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| 1 | The promise of γδ T cells and the γδ T cell receptor for cancer immunotherapy显示文摘γ δT 房间对感染和恶意的转变形成适应有免疫力的回答的重要部分。人的 γ 的分子的目标; δ大部分未知,却最近的 T 房间受体(TCR ) 遗体学习证实了 phosphorylated prenyl 代谢物的识别,在有 CD1 分子和细胞的应力的标记的建筑群的类脂化合物。所有这些分子是各种各样的癌症类型上的 upregulated,强调 γ 的潜在的重要性; δ在癌症 immunosurveillance 的 T 房间分隔空间并且为 γ 的使用铺平道路; δ在癌症治疗的 TCR。由 γ 的 Ligand 识别; δTCR 经常在 T 房间和目标 cells; 上要求 accessory/co-stimulatory 压力分子;这细胞的压力上下文因此提供一对有害自我反应保证不失灵。不同 α βT 房间, γ δ不管 HLA haplotype, T 房间认出他们的目标因此出现使可能性激动为现成,平底锅人口癌症免疫疗法。这里,我们在场人的 γ 的已知的 ligands 的评论; δT 房间并且讨论为癌症治疗利用这些房间的诺言。 | Mateusz Legut David K Cole Andrew K Sewell | 2015 | Cellular & Molecular Immunology2015，12，6： | 9 |
| 2 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 3 | CD8:Adhesion Molecule,Co-Receptor and Immuno-Modulator显示文摘CD8 is a cell surface glycoprotein found in cytotoxic T lymphocytes, which are important components in cellular immunity, esp. In the immune response to cancer and chronic infections. There are two forms of CD8,either as an αα homodimer or αβ heterodimer. It acts as an 'assistant' or co-receptor in the function of cytotoxic T cells where specific immunity is mediated by interaction of specific T cell receptor (αβTCR) and its ligand peptide major histocompatibility complex (pMHC). CD8 also binds to pMHC but away from the interface of pMHC and TCR contact, thereof no influence on the specificity of this interaction. If the TCR and CD8 bind to the same pMHC at the same time, CD8 is defined as a co-receptor, functioning through its signalling via its cytoplasmic tyrosine phosphorylation pathway; if CD8 binds to pMHC independently of the TCR, it is defined as an adhesion molecule. At present, the co-receptor function theory is dominated in the field.Recent study has also shown that murine CD8αα binds to TL antigen, an MHC homologue, therefore acts as an immuno-modulator. In this review, we discuss these current understandings of the three aspects of the CD8 functions and their structural basis. | David K Cole George F Gao | 2004 | Cellular & Molecular Immunology2004，1，2： | 4 |
| 4 | Ultrathin tunable terahertz absorber based on MEMS-driven metamaterial显示文摘The realization of high-performance tunable absorbers for terahertz frequencies is crucial for advancing applications such as single-pixel imaging and spectroscopy.Based on the strong position sensitivity of metamaterials’electromagnetic response,we combine meta-atoms that support strongly localized modes with suspended flat membranes that can be driven electrostatically.This design maximizes the tunability range for small mechanical displacements of the membranes.We employ a micro-electromechanical system technology and successfully fabricate the devices.Our prototype devices are among the best-performing tunable THz absorbers demonstrated to date,with an ultrathin device thickness(~1/50 of the working wavelength),absorption varying between 60%and 80%in the initial state when the membranes remain suspended,and fast switching speed(~27μs).The absorption is tuned by an applied voltage,with the most marked results achieved when the structure reaches the snap-down state.In this case,the resonance shifts by >200% of the linewidth(14% of the initial resonance frequency),and the absolute absorption modulation measured at the initial resonance can reach 65%.The demonstrated approach can be further optimized and extended to benefit numerous applications in THz technology. | Mingkai Liu Mohamad Susli Dilusha Silva Gino Putrino Hemendra Kala Shuting Fan Michael Cole Lorenzo Faraone Vincent P.Wallace Willie J.Padilla David A.Powell Ilya V.Shadrivov Mariusz Martyniuk | 2017 | Microsystems & Nanoengineering2017，3，1： | 2 |
| 5 | 微粒对多晶冰流变行为的影响——(Ⅱ)滞弹性行为显示文摘用反相直接加载的方法研究了微粒对多晶冰滞弹性的影响.结果表明:在较高频率时(1Hz和10-1Hz),滞弹性应变与应力峰值呈线性关系;在较低频率时(10-2Hz),其应力/应变偏离线性关系.微粒在高频时(1Hz)通过阻碍晶界滑移对晶界弛豫产生重要影响,增加了模量和降低了内耗.但微粒对低频时的位错弛豫没有明显的影响.通过滞弹性实验计算了非线性弛豫模型的两个重要参数,计算表明K值约为0.07Pa,α值约为0.54. | 宋旼 David M Cole Ian Baker | 2007 | 地球物理学报2007，50，4： | 2 |
