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| 1 | The Merits of Passive Compliant Joints in Legged Locomotion: Fast Learning, Superior Energy Efficiency and Versatile Sensing in a Quadruped Robot显示文摘有四个激活的新潮的关节和四个被动的高度顺从的膝关节的一个四足动物机器人被用来从二立场表明 underactuation 的潜力:学习运动和感觉。首先,我们显示出那:公寓上的前面的运动扎根了的(i) 能很快被学习(优化时间的分钟) ;(ii ) 模拟研究表明一种被动的膝配置与活跃的膝比机器人的变体导致更快、更稳定、更有效的运动;(iii ) 机器人能够学习也转步法。没有损害行为的通用性, underactuation (减少的控制器复杂性,重量,和精力消费) 的优点因此被保存。在活跃关节的减少的空间的直接优化导致没有模型的控制器的有效学习。第二,我们与电位计发现被动顺从的关节有效地在一项速度评价任务补充惯性的传感器并且超过惯性并且在一项地面察觉任务的压力传感器。被动顺从的关节上的编码器因此组成计量器连接的一台便宜、紧缩却强大的察觉到的设备位置和力量 / 转矩,和 —如果在 legged 机器人 — 比最后激活的关节更远侧地增长了它关于和地面的机器人的相互作用陈述珍贵信息。 | Matej Hoffmann Jakub Simanek | 2017 | Journal of Bionic Engineering2017，14，1： | 7 |
| 2 | Elevated pro-inflammatory and lipotoxic mucosal lipids characterise irritable bowel syndrome显示文摘AIM:To investigate the pathophysiology of irritable bowel syndrome(IBS)by comparing the global mucosal metabolic profiles of IBS patients with those of healthy controls.METHODS:Fifteen IBS patients fulfilling the Rome Ⅱcriteria,and nine healthy volunteers were included in the study.A combined lipidomics(UPLC/MS)and metabolomics(GC×GC-TOF)approach was used to achieve global metabolic profiles of mucosal biopsies from the ascending colon.RESULTS:Overall,lipid levels were elevated in patients with IBS.The most significant upregulation was seen for pro-inflammatory lysophosphatidylcholines.Other lipid groups that were significantly upregulated in IBS patients were lipotoxic ceramides,glycosphingolipids,and di-and triacylglycerols.Among the metabolites,the cyclic ester 2(3H)-furanone was almost 14-fold upregulated in IBS patients compared to healthy subjects(P=0.03).CONCLUSION:IBS mucosa is characterised by a distinct pro-inflammatory and lipotoxic metabolic profile.Especially,there was an increase in several lipid species such as lysophospholipids and ceramides. | Kajsa Kajander Eveliina Myllyluoma Sinikka Kyrnpalo Martin Rasmussen Pentti Sipponen Ismo Mattila Tuulikki Seppnen-Laakso Heikki Vapaatalo Matej Orei Riitta Korpela | 2009 | World Journal of Gastroenterology2009，15，48： | 5 |
| 3 | Risk of recurrence of primary sclerosing cholangitis after liver transplantation is associated with de novo inflammatory bowel disease显示文摘AIM To evaluate risk factors for primary sclerosing cholangitis(PSC) recurrence(rPSC) after orthotopic liver transplantation(OLT) in patients with well-preserved colons. METHODS We retrospectively evaluated the medical records of all patients transplanted for PSC in our center between July 1994 and May 2015 and selected 47 with followup of at least 60 mo for further analysis based on strict inclusion and exclusion criteria. rPSC was confirmed by magnetic resonance or endoscopic retrograde cholangiopancreatography and liver biopsy. All patients were evaluated by protocolary pre-OLT colonoscopy with randomized mucosal biopsies. Colonoscopy was repeated annually after OLT. Both organ donors and recipients were human leukocyte antigen(HLA) typed by serological and/or DNA methods. All input data were thoroughly analyzed employing relevant statistical methods.RESULTS Altogether, 31 men and 16 women with a median(range) age of 36(15-68) years at the time of OLT and a median follow-up of 122(60-249) mo were included. rPSC was confirmed in 21/47(44.7%) of patients, a median 63(12-180) mo after transplantation. De novo colitis [rPSC in 11/12, P ≤ 0.05, hazard ratio(HR): 4.02, 95% confidence interval(CI): 1.58-10.98] and history of acute cellular rejection(rPSC in 14/25, P ≤ 0.05; HR: 2.66, 95%CI: 1.03-7.86) showed strong positive associations with rPSC. According to the univariate analysis, overlapping features of autoimmune hepatitis(r PSC in 5/5, P ≤ 0.05) and HLA-DRB1*07 in the donor(r PSC in 10/15, P ≤ 0.05) represent other potential risk factors for rPSC, while the HLA-DRB1*04(rPSC in 0/6, P ≤ 0.05), HLA-DQB1*03(rPSC in 1/11, P ≤ 0.05), and HLA-DQB1*07(rPSC in 0/7, P ≤ 0.05) recipient alleles may have protective roles.CONCLUSION De novo colitis and acute cellular rejection are clinical conditions significantly predisposed towards recurrence of PSC after liver transplantation. | Lukas Bajer Antonij Slavcev Peter Macinga Eva Sticova Jan Brezina Matej Roder Radim Janousek Pavel Trunecka Julius Spicak Pavel Drastich | 2018 | World Journal of Gastroenterology2018，24，43： | 4 |
| 4 | Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist显示文摘 | Sama I. Sayin Annika Wahlstr?m Jenny Felin Sirkku J?ntti Hanns-Ulrich Marschall Krister Bamberg Bo Angelin Tuulia Hy?tyl?inen Matej Ore?i? Fredrik B?ckhed | 2013 | Cell Metabolism2013，，2： | 3 |
