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| 1 | Minimally invasive surgery for gastric cancer: A comparison between robotic, laparoscopic and open surgery显示文摘AIM To investigate the role of minimally invasive surgery for gastric cancer and determine surgical, clinical, and oncological outcomes.METHODS This is a propensity score-matched case-control study, comparing three treatment arms: robotic gastrectomy(RG), laparoscopic gastrectomy(LG), open gastrectomy(OG). Data collection started after sharing a specific study protocol. Data were recorded through a tailored and protected web-based system. Primary outcomes: harvested lymph nodes, estimated blood loss, hospital stay, complications rate. Among the secondary outcomes, there are: operative time, R0 resections, POD of mobilization, POD of starting liquid diet and soft solid diet. The analysis includes the evaluation of type and grade of postoperative complications. Detailed information of anastomotic leakages is also provided.RESULTS The present analysis was carried out of 1026 gastrectomies. To guarantee homogenous distribution of cases, patients in the RG, LG and OG groups were 1:1:2 matched using a propensity score analysis with a caliper = 0.2. The successful matching resulted in a total sample of 604 patients(RG = 151; LG = 151; OG = 302). The three groups showed no differences in all baseline patients characteristics, type of surgery(P = 0.42) and stage of the disease(P = 0.16). Intraoperative blood loss was significantly lower in the LG(95.93 ± 119.22) and RG(117.91 ± 68.11) groups compared to the OG(127.26 ± 79.50, P = 0.002). The mean number of retrieved lymph nodes was similar between the RG(27.78 ± 11.45), LG(24.58 ± 13.56) and OG(25.82 ± 12.07) approach. A benefit in favor of the minimally invasive approaches was found in the length of hospital stay(P < 0.0001). A similar complications rate was found(P = 0.13). The leakage rate was not different(P = 0.78) between groups.CONCLUSION Laparoscopic and robotic surgery can be safely performed and proposed as possible alternative to open surgery. The main highlighted benefit is a faster postoperative functional recovery. | Amilcare Parisi Daniel Reim Felice Borghi Ninh T Nguyen Feng Qi Andrea Coratti Fabio Cianchi Maurizio Cesari Francesca Bazzocchi Orhan Alimoglu Johan Gagnière Graziano Pernazza Simone D'Imporzano Yan-Bing Zhou Juan-Santiago Azagra Olivier Facy Steven T Brower Zhi-Wei Jiang Lu Zang Arda Isik Alessandro Gemini Stefano Trastulli Alexander Novotny Alessandra Marano Tong Liu Mario Annecchiarico Benedetta Badii Giacomo Arcuri Andrea Avanzolini Metin Leblebici Denis Pezet Shou-Gen Cao Martine Goergen Shu Zhang Giorgio Palazzini Vito D'Andrea Jacopo Desiderio | 2017 | World Journal of Gastroenterology2017，23，13： | 17 |
| 2 | Mixed antagonist response and sepsis severity-dependent dysbalance of pro- and anti-inflammatory responses at the onset of postoperative sepsis显示文摘 | Alexander R. Novotny Daniel Reim Volker Assfalg Felicitas Altmayr Helmut M. Friess Klaus Emmanuel Bernhard Holzmann | 2011 | Immunobiology2011，，6： | 3 |
