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| 1 | Correlation of N-myc downstream-regulated gene 1 expression with clinical outcomes of colorectal cancer patients of different race/ethnicity显示文摘AIM: To evaluate the role of N-myc downstream-regulated gene 1 (NDRG1) expression in prognosis and survival of colorectal cancer patients with different ethnic backgrounds. METHODS: Because NDRG1 is a downstream target of p53 and hypoxia inducible factor-1α (HIF-1α),we examined NDRG1 expression together with p53 and HIF-1α by immunohistochemistry. A total of 157 colorectal cancer specimens including 80 from Japanese patients and 77 from US patients were examined. The correlation between protein expression with clinicopathological features and survival after surgery was analyzed.in colorectal tumor compared with normal epithelium in both Japanese and US patient groups. Expression of NDRG1 protein was significantly correlated with lymphatic invasion,venous invasion,depth of invasion,histopathological type,and Dukes' stage in Japanese colorectal cancer patients. NDRG1 expression was correlated to histopathological type,Dukes' stage and HIF-1α expression in US-Caucasian patients but not in US-African American patients. Interestingly,Kaplan-Meier survival analysis demonstrated that NDRG1 expression correlated significantly with poorer survival in US-African American patients but not in other patient groups. However,in p53-positive US cases,NDRG1 positivity correlated significantly with better survival. In addition,NDRG1 expression also correlated significantly with improved survival in US patients with stages Ⅲ and Ⅳ tumors without chemotherapy. In Japanese patients with stages Ⅱ and Ⅲ tumors,strong NDRG1 staining in p53-positive tumors correlated significantly with improved survival but negatively in patients without chemotherapy. CONCLUSION: NDRG1 expression was correlated with various clinicopathological features and clinical outcomes in colorectal cancer depending on the race/ethnicity of the patients. NDRG1 may serve as a biological basis for the disparity of clinical outcomes of colorectal cancer patients with different ethnic backgrounds. | Minori Koshiji Kensuke Kumamoto Keiichirou Morimura Yasufumi Utsumi Michiko Aizawa Masami Hoshino Shinji Ohki Seiichi Takenoshita Max Costa Thérèse Commes David Piquemal Curtis C Harris Kam-Meng Tchou-Wong | 2007 | World Journal of Gastroenterology2007，13，20： | 25 |
| 2 | 急性运动对ADHD患儿和普通儿童认知表现的影响(英文)显示文摘背景:注意力缺失过动症(attention deficit hyperactivity disorder,ADHD)是一种普通的儿童疾病,影响到大约11%的美国儿童。已有研究支持一段时间的运动有益于儿童的认知表现,数量有限的研究已证明这种影响对ADHD患儿也有效。本研究旨在探讨急性运动对ADHD患儿和普通儿童认知表现的影响。方法:让ADHD患儿和普通儿童接受为期2天、顺序平衡随机的治疗,其中一天为30 min对照状态,另一天为中等强度运动。治疗后对受试者进行认知测试。结果:运动使受试者在斯特鲁测试(Stroop Test)3种情况下的表现均有显著提高,但对伦敦塔测试(Tower of London Test)和连线测试(Trail Making Test)表现影响不大。结论:一段时间的运动能改善ADHD患儿和正常儿童的处理速度和抑制控制,但对其计划和定势转换能力没有影响。 | Aaron T.Piepmeier Chia-Hao Shih Margaret Whedon Lauren M.Williams Matthew E.Davis David A.Henning Se Yun Park Susan D.Calkins Jennifer L.Etnier | 2015 | Journal of Sport and Health Science2015，4，1： | 3 |
| 3 | 治疗选择偏倚的存在与观察性研究分析:使用倾向积分法和工具变量法评价心脏介入治疗对AMI存活的影响显示文摘背景:对观察性研究中治疗与未治疗患者的结果进行比较时,由于患者预后存在组间差异,因此可发生偏倚,后者常常是因为存在未予观察的治疗选择偏倚。
目的:对下列4种去除观察性研究选择偏倚的分析方法进行比较:多变量模型危险校正法(muhivariable model risk adjustment)、倾向积分危险校正法(propensity score risk adjustment)、倾向匹配法(propensity—based matching)以及工具变量分析法(instrumental variable analysis)。
设计、地点及患者:122124例因急性心肌梗死(AMI)而于1994~1995年住院的、接受医疗保险的老年(年龄65~84岁)患者全国队列。这些患者适合心脏导管检查。基线图表审查取自心血管协作项目并与医疗保险健康管理数据联合以便提供系列预后变量。患者随访7年(至2001年12月31日)以便评估长期存活与住院30天内心脏导管检查两者的关系。
主要观测指标:使用各种分析方法获得的危险校正后相对死亡率。
结果:与未接受心导管检查的患者相比,接受心导管检检查的患者较年轻而且急性心肌梗死的严重度较低。采用标准的统计学危险校正法校正预后因素后,心导管检查与死亡率相对下降50%相关(多变量模型危险矫正法:校正后相对危险度[relative risk,RR],〉0.51;95%可信区间[confidence interval,CI],0.50~0.52。倾向积分危险校正法:校正后RR,0.54;95%CI,0.53~0.55]。倾向配对法:校正后RR,0.54;95%CI,0.52~0.56)。使用局部插管作为一种工具,工具变量分析显示死亡率相对下降16%(校正后RR,0.84;95%CI,0.79~0.90)。随机临床试验中常规介入治疗的生存获益在8%和21%之间。