| 5 | Novel approaches in schizophrenia-from risk factors and hypotheses to novel drug targets显示文摘Schizophrenia is a severe psychiatric disorder characterized by emotional,behavioral and cognitive disturbances, and the treatment of schizophrenia is oftencomplicated by noncompliance and pharmacoresistance. The search for thepathophysiological mechanisms underlying schizophrenia has resulted in theproposal of several hypotheses to explain the impacts of environmental, genetic,neurodevelopmental, immune and inflammatory factors on disease onset andprogression. This review discusses the newest insights into the pathophysiologyof and risk factors for schizophrenia and notes novel approaches in antipsychotictreatment and potential diagnostic and theranostic biomarkers. The currenthypotheses focusing on neuromediators (dopamine, glutamate, and serotonin),neuroinflammation, the cannabinoid hypothesis, the gut-brain axis model, andoxidative stress are summarized. Key genetic features, including small nucleotidepolymorphisms, copy number variations, microdeletions, mutations andepigenetic changes, are highlighted. Current pharmacotherapy of schizophreniarelies mostly on dopaminergic and serotonergic antagonists/partial agonists, butnew findings in the pathophysiology of schizophrenia have allowed theexpansion of novel approaches in pharmacotherapy and the establishment ofmore reliable biomarkers. Substances with promising results in preclinical andclinical studies include lumateperone, pimavanserin, xanomeline, roluperidone,agonists of trace amine-associated receptor 1, inhibitors of glycine transporters,AMPA allosteric modulators, mGLUR2-3 agonists, D-amino acid oxidase inhibitorsand cannabidiol. The use of anti-inflammatory agents as an add-on therapy ismentioned. | MatejĽupták Danica Michaličková Zdeněk Fišar Eva Kitzlerová Jana Hroudová | 2021 | World Journal of Psychiatry2021，11，7： | 3 |
| 6 | GIS-based landslide susceptibility modeling:A comparison between fuzzy multi-criteria and machine learning algorithms显示文摘Hazards and disasters have always negative impacts on the way of life.Landslide is an overwhelming natural as well as man-made disaster that causes loss of natural resources and human properties throughout theworld.The present study aimed to assess and compare the prediction efficiency of different models in landslide susceptibility in the Kysuca river basin,Slovakia.In this regard,the fuzzy decision-making trial and evaluation laboratory combining with the analytic network process(FDEMATEL-ANP),Naïve Bayes(NB)classifier,and random forest(RF)classifier were considered.Initially,a landslide inventory map was produced with 2000 landslide and nonlandslide points by randomly dividedwith a ratio of 70%:30%for training and testing,respectively.The geospatial database for assessing the landslide susceptibility was generated with the help of 16 landslide conditioning factors by allowing for topographical,hydrological,lithological,and land cover factors.The ReliefF methodwas considered for determining the significance of selected conditioning factors and inclusion in the model building.Consequently,the landslide susceptibility maps(LSMs)were generated using the FDEMATEL-ANP,Naïve Bayes(NB)classifier,and random forest(RF)classifier models.Finally,the area under curve(AUC)and different arithmetic evaluation were used for validating and comparing the results and models.The results revealed that random forest(RF)classifier is a promising and optimum model for landslide susceptibility in the study area with a very high value of area under curve(AUC=0.954),lower value of mean absolute error(MAE=0.1238)and root mean square error(RMSE=0.2555),and higher value of Kappa index(K=0.8435)and overall accuracy(OAC=92.2%). | Sk Ajim Ali Farhana Parvin Jana Vojteková Romulus Costache Nguyen Thi Thuy Linh Quoc Bao Pham Matej Vojtek Ljubomir Gigović Ateeque Ahmad Mohammad Ali Ghorbani | 2021 | Geoscience Frontiers2021，12，2： | 3 |
| 7 | Numerical analysis and thermographic investigation of induction heating显示文摘 | Matej Kranjc Anze Zupanic Damijan Miklavcic Tomaz Jarm | 2010 | International Journal of Heat and Mass Transfer2010，，17： | 2 |