| 6 | Theoretical and Experimental Investigation of Driver Noncooperative-Game Steering Control Behavior显示文摘This paper investigates two noncooperative-game strategies which may be used to represent a human driver's steering control behavior in response to vehicle automated steering intervention.The first strategy,namely the Nash strategy is derived based on the assumption that a Nash equilibrium is reached in a noncooperative game of vehicle path-following control involving a driver and a vehicle automated steering controller.The second one,namely the Stackelberg strategy is derived based on the assumption that a Stackelberg equilibrium is reached in a similar context.A simulation study is performed to study the differences between the two proposed noncooperativegame strategies.An experiment using a fixed-base driving simulator is carried out to measure six test drivers'steering behavior in response to vehicle automated steering intervention.The Nash strategy is then fitted to measured driver steering wheel angles following a model identification procedure.Control weight parameters involved in the Nash strategy are identified.It is found that the proposed Nash strategy with the identified control weights is capable of representing the trend of measured driver steering behavior and vehicle lateral responses.It is also found that the proposed Nash strategy is superior to the classic driver steering control strategy which has widely been used for modeling driver steering control over the past.A discussion on improving automated steering control using the gained knowledge of driver noncooperative-game steering control behavior was made. | Xiaoxiang Na David Cole | 2021 | IEEE/CAA Journal of Automatica Sinica2021，8，1： | 2 |
| 7 | Functional and pathological roles of the 12- and 15-lipoxygenases显示文摘 | Anca D. Dobrian David C. Lieb Banumathi K. Cole David A. Taylor-Fishwick Swarup K. Chakrabarti Jerry L. Nadler | 2010 | Progress in Lipid Research2010，，1： | 1 |
| 8 | Characterisation of a Zeta Class Glutathione Transferase from Arabidopsis thaliana with a Putative Role in Tyrosine Catabolism显示文摘 | David P Dixon David J Cole Robert Edwards | 2000 | Archives of Biochemistry and Biophysics2000，，2： | 1 |
| 9 | Electrochemical studies of group 3 alkyl derivatives: part 1 synthesis of trimethyl gallium adducts显示文摘 | Anthony Jones David Cole | 1983 | Journal of chemical industry1983，56，2： | 1 |
| 10 | Expression of the aryl hydrocarbon receptor is not required for the proliferation, migration, invasion, or estrogen‐dependent tumorigenesis of MCF‐7 breast cancer cells显示文摘 | Barbara C. Spink James A. Bennett Nicole Lostritto Jacquelyn R. Cole David C. Spink | 2013 | Mol. Carcinog2013，，7： | 1 |
| 11 | I Don' t Think So: Pinker on the Mentalese Monopoly显示文摘 | Cole David | 1999 | Philosophical Psychology (0951 - 5089)1999，12，3： | 1 |
| 12 | Purification and characterization of bovine liver β-glucuronidase显示文摘 | Brayce V Plapp R David Cole | 1966 | Archives of Biochemistry and Biophysics1966，116，： | 1 |
| 13 | P4显示文摘 | Pat Bosshart Dan Daly Glen Gibb Martin Izzard Nick McKeown Jennifer Rexford Cole Schlesinger Dan Talayco Amin Vahdat George Varghese David Walker | 2014 | ACM SIGCOMM Computer Communication Review2014，，： | 1 |
| 14 | Cancer theranostics ; the rise of targeted magnetic nanoparticles 显示文摘 | Cole AI Yang VC David AE | 2011 | Trends Biotechnol2011，29，7： | 1 |
| 15 | The impact of the Internet on information seeking in the Media1显示文摘 | David Nicholas Peter Williams Peter Cole Helen Martin | 2000 | Aslib Proceedings2000，，3： | 1 |
| 16 | Diabetic Peripheral Neuropathic Pain: Clinical and Quality-of-Life Issues显示文摘 | Charles E. Argoff B. Eliot Cole David A. Fishbain Gordon A. Irving | 2006 | Mayo Clinic Proceedings2006，，4： | 1 |
| 17 | Waist-to-Hip Ratio, but Not Body Mass Index, is Associated with an Increased Risk of Barrett’s Esophagus in White Men显示文摘 | Jennifer R. Kramer Lori A. Fischbach Peter Richardson Abeer Alsarraj Stephanie Fitzgerald Yasser Shaib Neena S. Abraham Maria Velez Rhonda Cole Bhupinderjit Anand Gordana Verstovsek Massimo Rugge Paola Parente David Y. Graham Hashem B. El-Serag | 2012 | Clinical Gastroenterology and Hepatology2012，，： | 1 |
| 18 | Genome-wide Map of Nucleosome Acetylation and Methylation in Yeast显示文摘 | Dmitry K. Pokholok Christopher T. Harbison Stuart Levine Megan Cole Nancy M. Hannett Tong Ihn Lee George W. Bell Kimberly Walker P. Alex Rolfe Elizabeth Herbolsheimer Julia Zeitlinger Fran Lewitter David K. Gifford Richard A. Young | 2005 | Cell2005，，4： | 1 |
| 19 | Solubilisation of zinc compounds by fungi associated with the hyperaccumulator Thlaspi caerulescens显示文摘 | COLES K E DAVID J C FISHER P J | 2001 | Botanical Journal of Scotland2001，51，2： | 1 |
| 20 | Effects of vehicle suspension design on dynamics of high- way bridges 显示文摘 | Mark F Green David Cebon David J Cole | 1995 | Journal of Structural Engineering1995，121，2： | 1 |
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