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| 1 | Norepinephrine:the next therapeutics frontier for Parkinson’s disease显示文摘Tissue concentrations of norepinephrine(NE)are markedly decreased in various regions of the Parkinson’s disease(PD)brain.As in the substantia nigra pars compacta,neuronal dropout and Lewy bodies are prominent changes affecting the locus coeruleus,which is the source of ascending NErgic projections.Despite the major roles of NE throughout the brain,there has been only minimal exploration of pharmacological intervention with NErgic neurotransmission.Cognitive operations,“freezing”of gait,tremor,dyskinesia,REM sleep regulation,and other aspects of brain function are tied into signaling by NE,and there is also evidence that it may have a role in the neurodegenerative process itself.This article reviews the reported pharmacological experience in PD therapeutics. | Peter A LeWitt | 2012 | Translational Neurodegeneration2012，1，1： | 3 |
| 2 | New options for treatment of Parkinson's disease显示文摘 | | 1997 | Baillie res Clin Neurol1997，6，1： | 1 |
| 3 | 2006a, Phytohemagglutinin-induced skin swelling in birds: histological support for a classic immunoecologi- cal technique显示文摘 | Martin LB Han P Lewittes J | 2006 | Functional Ecology2006，20，2： | 1 |
| 4 | Factors regulationg the rat inslin-like growth factor-binding protem-1 respons to octreotide显示文摘 | Lewitt M S Cameron-Smith D Clarke N M | 1998 | J Endocrinol1998，158，1： | 1 |
| 5 | Levodopa therapeutics:New treatment strategies显示文摘 | | 1993 | Neurol- ogy1993，43，6： | 1 |
| 6 | Advanced Parkinson disease treated with rotigotine transdermal system: PREFER Study显示文摘 | Lewitt PA Lyons KE Pahwa R | 2007 | Neurology2007，68，16： | 1 |
| 7 | Tissue inhibitors of matrix metalloproteinases are elevated in cerebrospinal fluid of neurodegenerative disease显示文摘 | Lorenzl S Albers DS LeWitt PA | 2003 | J Neurol Sci2003，20，7： | 1 |
| 8 | Time-dependent effects of levodopa on regional brain dopamine metabolism and lipid peroxidation显示文摘 | LeWitt PA Juneau PL | 1999 | Brain Res Bull1999，47，： | 1 |
| 9 | Treatment of patients with early and advanced Parkinson's disease with rotigotine transdermal system:age-relationship to safety and tolerability显示文摘 | Oertel W LeWitt P Giladi N | 2013 | Parkinsonism Relat Disord2013，19，： | 1 |
| 10 | Efficient 3D grids for image reconstruc tion-using sphe rically-symmetric volume elements显示文摘 | Lewitt RM | 1996 | IEEE Trans Nucl Sci1996，42，： | 1 |
| 11 | Assesment of genetic and nongenetic influences on pulmonary function显示文摘 | Pedline SPV Tishler RI Lewitter IB | 1987 | Am Rev Respir Dis1987，135，： | 1 |
| 12 | Reconstruction algorithms: Transform methods 显示文摘 | Lewitt RM | 1983 | Proe IEEE1983，71，3： | 1 |
| 13 | Image-reconstruction from projections 3: Projection completion methods (theory)显示文摘 | Lewitt R Bates R | 1978 | Optik1978，50，3： | 1 |
| 14 | Practical considerations for 3-D image reconstruction u sing spherically symmetric volume elements显示文摘 | Lewitt RM | 1996 | IEEE Trans Med Imaging1996，15，： | 1 |
| 15 | Urate as a predictor of the rate of clinical decline in Parkinson disease显示文摘 | Ascherio A Lewitt P A Xu K | 2009 | Arch Neurol2009，66，12： | 1 |
| 16 | Image reconstruction from projections( Ⅲ ): Projection completion methods显示文摘 | Lewitt R M Bates R H | 1978 | Optik1978，50，： | 1 |
| 17 | Complex formation by human insulin-like growth factor-binding protein-3 and human acid-labile subunit in growth hormone-deficient rats显示文摘 | Lewitt M S Sanders H | 1994 | Endocrinology1994，134，： | 1 |
| 18 | Radiometric levitation of micronsized spheres 显示文摘 | Lewittes M Arnold S | 1982 | Applied Physics Letters1982，40，6： | 1 |
| 19 | Processing of incomplete measurement data in computed tomography显示文摘 | Lewitt RM | | 0，，05： | 1 |
| 20 | TCI-D46 as a neuroprotective drug in Parkinson' s disease: a double-blind, randomised, controlled thai 显示文摘 | Olanow CW Schapira AH LeWitt PA | 2006 | Lancet Neuro12006，5，12： | 1 |
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