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| 1 | Diagnosis of pancreatic tumors by endoscopic ultrasound-guided fine-needle aspiration显示文摘AIM: To evaluate the diagnostic accuracy of endoscopic ultrasound-guided fi ne-needle aspiration (EUS-FNA) for pancreatic solid tumors larger or smaller than 3 cm, and cystic lesions. METHODS: From January/1997 to December/2006, 611 patients with pancreatic tumors were subjected to EUS-FNA. The fi nal diagnosis was obtained either by surgery (356 cases) or after a mean clinical follow-up of 11.8 mo in the remaining patients. RESULTS: There were 405 solid tumors, 189 cystic lesions and 17 mixed. Pancreatic specimens for cytological assessment were successfully obtained by EUS-FNA in 595 (97.4/) cases. There were 352 (57.6/) malignancies and 259 (42.4/) benign tumors. Among the malignancies, pancreatic adenocarcinomas accounted for 67/ of the lesions. Overall, the sensitivity, specifi city, positive and negative predictive values, and accuracy of EUS-FNA were, respectively, 78.4/, 99.2/, 99.3/, 77.2/ and 87.2/. Specif ically for solid tumors, the same parameters for neoplasms larger and smaller than 3 cm were, respectively, 78.8/ vs 82.4/, 100/ vs 98.4/, 100/ vs 99/, 54.8/ vs 74.1/ and 83.1/ vs 87.8/. For cystic lesions, the values were, respectively, 72.2/, 99.3/, 97.5/, 91/ and 92.2/. CONCLUSION: EUS-FNA can be used to sample pancreatic tumors in most patients. Even though the negative predictive value is inadequate for large solid tumors, the results are rather good for small solid tumors, especially concerning the sensitivity, negative predictive value and diagnostic accuracy. Among all pancreatic lesions, EUS-FNA for cystic lesions canreveal the best negative predictive value and diagnostic accuracy, both higher than 90/. | José Celso Ardengh César Vivian Lopes Luiz Felipe Pereira de Lima Juliano Rodrigues de Oliveira Filadélfi o Venco Giulio Cesare Santo José Luiz Pimenta Módena | 2007 | World Journal of Gastroenterology2007，13，22： | 17 |
| 2 | Ghrelin attenuates gastrointestinal epithelial damage induced by doxorubicin显示文摘AIM:To examine the influence of ghrelin on the regenerative potential of gastrointestinal(GI)epithelium.METHODS:Damage to GI epithelium was induced in mice by two intravenous injections of doxorubicin(10 and 6 mg/kg).Some of the doxorubicin-treated mice received a continuous subcutaneous infusion of ghrelin(1.25μg/h)for 10 d via implanted mini-osmotic pumps.To label dividing stem cells in the S-phase of the cell cycle,all mice received a single intraperitoneal injection of 5'-bromo-2'-deoxyuridine(BrdU)one hour before sacrifice.The stomach along with the duodenum were then removed and processed for histological examination and immunohistochemistry using anti-BrdU antibody.RESULTS:The results showed dramatic damage to the GI epithelium 3 d after administration of chemotherapy which began to recover by day 10.In ghrelintreated mice,attenuation of GI mucosal damage was evident in the tissues examined postchemotherapy.Immunohistochemical analysis showed an increase in the number of BrdUlabeled cells and an alteration in their distribution along the epithelial lining in response to damage by doxorubicin.In mice treated with both doxorubicin and ghrelin,the number of BrdUlabeled cells was reduced when compared with mice treated with doxorubicin alone.CONCLUSION:The present study suggests that ghrelin enhances the regenerative potential of the GI epithelium in doxorubicintreated mice,at least in part,by modulating cell proliferation. | Mohamed A Fahim Hazem Kataya Rkia El-Kharrag Dena AM Amer Basel al-Ramadi Sherif M Karam | 2011 | World Journal of Gastroenterology2011，17，33： | 3 |