| 3 | Intravenous iron supplementation may be superior to observation in acute isovolemic anemia after gastrectomy for cancer显示文摘AIM:To determine whether the application of postoperative intravenous(IV)-iron for acute isovolemic anemia after gastrectomy for cancer may be effective.METHODS:Among 2078 gastric cancer patients who underwent surgery between February 2007 and August2009 at the National Cancer Center Korea,368 patients developed post-operative anemia[hemoglobin-(Hb)-level<9 g/dL]within the first postoperative week.Patients requiring transfusions were excluded.IV-iron was administered to 63 patients(iron group).Sixty patients were observed without treatment(observation group).The clinical outcomes of the groups were compared concerning clinicopathologic data,morbidity,and changes in Hb levels using Fisher’s exact test,Student’s t-test and the Z-test.RESULTS:The initial Hb level was higher in the iron group than in the observation group(7.3±1.0 g/dL vs8.4±0.5 g/dL,P<0.001).The slope of the changes in the Hb level was significantly higher in the iron group than in the observation group(0.648±0.054 vs 0.349±0.038,P<0.001).The Hb level 1 and 3 mo postoperatively increased from 10.7±1.3 to 11.9±1.3g/dL in the iron group(P=0.033)and from 10.1±1.0to 10.8±1.4 g/dL in the observation group(P<0.001).The postoperative hospital stay was significantly longer in the iron group than in the observation group(10.5±6.8 d vs 7.6±5.5 d,P=0.011).There were no significant differences in the major and surgical complications between the groups(6.3%vs 13.3%,P=0.192;9.5%vs 3.3%,P=0.164).CONCLUSION:IV-iron supplementation may be an effective treatment for post-operative isovolemic postgastrectomy anemia and may be a better alternative than observation. | Hong Man Yoon Young-Woo Kim Byung Ho Nam Daniel Reim Bang Wool Eom Ji Yeon Park Keun Won Ryu | 2014 | World Journal of Gastroenterology2014，20，7： | 2 |
| 4 | Agonistic Autoantibodies as Vasodilators in Orthostatic Hypotension: A New Mechanism显示文摘 | Hongliang Li David C. Kem Sean Reim Muneer Khan Megan Vanderlinde-Wood Caitlin Zillner Daniel Collier Campbell Liles Michael A. Hill Madeleine W. Cunningham Christopher E. Aston Xichun Yu | 2012 | 2012 (2 Su)2012，，2： | 1 |
| 5 | Adenocarcinomas of the Esophagogastric Junction Are More Likely to Respond to Preoperative Chemotherapy than Distal Gastric Cancer显示文摘 | Daniel Reim Ralf Gertler Alexander Novotny Karen Becker Christian Büschenfelde Matthias Ebert Martin Dobritz Rupert Langer Heinz Hoefler Helmut Friess Christoph Schumacher | 2012 | Annals of Surgical Oncology2012，，7： | 1 |
| 6 | Agonistic Autoantibodies as Vasodilators in Orthostatic Hypotension: A New Mechanism显示文摘 | Hongliang Li David C. Kem Sean Reim Muneer Khan Megan Vanderlinde-Wood Caitlin Zillner Daniel Collier Campbell Liles Michael A. Hill Madeleine W. Cunningham Christopher E. Aston Xichun Yu | 2012 | Hypertension . 2012 (2 Su)2012，，2： | 1 |
| 7 | Improved survival after adding dissection of the superior mesenteric vein lymph node (14v) to standard D2 gastrectomy for advanced distal gastric cancer显示文摘 | Bang Wool Eom Jungnam Joo Young-Woo Kim Daniel Reim Ji Yeon Park Hong Man Yoon Keun Won Ryu Jong Yeul Lee Myeong-Cherl Kook | 2013 | Surgery2013，，： | 1 |
| 8 | Proposal for a Multifactorial Prognostic Score That Accurately Classifies 3 Groups of Gastric Carcinoma Patients With Different Outcomes After Neoadjuvant Chemotherapy and Surgery显示文摘 | Karen Becker Daniel Reim Alexander Novotny Christian Meyer zum Büschenfelde Jutta Engel Helmut Friess Heinz H?fler Rupert Langer | 2012 | Annals of Surgery2012，，6： | 1 |
| 9 | Synchronous adenocarcinoma of the lung and neuroendocrine carcinoma of the ileum显示文摘 | Daniel Reim Gregor Weirich Bruno Neu Monther Bajbouj Bj?rn L. D. M. Brücher | 2008 | International Journal of Colorectal Disease2008，，3： | 1 |
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