acute cholangitis undergoing ERCP: A single center experience显示文摘AIM: To identify potential factors that can predict adverse short-term outcomes in patients with acute cholangitis undergoing endoscopic retrograde cholangiopancreatography(ERCP). METHODS: Retrospective analysis of consecutive patients admitted to our center for acute cholangitis and underwent ERCP from 2001 to 2012. Involvement of two or more organ systems was termed as organ failure(OF). Cardiovascular failure was defined based on a systolic blood pressure of < 90 mmHg despite fluid replacement and/or requiring vasopressor treatment; respiratory failure if the Pa02 /Fi02 ratio was < 300 mmHg and/or required mechanical ventilation; coagulopathy if the platelet count was < 80; and renal insufficiency if serum creatinine was > 1.9 mg/dL. Variables associated with short term adverse clinical outcomes defined as persistent OF and/or 30-d mortality was determined. RESULTS: A total of 172 patients(median age 62 years, 56.4% female) were included. The median door to ERCP time was 17 h. Bile duct stones were the most common etiology(n = 67, 39.2%). In multivariate analysis, factors that were independently associated with persistent OF and/or 30-d mortality included American Society of Anesthesiology(ASA) physical classification score > 3(OR = 7.70; 95%CI: 2.73-24.40), presence of systemic inflammatory response syndrome(OR = 3.67; 95%CI: 1.34-10.3) and door to ERCP time greater than 72 h(OR = 3.36; 95%CI: 1.12-10.20). Door to ERCP time greater than 72 h was also associated with 70% increase in the mean length of stay(P < 0.001). Every one point increase in the ASA physical classification and every 1 mg/dL increase in the preERCP bilirubin level was associated with a 34% and 2% increase in the mean length of hospital stay, respectively. Transfer status did not impact clinical outcomes. CONCLUSION: Higher ASA physical classification and delays in ERCP are associated with adverse clinical outcomes and prolonged length of hospital stay in patients with acute cholangitis undergoing ERCP. | Udayakumar Navaneethan Norma G Gutierrez Ramprasad Jegadeesan Preethi GK Venkatesh Madhusudhan R Sanaka John J Vargo Mansour A Parsi | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，3： | 7 |
| 8 | 慢性肾脏病老年患者的非透析治疗显示文摘或许今天肾脏病学者面临的最困难的临床决策是他们的老年晚期CKD患者(年龄〉70岁)是否有可能从透析治疗中受益。澳大利亚的所有透析患者中,超过65岁的患者占50%,75岁以上的患者占26%。同样,在美国年龄超过75岁的透析群增长最快,在英国增长最快的透析群则是超过65岁。不幸的是,老年透析患者的生存期通常比大多数癌症患者都要差。 | Brown MA Collett GK Josland EA 王建中 | 2015 | 中华肾病研究电子杂志2015，4，2： | 7 |
| 9 | 诊断盆腔炎症性疾病为发展一种新模式的全面的分析和…显示文摘 | James,GK 秦新裕 | 1992 | 美国医学会杂志(中文版)1992，11，4： | 6 |
| 10 | 正常高值血压者心脏迷走神经调节、氧化应激和心血管疾病危险因素的横断面研究显示文摘高血压是心血管疾病的可控危险因素之一,与氧化应激增强和心脏迷走神经调节减弱相关。同样,正常高值血压也与心血管事件的风险增加相关。该研究探索正常高值血压和心脏迷走神经调节、氧化应激及心血管危险因素之间的相关性。 | Thiyagarajan R Pal P Pal GK Subramanian SK Bobby Z Das AK Trakroo M 罗冬梅 叶鹏 | 2013 | 中华高血压杂志2013，21，9： | 5 |
| 11 | Factors that predict response of patients with hepatitis B e antigen-positive chronic hepatitis B to peginterferon-alfa显示文摘 | Buster EH Hansen BE Lau GK | | Gastroenterology0，，： | 2 |
| 12 | Clostridium difficile infection is associated with worse long term outcome in patients with ulcerative colitis显示文摘 | Udayakumar Navaneethan Saurabh Mukewar Preethi GK Venkatesh Rocio Lopez Bo Shen | 2011 | Journal of Crohn’s and Colitis2011，，3： | 2 |
| 13 | Percutaneous ureterolitholapaxy: the best bet to clear large bulk impacted upper ureteral calculi显示文摘 | Kumar V Ahlawat R Banjeree GK | 1996 | Arch Esp Urol1996，49，： | 2 |
| 14 | Peginterferon alfa-2a.lamivudine,and the combination for HBeAg-positive chronic hepatitis B显示文摘 | Lau GK Piratvisuth T Luo KX | | 0，，： | 2 |
| 15 | In vitro differentiation of embryonic stem cells显示文摘 | Keller GK | 1995 | Curr Opin Cell Biol1995，7，： | 2 |
| 16 | Deep lamellar keratoplasty on air with lyophilised tissue显示文摘 | Chau GK Dilly SA Sheard CE | 1992 | Br J Ophthalmol1992，76，11： | 2 |
| 17 | Liver regeneration显示文摘 | Michalopoulos GK DeFrances MC | | 0，，： | 2 |
| 18 | In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica显示文摘 | Shukla A Rasik AM Jain GK | 1999 | J Ethnopharmacol1999，65，： | 2 |
| 19 | A simplified method for the analysis of hydroxyproline in biological tissues 显示文摘 | Reddy GK Enwemeka CS | 1996 | Clin Biochem1996，29，3： | 1 |
| 20 | PPARa activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells显示文摘 | Marx N Sukhova GK Collins T | 1999 | Circulation1999，99，24： | 1 |
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