| 8 | Near-infrared spectroscopy for evaluation of global and skeletal muscle tissue oxygenation显示文摘Non-invasive clinical examination has well-recognized limitations in detecting compensated and uncompensated low flow states and their severity.This paper describes the principles of near-infrared absorption spectroscopy(NIRS)and the basis for its proposed use in heart failure/cardiogenic and septic shock to assess global and regional tissue oxygenation.The vascular occlusion test is explained.Limitations of NIRS,current controversies,and what is necessary in the future to make this technology a part of the initial and ongoing assessment of a patient are also discussed.The ultimate goal of such techniques is to prevent miss-assessment and inadequate resuscitation of patients,two major factors in the development of multisystem organ failure and death. | Hugon Mozina Matej Podbegar | 2011 | World Journal of Cardiology2011，3，12： | 2 |
| 9 | Antimony powder-modified carbon paste electrodes for electrochemical stripping determination of trace heavy metals 显示文摘 | Eva S T Lucie B Matej S | 2011 | Electrochimica Acta2011，56，2： | 1 |
| 10 | Changes in muscle tissue oxygenation during stagnant ischemia in septic patients显示文摘 | Roman Pare?nik Rajko Knezevic Gorazd Voga Matej Podbregar | 2006 | Intensive Care Medicine2006，，1： | 1 |
| 11 | Con-sistent inelastic design spectra: strength and displace显示文摘 | Tomaz Vidic Peter Fajfar and Matej Fischinger | 1994 | Earthquake Engng1994，，23： | 1 |
| 12 | Nume- rical Analysis and Thermographic Investigation of Induction Heating显示文摘 | Matej Kranjc Anze Zupanic Damijan Miklavcic | 2010 | International Journal of Heat and Mass Trans- fer2010，53，1718： | 1 |
| 13 | Higher modes in simplied inelastie seismic analysis of single column bent viaducts显示文摘 | Tatjana Isakovie Matej Fisehinger | 2006 | Earthquake Engineering & Structural Dynamics2006，35，： | 1 |
| 14 | Numerical analysis and thermographic investigation of in- duction heating 显示文摘 | Matej Kranjc Anze Zupanic Damijan Miklavcic | 2010 | International Journal of Heat and Mass Transfer2010，，53： | 1 |
| 15 | Defect detection in analog and mixed circuits by neural networks using wavelet analysis显示文摘 | Stopjakov~i V Malosek P Matej M | 2005 | IEEE Transactions on Reliability2005，54，3： | 1 |
| 16 | Metabolomic changes in fatty liver can be modified by dietary protein and calcium during energy restriction显示文摘AIM: To characterise the effect of energy restriction (ER) on liver lipid and primary metabolite profile by using metabolomic approach. We also investigated whether the effect of energy restriction can be further enhanced by modif ication of dietary protein source and calcium. METHODS: Liver metabolomic profile of lean and obese C57Bl/6J mice (n = 10/group) were compared with two groups of weight-reduced mice. ER was performed on control diet and whey protein-based high-calcium diet (whey + Ca). The metabolomicanalyses were performed using the UPLC/MS based lipidomic platform and the HPLC/MS/MS based primary metabolite platform. RESULTS: ER on both diets significantly reduced hepatic lipid accumulation and lipid droplet size, while only whey + Ca diet significantly decreased blood glucose (P < 0.001) and serum insulin (P < 0.01). In hepatic lipid species the biggest reduction was in the level of triacylglycerols and ceramides while the level of cholesterol esters was significantly increased during ER. Interestingly, diacylglycerol to phospholipid ratio, an indicator of relative amount of diabetogenic diglyceride species, was increased in the control ER group, but decreased in the whey + Ca ER group (P < 0.001, vs obese). ER on whey + Ca diet also totally reversed the obesity induced increase in the relative level of lipotoxic ceramides (P < 0.001, vs obese; P > 0.05, vs lean). These changes were accompanied with up-regulated TCA cycle and pentose phosphate pathway metabolites. CONCLUSION: ER-induced changes on hepatic metabolomic profile can be significantly affected by dietary protein source. The therapeutic potential of whey protein and calcium should be further studied. | Taru K Pilvi Tuulikki Seppnen-Laakso Helena Simolin Piet Finckenberg Anne Huotari Karl-Heinz Herzig Riitta Korpela Matej Orei Eero M Mervaala | 2008 | World Journal of Gastroenterology2008，14，28： | 1 |
| 17 | Banks and information technology: marketability vs. relationships显示文摘 | Matej Marin? | 2013 | Electronic Commerce Research2013，，1： | 1 |
| 18 | A two-stage dynamic model for visual tracking显示文摘 | Matej K Stanislav K | 2010 | IEEE Transactions on SMC Part B2010，40，6： | 1 |
| 19 | Differential role of PI3K/Akt pathway in the infarct size limitation and antiarrhythmic protection in the rat heart显示文摘 | Ravingerová T Matejíková J Neckár J | 2007 | Mol Cell Biochem2007，297，12： | 1 |
| 20 | Model-based prognostics of gear health using stochastic dynamical models 显示文摘 | Matej G Dani J Pavle B | 2010 | Mechanical Systems and Signal Processing2010，25，2： | 1 |
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