结论:心导管检查与急性心肌梗死长期死亡率的关系对分析方法高度敏感。对于去除未测量的治疗选择偏倚而言,各种标准危险校正方法具有同样的局限。与标准建模法比较,工具变量分析法可以减少治疗效果偏倚。但是相对于特殊的临床问题,该法更适合回答政策策略问题。 | Thérèse A. Stukel Elliott S. Fisher David E. Wennberg 李呈亿(译) | 2007 | 美国医学会杂志(中文版)2007，26，6： | 2 |
| 4 | In vitro and pharmacophore insingts into CYP3A enzymes显示文摘 | David SE | 2003 | Phannacecological Sciences2003，24，3： | 1 |
| 5 | A survey of spinal and epidural techniques in adult cardiac surgery 显示文摘 | Sheldon G David D Se Jun K | 2001 | J Cardiothorac Vasc Anesth2001，15，2： | 1 |
| 6 | What Is communi- ty-associated methicillin-resistant Staphylococcus aureus显示文摘 | David MZ Glikman D Crawford SE | 2008 | In- feet Dis2008，197，12： | 1 |
| 7 | Predictors of Serological Cure and Serofast State After Treatment in HIV-Negative Persons With Earl Syphilis 显示文摘 | Se a Arlene C Wolff Mark Martin David H | 2011 | Clinical Infectious Diseases2011，53，11： | 1 |
| 8 | Understanding atomic structures of amorphous C-doped Ge 2 Sb 2 Te 5 phase-change memory materials显示文摘 | Konstantin B. Borisenko Yixin Chen David J.H. Cockayne Se Ahn Song Hong Sik Jeong | 2011 | Acta Materialia2011，，11： | 1 |
| 9 | effect of exercise training on pulmonary function in children with thermal injury 显示文摘 | Oscar SE Robert MP David HN | 2002 | J Bum Care Rehabil Clin N Am2002，23，： | 1 |
| 10 | Chlamydia antibodies, chlamydia heat shock protein, and adverse Sequelae after pelvic inflammatory disease: the PID evaluation and clinical health (PEACH) study 显示文摘 | Roberta NB David SE Holly RE | 2008 | Sexually Transmitted Diseases2008，35，： | 1 |
| 11 | Enteral glutamine infusion modulates ubiquitination of heat shock proteins, Grp-75 and Apg-2, in the human duodenal mucosa显示文摘 | Julien Bertrand Alexis Goichon Philippe Chan Saida Azhar Stéphane Lecleire Nathalie Donnadieu David Vaudry Anne-Fran?oise Cailleux Pierre Déchelotte Mo?se Co?ffier | 2014 | Amino Acids2014，，4： | 1 |
| 12 | Necrotizing enterocolitis and hypothyroidism in a newborn infant:treatment with intravenous L-thyroxine显示文摘 | Amer T David R Oberfield SE | | 0，，01： | 1 |
| 13 | Activity of Pemetrexed (ALIMTA?, Multitargeted Antifolate, LY231514) in Metastatic Breast Cancer Patients Previously Treated with an Anthracycline and a Taxane: An Interim Analysis显示文摘 | Marc Spielmann Miguel Martin Mo?se Namer Andreas duBois Clemens Unger David J. Dodwell | 2001 | Clinical Breast Cancer2001，，1： | 1 |
| 14 | Expression of Guanylin Is Downregulated in Mouse and Human Intestinal Adenomas显示文摘 | Kris A Steinbrecher Thérèse M.F Tuohy Kathleen Heppner Goss M.Catherine Scott David P Witte Joanna Groden Mitchell B Cohen | 2000 | Biochemical and Biophysical Research Communications2000，，1： | 1 |
| 15 | Result of a phase I trial of concurrent chemotherapy and escalating doses of radiation for unpresectable non-small-cell lung cancer显示文摘 | Schild SE McGinnis WL David Graham | 2006 | Int J Radiat Oncol Biol Phys2006，65，4： | 1 |
| 16 | A survey of spinal and epidural techniques in adult cardiac surgery显示文摘 | Sheldon G David D Se Jun K | 2001 | J Cardiothorac Vasc Anesth2001，15，2： | 1 |
| 17 | What is community-associated methicillin-resistant Staphylococcus aureus显示文摘 | MZ David D Glikman SE Crawford | 2008 | The Journal of Infectious Diseases2008，70，9： | 1 |
| 18 | Complications associated with internal fixation of high-energy bicondlar tibial plateau fractures utilizing a two-incision technique显示文摘 | David PB Nork SE Mills WJ | 2004 | J Orthop Trauma2004，18，10： | 1 |
| 19 | The Absence of a Mucosal Lesion on Standard Histological Examination Does Not Exclude Diagnosis of Celiac Disease显示文摘 | Bashir M. Mohamed Conleth Feighery Christian Coates Una O’Shea David Delaney Seán O’Briain Jacinta Kelly Mohamed Abuzakouk | 2008 | Digestive Diseases and Sciences2008，，1： | 1 |
| 20 | No association between functional catechol-O-methyltransferase 1947A》G polymorphism and smoking initiation,persistent smoking or smoking cessation显示文摘 | David SP Johnstone E Griffiths SE | 2002 | Pharmacogenetics2002，12，3： | 1 |
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