| 3 | High surface area materials prepared from sewage sludge-based precursors显示文摘 | Ros A Lillo-Ró denas M A Fuente E | 2006 | Chemosphere2006，17，2： | 1 |
| 4 | 显示文摘 | Denae M Smit I Musil V | 2005 | Composites:Part A: Applied Sci- ence and Manufacturing2005，36，8： | 1 |
| 5 | Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity显示文摘 | Ali IU Schriml LM Dena M | 1999 | J Natl Cancer Inst1999，91，22： | 1 |
| 6 | Rosiglitazone increased heart failure but did not differ from metformin plus sulphonylurea for other CV outcomes at interim analysis 显示文摘 | Mark A Hlatky MD Dena M | 2007 | Evid Based Med2007，12，6： | 1 |
| 7 | High surface area materials prepared from sewage sludge-based precursors 显示文摘 | ROS A LILLO-RO' M A DENAS FUENTE E | 2006 | Chemosphere2006，65，： | 1 |
| 8 | A procedure for efficient bayesian reliability demonstration, presented to the operations research society of america显示文摘 | Schick G J Denas T M | 1972 | New Orleans Louisiana April1972，26，： | 1 |
| 9 | Behaviour of activated carbons with different pore size distributions and surface oxygen groups for benzene and toluene adsorption at low concentrations显示文摘 | M A Lillo-Ródenas D Cazorla-Amorós A Linares-Solano | 2005 | Carbon2005，43，： | 1 |
| 10 | In vitro approaches to assess bioavailability and human gastrointestinal mobilization of food-borne polychlorinated biphenyls (PCBs) 显示文摘 | Adeola A A Dena W M Angus J B | 2008 | J Environ Sci Heal ( Part B)2008，43，： | 1 |
| 11 | Understanding chemical reactions between carbons and NaOH and KOH: An insight into the chemical activation mechanism显示文摘 | LILLO-RóDENAS M A CAZORLA-AMORóS D LINARES-SOLANO A | 2003 | Carbon2003，41，2： | 1 |
| 12 | Using Pedometers to Increase Physical Activity and Improve Health显示文摘 | Dena M Bravata S S C Sundaram V | 2007 | Clinician’s Corner2007，11，： | 1 |
| 13 | Closed-loop sequential signal processing and open-loop batch processing approaches for GNSS re- ceiver design显示文摘 | Van Graas Soloviev F A Haag M U de Gunawar- dena S | 2009 | IEEE Journal of Selected Topics in Signal Processing2009，3，4： | 1 |
| 14 | Spherical activated carbons for low concentration toluene adsorption显示文摘 | ROMERO-ANAYA A J LILLO-RóDENAS M A LINARES-SOLANO A | 2010 | Carbon2010，48，9： | 1 |
| 15 | Modeling Dynamic Experiments on the Anaerobie Degradation of Molasses Wastewater显示文摘 | Denae M Miguel A Dunn I J | 1988 | Biotechnology and Bioengineering1988，31，1： | 1 |
| 16 | A facies model for internalites(internal wave deposits)on a gently sloping carbonate ramp(Upper Jurassic,Ricla,NE Spain)显示文摘 | Bádenas B Pomar L Aurell M | 2012 | Sedimentary Geology2012，27，： | 1 |
| 17 | Nurses' communication of prognosis and implications for hospice referral:A study of nurses caring for terminality in hospitalized patients显示文摘 | Dena S G Ruth M C Emily C | 2005 | Am J Crit Care2005，14，1： | 1 |
| 18 | Human resource management,manufacturing strategy and firm performance显示文摘 | YOUNDT M A SNELL S A DENA J W | 1996 | A- cademy of Management Journal1996，39，4： | 1 |
| 19 | Evaluation of liquid chromatography-negative ion electrospray mass spectrometry for the determination of selected resin acids in river water 显示文摘 | Dena W M Kerry M P John V H | 2002 | J of Chromatography A2002，952，： | 1 |
| 20 | The optic nerve head in glaucomatous optic neuropathy显示文摘 | Dena JD | 1997 | Arch ophthalmol1997，115，： | 1 |
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